메뉴 건너뛰기




Volumn 48, Issue 12, 1999, Pages 2454-2462

Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; APOPTOSIS; ARTICLE; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; MOUSE; NEURAL TUBE DEFECT; NEUROEPITHELIUM; NONHUMAN; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0033513480     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.12.2454     Document Type: Article
Times cited : (180)

References (71)
  • 4
    • 0024386521 scopus 로고
    • Early pregnancy glycosylated hemoglobin, severity of diabetes, and fetal malformations
    • Lucas MJ, Leveno KJ, Williams L, Raskin P, Whalley PJ: Early pregnancy glycosylated hemoglobin, severity of diabetes, and fetal malformations. Am J Obstet Gynecol 161:426-431, 1989
    • (1989) Am J Obstet Gynecol , vol.161 , pp. 426-431
    • Lucas, M.J.1    Leveno, K.J.2    Williams, L.3    Raskin, P.4    Whalley, P.J.5
  • 5
    • 0024351588 scopus 로고
    • Significant decrease in congenital malformations in newborn infants of an unselected population of diabetic women
    • Damm P, Molsted-Pedersen L: Significant decrease in congenital malformations in newborn infants of an unselected population of diabetic women. Am J Obstet Gynecol 161:1163-1167, 1989
    • (1989) Am J Obstet Gynecol , vol.161 , pp. 1163-1167
    • Damm, P.1    Molsted-Pedersen, L.2
  • 7
    • 0025017481 scopus 로고
    • Diabetes mellitus during pregnancy and the risks for the specific birth defects: A population-based case-control study
    • Becerra JE, Khoury MJ, Cordero JF, Erickson JD: Diabetes mellitus during pregnancy and the risks for the specific birth defects: a population-based case-control study. Pediatrics 85:1-9, 1990
    • (1990) Pediatrics , vol.85 , pp. 1-9
    • Becerra, J.E.1    Khoury, M.J.2    Cordero, J.F.3    Erickson, J.D.4
  • 8
    • 0030745392 scopus 로고    scopus 로고
    • Prospective population based survey of outcome of pregnancy in diabetic women: Results of the Northern Diabetic Pregnancy Audit, 1994
    • Hawthorne G, Robson S, Ryall EA, Sen D, Roberts SH, Ward Platt MP: Prospective population based survey of outcome of pregnancy in diabetic women: results of the Northern Diabetic Pregnancy Audit, 1994. BMJ 315:279-281, 1997
    • (1997) BMJ , vol.315 , pp. 279-281
    • Hawthorne, G.1    Robson, S.2    Ryall, E.A.3    Sen, D.4    Roberts, S.H.5    Ward Platt, M.P.6
  • 10
    • 0030994305 scopus 로고    scopus 로고
    • Neural tube defects in embryos of diabetic mice: Role of the Pax-3 gene and apoptosis
    • Phelan SA, Ito M, Loeken MR: Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis. Diabetes 46:1189-1197, 1997
    • (1997) Diabetes , vol.46 , pp. 1189-1197
    • Phelan, S.A.1    Ito, M.2    Loeken, M.R.3
  • 11
    • 0031671230 scopus 로고    scopus 로고
    • Identification of Dep-1, a new gene that is regulated by the transcription factor, Pax-3, as a marker for altered embryonic gene expression during diabetic pregnancy
    • Cai J, Phelan SA, Hill AL, Loeken MR: Identification of Dep-1, a new gene that is regulated by the transcription factor, Pax-3, as a marker for altered embryonic gene expression during diabetic pregnancy. Diabetes 47:1803-1805, 1998
    • (1998) Diabetes , vol.47 , pp. 1803-1805
    • Cai, J.1    Phelan, S.A.2    Hill, A.L.3    Loeken, M.R.4
  • 12
    • 0031805136 scopus 로고    scopus 로고
    • Reduced expression of Pax-3 is associated with overexpression of cdc46 in the mouse embryo
    • Hill AL, Phelan SA, Loeken MR: Reduced expression of Pax-3 is associated with overexpression of cdc46 in the mouse embryo. Dev Genes Evol 208:128-134, 1998
    • (1998) Dev Genes Evol , vol.208 , pp. 128-134
    • Hill, A.L.1    Phelan, S.A.2    Loeken, M.R.3
  • 14
    • 0027393598 scopus 로고
    • A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant
    • Epstein DJ, Vogan KJ, Trasler DG, Gros P: A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant. Proc Natl Acad Sci U S A 90:532-536, 1993
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 532-536
    • Epstein, D.J.1    Vogan, K.J.2    Trasler, D.G.3    Gros, P.4
  • 15
    • 0025925068 scopus 로고
    • Splotch (Sp-2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3
    • Epstein DJ, Vekemans M, Gros P: Splotch (Sp-2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell 67:767-774, 1991
    • (1991) Cell , vol.67 , pp. 767-774
    • Epstein, D.J.1    Vekemans, M.2    Gros, P.3
  • 16
    • 0027338132 scopus 로고
    • The Splotch-Delayed (Sp-d) mouse mutant carries a point mutation within the paired box of the Pax-3 gene
    • Vogan KJ, Epstein DJ, Trasler DG, Gros P: The Splotch-Delayed (Sp-d) mouse mutant carries a point mutation within the paired box of the Pax-3 gene. Genomics 17:364-369, 1993
    • (1993) Genomics , vol.17 , pp. 364-369
    • Vogan, K.J.1    Epstein, D.J.2    Trasler, D.G.3    Gros, P.4
  • 17
    • 0024564676 scopus 로고
    • First-trimester hemoglobin A1 and risk for major malformation and spontaneous abortion in diabetic pregnancy
    • Greene MF, Hare JW, Cloherty JP, Benacerraf BR, Soeldner JS: First-trimester hemoglobin A1 and risk for major malformation and spontaneous abortion in diabetic pregnancy. Teratology 39:225-231, 1989
    • (1989) Teratology , vol.39 , pp. 225-231
    • Greene, M.F.1    Hare, J.W.2    Cloherty, J.P.3    Benacerraf, B.R.4    Soeldner, J.S.5
  • 18
    • 0030005968 scopus 로고    scopus 로고
    • Pregnancy outcomes in the diabetes control and complications trial
    • The Diabetes Control and Complications Trial Group: Pregnancy outcomes in the Diabetes Control and Complications Trial. Am J Obstet Gynecol 174:1343-1353, 1996
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 1343-1353
  • 19
    • 0026349330 scopus 로고
    • Diabetic embryopathy: Studies with animal and in vitro models
    • Eriksson UJ, Hakan Borg LA, Forsberg H, Styrud J: Diabetic embryopathy: studies with animal and in vitro models. Diabetes 40 (Suppl. 2):94-98, 1991
    • (1991) Diabetes , vol.40 , Issue.SUPPL. 2 , pp. 94-98
    • Eriksson, U.J.1    Hakan Borg, L.A.2    Forsberg, H.3    Styrud, J.4
  • 20
    • 0027328755 scopus 로고
    • Glucose and scyllo-inositol impair phosphoinositide hydrolysis in the 10.5-day cultured rat conceptus: A role in dysmorphogenesis
    • Strieleman PJ, Metzger BE: Glucose and scyllo-inositol impair phosphoinositide hydrolysis in the 10.5-day cultured rat conceptus: a role in dysmorphogenesis. Teratology 48:267-278, 1993
    • (1993) Teratology , vol.48 , pp. 267-278
    • Strieleman, P.J.1    Metzger, B.E.2
  • 21
    • 0027394254 scopus 로고
    • Diabetes and embryonic malformations: Role of substrate-induced free-oxygen radical production for dysmorphogenesis in cultured rat embryos
    • Eriksson UJ, Borg LAH: Diabetes and embryonic malformations: role of substrate-induced free-oxygen radical production for dysmorphogenesis in cultured rat embryos. Diabetes 42:411-419, 1993
    • (1993) Diabetes , vol.42 , pp. 411-419
    • Eriksson, U.J.1    Borg, L.A.H.2
  • 22
    • 0024592194 scopus 로고
    • Evidence for multifactorial origin of diabetes-induced embryopathies
    • Sadler TW, Hunter ESI, Wynn RE, Phillips LS: Evidence for multifactorial origin of diabetes-induced embryopathies. Diabetes 38:70-74, 1989
    • (1989) Diabetes , vol.38 , pp. 70-74
    • Sadler, T.W.1    Hunter, E.S.I.2    Wynn, R.E.3    Phillips, L.S.4
  • 23
    • 0029931302 scopus 로고    scopus 로고
    • Insulin treatment fails to abolish the teratogenic potential of serum from diabetic rats
    • Wentzel P, Eriksson UJ: Insulin treatment fails to abolish the teratogenic potential of serum from diabetic rats. Eur J Endocrinol 134:459-466, 1996
    • (1996) Eur J Endocrinol , vol.134 , pp. 459-466
    • Wentzel, P.1    Eriksson, U.J.2
  • 24
    • 0028216161 scopus 로고
    • Diabetic teratogenesis: In vitro evidence for a multifactorial etiology with little contribution from glucose per se
    • Buchanan TA, Denno KM, Sipos GF, Sadler TW: Diabetic teratogenesis: in vitro evidence for a multifactorial etiology with little contribution from glucose per se. Diabetes 43:656-660, 1994
    • (1994) Diabetes , vol.43 , pp. 656-660
    • Buchanan, T.A.1    Denno, K.M.2    Sipos, G.F.3    Sadler, T.W.4
  • 25
    • 0021267189 scopus 로고
    • Outcome of pregnancy complicated by diabetes: Experience with 232 patients in a 4 year period
    • Plehwe WE, Storey GN, Shearman RP, Turtle JR: Outcome of pregnancy complicated by diabetes: experience with 232 patients in a 4 year period. Diabetes Res 1:67-73, 1984
    • (1984) Diabetes Res , vol.1 , pp. 67-73
    • Plehwe, W.E.1    Storey, G.N.2    Shearman, R.P.3    Turtle, J.R.4
  • 27
    • 84995819759 scopus 로고
    • Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differently in patients with non-insulin-dependent diabetes mellitus versus healthy nonobese and obese subjects
    • Bang P, Brismar K, Rosenfeld RG, Hall K: Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differently in patients with non-insulin-dependent diabetes mellitus versus healthy nonobese and obese subjects. J Clin Endocrinol Metab 78:960-967, 1994
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 960-967
    • Bang, P.1    Brismar, K.2    Rosenfeld, R.G.3    Hall, K.4
  • 28
    • 0025217755 scopus 로고
    • Regulation of glucose transporter messenger RNA levels in rat adipose tissue by insulin
    • Sivitz WI, DeSautel SL, Kayano T, Bell GI, Pessin JE: Regulation of glucose transporter messenger RNA levels in rat adipose tissue by insulin. Mol Endocrinol 4:583-588, 1990
    • (1990) Mol Endocrinol , vol.4 , pp. 583-588
    • Sivitz, W.I.1    DeSautel, S.L.2    Kayano, T.3    Bell, G.I.4    Pessin, J.E.5
  • 29
    • 0029115950 scopus 로고
    • Mechanisms and time course of impaired skeletal muscle glucose transport activity in streptozocin diabetic rats
    • Napoli R, Hirshman MF, Horton ES: Mechanisms and time course of impaired skeletal muscle glucose transport activity in streptozocin diabetic rats. J Clin Invest 96:427-437, 1995
    • (1995) J Clin Invest , vol.96 , pp. 427-437
    • Napoli, R.1    Hirshman, M.F.2    Horton, E.S.3
  • 30
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501, 1992
    • (1992) J Cell Biol , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 31
    • 0025875226 scopus 로고
    • Pax-3, a novel murine DNA binding protein expressed during early neurogenesis
    • Goulding MD, Chalepakis G, Deutsch U, Erselius JR, Gruss P: Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 10:1135-1147, 1991
    • (1991) EMBO J , vol.10 , pp. 1135-1147
    • Goulding, M.D.1    Chalepakis, G.2    Deutsch, U.3    Erselius, J.R.4    Gruss, P.5
  • 32
    • 0025778925 scopus 로고
    • 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO
    • Laborda J: 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucl Acids Res 19:3998, 1991
    • (1991) Nucl Acids Res , vol.19 , pp. 3998
    • Laborda, J.1
  • 33
    • 0025094596 scopus 로고
    • Biochemical basis for D,L,-beta-hydroxybutyrate-induced teratogenesis
    • Shum L, Sadler TW: Biochemical basis for D,L,-beta-hydroxybutyrate-induced teratogenesis. Teratology 42:553-563, 1990
    • (1990) Teratology , vol.42 , pp. 553-563
    • Shum, L.1    Sadler, T.W.2
  • 34
    • 0028928950 scopus 로고
    • Correlations between maternal metabolism and deranged development in the offspring of normal and diabetic rats
    • Styrud J, Thunberg L, Nybacka O, Eriksson UJ: Correlations between maternal metabolism and deranged development in the offspring of normal and diabetic rats. Pediatr Res 37:343-353, 1995
    • (1995) Pediatr Res , vol.37 , pp. 343-353
    • Styrud, J.1    Thunberg, L.2    Nybacka, O.3    Eriksson, U.J.4
  • 35
    • 0029966376 scopus 로고    scopus 로고
    • The pathogenesis of diabetes-associated congenital malformations
    • Reece E, Eriksson U: The pathogenesis of diabetes-associated congenital malformations. Obstet Gynecol Clin North Am 23:29-45, 1996
    • (1996) Obstet Gynecol Clin North Am , vol.23 , pp. 29-45
    • Reece, E.1    Eriksson, U.2
  • 36
    • 0030452974 scopus 로고    scopus 로고
    • Multifactorial basis of the syndrome of diabetic embryopathy
    • Reece E, Homko C, Wu Y: Multifactorial basis of the syndrome of diabetic embryopathy. Teratology 54:171-182, 1996
    • (1996) Teratology , vol.54 , pp. 171-182
    • Reece, E.1    Homko, C.2    Wu, Y.3
  • 37
    • 0025811063 scopus 로고
    • Altered visceral yolk sac function produced by a low-molecular-weight somatomedin inhibitor
    • Hunter ES, Phillips LS, Goldstein S, Sadler TW: Altered visceral yolk sac function produced by a low-molecular-weight somatomedin inhibitor. Teratology 43:331-340, 1991
    • (1991) Teratology , vol.43 , pp. 331-340
    • Hunter, E.S.1    Phillips, L.S.2    Goldstein, S.3    Sadler, T.W.4
  • 38
    • 0026339326 scopus 로고
    • Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos
    • Engstrom E, Haglund A, Eriksson UJ: Effects of maternal diabetes or in vitro hyperglycemia on uptake of palmitic and arachidonic acid by rat embryos. Pediatr Res 30:150-153, 1991
    • (1991) Pediatr Res , vol.30 , pp. 150-153
    • Engstrom, E.1    Haglund, A.2    Eriksson, U.J.3
  • 39
    • 0026000995 scopus 로고
    • Biochemical basis of the diabetic embryopathy
    • Goldman AS, Goto MP: Biochemical basis of the diabetic embryopathy. Israel J Med Sci 27:469-477, 1991
    • (1991) Israel J Med Sci , vol.27 , pp. 469-477
    • Goldman, A.S.1    Goto, M.P.2
  • 40
    • 0024247097 scopus 로고
    • Diabetes affects sorbitol and myo-inositol levels of neuroectodermal tissue during embryogenesis in rat
    • Sussman I, Matschinsky FM: Diabetes affects sorbitol and myo-inositol levels of neuroectodermal tissue during embryogenesis in rat. Diabetes 37:974-981, 1988
    • (1988) Diabetes , vol.37 , pp. 974-981
    • Sussman, I.1    Matschinsky, F.M.2
  • 41
    • 0031874953 scopus 로고    scopus 로고
    • The role of free radicals and membrane lipids in diabetes-induced congenital malformations
    • Reece E, Homko C, Wu U, Wiznitzer A: The role of free radicals and membrane lipids in diabetes-induced congenital malformations. J Soc Gynecol Invest 5:178-187, 1998
    • (1998) J Soc Gynecol Invest , vol.5 , pp. 178-187
    • Reece, E.1    Homko, C.2    Wu, U.3    Wiznitzer, A.4
  • 42
    • 0028321899 scopus 로고
    • Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus
    • King GL, Shiba T, Oliver J, Inoguchi T, Bursell SE: Cellular and molecular abnormalities in the vascular endothelium of diabetes mellitus. Ann Rev Med 45:179-188, 1994
    • (1994) Ann Rev Med , vol.45 , pp. 179-188
    • King, G.L.1    Shiba, T.2    Oliver, J.3    Inoguchi, T.4    Bursell, S.5
  • 44
    • 0029946240 scopus 로고    scopus 로고
    • Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues
    • Kunisaki M, Fumio U, Nawata H, King GL: Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes 45:S117-S119, 1996
    • (1996) Diabetes , vol.45
    • Kunisaki, M.1    Fumio, U.2    Nawata, H.3    King, G.L.4
  • 45
    • 0031891448 scopus 로고    scopus 로고
    • Abnormalities of retinal metabolism in diabetes or experimental galactosemia. V. Relationship between protein kinase C and ATPases
    • Kowluru RA, Jirousek MR, Stramm L, Farid N, Engerman RL, Kern TS: Abnormalities of retinal metabolism in diabetes or experimental galactosemia. V. Relationship between protein kinase C and ATPases. Diabetes 47:464-469, 1998
    • (1998) Diabetes , vol.47 , pp. 464-469
    • Kowluru, R.A.1    Jirousek, M.R.2    Stramm, L.3    Farid, N.4    Engerman, R.L.5    Kern, T.S.6
  • 46
    • 0032534593 scopus 로고    scopus 로고
    • Antiproliferative effect of elevated glucose in human microvascular endothelial cells
    • Kamal K, Du W, Mills I, Sumpio BE: Antiproliferative effect of elevated glucose in human microvascular endothelial cells. J Cell Biochem 71:491-501, 1998
    • (1998) J Cell Biochem , vol.71 , pp. 491-501
    • Kamal, K.1    Du, W.2    Mills, I.3    Sumpio, B.E.4
  • 48
    • 0032543872 scopus 로고    scopus 로고
    • Pathogenesis, prevention, and treatment of diabetic nephropathy
    • Cooper ME: Pathogenesis, prevention, and treatment of diabetic nephropathy. Lancet 352:213-219, 1998
    • (1998) Lancet , vol.352 , pp. 213-219
    • Cooper, M.E.1
  • 49
    • 0030813477 scopus 로고    scopus 로고
    • Glycated proteins in diabetes
    • Furth AJ: Glycated proteins in diabetes. Br J Biomed Sci 54:192-200, 1997
    • (1997) Br J Biomed Sci , vol.54 , pp. 192-200
    • Furth, A.J.1
  • 50
    • 0031048334 scopus 로고    scopus 로고
    • Advanced glycation end products, oxidant stress and vascular lesions
    • Chappey O, Dosquet C, Wautier MP, Wautier JL: Advanced glycation end products, oxidant stress and vascular lesions. Eur J Clin Invest 27:97-108, 1997
    • (1997) Eur J Clin Invest , vol.27 , pp. 97-108
    • Chappey, O.1    Dosquet, C.2    Wautier, M.P.3    Wautier, J.L.4
  • 51
    • 0031725628 scopus 로고    scopus 로고
    • Diabetes, advanced glycation end products and vascular disease
    • Wautier JL, Guillausseau PJ: Diabetes, advanced glycation end products and vascular disease. Vasc Med 3:131-137, 1998
    • (1998) Vasc Med , vol.3 , pp. 131-137
    • Wautier, J.L.1    Guillausseau, P.J.2
  • 52
    • 0023476062 scopus 로고
    • Elevated glucose 6-phosphate levels are associated with plasmid mutations in vivo
    • Lee AT, Cerami A: Elevated glucose 6-phosphate levels are associated with plasmid mutations in vivo. Proc Natl Acad Sci U S A 84:8311-8314, 1987
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 8311-8314
    • Lee, A.T.1    Cerami, A.2
  • 53
    • 0028859265 scopus 로고
    • A role for DNA mutations in diabetes-associated teratogenesis in transgenic embryos
    • Lee AT, Plump A, DeSimone C, Cerami A, Bucala R: A role for DNA mutations in diabetes-associated teratogenesis in transgenic embryos. Diabetes 44:20-24, 1995
    • (1995) Diabetes , vol.44 , pp. 20-24
    • Lee, A.T.1    Plump, A.2    DeSimone, C.3    Cerami, A.4    Bucala, R.5
  • 54
    • 0032970019 scopus 로고    scopus 로고
    • Hyperglycemia-induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo
    • Lee AT, Reis D, Eriksson UJ: Hyperglycemia-induced embryonic dysmorphogenesis correlates with genomic DNA mutation frequency in vitro and in vivo. Diabetes 48:371-376, 1999
    • (1999) Diabetes , vol.48 , pp. 371-376
    • Lee, A.T.1    Reis, D.2    Eriksson, U.J.3
  • 55
    • 0025868649 scopus 로고
    • Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro
    • Eriksson UJ, Borg LAH: Protection by free oxygen radical scavenging enzymes against glucose-induced embryonic malformations in vitro. Diabetologia 34:325-331, 1991
    • (1991) Diabetologia , vol.34 , pp. 325-331
    • Eriksson, U.J.1    Borg, L.A.H.2
  • 56
    • 0029957231 scopus 로고    scopus 로고
    • Pregnant diabetic rats fed the antioxidant butylated hydroxytoluene show decreased occurrence of malformations in offspring
    • Eriksson U, Siman CM: Pregnant diabetic rats fed the antioxidant butylated hydroxytoluene show decreased occurrence of malformations in offspring. Diabetes 45:1497-1502, 1996
    • (1996) Diabetes , vol.45 , pp. 1497-1502
    • Eriksson, U.1    Siman, C.M.2
  • 57
    • 0028892376 scopus 로고
    • Prevention of diabetes-associated embryopathy by overexpression of the free radical scavenger copper zinc superoxide dismutase in transgenic mouse embryos
    • Hagay ZJ, Weiss Y, Zusman I, Peled-Kamar M, Reece EA, Eriksson UJ, Groner Y: Prevention of diabetes-associated embryopathy by overexpression of the free radical scavenger copper zinc superoxide dismutase in transgenic mouse embryos. Am J Obstet Gynecol 173:1036-1041, 1995
    • (1995) Am J Obstet Gynecol , vol.173 , pp. 1036-1041
    • Hagay, Z.J.1    Weiss, Y.2    Zusman, I.3    Peled-Kamar, M.4    Reece, E.A.5    Eriksson, U.J.6    Groner, Y.7
  • 59
    • 0031023058 scopus 로고    scopus 로고
    • The teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetylcysteine in rat embryo culture
    • Wentzel P, Thunberg L, Eridsson UJ: The teratogenic effect of diabetic serum is prevented by supplementation of superoxide dismutase and N-acetylcysteine in rat embryo culture. Diabetologia 40:7-14, 1997
    • (1997) Diabetologia , vol.40 , pp. 7-14
    • Wentzel, P.1    Thunberg, L.2    Eridsson, U.J.3
  • 60
    • 0342569099 scopus 로고
    • The antioxidants Trolox and N-acetylcysteine protect rat embryos from the teratogenic effects of a diabetic environment in vitro
    • Eriksson UJ: The antioxidants Trolox and N-acetylcysteine protect rat embryos from the teratogenic effects of a diabetic environment in vitro (Abstract). Diabetes 43 (Suppl. 1):136A, 1984
    • (1984) Diabetes , vol.43 , Issue.SUPPL. 1
    • Eriksson, U.J.1
  • 61
    • 0028838193 scopus 로고
    • Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression
    • Lee KS, Buck M, Houglum K, Chojkier M: Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96:2461-2468, 1995
    • (1995) J Clin Invest , vol.96 , pp. 2461-2468
    • Lee, K.S.1    Buck, M.2    Houglum, K.3    Chojkier, M.4
  • 62
    • 0028624685 scopus 로고
    • Altered oxidative stress responses in nickel-resistant mammalian cells
    • Salnikow K, Gao M, Voitkun V, Huang X, Costa M: Altered oxidative stress responses in nickel-resistant mammalian cells. Cancer Res 54:6407-6412, 1994
    • (1994) Cancer Res , vol.54 , pp. 6407-6412
    • Salnikow, K.1    Gao, M.2    Voitkun, V.3    Huang, X.4    Costa, M.5
  • 63
    • 0029058165 scopus 로고
    • Differential activation of heat-shock and oxidation-specific stress genes in chemically induced oxidative stress
    • Tacchini L, Poghiaghi G, Radice L, Anzon E, Bernelli-Zazzera A: Differential activation of heat-shock and oxidation-specific stress genes in chemically induced oxidative stress. Biochem J 309:453-459, 1995
    • (1995) Biochem J , vol.309 , pp. 453-459
    • Tacchini, L.1    Poghiaghi, G.2    Radice, L.3    Anzon, E.4    Bernelli-Zazzera, A.5
  • 64
    • 0030042987 scopus 로고    scopus 로고
    • Physical and functional sensitivity of zinc finger transcription factors to redox change
    • Wu X, Bishopric NH, Discher DJ, Murphy BJ, Webster KA: Physical and functional sensitivity of zinc finger transcription factors to redox change. Mol Cell Biol 16:1035-1046, 1996
    • (1996) Mol Cell Biol , vol.16 , pp. 1035-1046
    • Wu, X.1    Bishopric, N.H.2    Discher, D.J.3    Murphy, B.J.4    Webster, K.A.5
  • 65
    • 0030018011 scopus 로고    scopus 로고
    • Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroids FRTL-5 cells
    • Kambe F, Nomure Y, Okamot T, Seo H: Redox regulation of thyroid-transcription factors, Pax-8 and TTF-1, is involved in their increased DNA-binding activities by thyrotropin in rat thyroids FRTL-5 cells. Mol Endocrinol 10:801-812, 1996
    • (1996) Mol Endocrinol , vol.10 , pp. 801-812
    • Kambe, F.1    Nomure, Y.2    Okamot, T.3    Seo, H.4
  • 66
    • 0029028158 scopus 로고
    • A direct effect of activated human p53 on eukaryotic DNA replication
    • Cox LS, Hupp T, Midgley CA, Lane DP: A direct effect of activated human p53 on eukaryotic DNA replication. EMBO J 14:2099-2105, 1995
    • (1995) EMBO J , vol.14 , pp. 2099-2105
    • Cox, L.S.1    Hupp, T.2    Midgley, C.A.3    Lane, D.P.4
  • 68
    • 0029331089 scopus 로고
    • Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes
    • Hammes HP, Federoff HJ, Brownlee M: Nerve growth factor prevents both neuroretinal programmed cell death and capillary pathology in experimental diabetes. Mol Med 1:527-534, 1995
    • (1995) Mol Med , vol.1 , pp. 527-534
    • Hammes, H.P.1    Federoff, H.J.2    Brownlee, M.3
  • 69
    • 0029000956 scopus 로고
    • Erythropoietin in diabetic macular edema and renal insufficiency
    • Friedman EA, Brown CD, Berman DH: Erythropoietin in diabetic macular edema and renal insufficiency. Am J Kidney Dis 26:202-208, 1995
    • (1995) Am J Kidney Dis , vol.26 , pp. 202-208
    • Friedman, E.A.1    Brown, C.D.2    Berman, D.H.3
  • 71
    • 0031835957 scopus 로고    scopus 로고
    • Regulation of transcription by hypoxia requires a multi-protein complex that includes hypoxia-inducible factor 1, and adjacent transcription factor, and p300/CREB binding protein
    • Ebert BL, Bunn HF: Regulation of transcription by hypoxia requires a multi-protein complex that includes hypoxia-inducible factor 1, and adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol 18:4089-4096, 1998
    • (1998) Mol Cell Biol , vol.18 , pp. 4089-4096
    • Ebert, B.L.1    Bunn, H.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.