Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxiety

Pharmacology Biochemistry and Behavior

Volumn 71, Issue 4, 2002, Pages 615-625

  Martin, James R ^a   Ballard, Theresa M ^a   Higgins, Guy A ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

5 HT2C receptor antagonist; Anxiety models; CER; Fluoxetine; Ro60 0175; SB 242084

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; ALPRAZOLAM; AMPHETAMINE; DIAZEPAM; FLUOXETINE; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY NEUROSIS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; EMOTION; FEAR; LOCOMOTION; MALE; MAZE TEST; NONHUMAN; POLYDIPSIA; PRIORITY JOURNAL; RAT; STARTLE REFLEX; TASK PERFORMANCE; TRANQUILIZING ACTIVITY;

AMINOPYRIDINES; ANIMALS; ANXIETY; COMPULSIVE BEHAVIOR; CONDITIONING, OPERANT; CONFLICT (PSYCHOLOGY); DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; EMOTIONS; FEAR; GABA MODULATORS; INDOLES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; REINFORCEMENT SCHEDULE; SEROTONIN ANTAGONISTS; STARTLE REACTION; TASTE;

EID: 0036119272     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(01)00713-4     Document Type: Article

References (41)

1. A review of central 5-HT receptors and their function
2. Molecular biology of 5-HT receptors
3. 6-Chloro-5-methyl-1-[[2-](2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): The first selective and brain penetrant 5-HT2C receptor antagonist
4. Bidirectional control of palatable food consumption through a common benzodiazepine receptor: Theory and evidence
5. Acute administration of diazepam and buspirone in rats trained on conflict schedules having different degrees of predictability
6. Animal models of anxiety based on classical conditioning: The conditioned emotional response (CER) and the fear-potentiated startle effect
7. The role of the amygdala in fear-potentiated startle: Implications for animal models of anxiety
8. Evidence that the anxiolytic effects of chlordiazepoxide on the elevated plus-maze are confounded by increases in locomotor activity
9. Discriminataive stimulus properties of the novel serotonin (5-HT)2C receptor agonist, RO60-0175: A pharmacological analysis
10. The selective serotonin (5-HT)1A receptor ligand, S15535, displays anxiolytic-like effects in the social interaction and Vogel models and supresses dialysate levels of 5-HT in the dorsal hippocampus of freely-moving rats: A comparison with other anxiolytic agents
11. Role of 5-HT(2C) receptors in the control of central dopamine function
12. Role of serotonin2C receptors in the control of brain dopaminergic function
13. Differential effects of the 5-HT2A receptor antagonist M100,907 and the 5-HT2C receptor antagonist SB-242084 on cocaine induced locomotion, cocaine self-administration and cocaine induced reinstatement of responding
14. A comparative study of the effects of selective and non-selective 5-HT2 receptor subtype antagonists in rat and mouse models of anxiety
15. Contextual fear conditioning and baseline startle responses in the rat fear-potentiated startle test: A comparison of benzodiazepine/γ-aminobutyric acid-A receptor agonists
16. A paradoxical locomotor response in serotonin 5-HT2C receptor mutant mice
17. Influence of the 5-HT2C receptor antagonist SB-242084 on behavior produced by the 5-HT2 agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine
18. Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT2C/2B receptor antagonists: Neurochemical and behavioral studies
19. Activity of serotonergic neurons in behaving animals
20. 2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats
21. Brain 5HT2C receptors: Potential role in anxiety disorders
22. The medical benefit of 5-HT research
23. 5-HT1C receptors and their therapeutic relevance
24. Evidence that mCPP may have behavioral effects mediated by 5-HT1C receptors
25. In vivo properties of SB-200646, a 5-HT2C/2B receptor antagonist
26. In vitro and in vivo profile of SB-206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties
27. SB-242084, a selective and brain penetrant 5-HT2C receptor antagonist
28. Effects of Ro60-0175, a 5-HT2C receptor agonist, in three animal models of anxiety
29. Impairment of decision making in rats by diazepam: Implications for the "anticonflict" effects of benzodiazepines
30. Pharmacological characteristics of benzodiazepine receptor ligands with intrinsic efficacies ranging from high to zero
31. 5-HT2C receptor agonists: Pharmacological characteristics and therapeutic potential
32. 5-HT2C receptors are involved in the discriminative stimulus effects of citalopram in rats
33. 5HT2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in rats
34. Effect of LSD on prepulse inhibition and spontaneous behavior in the rat: A pharmacological analysis and comparison between two rat strains
35. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
36. 2C receptors in CHO-K1 cells
37. Mechanism of action of the benzodiazepines: Behavioral aspect
38. Effects of 5-HT1A receptor agonists, partial agonists and a silent antagonist on the performance of the conditioned emotional response test in the rat
39. Benzodiazepines reduce the tolerance to reward delay in rats
40. An investigation of the role of 5-HT2C receptors in modifying ethanol self-administration behaviour
41. Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: A potential model for obsessive compulsive disorder