Imaging the GABA-benzodiazepine receptor subtype containing the α-5-subunit in vivo with [11C]Ro15 4513 positron emission tomography

Journal of Cerebral Blood Flow and Metabolism

Volumn 22, Issue 7, 2002, Pages 878-889

  Lingford Hughes, Anne ^a   Hume, Susan P ^a   Feeney, Adrian ^a   Hirani, Ella ^a   Osman, Safiye ^a   Cunningham, Vincent J ^a   Pike, Victor W ^a   Brooks, David J ^a   Nutt, David J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Benzodiazepine; Human; Limbic system; PET; Rat; Ro15 4513

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE RECEPTOR; FLUMAZENIL; IOMAZENIL; L 655708; RECEPTOR SUBTYPE; RY 80; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; IMAGING; ISOTOPE LABELING; NONHUMAN; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

EID: 0036300772     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200207000-00013     Document Type: Article

References (44)

1. A receptors
2. 3H]flumazenil binding in rat central nervous system
3. Role of the alpha 5 subunit of the GABA-A receptor in learning and memory
4. Spectral analysis of dynamic PET studies
5. GABAA-receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
6. Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acid A receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acid A receptors
7. 11C]Ro 15-4513 a ligand for visualization of benzodiazepine receptor binding. Preparation, autoradiography and positron emission tomography
8. Density and pharmacology of alpha5 subunit-containing GABA(A) receptors are preserved in hippocampus of Alzheimer's disease patients
9. Pharmacophore/receptor models for GABA(A)/BzR subtypes (alphalbeta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach
10. IA receptors in rat brain, assessed using in vivo microdialysis and PET after fenfluramine
11. Quantitation of carbon-11-labelled raclopride in rat striatum using positron emission tomography
12. 11C]Ro15-4513 in human brain measured with PET
13. A novel benzodiazepine inverse agonist, S-8510, as a cognitive enhancer
14. The neurobiology of drug addiction
15. Down-regulation of benzodiazepine binding to alpha 5 subunit-containing gamma-aminobutyric acid(A) receptors in tolerant rat brain indicates particular involvement of the hippocampa1 CA1 region
16. Synthesis and pharmacological properties of novel 8-substituted imidazobenzo-diazepines: High-affinity, selective probes for alpha 5-containing GABAA receptors
17. Molecular and neuronal substrate for the selective attenuation of anxiety
18. 11C]Scherring 23390
19. Benzodiazepine receptors and positron emission tomography: Ten years of experience: A new beginning?
20. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype
21. Quantification of dopamine receptors and transporter in rat striatum using a small animal PET scanner
22. Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells
23. Abenzodiazepine receptor in psychiatric disorder
24. A subclass of GABAA/benzodiazepine receptor exclusively localized in the limbic system
25. A receptors containing α5 subunit
26. Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites: Current status
27. GABA(A) receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain
28. A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro15-1788, benzodiazepine tranquilizers, beta-carbolines, and phenobarbitone
29. 3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the alpha 5 subunit
30. 11C-flumazenil PET study
31. A software system for interactive and quantitative visualization of multidimensional biomedical images
32. Benzodiazepine pharmacodynamics: Utility of eye movement measures
33. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
34. 3H]Ro 15-4513
35. Treatment strategies for senile dementia: Antagonists B-carbolines
36. Structure and pharmacology of gamma-aminobutyric acid A receptor subtypes
37. 3H]RY 80: A high-affinity, selective ligand for gamma-aminobutyric acid A receptors containing alpha-5 sub-units
38. Physical performance of a positron tomograph for brain imaging with retractable septa
39. Physical characteristics of the ECAT EXACT3D positron tomograph
40. 11C]Ro 15-4513
41. Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain
42. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. Part I: Telencephalon, diencephalon, mesencephalon