PWZ-029, a compound with moderate inverse agonist functional selectivity at GABAA receptors containing α5 subunits, improves passive, but not active, avoidance learning in rats

Brain Research

Volumn 1208, Issue , 2008, Pages 150-159

  Savić, Miroslav M ^a   Clayton, Terry ^b   Furtmüller, Roman ^c   Gavrilović, Ivana ^a   Samardžić, Janko ^d   Savić, Snežana ^a   Huck, Sigismund ^c   Sieghart, Werner ^c   Cook, James M ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

GABAA; Inverse agonist; Locomotor activity; Memory; Subtype selectivity

Indexed keywords

ANIMALIA; RATTUS;

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 8 ETHYNYL 6 (2 FLUOROPHENYL) 4 METHYL 4H 2,5,10B TRIAZABENZO[E]AZULENE 3 CARBOXYLIC ACID ETHYL ESTER; BETA CARBOLINE 3 CARBOXYLIC ACID TERT BUTYL ESTER; FLUMAZENIL; METHYL (8 CHLORO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPIN 3 YL)METHYL ETHER; PWZ 029;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DOSE COMPARISON; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; GABAERGIC SYSTEM; GRIP STRENGTH; LEARNING; LOCOMOTION; MALE; MAZE TEST; MEMORY CONSOLIDATION; NEUROMODULATION; NONHUMAN; OOCYTE; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; XENOPUS LAEVIS;

ANALYSIS OF VARIANCE; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BENZODIAZEPINES; CARBOLINES; CONVULSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPLORATORY BEHAVIOR; GABA AGONISTS; LOCOMOTION; MALE; MAZE LEARNING; MICROINJECTIONS; MUSCLE STRENGTH; OOCYTES; PROTEIN BINDING; RATS; RATS, WISTAR; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 43049159557     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.02.020     Document Type: Article

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