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15
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46649098072
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For selected references on the cycloisomerization of enynes, see:
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For selected references on the cycloisomerization of enynes, see:
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18
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0032417755
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Alkenyl iodide 23 was prepared by hydrozirconation of the THP ether derived from but-3-yn-1-ol followed by iodinolysis, see:
-
Alkenyl iodide 23 was prepared by hydrozirconation of the THP ether derived from but-3-yn-1-ol followed by iodinolysis, see:. Yokomatsu T., Abe H., Sato M., Suemune K., Kihara T., Soeda S., Shimeno H., and Shibuya S. Bioorg. Med. Chem. 66 (1998) 2495-2505
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82
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-
58949090583
-
-
note
-
4o,p led to similar results in terms of yield and diastereoselectivity.
-
-
-
-
83
-
-
58949098520
-
-
note
-
3, MeOH, reflux), which led to a 50:50 mixture of diastereomers.
-
-
-
-
85
-
-
58949094624
-
-
note
-
The relative configuration of 46 has been indicated for the sake of clarity but the actual sense of 1,2-stereochemical induction for 1,6-ene-ynamides substituted at the β position of the nitrogen atom was only ascertained later with ene-ynamide 68 bearing a propargylic alcohol moiety (see Section 2.3).
-
-
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87
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0003417469
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Trost B.M., and Fleming I. (Eds), Pergamon, Oxford pp 1047-1082
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-
-
58949089658
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-
note
-
The gold-catalyzed cycloisomerization of 1,6-ene-ynamide 37 may generate dienamide 92 as a by-product. Hydrolysis of the latter compound may produce the β-dimethylphenylsilyl enone 49 through an intermediate allenamide 93.{A figure is presented}
-
-
-
-
94
-
-
58949091514
-
-
note
-
For the preparation of sulfonamide 64, see Refs. 8 and 9. Sulfonamide 65 was prepared from (benzyloxy)-acetaldehyde, see Section 4.
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