Synthesis of 1,1-difluoro-5-(1H-9-purinyl)-2-pentenylphosphonic acids and the related methano analogues. Remarkable effect of the nucleobases and the cyclopropane rings on inhibitory activity toward purine nucleoside phosphorylase

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 12, 1998, Pages 2495-2505

  Yokomatsu, Tsutomu ^a   Abe, Hiroshi ^a   Sato, Mutsumi ^a   Suemune, Kenji ^a   Kihara, Taro ^b   Soeda, Shinji ^b   Shimeno, Hiroshi ^b   Shibuya, Shiroshi ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

Author keywords

Enzyme inhibitors; Mimetics; Nucleotides; Phosphonic acids and derivatives

Indexed keywords

1,1 DIFLUORO 5 (1H 9 PURINYL) 2 PENTENYLPHOSPHONIC ACID; IMMUNOSUPPRESSIVE AGENT; PURINE DERIVATIVE; PURINE NUCLEOSIDE PHOSPHORYLASE; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELLULOMONAS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS SPECTROMETRY; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 0032417755     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)80023-0     Document Type: Article

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19. 10
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23. 8b
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30. 13C NMR data was not collected for this compound due to the poor solubility in deuterium oxide.