c-kit expression in pediatric solid tumors: A comparative immunohistochemical study

American Journal of Surgical Pathology

Volumn 26, Issue 4, 2002, Pages 486-492

  Smithey, Brandon E ^a   Pappo, Alberto S ^a   Hill, D Ashley ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

c kit; Desmoplastic small round cell tumor; Neuroblastoma; Rhabdomyosarcoma; Sarcoma; STI 571 (Gleevec); Synovial sarcoma; Tyrosine kinase; Wilms' tumor

Indexed keywords

AVIDIN; BCR ABL PROTEIN; BIOTIN; IMATINIB; PEROXIDASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; POLYCLONAL ANTIBODY; STEM CELL FACTOR; TYROSINE KINASE RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ALVEOLAR SOFT PART SARCOMA; ANTIGEN RETRIEVAL; ARTICLE; CHILD; CHILDHOOD CANCER; CHRONIC MYELOID LEUKEMIA; EWING SARCOMA; GASTROINTESTINAL TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MAST CELL; NEPHROBLASTOMA; NEUROBLASTOMA; OSTEOSARCOMA; PROTEIN EXPRESSION; RHABDOMYOSARCOMA; SMALL CELL SARCOMA; SOLID TUMOR; SYNOVIAL SARCOMA; TUMOR GROWTH;

BONE NEOPLASMS; CHILD; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; NEOPLASM METASTASIS; NEOPLASMS; NEUROBLASTOMA; NEUROECTODERMAL TUMORS, PRIMITIVE; OSTEOSARCOMA; PROTO-ONCOGENE PROTEINS C-KIT; RHABDOMYOSARCOMA; RHABDOMYOSARCOMA, ALVEOLAR; SARCOMA, EWING'S; SARCOMA, SYNOVIAL; WILMS TUMOR;

EID: 0036209138     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200204000-00011     Document Type: Article

References (39)

1. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms
2. Expression of stem cell factor and its receptor by human neuroblastoma cells and tumors
3. c-kit mutations in core binding factor leukemias
4. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
5. CD34, CD117, and actin expression in phyllodes tumor of the breast
6. Expression of stem cell factor and c-kit in human neuroblastoma: The Children's Cancer Group
7. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
8. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
9. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
10. The kit ligand, stem cell factor
11. Analysis of pleiotropism at the dominant white-spotting (W) locus of the house mouse: A description of ten new W alleles
12. Inhibition of c-kit receptor tyrosine kinase activity by ST1 571, a selective tyrosine kinase inhibitor
13. Coexpression of the stem cell factor and the c-kit genes in small-cell lung cancer
14. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
15. Gain-of-function mutation at the extracellular domain of KIT in gastrointestinal stromal tumours
16. KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma
17. Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2
18. Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors
19. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
20. A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis
21. Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase
22. Protein tyrosine kinases and cancer
23. The metastatic ability of Ewing's sarcoma cells is modulated by stem cell factor and by its receptor c-kit
24. Production of stem cell factor and expression of c-kit in human rhabdomyosarcoma cells: Lack of autocrine growth modulation
25. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
26. Gastrointestinal stromal tumors: Recent advances in understanding of their biology
27. KIT expression in angiosarcomas and fetal endothelial cells: Lack of mutations of exon 11 and exon 17 of C-kit
28. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD 117 (KIT)
29. Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form
30. A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors
31. Molecular analysis of the hematopoiesis supporting osteoblastic cell line U2-OS
32. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene
33. c-kit is expressed in soft tissue sarcoma of neuroectodermic origin and its ligand prevents apoptosis of neoplastic cells
34. CD117: A sensitive marker for gastrointestinal stromal tumors that is more specific than CD34
35. c-KIT and c-KIT ligand (SCF) in synovial sarcoma (SS): An mRNA expression analysis in 23 cases
36. Activating c-kit gene mutations in human germ cell tumors
37. Stem cell factor suppresses apoptosis in neuroblastoma cell lines
38. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: Immunohistochemical study on formalin-fixed, paraffin-embedded tissues
39. Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand