메뉴 건너뛰기




Volumn 50, Issue 6, 2008, Pages 1198-1206

Initial testing of dasatinib by the pediatric preclinical testing program

Author keywords

Dasatinib; Developmental therapeutics; Preclinical testing

Indexed keywords

DASATINIB;

EID: 42349094624     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21368     Document Type: Article
Times cited : (66)

References (44)
  • 1
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • Lombardo LJ, Lee FY, Chen P, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004;47:6658-6661.
    • (2004) J Med Chem , vol.47 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3
  • 2
    • 1542713480 scopus 로고    scopus 로고
    • P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
    • Illmer T, Schaich M, Platzbecker U, et al. P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. Leukemia 2004;18:401-408.
    • (2004) Leukemia , vol.18 , pp. 401-408
    • Illmer, T.1    Schaich, M.2    Platzbecker, U.3
  • 3
    • 9444282642 scopus 로고    scopus 로고
    • Active transport of imatinib into and out of cells: Implications for drug resistance
    • Thomas J, Wang L, Clark RE, et al. Active transport of imatinib into and out of cells: Implications for drug resistance. Blood 2004;104:3739-3745.
    • (2004) Blood , vol.104 , pp. 3739-3745
    • Thomas, J.1    Wang, L.2    Clark, R.E.3
  • 4
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'Hare T, Walters DK, Stoffregen EP, et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005;65:4500-4505.
    • (2005) Cancer Res , vol.65 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3
  • 5
    • 14744274624 scopus 로고    scopus 로고
    • Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance
    • Burgess MR, Skaggs BJ, Shah NP, et al. Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance. Proc Natl Acad Sci USA 2005;102:3395-3400.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 3395-3400
    • Burgess, M.R.1    Skaggs, B.J.2    Shah, N.P.3
  • 6
    • 34248324467 scopus 로고    scopus 로고
    • Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase
    • Guilhot F, Apperley J, Kim DW, et al. Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood 2007;109:4143-4150.
    • (2007) Blood , vol.109 , pp. 4143-4150
    • Guilhot, F.1    Apperley, J.2    Kim, D.W.3
  • 7
    • 0034693877 scopus 로고    scopus 로고
    • Role of Src expression and activation in human cancer
    • Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene 2000;19:5636-5642.
    • (2000) Oncogene , vol.19 , pp. 5636-5642
    • Irby, R.B.1    Yeatman, T.J.2
  • 8
    • 0025107309 scopus 로고
    • Expression of the neuronal form of pp60c-src in neuroblastoma in relation to clinical stage and prognosis
    • Bjelfman C, Hedborg F, Johansson I, et al. Expression of the neuronal form of pp60c-src in neuroblastoma in relation to clinical stage and prognosis. Cancer Res 1990;50:6908-6914.
    • (1990) Cancer Res , vol.50 , pp. 6908-6914
    • Bjelfman, C.1    Hedborg, F.2    Johansson, I.3
  • 9
    • 23044500874 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma
    • Azuma K, Tanaka M, Uekita T, et al. Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma. Oncogene 2005;24:4754-4764.
    • (2005) Oncogene , vol.24 , pp. 4754-4764
    • Azuma, K.1    Tanaka, M.2    Uekita, T.3
  • 10
    • 33745182564 scopus 로고    scopus 로고
    • PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation
    • Diaz-Montero CM, Wygant JN, McIntyre BW. PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation. Eur J Cancer 2006;42:1491-1500.
    • (2006) Eur J Cancer , vol.42 , pp. 1491-1500
    • Diaz-Montero, C.M.1    Wygant, J.N.2    McIntyre, B.W.3
  • 11
    • 21344470873 scopus 로고    scopus 로고
    • Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells
    • Stettner MR, Wang W, Nabors LB, et al. Lyn kinase activity is the predominant cellular SRC kinase activity in glioblastoma tumor cells. Cancer Res 2005;65:5535-5543.
    • (2005) Cancer Res , vol.65 , pp. 5535-5543
    • Stettner, M.R.1    Wang, W.2    Nabors, L.B.3
  • 12
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997;13:513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 13
    • 4544235743 scopus 로고    scopus 로고
    • c-Src and cooperating partners in human cancer
    • Ishizawar R, Parsons SJ. c-Src and cooperating partners in human cancer. Cancer cell 2004;6:209-214.
    • (2004) Cancer cell , vol.6 , pp. 209-214
    • Ishizawar, R.1    Parsons, S.J.2
  • 14
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. New Engl J Med 2006;354:2531-2541.
    • (2006) New Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 15
    • 33745914717 scopus 로고    scopus 로고
    • Phase I dose-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients (pts) with GIST and other solid tumors
    • Abstract
    • Evans TR, Morgan JA, Van den Abbeele AD, et al. Phase I dose-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients (pts) with GIST and other solid tumors. J Clin Oncol 2005;23: Abstract # 3034.
    • J Clin Oncol , vol.2005 , Issue.23 , pp. 3034
    • Evans, T.R.1    Morgan, J.A.2    Van den Abbeele, A.D.3
  • 16
    • 77953028335 scopus 로고    scopus 로고
    • Dasatinib (SPRYCEL) in children and adolescents with relapsed or refractory leukemia: Preliminary results of the CA180018 Phase I/II Study
    • Abstract
    • Zwaan CM, Den Boer ML, Beverloo B, et al. Dasatinib (SPRYCEL) in children and adolescents with relapsed or refractory leukemia: Preliminary results of the CA180018 Phase I/II Study. Blood 2006;108: Abstract # 2162.
    • (2006) Blood , Issue.108 , pp. 2162
    • Zwaan, C.M.1    Den Boer, M.L.2    Beverloo, B.3
  • 17
    • 33644623805 scopus 로고    scopus 로고
    • DIMSCAN: A microcomputer fluorescence-based cytotoxicity assay for preclinical testing of combination chemotherapy
    • Keshelava N, Frgala T, Krejsa J, et al. DIMSCAN: A microcomputer fluorescence-based cytotoxicity assay for preclinical testing of combination chemotherapy. Methods Mol Med 2005;110:139-1153.
    • (2005) Methods Mol Med , vol.110 , pp. 139-1153
    • Keshelava, N.1    Frgala, T.2    Krejsa, J.3
  • 18
    • 36849020943 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program
    • epub ahead of print
    • Houghton PJ, Morton CL, Kolb EA, et al. Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program. Pediatr Blood Cancer 2007; (epub ahead of print).
    • (2007) Pediatr Blood Cancer
    • Houghton, P.J.1    Morton, C.L.2    Kolb, E.A.3
  • 19
    • 0023731771 scopus 로고
    • Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents
    • Friedman HS, Colvin OM, Skapek SX, et al. Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents. Cancer Res 1988;48:4189-4195.
    • (1988) Cancer Res , vol.48 , pp. 4189-4195
    • Friedman, H.S.1    Colvin, O.M.2    Skapek, S.X.3
  • 20
    • 31544467339 scopus 로고    scopus 로고
    • Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo
    • Graham C, Tucker C, Creech J, et al. Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo. Clin Cancer Res 2006;12:223-234.
    • (2006) Clin Cancer Res , vol.12 , pp. 223-234
    • Graham, C.1    Tucker, C.2    Creech, J.3
  • 21
    • 26444507974 scopus 로고    scopus 로고
    • In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models
    • Peterson JK, Tucker C, Favours E, et al. In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models. Clin Cancer Res 2005;11:6950-6958.
    • (2005) Clin Cancer Res , vol.11 , pp. 6950-6958
    • Peterson, J.K.1    Tucker, C.2    Favours, E.3
  • 22
    • 2342531648 scopus 로고    scopus 로고
    • Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies
    • Liem NL, Papa RA, Milross CG, et al. Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies. Blood 2004;103:3905-3914.
    • (2004) Blood , vol.103 , pp. 3905-3914
    • Liem, N.L.1    Papa, R.A.2    Milross, C.G.3
  • 23
    • 34447249881 scopus 로고    scopus 로고
    • The pediatric preclinical testing program: Description of models and early testing results
    • epub ahead of print
    • Houghton PJ, Morton CL, Tucker C, et al. The pediatric preclinical testing program: Description of models and early testing results. Pediatr Blood Cancer 2006; (epub ahead of print).
    • (2006) Pediatr Blood Cancer
    • Houghton, P.J.1    Morton, C.L.2    Tucker, C.3
  • 24
    • 33846241683 scopus 로고    scopus 로고
    • Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib
    • Serrels A, Macpherson IR, Evans TR, et al. Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Molecular cancer therapeutics 2006;5:3014-3022.
    • (2006) Molecular cancer therapeutics , vol.5 , pp. 3014-3022
    • Serrels, A.1    Macpherson, I.R.2    Evans, T.R.3
  • 25
    • 27144547509 scopus 로고    scopus 로고
    • Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
    • Nam S, Kim D, Cheng JQ, et al. Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer research 2005;65:9185-9189.
    • (2005) Cancer research , vol.65 , pp. 9185-9189
    • Nam, S.1    Kim, D.2    Cheng, J.Q.3
  • 26
    • 33645687784 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis
    • Shah NP, Lee FY, Luo R, et al. Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood 2006;108:286-291.
    • (2006) Blood , vol.108 , pp. 286-291
    • Shah, N.P.1    Lee, F.Y.2    Luo, R.3
  • 27
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY, et al. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004;305:399-401.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3
  • 28
    • 0036045473 scopus 로고    scopus 로고
    • Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: A t(8;21)-Kit mutant model for acute myeloid leukemia
    • Beghini A, Magnani I, Ripamonti CB, et al. Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: A t(8;21)-Kit mutant model for acute myeloid leukemia. Hematol J 2002;3:157-163.
    • (2002) Hematol J , vol.3 , pp. 157-163
    • Beghini, A.1    Magnani, I.2    Ripamonti, C.B.3
  • 29
    • 34548701082 scopus 로고    scopus 로고
    • Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro
    • epub ahead of print
    • Finn RS, Dering J, Ginther C, et al. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro. Breast Cancer Res Treat 2007; (epub ahead of print).
    • (2007) Breast Cancer Res Treat
    • Finn, R.S.1    Dering, J.2    Ginther, C.3
  • 30
    • 33845723163 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) pharmacokinetics and pharmacodynamic biomarkers in animal models predict optimal clinical exposure
    • Luo FR, Yang Z, Camuso A, et al. Dasatinib (BMS-354825) pharmacokinetics and pharmacodynamic biomarkers in animal models predict optimal clinical exposure. Clin Cancer Res 2006;12:7180-7186.
    • (2006) Clin Cancer Res , vol.12 , pp. 7180-7186
    • Luo, F.R.1    Yang, Z.2    Camuso, A.3
  • 31
    • 85047696594 scopus 로고    scopus 로고
    • Src kinase contributes to the metastatic spread of carcinoma cells
    • Boyer B, Bourgeois Y, Poupon MF. Src kinase contributes to the metastatic spread of carcinoma cells. Oncogene 2002;21:2347-2356.
    • (2002) Oncogene , vol.21 , pp. 2347-2356
    • Boyer, B.1    Bourgeois, Y.2    Poupon, M.F.3
  • 32
    • 13944282937 scopus 로고    scopus 로고
    • Identification of Src-specific phosphorylation site on focal adhesion kinase: Dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior
    • Brunton VG, Avizienyte E, Fincham VJ, et al. Identification of Src-specific phosphorylation site on focal adhesion kinase: Dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res 2005;65:1335-1342.
    • (2005) Cancer Res , vol.65 , pp. 1335-1342
    • Brunton, V.G.1    Avizienyte, E.2    Fincham, V.J.3
  • 33
    • 0037021230 scopus 로고    scopus 로고
    • Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells
    • Jones RJ, Avizienyte E, Wyke AW, et al. Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells. Br J Cancer 2002;87:1128-1135.
    • (2002) Br J Cancer , vol.87 , pp. 1128-1135
    • Jones, R.J.1    Avizienyte, E.2    Wyke, A.W.3
  • 34
    • 0031471321 scopus 로고    scopus 로고
    • Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential
    • Irby R, Mao W, Coppola D, et al. Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential. Cell Growth Differ 1997;8:1287-1295.
    • (1997) Cell Growth Differ , vol.8 , pp. 1287-1295
    • Irby, R.1    Mao, W.2    Coppola, D.3
  • 35
    • 0030970723 scopus 로고    scopus 로고
    • Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src
    • Staley CA, Parikh NU, Gallick GE. Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src. Cell Growth Differ 1997;8:269-274.
    • (1997) Cell Growth Differ , vol.8 , pp. 269-274
    • Staley, C.A.1    Parikh, N.U.2    Gallick, G.E.3
  • 36
    • 0026023289 scopus 로고
    • Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
    • Soriano P, Montgomery C, Geske R, et al. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 1991;64:693-702.
    • (1991) Cell , vol.64 , pp. 693-702
    • Soriano, P.1    Montgomery, C.2    Geske, R.3
  • 37
    • 0034676060 scopus 로고    scopus 로고
    • Decreased c-Src expression enhances osteoblast differentiation and bone formation
    • Marzia M, Sims NA, Voit S, et al. Decreased c-Src expression enhances osteoblast differentiation and bone formation. J Cell Biol 2000;151:311-320.
    • (2000) J Cell Biol , vol.151 , pp. 311-320
    • Marzia, M.1    Sims, N.A.2    Voit, S.3
  • 38
    • 34047265691 scopus 로고    scopus 로고
    • Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival
    • Shor AC, Keschman EA, Lee FY, et al. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer Res 2007;67:2800-2808.
    • (2007) Cancer Res , vol.67 , pp. 2800-2808
    • Shor, A.C.1    Keschman, E.A.2    Lee, F.Y.3
  • 39
    • 2442465000 scopus 로고    scopus 로고
    • Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia
    • Hu Y, Liu Y, Pelletier S, et al. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Gen 2004;36:453-461.
    • (2004) Nat Gen , vol.36 , pp. 453-461
    • Hu, Y.1    Liu, Y.2    Pelletier, S.3
  • 40
    • 33747376361 scopus 로고    scopus 로고
    • The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells
    • Sprangers M, Feldhahn N, Herzog S, et al. The SRC family kinase LYN redirects B cell receptor signaling in human SLP65-deficient B cell lymphoma cells. Oncogene 2006;25:5056-5062.
    • (2006) Oncogene , vol.25 , pp. 5056-5062
    • Sprangers, M.1    Feldhahn, N.2    Herzog, S.3
  • 41
    • 20144385604 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis
    • Contri A, Brunati AM, Trentin L, et al. Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J Clin Invest 2005;115:369-378.
    • (2005) J Clin Invest , vol.115 , pp. 369-378
    • Contri, A.1    Brunati, A.M.2    Trentin, L.3
  • 42
    • 20844453394 scopus 로고    scopus 로고
    • Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: Implications for lymphomagenesis
    • Prakash O, Swamy OR, Peng X, et al. Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: Implications for lymphomagenesis. Blood 2005;105:3987-3994.
    • (2005) Blood , vol.105 , pp. 3987-3994
    • Prakash, O.1    Swamy, O.R.2    Peng, X.3
  • 43
    • 0037085809 scopus 로고    scopus 로고
    • Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6
    • Ishikawa H, Tsuyama N, Abroun S, et al. Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6. Blood 2002;99:2172-2178.
    • (2002) Blood , vol.99 , pp. 2172-2178
    • Ishikawa, H.1    Tsuyama, N.2    Abroun, S.3
  • 44
    • 20144388552 scopus 로고    scopus 로고
    • A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma
    • Li FJ, Tsuyama N, Ishikawa H, et al. A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma. Blood 2005;105:3295-3302.
    • (2005) Blood , vol.105 , pp. 3295-3302
    • Li, F.J.1    Tsuyama, N.2    Ishikawa, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.