Mutual regulation of hypoxia-inducible factor and mammalian target of rapamycin as a function of oxygen availability

Molecular Cancer Research

Volumn 7, Issue 1, 2009, Pages 88-98

  Knaup, Karl X ^a,b   Jozefowski, Katrin ^a   Schmidt, Regina ^a   Bernhardt, Wanja M ^b   Weidemann, Alexander ^b   Juergensen, Jan Steffen ^c   Warnecke, Christina ^b   Eckardt, Kai Uwe ^b   Wiesener, Michael S ^a,b  

^a Interdisciplinary Centre for Clinical Research   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EVEROLIMUS; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; OXYGEN; PROTEIN S6; RAPAMYCIN; S6 KINASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EXPERIMENTAL NEOPLASM; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXYGEN CONCENTRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

CELL HYPOXIA; CELL LINE, TUMOR; HELA CELLS; HOMEOSTASIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; IMMUNOHISTOCHEMISTRY; LUCIFERASES; OXYGEN CONSUMPTION; PROTEIN BIOSYNTHESIS; PROTEIN KINASES; RIBONUCLEASES; TRANSFECTION;

MAMMALIA;

EID: 58649097037     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-08-0288     Document Type: Article

References (43)

1. 2- regulated gene expression. FASEB J 2002;16:1151-62.
2. Schofield CJ,Ratcliffe PJ. Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol 2004;5:343-54.
3. Kaelin WG,Jr. The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res 2007;13:680-4s.
4. Treins C,Giorgetti-Peraldi S,Murdaca J,Semenza GL, Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 2002;277: 27975-81.
5. Zhong H,Chiles K,Feldser D,et al. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541 -5.
6. Dekanty A,Lavista-Llanos S,Irisarri M,Oldham S,Wappner P. The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-α/Sima. J Cell Sci 2005; 118:5431 -41.
7. Hudson CC,Liu M,Chiang GG,et al. Regulation of hypoxia-inducible factor 1a expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002;22:7004-14.
8. Thomas GV,Tran C,Mellinghoff IK,et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006; 12:122-7.
9. Fingar DC,Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004;23:3151 -71.
10. Proud CG. The multifaceted role of mTOR in cellular stress responses. DNA Repair (Amst) 2004;3:927-34.
11. Bjornsti MA,Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004;4:335-48.
12. Guba M,von Breitenbuch P,Steinbauer M,et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002;8:128-35.
13. Pouyssegur J,Dayan F,Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006;441:437 -43.
14. Koritzinsky M,Wouters BG. Hypoxia and regulation of messenger RNA translation. Methods Enzymol 2007;435:247-73.
15. Thomas JD,Johannes GJ. Identification of mRNAs that continue to associate with polysomes during hypoxia. RNA 2007;13:1116-31.
16. Pende M,Um SH,Mieulet V, et al. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5́-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 2004;24:3112-24.
17. RuvinskyI,SharonN,LererT,et al.Ribosomal protein S6 phosphorylationisa determinant of cell size and glucose homeostasis. Genes Dev2005;19:2199-211.
18. Wiesener MS,Turley H,Allen WE,et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1α. Blood 1998;92:2260-8.
19. Stiehl DP,Wirthner R,Koditz J,Spielmann P,Camenisch G,Wenger RH. Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system. J Biol Chem 2006; 281:23482-91.
20. Vaux EC,Wood SM,Cockman ME,et al. Selection of mutant CHO cells with constitutive activation of the HIF system and inactivation of the von Hippel-Lindau tumor suppressor. J Biol Chem 2001;276:44323 -30.
21. Williams AJ,Werner-Fraczek J,Chang IF,Bailey-Serres J. Regulated phosphorylation of 40S ribosomal protein S6 in root tips of maize. Plant Physiol 2003;132:2086-97.
22. Majumder PK,Febbo PG,Bikoff R,et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 2004;10:594-601.
23. Brugarolas JB,Vazquez F, Reddy A, Sellers WR, Kaelin WG,Jr. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell 2003;4:147-58.
24. Blouw B,Song H,Tihan T,et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 2003;4:133 -46.
25. Carmeliet P,Dor Y, Herbert JM, et al. Role of HIF-1α in hypoxia-mediated apoptosis,cell proliferation and tumour angiogenesis. Nature 1998;394:485 -90.
26. van den Beucken T,Koritzinsky M,Wouters BG. Translational control of gene expression during hypoxia. Cancer Biol Ther 2006;5:749-55.
27. Brugarolas J, Lei K, Hurley RL,et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev 2004;18:2893-904.
28. Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 2006;21:521 -31.
29. Li Y, Wang Y, Kim E, et al. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J Biol Chem 2007; 282:35803-13.
30. Bernardi R,Guernah I,Jin D,et al. PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR. Nature 2006;442:779 -85.
31. Arsham AM,Howell JJ,Simon MC. A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 2003;278:29655-60.
32. Lang KJ,Kappel A,Goodall GJ. Hypoxia-inducible factor-1α mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell 2002;13:1792-801.
33. Young RM, Wang SJ, Gordan JD, Ji X, Liebhaber SA, Simon MC. Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism. J Biol Chem 2008;283:16309-19.
34. Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma SC. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J 1998;17:6649-59.
35. Pende M,Kozma SC,Jaquet M,et al. Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice. Nature 2000;408:994-7.
36. Seagroves TN, Ryan HE, Lu H, et al. Transcription factor HIF-1 is a necessary mediator of the Pasteur effect in mammalian cells. Mol Cell Biol 2001; 21:3436-44.
37. Lum JJ, Bui T, Gruber M, et al. The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev 2007;21:1037-49.
38. Brahimi-Horn MC, Chiche J, Pouyssegur J. Hypoxia and cancer. J Mol Med 2007;85:1301 -7.
39. Lechler P, Wu X, Bernhardt W, et al. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Am J Pathol 2007;171:1483-98.
40. Grafe M, Steinheider G, Desaga U, et al. Characterization of two distinct mechanisms for induction of apoptosis in human vascular endothelial cells. Clin Chem Lab Med 1999;37:505-10.
41. Rosenberger C, Mandriota S, Jurgensen JS, et al. Expression of hypoxia-inducible factor-1α and -2α in hypoxic and ischemic rat kidneys. J Am Soc Nephrol 2002;13:1721 -32.
42. Bernhardt WM, Wiesener MS, Weidemann A, et al. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Am J Pathol 2007; 170:830 -42.
43. Warnecke C, Zaborowska Z, Kurreck J, et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1α and HIF-2α (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2α target gene in Hep3B and Kelly cells. FASEB J 2004;18:1462-4.