N-Methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss

Nature Medicine

Volumn 2, Issue 12, 1996, Pages 1338-1343

  Basile, Anthony S ^a   Huang, Jer Min ^b   Xie, Chen ^b   Webster, Douglas ^b   Berlin, Charles ^b   Skolnick, Phil ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; DIZOCILPINE; IFENPRODIL; KANAMYCIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; GUINEA PIG; HEARING LOSS; MALE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTI-BACTERIAL AGENTS; COCHLEA; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GUINEA PIGS; HAIR CELLS; HEARING LOSS; HEARING TESTS; KANAMYCIN; MALE; N-METHYLASPARTATE; NEOMYCIN; PIPERIDINES; PROSENCEPHALON; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0029850284     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1296-1338     Document Type: Article

References (39)

1. Begg, E.J. & Barclay, M.L. Aminoglycosides - 50 years on. Br. J. Clin. Pharmacol. 39, 597-603 (1995).
2. Brummett, R.E., Fox, K.E., Bendrick, T.W. & Himes, D.L. Ototoxicity of tobramycin, gentamicin, amikacin and sisomicin in the guinea pig. J. Antimicrob. Chemother. 4 (Suppl. A), 73-83, (1978).
3. Brummett, R.E. & Morrison, R.B. The incidence of aminoglycoside antibiotic-induced hearing loss. Arch. Otolaryngol. Head Neck Surg. 116, 405-410 (1990).
4. Stringer, S.P., Meyerhoff, W.L. & Wright, C.G. Ototoxicity. in Otolaryngology (eds. Paparella, M.M., Shumrick, D.A., Gluckman, J.L. & Meyerhoff, W.L.) 1653-1669 (Saunders, Philadelphia, 1991).
5. Hodges, G.R. Aminoglycoside toxicity. in The Aminoglycoside Antibiotics: A Guide to Therapy (eds. Barnes, W.G. & Hodges, G.R.) 153-179 (CRC Press, Boca Raton, Florida, 1984).
6. Kiang, N.Y.S., Liberman, M.C. & Levine, R.A. Auditory nerve activity in cats exposed to ototoxic drugs and high-intensity sounds. Ann. Otol. Rhinol. Laryngol. 85, 752-768 (1976).
7. Schacht, J. Biochemical basis of aminoglycoside toxicity. Otolaryngol. Clin. North Am. 26, 845-856 (1993).
8. Lim, D.J. Effects of noise and ototoxic drugs at the cellular level in the cochlea. Am. J. Otolaryngol. 7, 73-99 (1986).
9. Puel, J.-L., Ladrech, R., Chabert, R., Pujol, R. & Eybalin, M. Electrophysiological evidence for the presence of NMDA receptors in the guinea pig cochlea. Hear. Res. 51, 255-264 (1991).
10. Safieddine, S. & Eybalin, M. Co-expression of NMDA and AMPA/kainate receptor mRNAs in cochlear neurones. NeuroReport 3, 1145-1148 (1992).
11. Usami, S. Matsubara, A., Fujita S., Shinkawa, H. & Hayashi, M. NMDA (NMDAR1) and AMPA-type (GluR2/3) receptor subunits are expressed in the inner ear. NeuroReport 6, 1161-1164 (1995).
12. Pullan, L.M., Stumpo, R.J., Powel, R.J., Paschetto, K.A. & Britt, M. Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor. J. Neurochem. 59, 2087-2093 (1992).
13. Choi, D.W. Excitotoxic cell death. J. Neurobiol. 23, 1261-1276 (1992).
14. Wong, E. et al. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc. Narl. Acad. Sci. USA 83, 7104-7108 (1986).
15. Carter, C., Lloyd, K., Zivkovic, B. & Scatton, B. Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex. J. Pharmacol. Exp. Ther. 253, 475-482 (1990).
16. Oliveira, J.A.A. Methods for studying ototoxicity. in Audiovestibular Toxicity of Drugs (ed. Oliveira, J.A.A.) 71-74 (CRC Press, Boca Raton, Florida, 1989).
17. Huang, J.-M. Money, M.K., Berlin, C.I. & Keats, B.J.B. Auditory phenotyping of heterozygous sound-responsive (+/dn) and deafness (dn/dn) mice. Hear. Res. 88, 61-64 (1995).
18. Brown, A.M., McDowell, B. & Forge, A. Acoustic distortion products can be used to monitor the effects of chronic gentamicin treatment. Hear. Res. 42, 143-156 (1989).
19. Henley, C.M. & Ryback, L.P. Ototoxicity in developing mammals. Brain Res. Rev. 20, 68-90 (1995).
20. Revai, K., Katona, G., Pytel, J., Czinner, A. & Pataki, L. Evaluation of hearing loss by means of inner ear acoustic emission in neonates with aminoglycoside. Orv. Hetil. 136, 2615-2618 (1995).
21. Lenoir, M. & Pujol, R. Age-related structural investigation of the Bronx waltzer mutant mouse cochlea: Scanning and transmission electron microscopy. Hear. Res. 13, 123-134 (1984).
22. Chandler, P., Pennington, M., Maccecchini, M., Nashed, N. & Skolnick, P. Polyamine-like actions of peptides derived from conantokin-G, an NMDA antagonist. J. Biol. Chem. 268, 17173-17178 (1993).
23. 3H]ifenprodil binding in rat brain. Eur. J. Pharmacol., Mol. Pharmacol. Sect. 266, 67-77 (1994).
24. Akiyoshi, M., Yano, S. & Ikeda, T. Ototoxicity of spectinomycin. Jpn. J. Antibiot. 29, 771-782 (1976).
25. Reynolds, I.J. & Miller, R.J. Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: Interaction with polyamines. Mol. Pharmacol. 36, 758-765 (1989).
26. Eybalin, M. Neurotransmitters and neuromodulators in the mammalian cochlea. Physiol. Rev. 73, 309-373 (1993).
27. Benveniste, M. & Mayer, M.L. Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurons. J. Physiol. (Lond.) 464, 131-163 (1993).
28. Romano, C. & Williams, K. Modulation of NMDA receptors by polyamines. in The Neuropharmacology of Polyamines. (ed. Carter, C.) 81-106 (Academic Press, London, 1994).
29. Desrochers, C.S. & Schacht, J. Neomycin concentrations in inner ear tissues and other organs of the guinea pig after chronic drug administration. Acta Otolaryngol. 93, 233-236 (1982).
30. Reynolds, I.J. Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor. J. Pharmacol. Exp. Ther. 256, 1001-1007 (1990).
31. Ernfors, P., Duan, M.L., ElShamy, W.M. & Canlon, B. Protection of auditory neurons from aminoglycoside toxicity by neurotrophin-3. Nature Med. 2, 463-467 (1996).
32. Scatton, B. et al. Neuroprotective potential of the polyamine site-directed NMDA receptor antagonists-ifenprodil and eliprodil. in Direct and Allosteric Control of Glutamate Receptors. (eds. Palfreyman, M.G., Reynolds, I.J., & Skolnick, P.) 139-154 (CRC Press, Boca Raton, Florida, 1994).
33. Gill, R., Foster, A.C. & Woodruff, G.N. MK-801 is neuroprotective in gerbils when administered during the postischaemic period. Neuroscience 3, 847-855 (1988).
34. Sveinbjornsdottir, S. et al. The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy. Epilepsy Res. 16, 165-174 (1993).
35. Cherkofsky, S.C. 1-Aminocyclopropanecarboxylic acid: Mouse to man interspecies pharmacokinetic comparisons and allometric relationships. J. Pharm. Sci. 85, 1231-1235 (1995).
36. Patat, A. et al. Lack of amnestic psychotomimetic or impairing effect on psychomotor performance of eliprodil, a new NMDA antagonist. Int. Clin. Psychopharmacol. 9, 155-162 (1994).
37. Loscher, W., Nolting, B. & Honack, D. Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy: Comparison of other NMDA antagonists, and with diazepam and phenobarbital. Eur. J. Pharmacol. 152, 9-17 (1988).
38. Oliveira, J.A.A. Aminoglycoside antibiotics - Neomycin. in Audovestibular Toxicity of Drugs (ed. Oliveira, J.A.A.) 223-244 (CRC Press, Boca Raton, Florida, 1989).
39. Bamonte, F., Parravicini, L. & Arpini, A. Histological evaluation of ototoxic reaction due to some aminoglycoside antibiotics. Arch. Otorhinolaryngol. 228, 163-170 (1980).