The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis

European Journal of Immunology

Volumn 36, Issue 11, 2006, Pages 3071-3081

  Usui, Yoshihiko ^a,b   Akiba, Hisaya ^a   Takeuchi, Masaru ^b   Kezuka, Takeshi ^b   Takeuchi, Aya ^b   Hattori, Takaaki ^b   Okunuki, Yoko ^b   Yamazaki, Tomohide ^a   Yagita, Hideo ^a   Usui, Masahiko ^b   Okumura, Ko ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Costimulation; Experimental autoimmune encephalitis; Experimental autoimmune uveoretinitis

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN B7RP 1; PROTEIN ICOS; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; IN VITRO STUDY; LYMPH NODE CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM; T LYMPHOCYTE; UVEORETINITIS;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; INTERFERON TYPE II; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, MUTANT STRAINS; RETINA; RETINITIS; UVEITIS;

EID: 33751210607     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200636138     Document Type: Article

References (43)

1. Janeway, C. A., Jr. and Bottomly, K., Signals and signs for lymphocyte responses. Cell 1994. 76: 275-285.
2. Jenkins, M. K., The ups and downs of T cell costimulation. Immunity 1994. 1: 443-446.
3. Carreno, B. M. and Collins, M., The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 2002. 20: 29-53.
4. Greenwald, R. J., Freeman, G. J. and Sharpe, A. H., The B7 family revisited. Annu. Rev. Immunol. 2005. 23: 515-548.
5. Kuchroo, V. K., Das, M. P., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. I., et al., B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995. 80: 707-718.
6. Nakajima, A., Azuma, M., Kodera, S., Nuriya, S., Terashi, A., Abe, M., Hirose, S. et al., Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule. Eur. J. Immunol. 1995. 25: 3060-3069.
7. Webb, L. M., Walmsley, M. J. and Feldmann, M., Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2. Eur. J. Immunol. 1996. 26: 2320-2328.
8. Fukai T., Okada, A. A., Sakai, J., Kezuka, T., Keino, H., Usui, M., Yagita, H. et al., The role of costimulatory molecules B7-1 and B7-2 in mice with experimental autoinumme uveoretinitis. Graefes Arch. Chn. Erp. Ophthalmol. 1999. 237: 928-933.
9. Silver, P. B., Hathcock, K. S., Chan, C. C., Wiggert, B. and Caspi, R. R., Blockade of costimulation through B7/CD28 inhibits experimental autoimmune uveoretinitis, but does not induce long-term tolerance. J. Immunol. 2000. 165: 5041-5047.
10. Hutloff, A., Dittrich, A. M., Beier, K. C., Eljaschewitsch, B., Kraft, R., Anagnostopoulos, I. and Kroczek, R. A., ICOS is an inducible T-cell costimulator structurally and functionally related to CD28. Nature 1999. 397: 263-266.
11. Tezuka, K., Tsuji, T., Hirano, D., Tamatani, T., Sakamaki, K., Kobayashi, Y. and Kamada, M., Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/ CTLA4 family. Biochem. Biophys. Res. Commun. 2000. 276: 335-345.
12. Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., Sarmiento, U., Guo, J., Horan, T., Shih, G. et al., T-cell co-stimulation through B7RP-l and ICOS. Nature 1999. 402: 827-832.
13. Swallow, M. M., Wallin, J. J. and Sha, W. C., B7 h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity 1999. 11: 423-432.
14. Wang, S., Zhu, G., Chapoval, A. I., Dong, H., Tamada, K., Ni, J. and Chen, I., Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood 2000. 96: 2808-2813.
15. Ling, V., Wu, P. W., Finnerty, H. F., Bean, K. M., Spaulding, V., Fouser, L. A., Leonard, J. P. et al., Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J. Immunol. 2000. 164: 1653-1657.
16. Brodie, D., Collins, A. V., Iaboni, A., Fennelly, J. A., Sparks, L. M., Xu, X. N., van der Merwe, P. A. et al., LICOS, a primordial costimulatory ligand? Curr. Biol. 2000. 10: 333-336.
17. Beier, K. C., Hutloff, A., Dittrich, A. M., Heuck, C., Rauch, A., Buchner, K., Ludewig, B. et al., Induction, binding specificity and function of human ICOS. Eur. J. Immunol. 2000. 30: 3707-3717.
18. Iwai, H., Kozono, Y., Hirose, S., Akiba, H., Yagita, H., Okumura, K., Kohsaka, H. et al., Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. J. Immunol. 2002. 169: 4332-4339.
19. Nurieva, R. I., Treuting, P., Duong, J., Flavell, R. A. and Dong, C., Inducible costimulator is essential for collagen-induced arthritis. J. Clin. Invest. 2003. III: 701-706.
20. Dong, C., Juedes, A. E., Temann, U. A., Shresta, S., Allison, J. P., Ruddle, N. H. and Flavell, R. A., ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 2001. 409: 97-101.
21. Rottman, J. B., Smith, T., Tonra, J. R., Ganley, K., Bloom, T., Silva, R., Pierce, B. et al., The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat. Immunol. 2001. 2: 605-611.
22. Caspi, R. R., Immune mechanisms in uveitis. Springer Semin. Immunopathol. 1999. 21: 113-124.
23. Sanui, H., Redmond, T. M., Kotake, S., Wiggert, B., Hu, L. H., Margalit, H., Berzofsky, J. A. et al., Identification of an immunodominant and highly immunopathogenic determinant in the retinal interphotoreceptor retinoid-binding protein (IRBP). J. Exp. Med. 1989. 169: 1947-1960.
24. + T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice. J. Immunol. 1996. 156: 1654-1660.
25. Saoudi, A., Kuhn, J., Huygen, K., de Kozak, Y., Velu, T., Goldman, M., Druet, P. and Bellon, B., TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoinumme disease. Eur. J. Immunol. 1993. 23: 3096-3103.
26. Kezuka, T., Sakai J., Yokoi, H., Takeuchi, M., Okada, A., Taguchi, O., Usui, M. and Mizuguchi, J., Peptide-mediated suppression of experimental autoinumme uveoretinitis in mice: development of a peptide vaccine. Int. Immunol. 1996. 8: 1229-1235.
27. Caspi, R. R., Th1 and Th2 responses in pathogenesis and regulation of experimental autoimmune uveoretinitis. Int. Rev. Immunol. 2002. 21: 197-208.
28. Namba, K., Ogasawara, K., Kitaichi, N., Morohashi, T., Sasamoto, Y., Kotake, S., Matsuda, H. et al., Amelioration of experimental autoimmune uveoretinitis by pretreatment with a pathogenic peptide in liposome and anti-CD40 ligand monoclonal antibody. J. Immunol. 2000. 165: 2962-2969.
29. Gonzalo, J. A., Tian, J., Delaney, T., Corcoran, J., Rottman, J. B., Lora, J., Al-garawi A. et al., ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat. Immunol. 2001. 2: 597-604.
30. Croft, M., Bradley, L. M. and Swain, S. L., Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J. Immunol. 1994. 152: 2675-2685.
31. Flynn, K. and Mullbacher, A., Memory alloreactive cytotoxic T cells do not require costimulation for activation in vitro. Immunol. Cell. Biol. 1996. 74: 413-420.
32. Scholz, C., Patton, K. T., Anderson, D. E., Freeman, G. J. and Hafler, D. A., Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation. J. Immunol. 1998. 160: 1532-1538.
33. Lovett-Racke, A. E., Trotter, J. L, Lauber, J., Perrin, P. J., June, C. H. and Racke, M. K., Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells. J. Clin. Invest. 1998. 101: 725-730.
34. Ozkaynak, E., Gao, W., Shemmeri, N., Wang, C., Gutierrez-Ramos, J.C. Amaral, J., Qin, S. et al., Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat. Immunol. 2001. 2: 591-596.
35. Sporici, R. A., Beswick, R. L, von Allmen, C., Rumbley C. A., Hayden-Ledbetter, M., Ledbetter, J. A. and Perrin, P. J., ICOS ligand costimulation is required for T-cell encephalitogenicity. Clin. Immunol. 2001. 100: 277-288.
36. Zhang, B., Yamamura, T., Kondo, T., Fujiwara, M. and Tabira, T., Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J. Exp. Med. 1997 186: 1677-1687.
37. Kitaichi, N., Kotake, S., Morohashi, T., Onoe, K., Ohno, S. and Taylor, A. W., Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells. J. Leukoc. Biol. 2002. 72: 1117-1121.
38. Ogasawara, K., Yoshinaga, S. K. and Lanier, L. L., Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells. J. Immunol. 2002. 169: 3676-3685.
39. Kaneda, H., Takeda, K., Ota, T., Kaduka, Y., Akiba, H., Ikarashi, Y., Wakasugi, H. et al., ICOS costimulates invariant NKT cell activation. Biochem. Biophys. Res. Commun. 2005. 327: 201-207.
40. Iiyama, R., Kanai, T., Uraushihara, K., Totsuka, T., Nakamura, T., Miyata, T., Yagita, H. et al., The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches. Immunol. Lett. 2003. 88: 63-70.
41. Thurau, S. R., Chan, C. C., Nussenblatt, R. B. and Caspi R. R., Oral tolerance in a murine model of relapsing experimental autoinumme uveoretinitis (EAU): induction of protective tolerance in primed animals. Clin. Exp. Immunol. 1997 109: 370-376.
42. Chan, C. C., Caspi, R. R., Ni M., Leake, W. C., Wiggert, B., Chader, G. J. and Nussenblatt, R. B., Pathology of experimental autoimmune uveoretinitis in mice. J. Autoimmun. 1990. 3: 247-255.
43. Takeuchi, A., Usui, Y., Takeuchi, M., Hattori T., Kezuka, T., Suzuki J., Okunuki, Y. et al., CCR5-deficient mice develop experimental autoimmune uveoretinitis in the context of a deviant effector response. Invest. Ophthalmol. Vis. Sci 2005. 46: 3753-3760.