메뉴 건너뛰기




Volumn 7, Issue 4, 2008, Pages 270-278

Design and modifications of allergens for improving specific immunotherapy

Author keywords

Allergen; Allergoid; Hypoallergen; Immunotherapy; Modification

Indexed keywords

ALLERGEN; ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; DNA VACCINE; GRASS POLLEN VACCINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G4; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; POLLEN ANTIGEN; DNA;

EID: 58249089399     PISSN: 18715281     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152808786848432     Document Type: Review
Times cited : (8)

References (113)
  • 1
    • 33749016485 scopus 로고    scopus 로고
    • Immunological mechanisms of allergen-specific immunotherapy
    • Larche, M.; Akdis, C.A.; Valenta, R. Immunological mechanisms of allergen-specific immunotherapy. Nat. Rev. Immunol., 2006, 6, 761.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 761
    • Larche, M.1    Akdis, C.A.2    Valenta, R.3
  • 2
    • 34047161743 scopus 로고    scopus 로고
    • Allergic rhinitis and its impact on asthma update: Allergen immunotherapy
    • Passalacqua, G.; Durham, S. R. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J. Allerg. Clin. Immunol., 2007, 119, 881.
    • (2007) J. Allerg. Clin. Immunol , vol.119 , pp. 881
    • Passalacqua, G.1    Durham, S.R.2
  • 3
    • 0033197966 scopus 로고    scopus 로고
    • Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation
    • van Neerven, R.J.; Wikborg, T.; Lund, G.; Jacobsen, B.; Brinch-Nielsen, A.; Arnved, J.; Ipsen, H. Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation. J. Immunol., 1999, 163, 2944.
    • (1999) J. Immunol , vol.163 , pp. 2944
    • van Neerven, R.J.1    Wikborg, T.2    Lund, G.3    Jacobsen, B.4    Brinch-Nielsen, A.5    Arnved, J.6    Ipsen, H.7
  • 4
    • 44949122465 scopus 로고    scopus 로고
    • Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa
    • 1467, 1472 e1
    • Radulovic, S.; Jacobson, M.R.; Durham, S.R.; Nouri-Aria, K.T. Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa. J. Allergy Clin. Immunol., 2008, 121, 1467, 1472 e1.
    • (2008) J. Allergy Clin. Immunol , vol.121
    • Radulovic, S.1    Jacobson, M.R.2    Durham, S.R.3    Nouri-Aria, K.T.4
  • 7
    • 33745666983 scopus 로고    scopus 로고
    • Ultra-rush venom immunotherapy induces differential T cell activation and regulatory patterns according to the severity of allergy
    • Mamessier, E.; Birnbaum, J.; Dupuy, P.; Vervloet, D.; Magnan, A. Ultra-rush venom immunotherapy induces differential T cell activation and regulatory patterns according to the severity of allergy. Clin. Exp. Allergy, 2006, 36, 704.
    • (2006) Clin. Exp. Allergy , vol.36 , pp. 704
    • Mamessier, E.1    Birnbaum, J.2    Dupuy, P.3    Vervloet, D.4    Magnan, A.5
  • 8
    • 0037504093 scopus 로고    scopus 로고
    • Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy
    • Francis, J.N.; Till, S.J.; Durham, S.R. Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy. J. Allergy Clin. Immunol., 2003, 111, 1255.
    • (2003) J. Allergy Clin. Immunol , vol.111 , pp. 1255
    • Francis, J.N.1    Till, S.J.2    Durham, S.R.3
  • 10
    • 33644785795 scopus 로고    scopus 로고
    • Side-effects of allergen-specific immunotherapy: A prospective multi-centre study
    • Winther, L.; Arnved, J.; Malling, H.J.; Nolte, H.; Mosbech, H. Side-effects of allergen-specific immunotherapy: a prospective multi-centre study. Clin. Exp. Allergy, 2006, 36, 254.
    • (2006) Clin. Exp. Allergy , vol.36 , pp. 254
    • Winther, L.1    Arnved, J.2    Malling, H.J.3    Nolte, H.4    Mosbech, H.5
  • 11
    • 0023286915 scopus 로고
    • Standardized extracts modified allergens-allergoids
    • Maasch, H.J.; Marsh, D.G. Standardized extracts modified allergens-allergoids. Clin. Rev. Allergy, 1987, 5, 89.
    • (1987) Clin. Rev. Allergy , vol.5 , pp. 89
    • Maasch, H.J.1    Marsh, D.G.2
  • 12
    • 0020027190 scopus 로고
    • Studies of allergen and allergoid preparations from purified timothy (Phleum pratense) pollen extracts. I. Physicochemical characteristics and binding to allergen-specific human IgE
    • Puttonen, E.; Maasch, H.J.; Pilstrom, L. Studies of allergen and allergoid preparations from purified timothy (Phleum pratense) pollen extracts. I. Physicochemical characteristics and binding to allergen-specific human IgE. Int. Arch. Allergy Appl. Immunol., 1982, 68, 1.
    • (1982) Int. Arch. Allergy Appl. Immunol , vol.68 , pp. 1
    • Puttonen, E.1    Maasch, H.J.2    Pilstrom, L.3
  • 13
    • 0020046593 scopus 로고
    • Studies on allergen and allergoid preparations from purified timothy (Phleum pratense) pollen extracts. II. Anaphylaxis studies in rats and histamine release from human leukocytes
    • Puttonen, E.; Pilstrom, L.; Wahn, U.; Maasch, H.J. Studies on allergen and allergoid preparations from purified timothy (Phleum pratense) pollen extracts. II. Anaphylaxis studies in rats and histamine release from human leukocytes. Int. Arch. Allergy Appl. Immunol., 1982, 68, 7.
    • (1982) Int. Arch. Allergy Appl. Immunol , vol.68 , pp. 7
    • Puttonen, E.1    Pilstrom, L.2    Wahn, U.3    Maasch, H.J.4
  • 14
    • 0023124401 scopus 로고
    • Double-blind, placebo-controlled immunotherapy with a high-molecular-weight, formalinized allergoid in grass pollen allergy
    • Bousquet, J.; Frank, E.; Soussana, M.; Hejjaoui, A.; Maasch, H.J.; Michel, F.B. Double-blind, placebo-controlled immunotherapy with a high-molecular-weight, formalinized allergoid in grass pollen allergy. Int. Arch. Allergy Appl. Immunol., 1987, 82, 550.
    • (1987) Int. Arch. Allergy Appl. Immunol , vol.82 , pp. 550
    • Bousquet, J.1    Frank, E.2    Soussana, M.3    Hejjaoui, A.4    Maasch, H.J.5    Michel, F.B.6
  • 15
    • 0022622521 scopus 로고
    • The clinical and immunologic efficacy of immunotherapy with modified ragweed extract (allergoid) for ragweed hay fever
    • Meriney, D.K.; Kothari, H.; Chinoy, P.; Grieco, M.H. The clinical and immunologic efficacy of immunotherapy with modified ragweed extract (allergoid) for ragweed hay fever. Ann. Allergy, 1986, 56, 34.
    • (1986) Ann. Allergy , vol.56 , pp. 34
    • Meriney, D.K.1    Kothari, H.2    Chinoy, P.3    Grieco, M.H.4
  • 16
    • 31944443997 scopus 로고    scopus 로고
    • Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis
    • Frew, A. J.; Powell, R.J.; Corrigan, C.J.; Durham, S.R. Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis. J. Allergy Clin. Immunol., 2006, 117, 319.
    • (2006) J. Allergy Clin. Immunol , vol.117 , pp. 319
    • Frew, A.J.1    Powell, R.J.2    Corrigan, C.J.3    Durham, S.R.4
  • 18
    • 0001399408 scopus 로고    scopus 로고
    • Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: Hybrids of yellow jacket and paper wasp venom allergen antigen 5s
    • King, T.P.; Jim, S.Y.; Monsalve, R.I.; Kagey-Sobotka, A.; Lichtenstein, L.M.; Spangfort, M.D. Recombinant allergens with reduced allergenicity but retaining immunogenicity of the natural allergens: hybrids of yellow jacket and paper wasp venom allergen antigen 5s. J. Immunol., 2001, 166, 6057.
    • (2001) J. Immunol , vol.166 , pp. 6057
    • King, T.P.1    Jim, S.Y.2    Monsalve, R.I.3    Kagey-Sobotka, A.4    Lichtenstein, L.M.5    Spangfort, M.D.6
  • 19
    • 23244456566 scopus 로고    scopus 로고
    • Intranasal tolerance induction with polypeptides derived from 3 noncross-reactive major aeroallergens prevents allergic polysensitization in mice
    • Hufnagl, K.; Winkler, B.; Focke, M.; Valenta, R.; Scheiner, O.; Renz, H.; Wiedermann, U. Intranasal tolerance induction with polypeptides derived from 3 noncross-reactive major aeroallergens prevents allergic polysensitization in mice. J. Allergy Clin. Immunol., 2005, 116, 370.
    • (2005) J. Allergy Clin. Immunol , vol.116 , pp. 370
    • Hufnagl, K.1    Winkler, B.2    Focke, M.3    Valenta, R.4    Scheiner, O.5    Renz, H.6    Wiedermann, U.7
  • 21
    • 0036676925 scopus 로고    scopus 로고
    • Combination vaccines for the treatment of grass pollen allergy consisting of genetically engineered hybrid molecules with increased immunogenicity
    • Linhart, B.; Jahn-Schmid, B.; Verdino, P.; Keller, W.; Ebner, C.; Kraft, D.; Valenta, R. Combination vaccines for the treatment of grass pollen allergy consisting of genetically engineered hybrid molecules with increased immunogenicity. FASEB J. 2002, 16, 1301.
    • (2002) FASEB J , vol.16 , pp. 1301
    • Linhart, B.1    Jahn-Schmid, B.2    Verdino, P.3    Keller, W.4    Ebner, C.5    Kraft, D.6    Valenta, R.7
  • 22
    • 0036964533 scopus 로고    scopus 로고
    • Allergen-immunostimulatory oligodeoxynucleotide conjugate: A novel allergoid for immunotherapy
    • Spiegelberg, H.L.; Horner, A.A.; Takabayashi, K.; Raz, E. Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy. Curr. Opin. Allergy Clin. Immunol., 2002, 2, 547.
    • (2002) Curr. Opin. Allergy Clin. Immunol , vol.2 , pp. 547
    • Spiegelberg, H.L.1    Horner, A.A.2    Takabayashi, K.3    Raz, E.4
  • 25
    • 4043133762 scopus 로고    scopus 로고
    • Vaccine engineering improved by hybrid technology
    • Linhart, B.; Valenta, R. Vaccine engineering improved by hybrid technology. Int. Arch. Allergy Immunol., 2004, 134, 324.
    • (2004) Int. Arch. Allergy Immunol , vol.134 , pp. 324
    • Linhart, B.1    Valenta, R.2
  • 27
    • 38949189510 scopus 로고    scopus 로고
    • Accentuate the negative, eliminate the positive: Engineering allergy therapeutics to block allergic reactivity through negative signaling
    • Saxon, A.; Kepley, C.; Zhang, K. "Accentuate the negative, eliminate the positive": engineering allergy therapeutics to block allergic reactivity through negative signaling. J. Allergy Clin. Immunol., 2008, 121, 320.
    • (2008) J. Allergy Clin. Immunol , vol.121 , pp. 320
    • Saxon, A.1    Kepley, C.2    Zhang, K.3
  • 28
    • 0017370729 scopus 로고
    • Chemical modification of crude timothy grass pollen extract. III. The effect of glutaraldehyde-induced aggregation on antigenic and immunogenic properties
    • Moran, D.M.; Wheeler, A.W.; Overell, B.G.; Woroniecki, S.R. Chemical modification of crude timothy grass pollen extract. III. The effect of glutaraldehyde-induced aggregation on antigenic and immunogenic properties. Int. Arch. Allergy Appl. Immunol., 1977, 54, 315.
    • (1977) Int. Arch. Allergy Appl. Immunol , vol.54 , pp. 315
    • Moran, D.M.1    Wheeler, A.W.2    Overell, B.G.3    Woroniecki, S.R.4
  • 29
    • 0030300208 scopus 로고    scopus 로고
    • Characterization of allergoids from ovalbumin in vitro and in vivo
    • Salgado, J.; Casadevall, G.; Puignero, V.; Queralt, J. Characterization of allergoids from ovalbumin in vitro and in vivo. Immunobiology, 1996, 196, 375.
    • (1996) Immunobiology , vol.196 , pp. 375
    • Salgado, J.1    Casadevall, G.2    Puignero, V.3    Queralt, J.4
  • 32
    • 0028142054 scopus 로고
    • Modified par j I allergen from P judaica pollen and its rate of absorption in rats
    • Mistrello, G.; Roncarolo, D.; Gentili, M.; Zanoni, D.; Falagiani, P. Modified par j I allergen from P judaica pollen and its rate of absorption in rats. Immunol. Lett., 1994, 40, 31.
    • (1994) Immunol. Lett , vol.40 , pp. 31
    • Mistrello, G.1    Roncarolo, D.2    Gentili, M.3    Zanoni, D.4    Falagiani, P.5
  • 33
    • 0029866066 scopus 로고    scopus 로고
    • Monomeric chemically modified allergens: Immunologic and physicochemical characterization
    • Mistrello, G.; Brenna, O.; Roncarolo, D.; Zanoni, D.; Gentili, M.; Falagiani, P. Monomeric chemically modified allergens: immunologic and physicochemical characterization. Allergy, 1996, 51, 8.
    • (1996) Allergy , vol.51 , pp. 8
    • Mistrello, G.1    Brenna, O.2    Roncarolo, D.3    Zanoni, D.4    Gentili, M.5    Falagiani, P.6
  • 34
    • 0000670417 scopus 로고    scopus 로고
    • Physicochemical and immunologic characterization of low-molecular-weight allergoids of Dactylis glomerata pollen proteins
    • Cirkovic, T.D.; Bukilica, M.N.; Gavrovic, M.D.; Vujcic, Z.M.; Petrovic, S.; Jankov, R.M. Physicochemical and immunologic characterization of low-molecular-weight allergoids of Dactylis glomerata pollen proteins. Allergy, 1999, 54, 128.
    • (1999) Allergy , vol.54 , pp. 128
    • Cirkovic, T.D.1    Bukilica, M.N.2    Gavrovic, M.D.3    Vujcic, Z.M.4    Petrovic, S.5    Jankov, R.M.6
  • 35
    • 0036828313 scopus 로고    scopus 로고
    • The influence of a residual group in low-molecular-weight allergoids of Artemisia vulgaris pollen on their allergenicity, IgE- and IgG-binding properties
    • Cirkovic, T.; Gavrovic-Jankulovic, M.; Prisic, S.; Jankov, R.M.; Burazer, L.; Vuckovic, O.; Sporcic, Z.; Paranos, S. The influence of a residual group in low-molecular-weight allergoids of Artemisia vulgaris pollen on their allergenicity, IgE- and IgG-binding properties. Allergy, 2002, 57, 1013.
    • (2002) Allergy , vol.57 , pp. 1013
    • Cirkovic, T.1    Gavrovic-Jankulovic, M.2    Prisic, S.3    Jankov, R.M.4    Burazer, L.5    Vuckovic, O.6    Sporcic, Z.7    Paranos, S.8
  • 38
    • 2542609846 scopus 로고    scopus 로고
    • Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells
    • Shakushiro, K.; Yamasaki, Y.; Nishikawa, M.; Takakura, Y. Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells. Immunology, 2004, 112, 211.
    • (2004) Immunology , vol.112 , pp. 211
    • Shakushiro, K.1    Yamasaki, Y.2    Nishikawa, M.3    Takakura, Y.4
  • 40
  • 41
    • 0242657101 scopus 로고
    • Scavenger receptor-mediated recognition of maleyl bovine plasma albumin and the demaleylated protein in human monocyte macrophages
    • Haberland, M.E.; Fogelman, A.M. Scavenger receptor-mediated recognition of maleyl bovine plasma albumin and the demaleylated protein in human monocyte macrophages. Proc. Natl. Acad. Sci. USA, 1985, 82, 2693.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 2693
    • Haberland, M.E.1    Fogelman, A.M.2
  • 42
    • 0034014743 scopus 로고    scopus 로고
    • Modulation of allergen-specific immune responses to the major shrimp allergen, tropomyosin, by specific targeting to scavenger receptors on macrophages
    • Rajagopal, D.; Ganesh, K.A.; Subba Rao, P.V. Modulation of allergen-specific immune responses to the major shrimp allergen, tropomyosin, by specific targeting to scavenger receptors on macrophages. Int. Arch. Allergy Immunol., 2000, 121, 308.
    • (2000) Int. Arch. Allergy Immunol , vol.121 , pp. 308
    • Rajagopal, D.1    Ganesh, K.A.2    Subba Rao, P.V.3
  • 43
    • 0036174147 scopus 로고    scopus 로고
    • Scavenger receptor-specific allergen delivery elicits IFN-gamma-dominated immunity and directs established TH2-dominated responses to a nonallergic phenotype
    • Bhatia, S.; Mukhopadhyay, S.; Jarman, E.; Hall, G.; George, A.; Basu, S.K.; Rath, S.; Lamb, J.R.; Bal, V. Scavenger receptor-specific allergen delivery elicits IFN-gamma-dominated immunity and directs established TH2-dominated responses to a nonallergic phenotype. J. Allergy Clin. Immunol., 2002, 109, 321.
    • (2002) J. Allergy Clin. Immunol , vol.109 , pp. 321
    • Bhatia, S.1    Mukhopadhyay, S.2    Jarman, E.3    Hall, G.4    George, A.5    Basu, S.K.6    Rath, S.7    Lamb, J.R.8    Bal, V.9
  • 46
    • 0022508902 scopus 로고
    • Specific IgE response before and after rush immunotherapy with a standardized allergen or allergoid in grass pollen allergy
    • Bousquet, J.; Braquemond, P.; Feinberg, J.; Guerin, B.; Maasch, H.; Michel, F. B. Specific IgE response before and after rush immunotherapy with a standardized allergen or allergoid in grass pollen allergy. Ann. Allergy, 1986, 56, 456.
    • (1986) Ann. Allergy , vol.56 , pp. 456
    • Bousquet, J.1    Braquemond, P.2    Feinberg, J.3    Guerin, B.4    Maasch, H.5    Michel, F.B.6
  • 47
    • 0023617179 scopus 로고
    • Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. I. Rush immunotherapy with allergoids and standardized orchard grass-pollen extract
    • Bousquet, J.; Hejjaoui, A.; Skassa-Brociek, W.; Guerin, B.; Maasch, H.J.; Dhivert, H.; Michel, F.B. Double-blind, placebo-controlled immunotherapy with mixed grass-pollen allergoids. I. Rush immunotherapy with allergoids and standardized orchard grass-pollen extract. J. Allergy Clin. Immunol., 1987, 80, 591.
    • (1987) J. Allergy Clin. Immunol , vol.80 , pp. 591
    • Bousquet, J.1    Hejjaoui, A.2    Skassa-Brociek, W.3    Guerin, B.4    Maasch, H.J.5    Dhivert, H.6    Michel, F.B.7
  • 48
    • 33845927948 scopus 로고    scopus 로고
    • Safety, tolerability and efficacy of sublingual allergoid immunotherapy with a 4-day shortened build-up phase
    • Giordano, T.; Quarta, C.; Bruno, M.E.; Falagiani, P.; Riva, G. Safety, tolerability and efficacy of sublingual allergoid immunotherapy with a 4-day shortened build-up phase. Allerg. Immunol (Paris), 2006, 38, 310.
    • (2006) Allerg. Immunol (Paris) , vol.38 , pp. 310
    • Giordano, T.1    Quarta, C.2    Bruno, M.E.3    Falagiani, P.4    Riva, G.5
  • 49
    • 0032574206 scopus 로고    scopus 로고
    • Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis
    • Passalacqua, G.; Albano, M.; Fregonese, L.; Riccio, A.; Pronzato, C.; Mela, G.S.; Canonica, G.W. Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis. Lancet, 1998, 351, 629.
    • (1998) Lancet , vol.351 , pp. 629
    • Passalacqua, G.1    Albano, M.2    Fregonese, L.3    Riccio, A.4    Pronzato, C.5    Mela, G.S.6    Canonica, G.W.7
  • 50
    • 33644746130 scopus 로고    scopus 로고
    • Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production
    • Cosmi, L.; Santarlasci, V.; Angeli, R.; Liotta, F.; Maggi, L.; Frosali, F.; Rossi, O.; Falagiani, P.; Riva, G.; Romagnani, S.; Annunziato, F.; Maggi, E. Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production. Clin. Exp. Allergy, 2006, 36, 261.
    • (2006) Clin. Exp. Allergy , vol.36 , pp. 261
    • Cosmi, L.1    Santarlasci, V.2    Angeli, R.3    Liotta, F.4    Maggi, L.5    Frosali, F.6    Rossi, O.7    Falagiani, P.8    Riva, G.9    Romagnani, S.10    Annunziato, F.11    Maggi, E.12
  • 51
    • 34248355612 scopus 로고    scopus 로고
    • Additional benefit of a third year of specific grass pollen allergoid immunotherapy in patients with seasonal allergic rhinitis
    • Williams, A.; Henzgen, M.; Rajakulasingam, K. Additional benefit of a third year of specific grass pollen allergoid immunotherapy in patients with seasonal allergic rhinitis. Eur. Ann. Allergy Clin. Immunol., 2007, 39, 123.
    • (2007) Eur. Ann. Allergy Clin. Immunol , vol.39 , pp. 123
    • Williams, A.1    Henzgen, M.2    Rajakulasingam, K.3
  • 53
    • 33845337329 scopus 로고    scopus 로고
    • Clinical efficacy and safety of preseasonal sublingual immunotherapy with grass pollen carbamylated allergoid in rhinitic patients. A double-blind, placebo-controlled study
    • Palma-Carlos, A.G.; Santos, A.S.; Branco-Ferreira, M.; Pregal, A.L.; Palma-Carlos, M.L.; Bruno, M.E.; Falagiani, P.; Riva, G. Clinical efficacy and safety of preseasonal sublingual immunotherapy with grass pollen carbamylated allergoid in rhinitic patients. A double-blind, placebo-controlled study. Allergol. Immunopathol (Madr), 2006, 34, 194.
    • (2006) Allergol. Immunopathol (Madr) , vol.34 , pp. 194
    • Palma-Carlos, A.G.1    Santos, A.S.2    Branco-Ferreira, M.3    Pregal, A.L.4    Palma-Carlos, M.L.5    Bruno, M.E.6    Falagiani, P.7    Riva, G.8
  • 54
    • 33747887028 scopus 로고    scopus 로고
    • The effects of grass pollen allergoid immunotherapy on clinical and immunological parameters in children with allergic rhinitis
    • Keskin, O.; Tuncer, A.; Adalioglu, G.; Sekerel, B.E.; Sackesen, C.; Kalayci, O. The effects of grass pollen allergoid immunotherapy on clinical and immunological parameters in children with allergic rhinitis. Pediatr. Allergy Immunol., 2006, 17, 396.
    • (2006) Pediatr. Allergy Immunol , vol.17 , pp. 396
    • Keskin, O.1    Tuncer, A.2    Adalioglu, G.3    Sekerel, B.E.4    Sackesen, C.5    Kalayci, O.6
  • 55
    • 33947098571 scopus 로고    scopus 로고
    • Safety of immunotherapy with therapeutic vaccines containing depigmented and polymerized allergen extracts
    • Casanovas, M.; Martin, R.; Jimenez, C.; Caballero, R.; Fernandez-Caldas, E. Safety of immunotherapy with therapeutic vaccines containing depigmented and polymerized allergen extracts. Clin. Exp. Allergy, 2007, 37, 434.
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 434
    • Casanovas, M.1    Martin, R.2    Jimenez, C.3    Caballero, R.4    Fernandez-Caldas, E.5
  • 56
    • 12444268971 scopus 로고    scopus 로고
    • Safety of sublingual immunotherapy with a monomeric allergoid in very young children
    • Agostinis, F.; Tellarini, L.; Canonica, G.W.; Falagiani, P.; Passalacqua, G. Safety of sublingual immunotherapy with a monomeric allergoid in very young children. Allergy, 2005, 60, 133.
    • (2005) Allergy , vol.60 , pp. 133
    • Agostinis, F.1    Tellarini, L.2    Canonica, G.W.3    Falagiani, P.4    Passalacqua, G.5
  • 57
    • 34047192679 scopus 로고    scopus 로고
    • Comparison of allergenicity and immunogenicity of an intact allergen vaccine and commercially available allergoid products for birch pollen immunotherapy
    • Lund, L.; Henmar, H.; Wurtzen, P.A.; Lund, G.; Hjortskov, N.; Larsen, J.N. Comparison of allergenicity and immunogenicity of an intact allergen vaccine and commercially available allergoid products for birch pollen immunotherapy. Clin. Exp. Allergy, 2007, 37, 564.
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 564
    • Lund, L.1    Henmar, H.2    Wurtzen, P.A.3    Lund, G.4    Hjortskov, N.5    Larsen, J.N.6
  • 58
    • 36248939777 scopus 로고    scopus 로고
    • Chemical modification of birch allergen extract leads to a reduction in allergenicity as well as immunogenicity
    • Wurtzen, P.A.; Lund, L.; Lund, G.; Holm, J.; Millner, A.; Henmar, H. Chemical modification of birch allergen extract leads to a reduction in allergenicity as well as immunogenicity. Int. Arch. Allergy Immunol., 2007, 144, 287.
    • (2007) Int. Arch. Allergy Immunol , vol.144 , pp. 287
    • Wurtzen, P.A.1    Lund, L.2    Lund, G.3    Holm, J.4    Millner, A.5    Henmar, H.6
  • 61
    • 33747644328 scopus 로고    scopus 로고
    • Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen
    • Schenk, M.F.; Gilissen, L.J.; Esselink, G.D.; Smulders, M.J. Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen. BMC Genomics, 2006, 7, 168.
    • (2006) BMC Genomics , vol.7 , pp. 168
    • Schenk, M.F.1    Gilissen, L.J.2    Esselink, G.D.3    Smulders, M.J.4
  • 63
    • 0033949742 scopus 로고    scopus 로고
    • Rapid production of the major birch pollen allergen Bet v 1 in Nicotiana benthamiana plants and its immunological in vitro and in vivo characterization
    • Krebitz, M.; Wiedermann, U.; Essl, D.; Steinkellner, H.; Wagner, B.; Turpen, T. H.; Ebner, C.; Scheiner, O.; Breiteneder, H. Rapid production of the major birch pollen allergen Bet v 1 in Nicotiana benthamiana plants and its immunological in vitro and in vivo characterization. FASEB J., 2000, 14, 1279.
    • (2000) FASEB J , vol.14 , pp. 1279
    • Krebitz, M.1    Wiedermann, U.2    Essl, D.3    Steinkellner, H.4    Wagner, B.5    Turpen, T.H.6    Ebner, C.7    Scheiner, O.8    Breiteneder, H.9
  • 64
    • 0037408201 scopus 로고    scopus 로고
    • Identification of the antigenic determinants of the American cockroach allergen Per a 1 by error-prone PCR
    • Tsai, W.J.; Liu, C.H.; Chen, S.T.; Yang, C.Y. Identification of the antigenic determinants of the American cockroach allergen Per a 1 by error-prone PCR. J. Immunol. Methods, 2003, 276, 163.
    • (2003) J. Immunol. Methods , vol.276 , pp. 163
    • Tsai, W.J.1    Liu, C.H.2    Chen, S.T.3    Yang, C.Y.4
  • 69
    • 39749123322 scopus 로고    scopus 로고
    • Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy
    • Kahlert, H.; Suck, R.; Weber, B.; Nandy, A.; Wald, M.; Keller, W.; Cromwell, O.; Fiebig, H. Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy. Int. Arch. Allergy Immunol., 2008, 145, 193.
    • (2008) Int. Arch. Allergy Immunol , vol.145 , pp. 193
    • Kahlert, H.1    Suck, R.2    Weber, B.3    Nandy, A.4    Wald, M.5    Keller, W.6    Cromwell, O.7    Fiebig, H.8
  • 73
    • 7244229987 scopus 로고    scopus 로고
    • Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity
    • Buhot, C.; Chenal, A.; Sanson, A.; Pouvelle-Moratille, S.; Gelb, M. H.; Menez, A.; Gillet, D.; Maillere, B. Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity. Protein Sci., 2004, 13, 2970.
    • (2004) Protein Sci , vol.13 , pp. 2970
    • Buhot, C.1    Chenal, A.2    Sanson, A.3    Pouvelle-Moratille, S.4    Gelb, M.H.5    Menez, A.6    Gillet, D.7    Maillere, B.8
  • 74
    • 1642344674 scopus 로고    scopus 로고
    • The recombinant major allergen of Parietaria judaica and its hypoallergenic variant: In vivo evaluation in a murine model of allergic sensitization
    • Orlandi, A.; Grasso, F.; Corinti, S.; Marinaro, M.; Bonura, A.; Boirivant, M.; Colombo, P.; Di Felice, G. The recombinant major allergen of Parietaria judaica and its hypoallergenic variant: in vivo evaluation in a murine model of allergic sensitization. Clin. Exp. Allergy, 2004, 34, 470.
    • (2004) Clin. Exp. Allergy , vol.34 , pp. 470
    • Orlandi, A.1    Grasso, F.2    Corinti, S.3    Marinaro, M.4    Bonura, A.5    Boirivant, M.6    Colombo, P.7    Di Felice, G.8
  • 76
    • 33846439330 scopus 로고    scopus 로고
    • Hypoallergenic mutants of Ole e 1, the major olive pollen allergen, as candidates for allergy vaccines
    • Marazuela, E.G.; Rodriguez, R.; Barber, D.; Villalba, M.; Batanero, E. Hypoallergenic mutants of Ole e 1, the major olive pollen allergen, as candidates for allergy vaccines. Clin. Exp. Allergy, 2007, 37, 251.
    • (2007) Clin. Exp. Allergy , vol.37 , pp. 251
    • Marazuela, E.G.1    Rodriguez, R.2    Barber, D.3    Villalba, M.4    Batanero, E.5
  • 78
    • 33747424314 scopus 로고    scopus 로고
    • Ablation of ovomucoid-induced allergic response by desensitization with recombinant ovomucoid third domain in a murine model
    • Rupa, P.; Mine, Y. Ablation of ovomucoid-induced allergic response by desensitization with recombinant ovomucoid third domain in a murine model. Clin. Exp. Immunol., 2006, 145, 493.
    • (2006) Clin. Exp. Immunol , vol.145 , pp. 493
    • Rupa, P.1    Mine, Y.2
  • 79
    • 33644631475 scopus 로고    scopus 로고
    • Engineered recombinant ovomucoid third domain can modulate allergenic response in Balb/c mice model
    • Rupa, P.; Mine, Y. Engineered recombinant ovomucoid third domain can modulate allergenic response in Balb/c mice model. Biochem. Biophys. Res. Commun., 2006, 342, 710.
    • (2006) Biochem. Biophys. Res. Commun , vol.342 , pp. 710
    • Rupa, P.1    Mine, Y.2
  • 82
    • 15544382364 scopus 로고
    • Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure
    • Nakazawa, T.; Takai, T.; Hatanaka, H.; Mizuuchi, E.; Nagamune, T.; Okumura, K.; Ogawa, H. Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure. FEBS Lett., 2005, 579, 1988.
    • (1988) FEBS Lett , vol.2005 , pp. 579
    • Nakazawa, T.1    Takai, T.2    Hatanaka, H.3    Mizuuchi, E.4    Nagamune, T.5    Okumura, K.6    Ogawa, H.7
  • 85
    • 33947275894 scopus 로고    scopus 로고
    • A hybrid expressing genetically engineered major allergens of the Parietaria pollen as a tool for specific allergy vaccination
    • Bonura, A.; Corinti, S.; Artale, A.; Di Felice, G.; Amoroso, S.; Melis, M.; Geraci, D.; Colombo, P. A hybrid expressing genetically engineered major allergens of the Parietaria pollen as a tool for specific allergy vaccination. Int. Arch. Allergy Immunol., 2007, 142, 274.
    • (2007) Int. Arch. Allergy Immunol , vol.142 , pp. 274
    • Bonura, A.1    Corinti, S.2    Artale, A.3    Di Felice, G.4    Amoroso, S.5    Melis, M.6    Geraci, D.7    Colombo, P.8
  • 86
    • 0028120683 scopus 로고
    • IgE epitopes on the cat (Felis domesticus) major allergen Fel d I: A study with overlapping synthetic peptides
    • van Milligen, F.J.; van 't Hof, W.; van den Berg, M.; Aalberse, R.C. IgE epitopes on the cat (Felis domesticus) major allergen Fel d I: a study with overlapping synthetic peptides. J. Allergy Clin. Immunol., 1994, 93, (1 Pt 1), 34.
    • (1994) J. Allergy Clin. Immunol , vol.93 , Issue.1 PART 1 , pp. 34
    • van Milligen, F.J.1    van 't Hof, W.2    van den Berg, M.3    Aalberse, R.C.4
  • 89
    • 33845373253 scopus 로고    scopus 로고
    • Cry-consensus peptide, a novel peptide for immunotherapy of Japanese cedar pollinosis, induces Th1-predominant response in Cry j 1-sensitized B10.S mice
    • Kozutsumi, D.; Tsunematsu, M.; Yamaji, T.; Murakami, R.; Yokoyama, M.; Kino, K. Cry-consensus peptide, a novel peptide for immunotherapy of Japanese cedar pollinosis, induces Th1-predominant response in Cry j 1-sensitized B10.S mice. Biol. Pharm. Bull., 2006, 29, 2506.
    • (2006) Biol. Pharm. Bull , vol.29 , pp. 2506
    • Kozutsumi, D.1    Tsunematsu, M.2    Yamaji, T.3    Murakami, R.4    Yokoyama, M.5    Kino, K.6
  • 90
    • 33846949713 scopus 로고    scopus 로고
    • Peptide immunotherapy for allergic diseases
    • Larche, M. Peptide immunotherapy for allergic diseases. Allergy, 2007, 62, 325.
    • (2007) Allergy , vol.62 , pp. 325
    • Larche, M.1
  • 91
    • 0033591638 scopus 로고    scopus 로고
    • Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions
    • Haselden, B.M.; Kay, A.B.; Larche, M. Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions. J. Exp. Med., 1999, 189, 1885.
    • (1999) J. Exp. Med , vol.189 , pp. 1885
    • Haselden, B.M.1    Kay, A.B.2    Larche, M.3
  • 92
    • 0034819825 scopus 로고    scopus 로고
    • Late asthmatic reactions provoked by intradermal injection of T-cell peptide epitopes are not associated with bronchial mucosal infiltration of eosinophils or T(H)2-type cells or with elevated concentrations of histamine or eicosanoids in bronchoalveolar fluid
    • Haselden, B.M.; Larche, M.; Meng, Q.; Shirley, K.; Dworski, R.; Kaplan, A.P.; Bates, C.; Robinson, D.S.; Ying, S.; Kay, A.B. Late asthmatic reactions provoked by intradermal injection of T-cell peptide epitopes are not associated with bronchial mucosal infiltration of eosinophils or T(H)2-type cells or with elevated concentrations of histamine or eicosanoids in bronchoalveolar fluid. J. Allergy Clin. Immunol., 2001, 108, 394.
    • (2001) J. Allergy Clin. Immunol , vol.108 , pp. 394
    • Haselden, B.M.1    Larche, M.2    Meng, Q.3    Shirley, K.4    Dworski, R.5    Kaplan, A.P.6    Bates, C.7    Robinson, D.S.8    Ying, S.9    Kay, A.B.10
  • 93
    • 0035423535 scopus 로고    scopus 로고
    • Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects
    • Oldfield, W.L.; Kay, A.B.; Larche, M. Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects. J. Immunol., 2001, 167, 1734.
    • (2001) J. Immunol , vol.167 , pp. 1734
    • Oldfield, W.L.1    Kay, A.B.2    Larche, M.3
  • 97
    • 23244437462 scopus 로고    scopus 로고
    • Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity
    • Reisinger, J.; Horak, F.; Pauli, G.; van Hage, M.; Cromwell, O.; Konig, F.; Valenta, R.; Niederberger, V. Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity. J. Allergy Clin. Immunol., 2005, 116, 347.
    • (2005) J. Allergy Clin. Immunol , vol.116 , pp. 347
    • Reisinger, J.1    Horak, F.2    Pauli, G.3    van Hage, M.4    Cromwell, O.5    Konig, F.6    Valenta, R.7    Niederberger, V.8
  • 98
    • 33748565624 scopus 로고    scopus 로고
    • Immune stimulatory strategies for the prevention and treatment of asthma
    • Wohlleben, G.; Erb, K.J. Immune stimulatory strategies for the prevention and treatment of asthma. Curr. Pharm. Des., 2006, 12, 3281.
    • (2006) Curr. Pharm. Des , vol.12 , pp. 3281
    • Wohlleben, G.1    Erb, K.J.2
  • 101
    • 0032739070 scopus 로고    scopus 로고
    • Oligodeoxynucleotides containing CpG motifs modulate the allergic TH2 response of BALB/c mice to Bet v 1, the major birch pollen allergen
    • Jahn-Schmid, B.; Wiedermann, U.; Bohle, B.; Repa, A.; Kraft, D.; Ebner, C. Oligodeoxynucleotides containing CpG motifs modulate the allergic TH2 response of BALB/c mice to Bet v 1, the major birch pollen allergen. J. Allergy Clin. Immunol., 1999, 104, 1015.
    • (1999) J. Allergy Clin. Immunol , vol.104 , pp. 1015
    • Jahn-Schmid, B.1    Wiedermann, U.2    Bohle, B.3    Repa, A.4    Kraft, D.5    Ebner, C.6
  • 102
    • 0038758932 scopus 로고    scopus 로고
    • Prevention of allergen-specific IgE production and suppression of an established Th2-type response by immunization with DNA encoding hypoallergenic allergen derivatives of Bet v 1, the major birch-pollen allergen
    • Hochreiter, R.; Stepanoska, T.; Ferreira, F.; Valenta, R.; Vrtala, S.; Thalhamer, J.; Hartl, A. Prevention of allergen-specific IgE production and suppression of an established Th2-type response by immunization with DNA encoding hypoallergenic allergen derivatives of Bet v 1, the major birch-pollen allergen. Eur. J. Immunol., 2003, 33, 1667.
    • (2003) Eur. J. Immunol , vol.33 , pp. 1667
    • Hochreiter, R.1    Stepanoska, T.2    Ferreira, F.3    Valenta, R.4    Vrtala, S.5    Thalhamer, J.6    Hartl, A.7
  • 103
    • 28544449710 scopus 로고    scopus 로고
    • Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction
    • Hessel, E.M.; Chu, M.; Lizcano, J.O.; Chang, B.; Herman, N.; Kell, S.A.; Wills-Karp, M.; Coffman, R.L. Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction. J. Exp. Med., 2005, 202, 1563.
    • (2005) J. Exp. Med , vol.202 , pp. 1563
    • Hessel, E.M.1    Chu, M.2    Lizcano, J.O.3    Chang, B.4    Herman, N.5    Kell, S.A.6    Wills-Karp, M.7    Coffman, R.L.8
  • 104
    • 0036126748 scopus 로고    scopus 로고
    • Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma
    • Santeliz, J.V.; Van Nest, G.; Traquina, P.; Larsen, E.; Wills-Karp, M. Amb a 1-linked CpG oligodeoxynucleotides reverse established airway hyperresponsiveness in a murine model of asthma. J. Allergy Clin. Immunol., 2002, 109, 455.
    • (2002) J. Allergy Clin. Immunol , vol.109 , pp. 455
    • Santeliz, J.V.1    Van Nest, G.2    Traquina, P.3    Larsen, E.4    Wills-Karp, M.5
  • 105
    • 33750506943 scopus 로고    scopus 로고
    • Hypoallergenic fragment of Par j 2 increases functional expression of Toll-like receptors in atopic children
    • Pace, E.; Duro, G.; La Grutta, S.; Ferraro, M.; Bruno, A.; Bousquet, J.; Bonsignore, G.; Gjomarkaj, M. Hypoallergenic fragment of Par j 2 increases functional expression of Toll-like receptors in atopic children. Allergy, 2006, 61, 1459.
    • (2006) Allergy , vol.61 , pp. 1459
    • Pace, E.1    Duro, G.2    La Grutta, S.3    Ferraro, M.4    Bruno, A.5    Bousquet, J.6    Bonsignore, G.7    Gjomarkaj, M.8
  • 106
    • 0242641243 scopus 로고    scopus 로고
    • Efficacy and tolerability of short-term specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A (MPL) for children and adolescents
    • Drachenberg, K.J.; Heinzkill, M.; Urban, E.; Woroniecki, S.R. Efficacy and tolerability of short-term specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A (MPL) for children and adolescents. Allergol. Immunopathol. (Madr), 2003, 31, 270.
    • (2003) Allergol. Immunopathol. (Madr) , vol.31 , pp. 270
    • Drachenberg, K.J.1    Heinzkill, M.2    Urban, E.3    Woroniecki, S.R.4
  • 107
    • 0043264799 scopus 로고    scopus 로고
    • Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: Reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
    • Mothes, N.; Heinzkill, M.; Drachenberg, K.J.; Sperr, W.R.; Krauth, M.T.; Majlesi, Y.; Semper, H.; Valent, P.; Niederberger, V.; Kraft, D.; Valenta, R. Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin. Exp. Allergy, 2003, 33, 1198.
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 1198
    • Mothes, N.1    Heinzkill, M.2    Drachenberg, K.J.3    Sperr, W.R.4    Krauth, M.T.5    Majlesi, Y.6    Semper, H.7    Valent, P.8    Niederberger, V.9    Kraft, D.10    Valenta, R.11
  • 109
    • 9644266790 scopus 로고    scopus 로고
    • Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases
    • Saxon, A.; Zhu, D.; Zhang, K.; Allen, L.C.; Kepley, C.L. Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases. Curr. Opin. Allergy Clin. Immunol., 2004, 4, 563.
    • (2004) Curr. Opin. Allergy Clin. Immunol , vol.4 , pp. 563
    • Saxon, A.1    Zhu, D.2    Zhang, K.3    Allen, L.C.4    Kepley, C.L.5
  • 110
    • 0036100524 scopus 로고    scopus 로고
    • A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation
    • Zhu, D.; Kepley, C.L.; Zhang, M.; Zhang, K.; Saxon, A. A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Nat. Med., 2002, 8, 518.
    • (2002) Nat. Med , vol.8 , pp. 518
    • Zhu, D.1    Kepley, C.L.2    Zhang, M.3    Zhang, K.4    Saxon, A.5
  • 111
    • 4344605211 scopus 로고    scopus 로고
    • Inhibition of allergen-specific IgE reactivity by a human Ig Fcgamma-Fcepsilon bifunctional fusion protein
    • Zhang, K.; Kepley, C.L.; Terada, T.; Zhu, D.; Perez, H.; Saxon, A. Inhibition of allergen-specific IgE reactivity by a human Ig Fcgamma-Fcepsilon bifunctional fusion protein. J. Allergy Clin. Immunol., 2004, 114, 321.
    • (2004) J. Allergy Clin. Immunol , vol.114 , pp. 321
    • Zhang, K.1    Kepley, C.L.2    Terada, T.3    Zhu, D.4    Perez, H.5    Saxon, A.6
  • 112
    • 17644388057 scopus 로고    scopus 로고
    • A chimeric human-cat fusion protein blocks cat-induced allergy
    • Zhu, D.; Kepley, C.L.; Zhang, K.; Terada, T.; Yamada, T.; Saxon, A. A chimeric human-cat fusion protein blocks cat-induced allergy. Nat. Med., 2005, 11, 446.
    • (2005) Nat. Med , vol.11 , pp. 446
    • Zhu, D.1    Kepley, C.L.2    Zhang, K.3    Terada, T.4    Yamada, T.5    Saxon, A.6
  • 113
    • 33745117302 scopus 로고    scopus 로고
    • A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic, pulmonary, and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1, the major cat allergen
    • Terada, T.; Zhang, K.; Belperio, J.; Londhe, V.; Saxon, A. A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic, pulmonary, and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1, the major cat allergen. Clin. Immunol., 2006, 120, 45.
    • (2006) Clin. Immunol , vol.120 , pp. 45
    • Terada, T.1    Zhang, K.2    Belperio, J.3    Londhe, V.4    Saxon, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.