"Accentuate the negative, eliminate the positive": Engineering allergy therapeutics to block allergic reactivity through negative signaling

Journal of Allergy and Clinical Immunology

Volumn 121, Issue 2, 2008, Pages 320-325

  Saxon, Andrew ^a   Kepley, Chris ^b   Zhang, Ke ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

allergy therapy; basophils; Fc RII; Fc lunate RI; IgE therapeutics; immune response modifiers; mast cells

Indexed keywords

ALLERGEN; ANTIGEN; CHIMERIC PROTEIN; FC RECEPTOR IIB; HYBRID PROTEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; PROTEIN GE2; PROTEIN GFD; UNCLASSIFIED DRUG;

ALLERGENICITY; ALLERGIC REACTION; BASOPHIL; DEGRANULATION; DRUG BINDING; DRUG EFFECT; DRUG INHIBITION; DRUG MEGADOSE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SKIN TEST;

ALLERGENS; ANIMALS; GENETIC ENGINEERING; GLYCOPROTEINS; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION;

EID: 38949189510     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.10.017     Document Type: Review

References (23)

1. Arlen H., and Mercer J. "Ac-Cent-Tchu-Ate the Positive.". Capitol Records (1944)
2. Daëron M., Malbec O., Latour S., Arock M., and Fridman W.H. Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors. J Clin Invest 95 (1995) 577-585
3. Zhu D., Kepley C.L., Zhang M., Zhang K., and Saxon A. A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Nat Med 8 (2002) 518-521
4. Zhu D., Kepley C.L., Zhang K., Terada T., Yamada T., and Saxon A. A chimeric human -cat fusion protein blocks cat-induced allergy. Nat Med 11 (2005) 446-449
5. Munitz A., and Levi-Schaffer F. Inhibitory receptors on eosinophils: a direct hit to a possible Achilles heel?. J Allergy Clin Immunol 119 (2007) 1382-1387
6. Ott V.L., and Cambier J.C. Activating and inhibitory signaling in mast cells: new opportunities for therapeutic intervention?. J Allergy Clin Immunol 106 (2000) 429-440
7. Kepley C.L., Cambier J.C., Morel P.A., Lujan D., Ortega E., Wilson B.S., et al. Negative regulation of Fcε{lunate}RI signaling by FcγRII costimulation in human blood basophils. J Allergy Clin Immunol 106 (2000) 337-348
8. Oliver J.M., Kepley C.L., Ortega E., and Wilson B.S. Immunologically mediated signaling in basophils and mast cells: finding therapeutic targets for allergic diseases in the human Fcε{lunate}RI signaling pathway. Immunopharmacology 48 (2000) 269-281
9. Daeron M. Fc receptor biology. Annu Rev Immunol 15 (1997) 203-234
10. Suzuki H., Takei M., Yanagida M., Nakahata T., Kawakami T., and Fukamachi H. Early and late events in Fc epsilon RI signal transduction in human cultured mast cells. J Immunol 159 (1997) 5881-5888
11. Malbec O., Fong D.C., Turner M., Tybulewicz V.L., Cambier J.C., Fridman W.H., et al. Fcε{lunate} receptor I-associated lyn-dependent phosphorylation of Fcγ receptor IIB during negative regulation of mast cell activation. J Immunol 160 (1998) 1647-1658
12. Kepley C.L., Zhang K., Zhu D., and Saxon A. Fcε{lunate}RI-FcγRII co-aggregation inhibits IL-16 production from human Langerhans-like dendritic cells. Clin Immunol 108 (2003) 89-94
13. Kepley C.L., Mackay G., Zhu D., Morel P.A., Zhang K., and Saxon A. SHIP-Grb2-Dok complexes prevent Fcε{lunate}RI-mediated human mast cell activation and regulate FcγRII-mediated inhibition. J Biol Chem 279 (2004) 35139-35149
14. Zhang K., Kepley C.L., Terada T., Zhu D., Perez H., and Saxon A. Inhibition of allergen specific IgE reactivity by a human Ig Fcγ-Fcε{lunate} bifunctional fusion protein. J Allergy Clin Immunol 114 (2004) 321-327
15. Allen L.C., Kepley C.L., Saxon A., and Zhang K. Modifications to an Fcgamma-Fcvarepsilon fusion protein alter its effectiveness in the inhibition of FcvarepsilonRI-mediated functions. J Allergy Clin Immunol 120 (2007) 462-468
16. Mertsching E., Bafetti L., Hess H., Perper S., Giza K., Allen L.C., et al. A mouse Fcγ-Fcε{lunate} protein that inhibits mast cells through activation of FcγRIIB, SHIP-1 and SHP. J Allergy Clin Immunol (2007) [Epub ahead of print]
17. Zhao W., Kepley C.L., Morel P.A., Okomoto L.M., Fukuoka Y., and Schwartz L.B. Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin derived human mast cells. J Immunol 177 (2006) 694-701
18. Yamada T., Zhu D., Zhang K., and Saxon A. Inhibition of human IgE class switch recombination by a human Ig Fc gamma-Fc epsilon chimeric protein. J Biol Chem 278 (2003) 32818-32824
19. Schelegle E.S., Gershwin L.J., Miller L.A., Fanucchi M.V., Van Winkle L.S., Gerriets J.P., et al. Allergic asthma induced in rhesus monkeys by house dust mite (Dermatophagoides farinae). Am J Pathol 158 (2001) 333-341
20. Van Scott M.R., Hooker J.L., Ehrmann D., Shibata Y., Kukoly C., Salleng K., et al. Dust mite-induced asthma in cynomolgus monkeys. J Appl Physiol 96 (2004) 1433-1444
21. Van Scott M.R., Aycock D., Cozzi E., and Salleng K. Stallings HW III. Separation of bronchoconstriction from increased ventilatory drive in a nonhuman primate model of chronic allergic asthma. J Appl Physiol 99 (2005) 2080-2086
22. Terada T., Zhang K., Belperio J., and Saxon A. A chimeric human-cat Fcgamma-Fel d1 fusion protein inhibits systemic, pulmonary, and cutaneous allergic reactivity to intratracheal challenge in mice sensitized to Fel d1, the major cat allergen. Clin Immunol 120 (2006) 45-56
23. Tam S.W., Demissie S., and Thomas D. A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils. Allergy 59 (2004) 772-780