Relaxing effects of 17(18)-EpETE on arterial and airway smooth muscles in human lung

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 296, Issue 1, 2009, Pages

  Morin, Caroline ^a   Sirois, Marco ^a   Echave, Vincent ^a   Rizcallah, Edmond ^a   Rousseau, Eric ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

17(18) eicosatetraenoic acid; Isometric tension; Membrane potential; Potassium channels; Relaxation

Indexed keywords

17(18) EPOXYICOSATETRIENOIC ACID; ADENOSINE TRIPHOSPHATE; BETA ESCIN; CALCIUM ION; EPOXYICOSATRIENOIC ACID; GLIBENCLAMIDE; IBERIOTOXIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; BILAYER MEMBRANE; BRONCHUS MUSCLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; LUNG ARTERY; LUNG PARENCHYMA; MEMBRANE POTENTIAL; MICROELECTRODE; MUSCLE CELL; MUSCLE RELAXATION; MYOFILAMENT; PRIORITY JOURNAL;

EID: 58149529357     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.90436.2008     Document Type: Article

References (39)

1. Abeywardena MY, Head RJ. Longchain n-3 polyunsaturated fatty acids and blood vessel function. Cardiovasc Res 52: 361-371, 2001.
2. Arm JP, Thien FC, Lee TH. Leukotrienes, fish-oil, and asthma. Allergy Proc 15: 129-134, 1994.
3. ca channel activation and hyper-polarization. Am J Physiol Lung Cell Mol Physiol 280: L965-L973, 2001.
4. Brightling C, Berry M, Amrani Y. Targeting TNF-alpha: a novel therapeutic approach for asthma. J Allergy Clin Immunol 121: 5-10, 2008.
5. Capdevila JH, Falck JR, Harris RC. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res 41: 163-181, 2000.
6. Connor WE. Importance of n-3 fatty acids in health and disease. Am J Clin Nutr 71: 171S-175S, 2000.
7. Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, van der Meer JW, Cannon JG, Rogers TS, Klempner MS, Weber PC. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 320: 265-271, 1989.
8. Fisslthaler B, Popp R, Kiss L, Potente M, Harder DR, Fleming I, Busse R. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 401: 493-497, 1999.
9. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294: 1871-1875, 2001.
10. Ghatta S, Nimmagadda D, Xu X, O'Rourke ST. Large-conductance, calcium-activated potassium channels: structural and functional implications. Pharmacol Ther 110: 103-116, 2006.
11. Hercule HC, Salanova B, Essin K, Honeck H, Falck JR, Sausbier M, Ruth P, Schunck WH, Luft FC, Gollasch M. The vasodilator 17,18- epoxyeicosatetraenoic acid targets the pore-forming BK alpha channel subunit in rodents. Exp Physiol 92: 1067-1076, 2007.
12. Hirafuji M, Machida T, Hamaue N, Minami M. Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. J Pharm Sci 92: 308 -316, 2003.
13. Jacobs ER, Zeldin DC. The lung HETEs (and EETs) up. Am J Physiol Heart Circ Physiol 280: H1-H10, 2001.
14. Kris-Etherton PM, Harris WS, Appel LJ. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106: 2747-2757, 2002.
15. Ca channels: implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol 290: H491-H499, 2006.
16. Lauterbach B, Barbosa-Sicard E, Wang MH, Honeck H, Kärgel E, Theuer J, Schwartzman ML, Haller H, Luft FC, Gollasch M, Schunck WH. Cytochrome P450-dependent eicosapentaenoic acid metabolites are novel BK channel activators. Hypertension 39: 609-613, 2002.
17. Lee TH, Arm JP, Horton CE, Crea AE, Mencia-Huerta JM, Spur BW. Effects of dietary fish oil lipids on allergic and inflammatory diseases. Allergy Proc 12: 299-303, 1991.
18. Mizutani M, Asano M, Roy S. Omega-3 polyunsaturated fatty acids inhibit migration of human vascular smooth muscle cells in vitro. Life Sci 61: PL269-PL274, 1997.
19. Morin C, Sirois M, Echave V, Gomes MM, Rousseau E. 14, 15-EET displays anti-inflammatory effects in TNFα-stimulated human bronchi: putative role of CPI-17. Am J Respir Cell Mol Biol 38: 192-201, 2008.
20. + channel activation and CPI-17 dephosphorylation in human bronchi. Am J Respir Cell Mol Biol 36: 633-641, 2007.
21. Ca channel activation. Am J Physiol Lung Cell Mol Physiol 293: L1037-L1044, 2007.
22. Nguyen X, Wang MH, Reddy KM, Falck JR, Schwartzman ML. Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. Am J Physiol Regul Integr Comp Physiol 276: R1691-R1700, 1999.
23. Node K, Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, Liao JK. Anti-inflammatory properties of cytochrome P450 epoxygenase-de-rived eicosanoids. Science 285: 1276 -1279, 1999.
24. Nyby MD, Matsumoto K, Yamamoto K, Abedi K, Eslami P, Hernandez G, Smutko V, Berger ME, Tuck ML. Dietary fish oil prevents vascular dysfunction and oxidative stress in hyperinsulinemic rats. Am J Hypertens 18: 213-219, 2005.
25. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 82: 131-185, 2002.
26. Sakai H, Chiba Y, Hirano T, Misawa M. Possible involvement of CPI-17 in augmented bronchial smooth muscle contraction in antigen-induced airway hyper-responsive rats. Mol Pharmacol 68: 145-151, 2005.
27. Schwarz D, Kisselev P, Ericksen SS, Szklarz GD, Chernogolov A, Honeck H, Schunck WH, Roots I. Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)- epoxyeicosatetraenoic acid. Biochem Pharmacol 67: 1445-1457, 2004.
28. Simopoulos AP. Essential fatty acids in health and chronic diseases. Forum Nutr 56: 67-70, 2003.
29. Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases. J Am Coll Nutr 21: 495-505, 2002.
30. 2+ sensitivity of smooth muscle and non-muscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
31. Spector AA, Norris AW. Action of epoxyeicosatrienoic acids on cellular function. Am J Physiol Cell Physiol 292: C996-C1012, 2007.
32. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389: 990-994, 1997.
33. Van Rollins M, Frade PD, Carretero OA. Oxidation of 5,8,11,14,17-eicosapentaenoic acid by hepatic and renal microsomes. Biochim Biophys Acta 966: 133-149, 1988.
34. Wang MH, Brand-Schieber E, Zand BA, Nguyen X, Falck JR, Balu N, Schwartzman ML. Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J Pharmacol Exp Ther 284: 966-973, 1998.
35. Weiger TM, Hermann A, Levitan IB. Modulation of calcium-activated potassium channels. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 188: 79-87, 2002.
36. Ye D, Zhang D, Oltman C, Dellsperger K, Lee HC, VanRollins M. Cytochrome p-450 epoxygenase metabolites of docosahexaenoate potently dilate coronary arterioles by activating large-conductance calcium-activated potassium channels. J Pharmacol Exp Ther 303: 768 -776, 2002.
37. Zeldin DC, Foley J, Ma J, Boyle JE, Pascual JM, Moomaw CR, Tomer KB, Steenbergen C, Wu S. CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. Mol Pharmacol 50: 1111-1117, 1996.
38. Ca channels. Am J Physiol Heart Circ Physiol 280: H2430-H2440, 2001.
39. Zhang Y, Tazzeo T, Chu V, Janssen LJ. Membrane potassium currents in human radial artery and their regulation by nitric oxide donor. Cardio-vasc Res 71: 383-392, 2006.