Epoxyeicosatrienoic acid relaxing effects involve Ca2+ activated K+ channel activation and CPI-17 dephosphorylation in human bronchi

American Journal of Respiratory Cell and Molecular Biology

Volumn 36, Issue 5, 2007, Pages 633-641

  Morin, Caroline ^b   Sirois, Marco ^b   Echave, Vincent ^b   Gomes, Marcio M ^b   Rousseau, Eric ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b NONE

Author keywords

Calcium sensitivity; CPI 17; Epoxyeicosatrienoic acid; Membrane potential; Organ culture

Indexed keywords

ARACHIDONIC ACID; BETA ESCIN; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; EPOXYICOSATRIENOIC ACID; INDOMETACIN; INHIBITOR PROTEIN; ISOPROTEIN; METHACHOLINE; PHORBOL ESTER DERIVATIVE; PROTEIN CPI 17; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; BREATHING MUSCLE; BRONCHUS MUSCLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPLANT; HUMAN; HUMAN TISSUE; MUSCLE CONTRACTION; MUSCLE FIBER MEMBRANE POTENTIAL; MUSCLE RELAXATION; MUSCLE TONE; MYOFILAMENT; PROTEIN DEPHOSPHORYLATION; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

8,11,14-EICOSATRIENOIC ACID; AMIDES; BRONCHI; CALCIUM; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUSCLE RELAXATION; MUSCLE TONUS; MYOCYTES, SMOOTH MUSCLE; PHORBOL ESTERS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; POTASSIUM; POTASSIUM CHANNELS, CALCIUM-ACTIVATED;

EID: 34247620721     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2006-0281OC     Document Type: Article

References (41)

1. Funk CD. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001;294:1871-1875.
2. Roman RJ. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev 2002;82:131-185.
3. Zeldin DC, Plitman JD, Kobayashi J, Miller RF, Snapper JR, Falck JR, Szarck JL, Philpot RM, Capdevila JH. The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. J Clin Invest 1995;95:2150-2160.
4. Chen JK, Wang DW, Falck JR, Capdevila J, Harris RC. Transfection of an active cytochrome P-450 arachidonic add epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. J Biol Chem 1999; 274:4764-4769.
5. Homma T, Zhang JY, Shimizu T, Prakash C, Blair IA, Harris RC. Cyclooxygenase-derived metabolites of 8,9-epoxyeicosatrienoic acid are potent mitogens for cultured rat glomerular mesangial cells. Biochem Biophys Res Commun 1993;191:282-288.
6. Fleming I, Fisslthaler B, Michaelis UR, Kiss L, Popp R, Busse R. The coronary endothelium-derived hyperpolarizing factor (EDHF) stimulates multiple signalling pathways and proliferation in vascular cells. Pflugers Arch 2001;442:511-518.
7. Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER, Harder DR. Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. Am J Physiol Heart Circ Physiol 2003;284: H215-H224.
8. Michaelis UR, Fisslthaler B, Barbosa-Sicard E, Falck JR, Fleming I, Busse R. Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. J Cell Sci 2005;118:5469-5498.
9. Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BK(Ca) channels: implications for soluble epoxide hydrolase inhibition. Am J Physiol Heart Circ Physiol 2006;290:H491-H499.
10. Ca channel activation and hyperpolarization. Am J Physiol Lung Cell Mol Physiol 2001;280:L965-L973.
11. Cloutier M, Campbell S, Basera N, Proteau S, Payet MD, Rousseau E. 20-HETE inotropic effects involve the activation of non-selective cationic current in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 2003;285:L560-L568.
12. 2+ sensitivity in guinea pig bronchi. Prostaglandins Other Lipid Mediat 2007;82:30-41.
13. Zhang C, Harder DR. Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic acid. Stroke 2002;33:2957-2964.
14. Pozzi A, Macias-Perez I, Abair T, Wei S, Su Y, Zent R, Falck JR, Capdevila JH. Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. J Biol Chem 2005;280:27138-27146.
15. Alkayed NJ, Goyagi T, Joh HD, Klaus J, Harder DR, Traystman RJ, Hurn PD. Neuroprotection and P450 2CH upregulation after experimental transient ischemic attack. Stroke 2002;33:1677-1684.
16. Gross GJ, Falck JR, Gross ER, Isbell M, Moore J, Nithipatikom K. Cytochrome P-450 and arachidonic acid metabolites: role in myocardial ischemia/reperfusion injury revisited. Cardiovasc Res 2005;68: 18-25.
17. + channels and p42/p44 MAPK pathway. Circ Res 2004;95:506-514.
18. Chen JK, Capdevila J, Harris RC. Cytochrome P-450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Mol Cell Biol 2001;21:6322-6331.
19. Somlyo AP, Somlyo AV. Signal transduction by G-protein, p-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000;522:177-185.
20. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003;83:1325-1358.
21. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, et al. Calcium sensitization of smooth muscle mediated by a ρ-associated protein kinase in hypertension. Nature 1997;389:990-994.
22. Sakai H, Chiba Y, Hirano T, Misawa M. Possible involvement of CPI-17 in augmented bronchial smooth muscle contraction in antigen-induced airway hyper-responsive rats. Mol Pharmacol 2005;68:145-151.
23. Morin C, Protean S, Brayden J, Rousseau E. Organ-cultured airway explants: a new model of airway hyperresponsiveness. Exp Lung Res 2005;31:7l9-744.
24. Hichami A, Morin C, Rousseau E, Khan NA. Diacylglycerol-containing docosahexaenoic acid in acyl chain modulates airway smooth muscle tone. Am J Respir Cell Mol Biol 2005;33:378-386.
25. 2+ pools and ρ-kinase pathway. Am J Physiol Lung Cell Mol Physiol 2004;287:L631-L640.
26. Janssen LJ, Tazzeo T, Zuo J, Pertens E, Keshavjee S. KCl evokes contraction of airway smooth muscle via activation of ρA and ρ-kinase. Am J Physiol Lung Cell Mol Physiol 2004;287:L852-L858.
27. 2+ sensilizaiion of rabbit smooth muscle. J Physiol 1997;500:95-109.
28. Koga Y, Ikebe M. p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating ρA. J Biol Chem 2005;280:4983-4991.
29. Zhu D, Bousamra M II, Zeldin DC, Falck JR, Townsley M, Harder DR, Roman RJ, Jacobs ER. Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 2000;278:L335-L343.
30. Jacobs ER. Zeldin DC. The lung HETEs (and EETs) up. Am J Physiol Heart Circ Physiol 2001;280:H1-H10.
31. Zeldin DC, Foley J, Ma J, Boyle JE, Pascual JM, Moomaw CR, Tomer KB, Steenhergen C, Wu S. CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance. Mol Pharmacol 1996;50:1111-1117.
32. Capdevila JH, Falck JR, Harris RC. Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase. J Lipid Res 2000;41:163-181.
33. McSherry IN, Sandow SL, Campbell WB, Falck JR, Hill MA, Dora KA. A role for heterocellular coupling and EETs in dilation of rat cremaster arteries. Microcirculation 2006;13:119-130.
34. Wang MH, Brand-Schieber E, Zand BA, Nguyen X, Falck JR, Balu N, Schwartzman ML. Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors. J Pharmacol Exp Ther 1998;284:966-973.
35. Michaelis UR, Fisslthaler B, Barbosa-Sicard E, Falck JR, Fleming I, Busse R. Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. J Cell Sci 2005;118:5489-5498.
36. Eckman DM, Hopkins N, McBride C, Keef KD. Endothelium-dependent relaxation and Hyperpolarization in guinea-pig coronary artery: role of epoxyeicosatrienoic acid. Br J Pharmacol 1998;124:181-189.
37. Fang X, Kaduce TL, Weintraub NL, VanRollins M, Spector AA. Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscle. Circ Res 1996;79:784-793.
38. 2+ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness. J Smooth Muscle Res 2004;40:155-167.
39. 2+ sensitization and mobilization by MCh in tracheal smooth muscle. Am J Physiol Lung Cell Mol Physiol 2001;280:L1218-L1224.
40. Losapio JL, Sprague RS, Lonigro AJ, Stephenson AH. 5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of ρ-kinase. J Appl Physiol 2005;99:1391-1396.
41. Node K, Huo Y, Ruan X, Yang B, Spiecker M, Ley K, Zeldin DC, Liao JK. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 1999;285:1276-1279.