Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor

Protein Science

Volumn 18, Issue 1, 2009, Pages 92-100

  Lountos, George T ^a   Tropea, Joseph E ^a   Zhang, Di ^a   Jobson, Andrew G ^b   Pommier, Yves ^b   Shoemaker, Robert H ^a   Waugh, David S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Checkpoint kinase inhibitor; Cocrystal structure; Structure assisted drug design

Indexed keywords

ADENOSINE DIPHOSPHATE; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DEBROMOHYMENIALDISINE; NSC 109555; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; HYDROPHOBICITY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AZEPINES; CARBANILIDES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 58149469076     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.16     Document Type: Article

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