Food allergens

Allergens and Allergen Immunotherapy, Fourth Edition

Volumn , Issue , 2008, Pages 219-235

  Helm, Ricki M ^a   Burks, A Wesley ^b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN;

DESENSITIZATION; FOOD ALLERGY; HUMAN; IMMUNOLOGY; REVIEW;

ALLERGENS; DESENSITIZATION, IMMUNOLOGIC; FOOD HYPERSENSITIVITY; HUMANS;

EID: 58149462857     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (146)

1. Sampson HA. Update on food allergy. J Allergy Clin Immunol 2004; 113: 805-819.
2. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol 2006; 117: S470-S475.
3. Bock SA, Munoz-Furlong A, Sampson HA. Further fatalities caused by anaphylactic reactions to food, 2001-2006. J Allergy Clin Immunol 2007; 119: 1016-1018.
4. Pumphrey RSH, Gowland MH. Further fatalities caused by anaphylactic reactions to food, 2001-2006. J Allergy Clin Immunol 119: 118-119.
5. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey. J Allergy Clin Immunol 2003; 112: 1203-1207.
6. Sicherer SH, Leung DYM. Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. J Allergy Clin Immunol 2007; 119: 1463-1469.
7. Wood RA. The natural history of food allergy. Pediatrics 2003; 111: 1631-1637.
8. Wang J, Sampson HA. Food anaphylaxis. Clin Exp Allergy 2007; 37: 651-660.
9. Uguz A, Lack G, Pumphrey R, et al. Allergic reactions in the community: a questionnaire survey of members of the anaphylaxis campaign. Clin Exp Allergy 2005; 35: 746-750.
10. Clark S, Bock SA, Gaeta TJ, et al. Multicenter study of emergency department visits for food allergies. J Allergy Clin Immunol 2004; 113: 346-352.
11. Golden DB. Patterns of anaphylaxis: acute and late phase features of allergic reactions. Novartis Found Symp 2004; 257: 101-115.
12. Dirks CG, Pedersen MH, Platzer MH, et al. Does absorption across the buccal mucosa explain early onset of food-induced allergic systemic reactions. J Allergy Clin Immunol 2005; 115: 1321-1323.
13. Strid J, Hourihane J, Kimber I, et al. Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization. Clin Exp Allergy 2005; 35(6): 757-766.
14. Chambers SJ, Wickman MS, Regoi M, et al. Rapid in vivo transport of proteins from digested allergens across pre-sensitized gut. Biochem Biophys Res Commun 2004; 325: 1258-1263.
15. Jensen-Jarolim E, Untersmayr E. Food safety: in vitro digestion tests are non-predictive for allergenic potential of food in stomach insufficiency. Immunol Lett 2006; 102: 118-119.
16. The InformAll Database. Available at: http://food allergens.ifr.ac.uk.
17. Lemanske RF Jr., Taylor SL. Standardized extracts, foods. Clin Rev Allergy 1987; 5(1): 23-36.
18. Wopfner N, Willeroidee M, Hebenstreit D, et al. Molecular and immunological characterization of profilin from mugwort pollen. Biol Chem 2002; 383(11): 1779-1789.
19. Das Dores S, Chopin C, Villaume C, et al. A new oligomeric parvalbumin allergen of Atlantic cod (Gad m I) encoded by a gene distinct from that of Gad c I. Allergy 2002; 57(suppl 72): 79-83.
20. van Boxtel EL, van Beers MM, Koppelman SJ, et al. Allergen Ara h 1 occurs in peanuts as a large oligomer rather than as a trimer. J Agric Food Chem 2006; 54(19): 7180-7186.
21. Breiteneder H, Radauer C. A classification of plant food allergens. J Allergy Clin Immunol 2004; 113: 821-830.
22. Jenkins JA, Griffiths-Jones S, Shewry PR, et al. Structural relatedness of plant food allergens with specific reference to cross-reactive allergens: an in silico analysis. J Allergy Clin Immunol 2005; 115: 163-170.
23. King TP, Hoffman D, Lowenstein H, et al. Allergen nomenclature. Bull World Health Organ 1994; 72: 797-780.
24. Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October, 2003. J Allergy Clin Immunol 2004; 113: 832-836.
25. Chapman MD, Pomes A, Breiteneder H, et al. Nomenclature and structural biology of allergens. J Allergy Clin Immunol 2007; 119: 414-420.
26. Zuidmeer L, van Rhee R. Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases. Curr Opin Allergy Clin Immunol 2007; 7: 269-273.
27. AllFAm allergen family chart. Downloaded from AllFam version of May 5, 2007. Available at: http://www.meduniwien.ac.at/allergens/allfam/.
28. Radauer C, Marl A, Breiteneder H. The AllFam database-a resource for classifying allergenic proteins. Allergy 2007; 62(suppl 83): 154.
29. Strobel S, Mowat AM. Immune responses to dietary antigens: oral tolerance. Immunol Today 1998; 19(4): 173-181.
30. Busse PJ, Jarvinen KM, Vila L, et al. Identification of sequential IgE-binding epitopes on bovine alpha(s2)- casein in cow’s milk allergic patients. Int Arch Allergy Immunol 2002; 129: 93-96.
31. Jarvinen KM, Chatchatee P, Bardina L, et al. IgE and IgG binding epitopes on alpha-lactalbumin and beta-lactoglobulin in cow’s milk allergy. Int Arch Allergy Immunol 2001; 126(2): 111-118.
32. Jarvinen KM, Beyer K, Vila L, et al. B-cell epitopes as a screening instrument for persistent cow’s milk allergy. J Allergy Clin Immunol 2002; 110(2): 293-297.
33. Chatchatee P, Jarvinen KM, Bardina L, et al. Identification of IgE- and IgG-binding epitopes on alpha (s1)-casein: differences in patients with persistent and transient cow’s milk allergy. J Allergy Clin Immunol 2001; 107(2): 379-383.
34. Taylor SL, Hefle SL, Bindslev-Jensen C, et al. Factors affecting the determination of threshold doses for allergenic foods: how much is too much? J Allergy Clin Immunol 2002; 109: 24-30.
35. Morisset M, Moneret-Vautrin DA, Kanny G, et al. Thresholds of clinical reactivity to milk, egg, peanut, and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or singleblind placebo-controlled oral challenges. Clin Exp Allergy 2003; 33: 1046-1051.
36. Wal JM. Bovine milk allergenicity. Ann Allergy Asthma Immunol 2004; 93: 2-11.
37. Anet J, Back JF, Baker RS, et al. Allergens in the white and yolk of hen’s egg. A study of IgE binding by egg proteins. Int Arch Allergy Appl Immunol 1985; 77(3): 364-371.
38. Hoffman DR. Immunochemical identification of the allergens in egg white. J Allergy Clin Immunol 1983; 71(5): 481-486.
39. Bernhisel-Broadbent J, Dintzis HM, Dintzis RZ, et al. Allergenicity and antigenicity of chicken egg ovomucoid (Gal d III) compared with ovalbumin (Gal d I) in children with egg allergy and in mice. J Allergy Clin Immunol 1994; 93(6): 1047-1059.
40. Mine Y, Wei ZJ. Identification and fine mapping of IgG and IgE epitopes in ovomucoid. Biochem Biophys Res Commun 2002; 292(4): 1070-1074.
41. Walsh BJ, Hill DJ, Macoun P, et al. Detection of four distinct groups of hen egg allergens binding IgE in sera of children with egg allergy. Allergol Immunopathol (Madrid) 2005; 33: 183-191.
42. Allen CW, Campbell DE, Kemp AS. Egg allergy: are all childhood food allergies the same? J Paediatr Child Health 2007; 43: 214-218.
43. Hourihane JO, Roberts SA, Warner JO. Resolution of peanut allergy: case-control study. Br Med J 1998; 316: 1271-1275.
44. Fleischer DM, Conover-Walker MK, Christie L, et al. Peanut allergy: recurrence and its management. J Allergy Clin Immunol 2004; 114: 1195-1201.
45. Burks AW, Cockrell G, Stanley JS, et al. Recombinant peanut allergen Ara h I expression and IgE binding in patients with peanut hypersensitivity. J Clin Invest 1995; 96(4): 1715-1721.
46. Rabjohn P, West CM, Connaughton C, et al. Modification of peanut allergen Ara h 3: effects on IgE binding and T cell stimulation. Int Arch Allergy Immunol 2002; 128(1): 15-23.
47. Rabjohn P, Helm EM, Stanley JS, et al. Molecular cloning and epitope analysis of the peanut allergen Ara h 3. J Clin Invest 1999; 103(4): 535-542.
48. Palmer GW, Dibbern DA, Burks AW, et al. Comparative potency of Ara h 1 and Ara h 2 in immunochemical and functional assays of allergenicity. Clin Immunol 2005; 115: 302-312.
49. Shreffler WG, Castro RR, Kucuk ZY, et al. The major glycoprotein form Arachis hyogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol 2006; 177: 3677-3685.
50. Allergen Nomenclature-The Official “List of Allergy.” WHO/IUIS Allergen Nomenclature Sub-Committee, 2006. Available at: http://www.allergen.org.
51. Shreffler WG, Beyer K, Chu TH, et al. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol 2004; 113: 776-782.
52. Shreffler WG, Lencer DA, Bardina L, et al. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen Ara h 2. J Allergy Clin Immunol 2005; 116: 893-899.
53. Palmer K, Burks W. Current development in peanut allergy. Curr Opin Allergy Clin Immunol 2006; 6: 202-206.
54. Burks AW Jr., Brooks JR, Sampson HA. Allergenicity of major component proteins of soybean determined by enzyme-linked immunosorbent assay (ELISA) and immunoblotting in children with atopic dermatitis and positive soy challenges. J Allergy Clin Immunol 1988; 81(6): 1135-1142.
55. Ogawa A, Samoto M, Takahashi K. Soybean allergens and hypoallergenic soybean products. J Nutr Sci Vitaminol (Tokyo) 2000; 46(6): 271-279.
56. Ogawa T, Tsuji H, Bando N, et al. Identification of the soybean allergenic protein, Gly m Bd 30K, with the soybean seed 34-kDa oil-body-associated protein. Biosci Biotechnol Biochem 1993; 57(6): 1030-1033.
57. L’Hocine L, Boye JI. Allergenicity of soybean: new developments in identification of allergenic proteins, cross-reactivities and hypoallergenization technologies. Crit Rev Food Sci Nutr 2007; 47: 127-143.
58. Sutton R, Hill DJ, Baldo BA, et al. Immunoglobulin E antibodies to ingested cereal flour components: studies with sera from subjects with asthma and eczema. Clin Allergy 1982; 12(1): 63-74.
59. Jones SM, Magnolfi CF, Cooke SK, et al. Immunologic cross-reactivity among cereal grains and grasses in children with food hypersensitivity. J Allergy Clin Immunol 1995; 96(3): 341-351.
60. James JM, Helm RM, Burks AW, et al. Comparison of pediatric and adult IgE antibody binding to fish proteins. Ann Allergy Asthma Immunol 1997; 79(2): 131-137.
61. Battais F, Pineau F, Popineau Y, et al. Food allergy to wheat: identification of immunoglobulin Eand immunoglobulin G-binding proteins with sequential extracts and purified proteins from wheat flour. Clin Exp Allergy 2003; 33: 962-970.
62. Battais F, Mothes T, Moneret-Vautrin DA, et al. Identification of IgE-binding epitopes on gliadins for patients with food allergy to wheat. Allergy 2005; 60: 815-821.
63. Battaiis F, Richard C, Szustakowski G, et al. Wheat flour allergy: an entire diagnostic tool for complex allergy. Eur Annals Allergy Clin Immunol 2006; 38: 59-61.
64. Wild LG, Lehrer SB. Fish and shell fish allergy. Curr Allergy Asthma Rep 2005; 5: 74-79.
65. Chua KH, Tang CY, Wu A, et al. Seafood allergy: lessons from clinical symptoms, immunological mechanisms and molecular biology. Adv Biochem Eng Biotechnol 2005; 97: 205-235.
66. Aas K. Studies of hypersensitivity to fish. A clinical study. Int Arch Allergy Appl Immunol 1966; 29(4): 346-363.
67. Rosmilah M, Shahnaz M, Masita A, et al. Identification of major allergens of two species of local snappers: Lutjanus argentimaculatus (mera/red snapper) and Lutjanus johnii (janahak/golden snapper). Trop Biomed 2005; 22: 171-177.
68. Elsayed S, Apol J. Immunochemical analysis of cod fish allergen M: locations of the immunoglobulin binding sites as demonstrated by the native and synthetic peptides. Allergy 1983; 38: 449-459.
69. Chatterjee U, Mondal G, Chakraborti P, et al. Changes in the allergenicity during different preparations of pomfret, hilsa, bhetki and mackerel fish as illustrated by enzyme-linked immunosorbent assay and immunoblotting. Int Arch Allergy Immunol 2006; 141: 1-10.
70. Lehrer SB, Ibanez MD, McCants ML, et al. Characterization of water-soluble shrimp allergens released during boiling. J Allergy Clin Immunol 1990; 85(6): 1005-1013.
71. Daul CB, Morgan JE, Waring NP, et al. Immunologic evaluation of shrimp-allergic individuals. J Allergy Clin Immunol 1987; 80(5): 716-722.
72. Ayuso R, Lehrer SB, Reese G. Identification of continuous, allergenic regions of the major shrimp allergen Pen a 1 (tropomysin). Int Arch Allergy Immunol 2002; 127(1): 27-37.
73. Reese G, Ayuso R, Leong-Kee SM, et al. Characterization and identification of allergen epitopes: recombinant peptide libraries and synthetic, overlapping peptides. J Chromatogr B Biomed Sci Appl 2001; 756(1-2): 157-163.
74. Reese G, Schicktanz S, Lauraer I, et al. Structural, immunological and functional properties of natural recombinant Pan a 1, the major allergen of Brown shrimp. Penaeus aztecus. Clin Exp Allergy 2006; 36: 517-524.
75. Roux KH, Teuber SS, Sathe SK. Tree nut allergens. Int Archives Allergy Immunol 2003; 131: L234-L244.
76. Clark AT, Ewan PW. The development and progression of allergy to multiple nuts at different ages. Pediatr Allergy Immunol 2005; 16: 507-511.
77. Nordlee JA, Taylor SL, Townsend JA, et al. Identification of a Brazil-nut allergen in transgenic soybeans. N Engl J Med 1996; 334(11): 688-692.
78. Robotham JM, Teuber SS, Sathe SK, et al. Linear IgE epitope mapping of the English walnut (Juglans regia) major food allergen, Jug r 1. J Allergy Clin Immunol 2002; 109(1): 143-149.
79. Gangur V, Kelly C, Navulure L. Sesame allergy: a growing allergy of global proportions? Ann Allergy Asthma Immunol 2005; 95: 11-13.
80. Guarneri F, Guarneri C, Benvenga S. Identification of potentially cross-reactive peanut-lupine proteins by computer-assisted search of amino acid sequence homology. Int Arch Allergy Immunol 2005; 138: 273-277.
81. Magni C, Herndl A, Sironi E, et al. One- and two-dimensional electrophoretic identification of IgE-binding polypeptides of Lupinus albus and other legume seeds. J Agric Food Chem 2005; 53: 4567-4571.
82. Lucas JS, Grimshaw KE, Collins K, et al. Kiwi fruit is a significant allergen and is associated with differing patterns of reactivity in children and adults. Clin Exp Allergy 2004; 34: 1115-1121.
83. Lucans JS, Lewis SA, Trewin JB, et al. Comparison of the allergenicity of Actnidia deliciosa (kiwi fruit) and Actinidia chinensis (gold kiwi). Pediatr Allergy Immunol 2005; 16: 647-654.
84. Tamburrini M, Cerasuolo I, Carratore V, et al. Kiwellin, a novel protein from kiwi fruit. Purification, biochemical characterization and identification as an allergen. Protein J 2005; 24: 423-429.
85. Carnes J, Ferrer A, Fernandez-Caldas E. Allergenicity of 10 different apple varieties. Ann Allergy Asthma Immunol 2006; 96: 564-570.
86. Puumalainen TJ, Poikonen S, Kotovuori A, et al. Napins, 2S albumins, is major allergens in oilseed rape and turnip rape. J Allergy Clin Immunol 2006; 117: 426-432.
87. Ahrazem O, Ibanez MD, Lopez-Torrejon G, et al. Orange germin-like glycoprotein Cit s 1: an equivocal allergen. Int Arch Allergy Immunol 2006; 139: 96-103.
88. Egger M, Mutschlechner S, Wopfner N, et al. Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view. Allergy 2006; 61: 461-476.
89. Hemmer W, Focke M, Gotz M, et al. Sensitization to Ficus benjamina: relationship to natural rubber latex allergy and identification of foods implicated in the Ficus-fruit syndrome. Clin Exp Allergy 2004; 34: 1251-1258.
90. Blanco C. Latex-fruit syndrome. Curr Allergy Asthma Rep 2003; 3: 467-453.
91. Yagami T, Osuna H, Kuono M, et al. Significance of carbohydrate epitopes in a latex allergen with beta-1,3-glucanase activity. Int Arch Allergy Immunol 2002; 129: 27-37.
92. Purohit-Sheth TS, Carr WW. Oral allergy syndrome (pollen-food allergy syndrome). Allergy Asthma Proc 2005; 26: 229-230.
93. Hoffman HJ, Skjold T, Raithel M, et al. Response of respiratory flour allergics in an ingested flour challenge may involve plasmacytoid dendritic cells, CD25+and CD152+T cells. Int Arch Allergy Immunol 2006; 140: 252-260.
94. Goetz DW, Whisman BA. Occupational asthma in a seafood restaurant worker: cross-reactivity of shrimp and scallops. Ann Allergy Asthma Immunol 2000; 85: 461-466.
95. Bock SA, Munoz-Furlong A, Sampson. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001; 107: 191-193.
96. Anibarro B, Seone FJ, Mugica MV. Involvement of hidden allergens in food allergic reactions. J Investig Allergol Clin Immunol 2007; 17: 168-172.
97. Rojas-Hijazo B, Garcés MM, Caballero ML, et al. Unsuspected lupine allergens hidden in food. Int Arch Allergy Immunol 2006; 141(1): 47-50.
98. Schäppi GF, Konrad V, Imhof D, et al. Hidden peanut allergens detected in various foods: findings and legal measures. Allergy 2001; 56: 1216-1220.
99. Bischoff SC. Food allergies. Curr Treat Options Gastroenterol 2007; 10: 34-43.
100. Bischoff S, Crowe SE. Gastrointestinal food allergy: new insights into pathophysiology and clinical perspectives. Gastroenterology 2005; 128: 1089-1013.
101. Sicherer SH. Clinical aspects of gastrointestinal food allergy in childhood. Pediatrics 2003; 111: 1609-1616.
102. Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001; 107: 191-193.
103. Asero R, Ballmer-Weber BK, Beyer K, et al. IgE-mediated food allergy diagnosis: current status and new perspectives. Mol Nutr Food Res 2007; 51: 135-147.
104. Kiel T. Epidemiology of food allergy: what’s new? A critical appraisal of recent population-based studies. Curr Op Allergy Clin Immunol 2007; 7: 259-263.
105. Nowak-Wergrzyn A. Food allergy to proteins. In: Cooke RJ, Vanderplas Y, Wahn U, eds. Nutrition Support for Infants at Risk. Nestle Nutr Workshop Ser Pediatr Program 2007; 59: 17-35.
106. Sampson HA. Utility of food-specific concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001; 107: 891-896.
107. Sporik R, Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting positive food challenges to milk, egg, and peanut in children. Clin Exp Allergy 2000; 30: 1540-1546.
108. Perry TT, Matsui EC, Conover-Walker M, et al. The relationship of allergen-specific IgE levels and oral food challenge outcome. J Allergy Clin Immunol 2004; 114: 144-149.
109. Celik-Bilgili S, Mehl A, Verstege A, et al. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. Clin Exp Allergy 2005; 35: 268-273.
110. Nowak-Wegrzyn A. Food allergy to proteins. Nestle Nutr Workshop Ser Pediatr Program 2004; 59: 17-36.
111. Leung DY, Sampson HA, Yunginger JY, et al. Effect of anti-IgE therapy in patients with peanut allergy. New Eng J Med 2003; 348: 986-993.
112. Li XM, Zhang TF, Huang CK, et al. Food allergy herbal formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol 2001; 108: 639-646.
113. Bolhaar T, Tiemessen MM, Zuidmeer L, et al. Efficacy of birch-pollen immunotherapy on crossreactive food allergy confirmed by skin tests and double-blind food challenges. Clin Exp Allergy 2004; 34: 761-769.
114. Zhu D, Kepley CL, Zhang K, et al. A chimeric human-cat fusion protein blocks cat-induced allergy. Nat Med 2005; 60: 11: 446-449.
115. Frick OL, Teuber SS, Buchanan BB, et al. Allergen immunotherapy with heat-killed Listeria monocytogenes alleviates peanut and food-induced anaphylaxis in dogs. Allergy 2005; 60: 243-250.
116. Muraro A, Dreborg S, Halken S, et al. Dietary prevention of allergic disease in infant and small children. Part III: Critical review of published peer-reviewed observations and interventional studies and final recommendations. Pediatr Allergy Immunol 2003; 15: 291-307.
117. American Academy of Pediatrics Committee on Nutrition. Hypoallergenic infant formulas. Pediatrics 2000; 106: 346-349.
118. Astier C, Morisset M, Roitel O, et al. Predictive value of skin prick tests using recombinant allergens for diagnosis of peanut allergy. J Allergy Clin Immunol 2006; 118: 250-256.
119. Nowak-Wergrzyn A, Sampson HA. Food allergy therapy. Immunol Allergy Clin North Am 2004; 113: 705-725.
120. Sampson HA. Utility of food-specific IgE concentrations in predicting food allergy. J Allergy Clin Immunol 2001; 107: 891-896.
121. Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol 1997; 100: 444-451.
122. McCone KL, Sickles-Wright H, Birch LL, et al. Food portions are positively related to energy intake and body weight in children. J Pediatr 2002; 140: 340-347.
123. Moneret-Vautrin DA, Kanny G. Update on threshold doses of food allergens: implications for patients and the food industry. Curr Opin Allergy Clin Immunol 2004; 4: 215-219.
124. Leung DYM, Sampson HA, Yunginger JY, et al Effect of anti-IgE therapy in patients with food allergy. NEJM 2003; 348: 986-993.
125. Pons L, Palmer K, Burks W. Towards immunotherapy for peanut allergy. Curr Opin Allergy Clin Immunol 2005; 5: 558-562.
126. Morriset M, Moneret-Vautrin DA, Guenard L, et al. Oral desensitization in children with milk and egg allergies obtains recovery in significant proportion of cases. A randomized study of 60 children with cow’s milk allergy and 90 children with egg allergy. Allerg Immunol (Paris) 2007: 39: 12-19.
127. Malmheden Yman I, Eriksson A, Everitt G, et al. Analysis of food proteins for verification of contamination or mislabeling. Food Agric Immunol 1994; 6: 167-172.
128. Taylor SL, Hefle S, Bindslev-Jensen C, et al. Factors affecting the determination of threshold doses for allergenic foods: how much is too much? J Allergy Clin Immunol 2002; 109: 24-30.
129. Morisset M, Moneret-Vautrin DA, Kanny G, et al. Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or singleblind placebo-controlled oral challenges. Clin Exp Allergy 2003; 33: 1046-1051.
130. Thomas K, Herouet-Guicheney C, Ladics G, et al. Evaluation the effect of food processing on the potential human allergenicity on novel proteins: international workshop report. Food Chem Toxicol 2007; 45: 1116-1122.
131. Bohle B. T-cell epitopes of food allergens. Clin Rev Allergy Immunol 2006; 30: 97-108.
132. Scott-Taylor TH, Hourihane JB, Harper J, et al. Patterns of food allergen-specific cytokine production by T lymphocytes of children with multiple allergies. Clin Exp Allergy 2005; 35: 1473-1480.
133. Turcanu V, Maleki SJ, Lack G. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children and allergic children who acquired tolerance to peanuts. J Clin Invest 2003; 111: 1065-1072.
134. Noma T, Yoshizawa I, Aoki K, et al. Cytokine production in children outgrowing hen egg allergy. Clin Exp Allergy 1996: 26: 1298-1307.
135. Thottingal TB, Setfura BP, Simons FER, et al. Human subjects without peanut allergy demonstrate T cell-dependent, Th2-based, peanut-specific cytokine and chemokine responses independent of th1 expression. J Allergy Clin Immunol 2006; 118: 905-914.
136. Karlsson MR, Rugtveit J, Brandtzaeg P. Allergen-responsive CD4+CD25+regulatory T cells in children who have outgrown cow’s milk allergy. J Exp Med 2004; 199: 1679-1688.
137. Vieths S, Scheurer S, Ballmer-Weber B. Current understanding of cross-reactivity of food allergens and pollen. Ann N Y Acad Sci 2002; 964: 47-68.
138. Holm J, Gajhede M, Ferreras M, et al. Allergy vaccine engineering: epitope modulation of recombinant Bet v 1 reduces IgE-binging but retains protein folding pattern for induction of protective blocking-antibody responses. J Immunol 2004; 173: 5258-5267.
139. Reese G, Ayuso R, Leon-Kee SM, et al. Characterization and identification of allergen epitopes: recombinant peptide libraries and synthetic, overlapping peptides. J Chromatogr B Biomed Sci Appl 2001; 756: 157-163.
140. Mirza O, Henriksen A, Ipsen H, et al. Dominant epitopes and allergic cross-reactivity: complex formation between a fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen. J Immunol 2000; 165: 331-338.
141. Wiche R, Gubesch M, Konig H, et al. Molecular basis of pollen-related food allergy: identification of a second cross-reactive IgE epitope on Pru a 1, the major cherry allergen (Prunus avium). Biochem J 2005; 385: 319-327.
142. Neudecker P, Lehmann K, Nerkamp J, et al. Mutational epitope analysis of Pru av 1 and Api g 1, the major allergens of cherry (Prunus avium) and celery (Apium graveolens): correlating IgE reactivity with three-dimensional structure. Biochem J 2003; 15; 376: 97-107.
143. Suphioglu C, Schäppi G, Kenrick J, et al. A novel grass pollen allergen mimotope identified by phage display peptide library inhibits allergen-human IgE antibody interaction. FEBS Lett 2001; 27: 502: 46-52.
144. Mittag D, Batori V, Neudecker P, et al. A novel approach for investigation of specific and crossreactive IgE epitopes on Bet v 1 and homologous food allergens in individual patients. Mol Immunol 2006; 43: 268-278.
145. Aalberse RC, Stadler BM. In silica predictability of allergenicity: from amino acid sequence via 3-D structure to allergenicity. Mol Nutr Food Res 2006; 50: 625-627.
146. Untersmayr E, Jensen Jarolim E. Mechanisms of type I food allergy. Pharmacol Ther 2006; 112: 787-798.