β-arrestin recruitment assay for the identification of agonists of the sphingosine 1-phosphate receptor EDG1

Journal of Biomolecular Screening

Volumn 13, Issue 10, 2008, Pages 986-998

  Van Der Lee, Miranda M C ^a   Bras, Maaike ^a   Van Koppen, Chris J ^a   Zaman, Guido J R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

arrestin; galactosidase; EDG1; Enzyme fragment complementation; G protein coupled receptor; S1P1

Indexed keywords

BETA ARRESTIN; CYCLIC AMP; ENDOTHELIAL DIFFERENTIATION SPHINGOLIPID GPCR 1; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; SCREENING;

ANIMALS; ARRESTINS; BETA-ALANINE; BIOLOGICAL ASSAY; CELL DIFFERENTIATION; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP-BINDING PROTEINS; HUMANS; OXADIAZOLES; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, INTERLEUKIN-8B; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; THIOPHENES; TIME FACTORS;

EID: 58149392408     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057108326144     Document Type: Article

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