Characterization of the molecular interactions of interleukin-8 (CXCL8), growth related oncogen α (CXCL1) and a non-peptide antagonist (SB 225002) with the human CXCR2

Biochemical Pharmacology

Volumn 65, Issue 5, 2003, Pages 813-821

  Catusse, Julie ^a   Liotard, Anne ^a   Loillier, Bruno ^a   Pruneau, Didier ^a   Paquet, Jean Luc ^a  

^a Laboratoires Fournier SA   (France)

Author keywords

Activation; Binding; CXCL1; CXCL8; G protein coupled receptor; SB 225002

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; CALCIUM ION; CHEMOKINE; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; EPITOPE; GROWTH RELATED ONCOGEN ALPHA; INTERLEUKIN 8; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM MOBILIZATION; CHIMERA; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; RECEPTOR UPREGULATION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BINDING, COMPETITIVE; CALCIUM; CHEMOKINES; CHEMOKINES, CXC; CHEMOTACTIC FACTORS; CHIMERA; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-8; IODINE RADIOISOTOPES; MOLECULAR SEQUENCE DATA; MUTATION; PHENYLUREA COMPOUNDS;

EID: 0037334380     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01619-2     Document Type: Article

References (27)

1. Murphy P.M. International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature. Pharmacol. Rev. 54:2002;227-229.
2. Proost P., De Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., Van Damme J. Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. J. Immunol. 150:1993;1000-1010.
3. Haskill S., Peace A., Morris J., Sporn S.A., Anisowicz A., Lee S.W., Smith T., Martin G., Ralph P., Sager R. Identification of three related human GRO genes encoding cytokine functions. Proc. Natl. Acad. Sci. U.S.A. 87:1990;7732-7736.
4. Walz A., Baggiolini M. A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils. Biochem. Biophys. Res. Commun. 159:1989;969-975.
5. Walz A., Peveri P., Aschauer H., Thelen M., Kernen P., Dewald B., Baggiolini M. Structure and properties of a novel neutrophil-activating factor (NAF) produced by human monocytes. Agents Actions. 26:1989;148-150.
6. Jones S.A., Dewald B., Clark-Lewis I., Baggiolini M. Chemokine antagonists that discriminate between interleukin-8 receptors. Selective blockers of CXCR2. J. Biol. Chem. 272:1997;16166-16169.
7. L'Heureux G.P., Bourgoin S., Jean N., McColl S.R., Naccache P.H. Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity. Blood. 85:1995;522-531.
8. Feniger-Barish R., Ran M., Zaslaver A., Ben-Baruch A. Differential modes of regulation of cxc chemokine-induced internalization and recycling of human CXCR1 and CXCR2. Cytokine. 11:1999;996-1009.
9. Katancik J.A., Sharma A., de Nardin E. Interleukin 8, neutrophil-activating peptide-2 and GRO-alpha bind to and elicit cell activation via specific and different amino acid residues of CXCR2. Cytokine. 12:2000;1480-1488.
10. Gayle R.B. III, Sleath P.R., Srinivason S., Birks C.W., Weerawarna K.S., Cerretti D.P., Kozlosky C.J., Nelson N., Vanden Bos T., Beckmann M.P. Importance of the amino terminus of the interleukin-8 receptor in ligand interactions. J. Biol. Chem. 268:1993;7283-7289.
11. Wu L., Ruffing N., Shi X., Newman W., Soler D., Mackay C.R., Qin S. Discrete steps in binding and signaling of interleukin-8 with its receptor. J. Biol. Chem. 271:1996;31202-31209.
12. Ahuja S.K., Lee J.C., Murphy P.M. CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. Determinants of high affinity binding and receptor activation are distinct. J. Biol. Chem. 271:1996;225-232.
13. Katancik J.A., Sharma A., Radel S.J., De Nardin E. Mapping of the extracellular binding regions of the human interleukin-8 type B receptor. Biochem. Biophys. Res. Commun. 232:1997;663-668.
14. White J.R., Lee J.M., Young P.R., Hertzberg R.P., Jurewicz A.J., Chaikin M.A., Widdowson K., Foley J.J., Martin L.D., Griswold D.E., Sarau H.M. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J. Biol. Chem. 273:1998;10095-10098.
15. Lane B.R., Lore K., Bock P.J., Andersson J., Coffey M.J., Strieter R.M., Markovitz D.M., Matsumoto Y., Matsushima K., White J.R., Lee J.M., Young P.R., Hertzberg R.P., Jurewicz A.J., Chaikin M.A., Widdowson K., Foley J.J., Martin L.D., Griswold D.E., Sarau H.M. Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for antiretroviral therapy. J. Virol. 75:2001;8195-8202.
16. Auten R.L., Richardson R.M., White J.R., Mason S.N., Vozzelli M.A., Whorton M.H. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J. Pharmacol. Exp. Ther. 299:2001;90-95.
17. Ben-Baruch A., Bengali K.M., Biragyn A., Johnston J.J., Wang J.M., Kim J., Chuntharapai A., Michiel D.F., Oppenheim J.J., Kelvin D.J. Interleukin-8 receptor beta. The role of the carboxyl terminus in signal transduction. J. Biol. Chem. 270:1995;9121-9128.
18. Bockaert J., Pin J.P. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 18:1999;1723-1729.
19. Lee J., Horuk R., Rice G.C., Bennett G.L., Camerato T., Wood W.I. Characterization of two high affinity human interleukin-8 receptors. J. Biol. Chem. 267:1992;16283-16287.
20. Moser B., Schumacher C., von Tscharner V., Clark-Lewis I., Baggiolini M. Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils. J. Biol. Chem. 266:1991;10666-10671.
21. Luo Z., Butcher D.J., Huang Z. Molecular modeling of interleukin-8 receptor beta and analysis of the receptor-ligand interaction. Protein Eng. 10:1997;1039-1045.
22. Doranz B.J., Orsini M.J., Turner J.D., Hoffman T.L., Berson J.F., Hoxie J.A., Peiper S.C., Brass L.F., Doms R.W. Identification of CXCR4 domains that support coreceptor and chemokine receptor functions. J. Virol. 73:1999;2752-2761.
23. Gether U. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr. Rev. 21:2000;90-113.
24. Marie J., Richard E., Pruneau D., Paquet J.L., Siatka C., Larguier R., Ponce C., Vassault P., Groblewski T., Maigret B., Bonnafous J.C. Control of conformational equilibria in the human B2 bradykinin receptor. Modeling of nonpeptidic ligand action and comparison to the rhodopsin structure. J. Biol. Chem. 276:2001;41100-41111.
25. Gerlach L.O., Skerlj R.T., Bridger G.J., Schwartz T.W. Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. J. Biol. Chem. 276:2001;14153-14160.
26. Rodriguez-Frade J.M., Mellado M., Martinez A.C. Chemokine receptor dimerization: two are better than one. Trends Immunol. 22:2001;612-617.
27. Ayoub M.A., Couturier C., Lucas-Meunier E., Angers S., Fossier P., Bouvier M., Jockers R. Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J. Biol. Chem. 277:2002;21522-21528.