A Monoselective Sphingosine-1-Phosphate Receptor-1 Agonist Prevents Allograft Rejection in a Stringent Rat Heart Transplantation Model

Chemistry and Biology

Volumn 13, Issue 11, 2006, Pages 1227-1234

  Pan, Shifeng ^a   Mi, Yuan ^a   Pally, Charles ^b   Beerli, Christian ^b   Chen, Alice ^a   Guerini, Danilo ^b   Hinterding, Klaus ^b   Nuesslein Hildesheim, Barbara ^b   Tuntland, Tove ^a   Lefebvre, Sophie ^a   Liu, Yi ^a   Gao, Wenqi ^a   Chu, Alan ^a   Brinkmann, Volker ^b   Bruns, Christian ^b   Streiff, Markus ^b   Cannet, Catherine ^b   Cooke, Nigel ^b   Gray, Nathanael ^a,c  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CHEMBIO; MOLIMMUNO

Indexed keywords

AUY 954; BETA ALANINE; DRUG DERIVATIVE; EVEROLIMUS; IMMUNOSUPPRESSIVE AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; RAPAMYCIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR; THIOPHENE DERIVATIVE;

ALLOTRANSPLANTATION; ANIMAL; ARTICLE; CHO CELL; CRICETULUS; DRUG EFFECT; DRUG POTENTIATION; GRAFT REJECTION; HAMSTER; HEART TRANSPLANTATION; HUMAN; LEWIS RAT; LYMPHOCYTE; MALE; METABOLISM; RAT; SYNTHESIS;

ANIMALS; BETA-ALANINE; CHO CELLS; CRICETINAE; CRICETULUS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTES; MALE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED LEW; RECEPTORS, LYSOSPHINGOLIPID; SIROLIMUS; THIOPHENES; TRANSPLANTATION, HOMOLOGOUS;

ANIMALIA; MAMMALIA;

EID: 33751093316     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2006.09.017     Document Type: Article

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