메뉴 건너뛰기




Volumn 126, Issue 2, 2009, Pages 147-164

Tricks with tetramers: how to get the most from multimeric peptide-MHC

Author keywords

Antigen; Flow cytometry; Peptide MHC; T cell; TCR; Tetramer

Indexed keywords

AVIDIN; BIOTIN; CD4 ANTIGEN; DIMER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; POLYMER; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR; TETRAMER;

EID: 58149291771     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2008.02848.x     Document Type: Review
Times cited : (144)

References (117)
  • 1
    • 19944432399 scopus 로고    scopus 로고
    • Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition
    • Laugel B, Boulter JM, Lissin N et al. Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition. J Biol Chem 2005 280 : 1882 92.
    • (2005) J Biol Chem , vol.280 , pp. 1882-92
    • Laugel, B.1    Boulter, J.M.2    Lissin, N.3
  • 3
    • 23044469067 scopus 로고    scopus 로고
    • Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface
    • Wooldridge L, van den Berg HA, Glick M et al. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. J Biol Chem 2005 280 : 27491 501.
    • (2005) J Biol Chem , vol.280 , pp. 27491-501
    • Wooldridge, L.1    Van Den Berg, H.A.2    Glick, M.3
  • 4
    • 0038136973 scopus 로고    scopus 로고
    • Soluble major histocompatibility complex-peptide octamers with impaired CD8 binding selectively induce Fas-dependent apoptosis
    • Guillaume P, Legler DF, Boucheron N, Doucey MA, Cerottini JC, Luescher IF. Soluble major histocompatibility complex-peptide octamers with impaired CD8 binding selectively induce Fas-dependent apoptosis. J Biol Chem 2003 278 : 4500 9.
    • (2003) J Biol Chem , vol.278 , pp. 4500-9
    • Guillaume, P.1    Legler, D.F.2    Boucheron, N.3    Doucey, M.A.4    Cerottini, J.C.5    Luescher, I.F.6
  • 5
    • 20544465572 scopus 로고    scopus 로고
    • MHC multimer technology: current status and future prospects
    • Bakker AH, Schumacher TN. MHC multimer technology: current status and future prospects. Curr Opin Immunol 2005 17 : 428 33.
    • (2005) Curr Opin Immunol , vol.17 , pp. 428-33
    • Bakker, A.H.1    Schumacher, T.N.2
  • 7
    • 0344631674 scopus 로고    scopus 로고
    • Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent
    • Whelan JA, Dunbar PR, Price DA et al. Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent. J Immunol 1999 163 : 4342 8.
    • (1999) J Immunol , vol.163 , pp. 4342-8
    • Whelan, J.A.1    Dunbar, P.R.2    Price, D.A.3
  • 8
    • 0027301982 scopus 로고
    • A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations
    • Dal Porto J, Johansen TE, Catipovic B et al. A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations. Proc Natl Acad Sci U S A 1993 90 : 6671 5.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 6671-5
    • Dal Porto, J.1    Johansen, T.E.2    Catipovic, B.3
  • 9
    • 0032560535 scopus 로고    scopus 로고
    • Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients
    • Greten TF, Slansky JE, Kubota R et al. Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients. Proc Natl Acad Sci USA 1998 95 : 7568 73.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7568-73
    • Greten, T.F.1    Slansky, J.E.2    Kubota, R.3
  • 10
    • 34548264739 scopus 로고    scopus 로고
    • Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties
    • Laugel B, van den Berg HA, Gostick E et al. Different T cell receptor affinity thresholds and CD8 coreceptor dependence govern cytotoxic T lymphocyte activation and tetramer binding properties. J Biol Chem 2007 282 : 23799 810.
    • (2007) J Biol Chem , vol.282 , pp. 23799-810
    • Laugel, B.1    Van Den Berg, H.A.2    Gostick, E.3
  • 11
    • 34447306898 scopus 로고    scopus 로고
    • The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor
    • Purbhoo MA, Li Y, Sutton DH et al. The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor. Mol Cancer Ther 2007 6 : 2081 91.
    • (2007) Mol Cancer Ther , vol.6 , pp. 2081-91
    • Purbhoo, M.A.1    Li, Y.2    Sutton, D.H.3
  • 12
    • 34247605947 scopus 로고    scopus 로고
    • Human TCR-binding affinity is governed by MHC class restriction
    • Cole DK, Pumphrey NJ, Boulter JM et al. Human TCR-binding affinity is governed by MHC class restriction. J Immunol 2007 178 : 5727 34.
    • (2007) J Immunol , vol.178 , pp. 5727-34
    • Cole, D.K.1    Pumphrey, N.J.2    Boulter, J.M.3
  • 13
    • 20744449952 scopus 로고    scopus 로고
    • Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen
    • Falta MT, Fontenot AP, Rosloniec EF et al. Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen. Arthritis Rheum 2005 52 : 1885 96.
    • (2005) Arthritis Rheum , vol.52 , pp. 1885-96
    • Falta, M.T.1    Fontenot, A.P.2    Rosloniec, E.F.3
  • 15
    • 17944367867 scopus 로고    scopus 로고
    • Discrepancy between ELISPOT IFN-γ secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life
    • Rubio-Godoy V, Dutoit V, Rimoldi D et al. Discrepancy between ELISPOT IFN-γ secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life. Proc Natl Acad Sci USA 2001 98 : 10302 7.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10302-7
    • Rubio-Godoy, V.1    Dutoit, V.2    Rimoldi, D.3
  • 16
    • 33744496545 scopus 로고    scopus 로고
    • T-cell receptor tetramer binding or the lack there of does not necessitate antigen reactivity in T-cell receptor transduced T cells
    • Lyons GE, Roszkowski JJ, Man S, Kast WM, Nishimura MI. T-cell receptor tetramer binding or the lack there of does not necessitate antigen reactivity in T-cell receptor transduced T cells. Cancer Immunol Immunother 2006 55 : 1142 50.
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 1142-50
    • Lyons, G.E.1    Roszkowski, J.J.2    Man, S.3    Kast, W.M.4    Nishimura, M.I.5
  • 17
    • 42249088418 scopus 로고    scopus 로고
    • Profound inhibition of antigen-specific T-cell effector functions by dasatinib
    • Weichsel R, Dix C, Wooldridge L et al. Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clin Cancer Res 2008 14 : 2484 91.
    • (2008) Clin Cancer Res , vol.14 , pp. 2484-91
    • Weichsel, R.1    Dix, C.2    Wooldridge, L.3
  • 18
    • 58149304618 scopus 로고    scopus 로고
    • Protein kinase inhibitors substantially improve the physical detection of T cells with peptide-MHC tetramers
    • in press).
    • Lissina A, Ladell K, Skowera A et al. Protein kinase inhibitors substantially improve the physical detection of T cells with peptide-MHC tetramers. J Immunol Methods 2008 (in press).
    • (2008) J Immunol Methods
    • Lissina, A.1    Ladell, K.2    Skowera, A.3
  • 19
    • 10744222630 scopus 로고    scopus 로고
    • Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface
    • Wooldridge L, Hutchinson SL, Choi EM et al. Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface. J Immunol 2003 171 : 6650 60.
    • (2003) J Immunol , vol.171 , pp. 6650-60
    • Wooldridge, L.1    Hutchinson, S.L.2    Choi, E.M.3
  • 21
    • 0034677055 scopus 로고    scopus 로고
    • Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers
    • Daniels MA, Jameson SC. Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers. J Exp Med 2000 191 : 335 46.
    • (2000) J Exp Med , vol.191 , pp. 335-46
    • Daniels, M.A.1    Jameson, S.C.2
  • 22
    • 33746788900 scopus 로고    scopus 로고
    • Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry
    • Chattopadhyay PK, Price DA, Harper TF et al. Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry. Nat Med 2006 12 : 972 7.
    • (2006) Nat Med , vol.12 , pp. 972-7
    • Chattopadhyay, P.K.1    Price, D.A.2    Harper, T.F.3
  • 23
    • 3242687258 scopus 로고    scopus 로고
    • Ultra-sensitive class I tetramer analysis reveals previously undetectable populations of antiviral CD8+ T cells
    • Barnes E, Ward SM, Kasprowicz VO, Dusheiko G, Klenerman P, Lucas M. Ultra-sensitive class I tetramer analysis reveals previously undetectable populations of antiviral CD8+ T cells. Eur J Immunol 2004 34 : 1570 7.
    • (2004) Eur J Immunol , vol.34 , pp. 1570-7
    • Barnes, E.1    Ward, S.M.2    Kasprowicz, V.O.3    Dusheiko, G.4    Klenerman, P.5    Lucas, M.6
  • 24
    • 0036845911 scopus 로고    scopus 로고
    • Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load
    • Oxenius A, Sewell AK, Dawson SJ et al. Functional discrepancies in HIV-specific CD8+ T-lymphocyte populations are related to plasma virus load. J Clin Immunol 2002 22 : 363 74.
    • (2002) J Clin Immunol , vol.22 , pp. 363-74
    • Oxenius, A.1    Sewell, A.K.2    Dawson, S.J.3
  • 25
    • 0034630306 scopus 로고    scopus 로고
    • Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection
    • Alexander-Miller MA. Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection. Cell Immunol 2000 201 : 58 62.
    • (2000) Cell Immunol , vol.201 , pp. 58-62
    • Alexander-Miller, M.A.1
  • 26
    • 0029965055 scopus 로고    scopus 로고
    • Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy
    • Alexander-Miller MA, Leggatt GR, Berzofsky JA. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc Natl Acad Sci USA 1996 93 : 4102 7.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4102-7
    • Alexander-Miller, M.A.1    Leggatt, G.R.2    Berzofsky, J.A.3
  • 27
    • 0036467414 scopus 로고    scopus 로고
    • Functional avidity of tumor antigen-specific CTL recognition directly correlates with the stability of MHC/peptide multimer binding to TCR
    • Dutoit V, Rubio-Godoy V, Doucey MA et al. Functional avidity of tumor antigen-specific CTL recognition directly correlates with the stability of MHC/peptide multimer binding to TCR. J Immunol 2002 168 : 1167 71.
    • (2002) J Immunol , vol.168 , pp. 1167-71
    • Dutoit, V.1    Rubio-Godoy, V.2    Doucey, M.A.3
  • 28
    • 0032543212 scopus 로고    scopus 로고
    • Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides
    • Gallimore A, Dumrese T, Hengartner H, Zinkernagel RM, Rammensee HG. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. J Exp Med 1998 187 : 1647 57.
    • (1998) J Exp Med , vol.187 , pp. 1647-57
    • Gallimore, A.1    Dumrese, T.2    Hengartner, H.3    Zinkernagel, R.M.4    Rammensee, H.G.5
  • 29
    • 2242419092 scopus 로고    scopus 로고
    • Direct link between MHC polymorphism, T-cell avidity, and diversity in immune defense
    • Messaoudi I, Guevara Patino JA, Dyall R, LeMaoult J, Nikolich-Zugich J. Direct link between MHC polymorphism, T-cell avidity, and diversity in immune defense. Science 2002 298 : 1797 800.
    • (2002) Science , vol.298 , pp. 1797-800
    • Messaoudi, I.1    Guevara Patino, J.A.2    Dyall, R.3    LeMaoult, J.4    Nikolich-Zugich, J.5
  • 30
    • 0034130519 scopus 로고    scopus 로고
    • In vivo induction of a high-avidity, high-frequency cytotoxic T-lymphocyte response is associated with antiviral protective immunity
    • Sedlik C, Dadaglio G, Saron MF, Deriaud E, Rojas M, Casal SI, Leclerc C. In vivo induction of a high-avidity, high-frequency cytotoxic T-lymphocyte response is associated with antiviral protective immunity. J Virol 2000 74 : 5769 75.
    • (2000) J Virol , vol.74 , pp. 5769-75
    • Sedlik, C.1    Dadaglio, G.2    Saron, M.F.3    Deriaud, E.4    Rojas, M.5    Casal, S.I.6    Leclerc, C.7
  • 31
    • 0033558363 scopus 로고    scopus 로고
    • Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
    • Yee C, Savage PA, Lee PP, Davis MM, Greenberg PD. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J Immunol 1999 162 : 2227 34.
    • (1999) J Immunol , vol.162 , pp. 2227-34
    • Yee, C.1    Savage, P.A.2    Lee, P.P.3    Davis, M.M.4    Greenberg, P.D.5
  • 32
    • 0037370364 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells
    • Molldrem JJ, Lee PP, Kant S, Wieder E, Jiang W, Lu S, Wang C, Davis MM. Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells. J Clin Invest 2003 111 : 639 47.
    • (2003) J Clin Invest , vol.111 , pp. 639-47
    • Molldrem, J.J.1    Lee, P.P.2    Kant, S.3    Wieder, E.4    Jiang, W.5    Lu, S.6    Wang, C.7    Davis, M.M.8
  • 33
    • 0033556322 scopus 로고    scopus 로고
    • High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy
    • Zeh HJ 3rd., Perry-Lalley D, Dudley ME, Rosenberg SA, Yang JC. High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy. J Immunol 1999 162 : 989 94.
    • (1999) J Immunol , vol.162 , pp. 989-94
    • Zeh III, H.J.1    Perry-Lalley, D.2    Dudley, M.E.3    Rosenberg, S.A.4    Yang, J.C.5
  • 34
    • 0029063148 scopus 로고
    • Kinetic proofreading in T-cell receptor signal transduction
    • McKeithan TW. Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci U S A 1995 92 : 5042 6.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5042-6
    • McKeithan, T.W.1
  • 35
    • 34548794941 scopus 로고    scopus 로고
    • Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells
    • Kroger CJ, Alexander-Miller MA. Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells. J Immunol 2007 179 : 748 51.
    • (2007) J Immunol , vol.179 , pp. 748-51
    • Kroger, C.J.1    Alexander-Miller, M.A.2
  • 36
    • 0035914485 scopus 로고    scopus 로고
    • CD8β endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes
    • Arcaro A, Gregoire C, Bakker TR et al. CD8β endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes. J Exp Med 2001 194 : 1485 95.
    • (2001) J Exp Med , vol.194 , pp. 1485-95
    • Arcaro, A.1    Gregoire, C.2    Bakker, T.R.3
  • 37
    • 38349108802 scopus 로고    scopus 로고
    • Kinetics of MHC-CD8 interaction at the T cell membrane
    • Huang J, Edwards LJ, Evavold BD, Zhu C. Kinetics of MHC-CD8 interaction at the T cell membrane. J Immunol 2007 179 : 7653 62.
    • (2007) J Immunol , vol.179 , pp. 7653-62
    • Huang, J.1    Edwards, L.J.2    Evavold, B.D.3    Zhu, C.4
  • 38
    • 0027364273 scopus 로고
    • Is CD8 dependence a true reflection of TCR affinity for antigen?
    • Kwan-Lim GE, Ong T, Aosai F, Stauss H, Zamoyska R. Is CD8 dependence a true reflection of TCR affinity for antigen? Int Immunol 1993 5 : 1219 28.
    • (1993) Int Immunol , vol.5 , pp. 1219-28
    • Kwan-Lim, G.E.1    Ong, T.2    Aosai, F.3    Stauss, H.4    Zamoyska, R.5
  • 39
    • 0035451399 scopus 로고    scopus 로고
    • Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8αβ versus CD8αα expression
    • Cawthon AG, Lu H, Alexander-Miller MA. Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8αβ versus CD8αα expression. J Immunol 2001 167 : 2577 84.
    • (2001) J Immunol , vol.167 , pp. 2577-84
    • Cawthon, A.G.1    Lu, H.2    Alexander-Miller, M.A.3
  • 40
    • 0030926140 scopus 로고    scopus 로고
    • Crystal structure of the complex between human CD8α(α) and HLA-A2
    • Gao GF, Tormo J, Gerth UC et al. Crystal structure of the complex between human CD8α(α) and HLA-A2. Nature 1997 387 : 630 4.
    • (1997) Nature , vol.387 , pp. 630-4
    • Gao, G.F.1    Tormo, J.2    Gerth, U.C.3
  • 42
    • 0037331525 scopus 로고    scopus 로고
    • Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
    • Holler PD, Kranz DM. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity 2003 18 : 255 64.
    • (2003) Immunity , vol.18 , pp. 255-64
    • Holler, P.D.1    Kranz, D.M.2
  • 43
    • 0026681679 scopus 로고
    • The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation
    • Janeway CA Jr. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu Rev Immunol 1992 10 : 645 74.
    • (1992) Annu Rev Immunol , vol.10 , pp. 645-74
    • Janeway Jr., C.A.1
  • 44
    • 34249730105 scopus 로고    scopus 로고
    • CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions
    • Laugel B, Price DA, Milicic A, Sewell AK. CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. Eur J Immunol 2007 37 : 905 13.
    • (2007) Eur J Immunol , vol.37 , pp. 905-13
    • Laugel, B.1    Price, D.A.2    Milicic, A.3    Sewell, A.K.4
  • 45
    • 34548748171 scopus 로고    scopus 로고
    • 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
    • Park JH, Adoro S, Lucas PJ et al. 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. Nat Immunol 2007 8 : 1049 59.
    • (2007) Nat Immunol , vol.8 , pp. 1049-59
    • Park, J.H.1    Adoro, S.2    Lucas, P.J.3
  • 46
    • 0025924502 scopus 로고
    • Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells
    • Glaichenhaus N, Shastri N, Littman DR, Turner JM. Requirement for association of p56lck with CD4 in antigen-specific signal transduction in T cells. Cell 1991 64 : 511 20.
    • (1991) Cell , vol.64 , pp. 511-20
    • Glaichenhaus, N.1    Shastri, N.2    Littman, D.R.3    Turner, J.M.4
  • 47
    • 0035980059 scopus 로고    scopus 로고
    • The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain
    • Purbhoo MA, Boulter JM, Price DA et al. The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain. J Biol Chem 2001 276 : 32786 92.
    • (2001) J Biol Chem , vol.276 , pp. 32786-92
    • Purbhoo, M.A.1    Boulter, J.M.2    Price, D.A.3
  • 48
    • 0023737931 scopus 로고
    • The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
    • Veillette A, Bookman MA, Horak EM, Bolen JB. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 1988 55 : 301 8.
    • (1988) Cell , vol.55 , pp. 301-8
    • Veillette, A.1    Bookman, M.A.2    Horak, E.M.3    Bolen, J.B.4
  • 49
    • 0033571795 scopus 로고    scopus 로고
    • Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T-cell receptor signal transduction
    • Bosselut R, Zhang W, Ashe JM, Kopacz JL, Samelson LE, Singer A. Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T-cell receptor signal transduction. J Exp Med 1999 190 : 1517 26.
    • (1999) J Exp Med , vol.190 , pp. 1517-26
    • Bosselut, R.1    Zhang, W.2    Ashe, J.M.3    Kopacz, J.L.4    Samelson, L.E.5    Singer, A.6
  • 53
    • 0031937333 scopus 로고    scopus 로고
    • Co-capping studies reveal CD8/TCR interactions after capping CD8 beta polypeptides and intracellular associations of CD8 with p56(lck)
    • Kwan Lim GE, McNeill L, Whitley K, Becker DL, Zamoyska R. Co-capping studies reveal CD8/TCR interactions after capping CD8 beta polypeptides and intracellular associations of CD8 with p56(lck). Eur J Immunol 1998 28 : 745 54.
    • (1998) Eur J Immunol , vol.28 , pp. 745-54
    • Kwan Lim, G.E.1    McNeill, L.2    Whitley, K.3    Becker, D.L.4    Zamoyska, R.5
  • 54
    • 0037105508 scopus 로고    scopus 로고
    • A role for the alpha-chain connecting peptide motif in mediating TCR-CD8 cooperation
    • Naeher D, Luescher IF, Palmer E. A role for the alpha-chain connecting peptide motif in mediating TCR-CD8 cooperation. J Immunol 2002 169 : 2964 70.
    • (2002) J Immunol , vol.169 , pp. 2964-70
    • Naeher, D.1    Luescher, I.F.2    Palmer, E.3
  • 55
    • 0026802331 scopus 로고
    • Biochemical evidence of the physical association of the majority of CD3 delta chains with the accessory/co-receptor molecules CD4 and CD8 on nonactivated T lymphocytes
    • Suzuki S, Kupsch J, Eichmann K, Saizawa MK. Biochemical evidence of the physical association of the majority of CD3 delta chains with the accessory/co-receptor molecules CD4 and CD8 on nonactivated T lymphocytes. Eur J Immunol 1992 22 : 2475 9.
    • (1992) Eur J Immunol , vol.22 , pp. 2475-9
    • Suzuki, S.1    Kupsch, J.2    Eichmann, K.3    Saizawa, M.K.4
  • 56
    • 40249098634 scopus 로고    scopus 로고
    • Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes
    • Demotte N, Stroobant V, Courtoy PJ, et al. Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes. Immunity 2008 28 : 414 24.
    • (2008) Immunity , vol.28 , pp. 414-24
    • Demotte, N.1    Stroobant, V.2    Courtoy, P.J.3
  • 58
    • 40849095843 scopus 로고    scopus 로고
    • Co-engagement of the CD8αα co-receptor to peptide-major histocompatibility complexes: the effect of T-cell receptor docking on CD8 binding
    • Cole DK, Dunn SM, Sami M, Boulter JM, Sewell AK, Jakobsen BK. Co-engagement of the CD8αα co-receptor to peptide-major histocompatibility complexes: the effect of T-cell receptor docking on CD8 binding. Mol Immunol 2008 45 : 2700 9.
    • (2008) Mol Immunol , vol.45 , pp. 2700-9
    • Cole, D.K.1    Dunn, S.M.2    Sami, M.3    Boulter, J.M.4    Sewell, A.K.5    Jakobsen, B.K.6
  • 59
    • 35548935219 scopus 로고    scopus 로고
    • Coreceptor CD8-driven modulation of T cell antigen receptor specificity
    • van den Berg HA, Wooldridge L, Laugel B, Sewell AK. Coreceptor CD8-driven modulation of T cell antigen receptor specificity. J Theor Biol 2007 249 : 395 408.
    • (2007) J Theor Biol , vol.249 , pp. 395-408
    • Van Den Berg, H.A.1    Wooldridge, L.2    Laugel, B.3    Sewell, A.K.4
  • 60
    • 11844263392 scopus 로고    scopus 로고
    • Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo
    • Maile R, Siler CA, Kerry SE, Midkiff KE, Collins EJ, Frelinger JA. Peripheral "CD8 tuning" dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J Immunol 2005 174 : 619 27.
    • (2005) J Immunol , vol.174 , pp. 619-27
    • Maile, R.1    Siler, C.A.2    Kerry, S.E.3    Midkiff, K.E.4    Collins, E.J.5    Frelinger, J.A.6
  • 61
    • 34548597082 scopus 로고    scopus 로고
    • Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter
    • Kroger CJ, Alexander-Miller MA. Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter. Immunology 2007 122 : 167 78.
    • (2007) Immunology , vol.122 , pp. 167-78
    • Kroger, C.J.1    Alexander-Miller, M.A.2
  • 63
    • 0031874919 scopus 로고    scopus 로고
    • Negative regulation of antigen receptor signaling in lymphocytes
    • Plas DR, Thomas ML. Negative regulation of antigen receptor signaling in lymphocytes. J Mol Med 1998 76 : 589 95.
    • (1998) J Mol Med , vol.76 , pp. 589-95
    • Plas, D.R.1    Thomas, M.L.2
  • 64
    • 0033120082 scopus 로고    scopus 로고
    • TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1
    • Johnson KG, LeRoy FG, Borysiewicz LK, Matthews RJ. TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1. J Immunol 1999 162 : 3802 13.
    • (1999) J Immunol , vol.162 , pp. 3802-13
    • Johnson, K.G.1    LeRoy, F.G.2    Borysiewicz, L.K.3    Matthews, R.J.4
  • 65
    • 33845941583 scopus 로고    scopus 로고
    • Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function
    • Sathish JG, Dolton G, Leroy FG, Matthews RJ. Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL function. J Immunol 2007 178 : 330 7.
    • (2007) J Immunol , vol.178 , pp. 330-7
    • Sathish, J.G.1    Dolton, G.2    Leroy, F.G.3    Matthews, R.J.4
  • 66
    • 0035253434 scopus 로고    scopus 로고
    • High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL
    • Derby M, Alexander-Miller M, Tse R, Berzofsky J. High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL. J Immunol 2001 166 : 1690 7.
    • (2001) J Immunol , vol.166 , pp. 1690-7
    • Derby, M.1    Alexander-Miller, M.2    Tse, R.3    Berzofsky, J.4
  • 67
    • 0029813121 scopus 로고    scopus 로고
    • Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL
    • Alexander-Miller MA, Leggatt GR, Sarin A, Berzofsky JA. Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL. J Exp Med 1996 184 : 485 92.
    • (1996) J Exp Med , vol.184 , pp. 485-92
    • Alexander-Miller, M.A.1    Leggatt, G.R.2    Sarin, A.3    Berzofsky, J.A.4
  • 68
    • 1642415940 scopus 로고    scopus 로고
    • Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections
    • Fuller MJ, Khanolkar A, Tebo AE, Zajac AJ. Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections. J Immunol 2004 172 : 4204 14.
    • (2004) J Immunol , vol.172 , pp. 4204-14
    • Fuller, M.J.1    Khanolkar, A.2    Tebo, A.E.3    Zajac, A.J.4
  • 69
    • 0037221289 scopus 로고    scopus 로고
    • Ablation of CD8 and CD4 T cell responses by high viral loads
    • Fuller MJ, Zajac AJ. Ablation of CD8 and CD4 T cell responses by high viral loads. J Immunol 2003 170 : 477 86.
    • (2003) J Immunol , vol.170 , pp. 477-86
    • Fuller, M.J.1    Zajac, A.J.2
  • 70
    • 0032482176 scopus 로고    scopus 로고
    • Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes
    • Gallimore A, Glithero A, Godkin A, Tissot AC, Pluckthun A, Elliott T, Hengartner H, Zinkernagel R. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J Exp Med 1998 187 : 1383 93.
    • (1998) J Exp Med , vol.187 , pp. 1383-93
    • Gallimore, A.1    Glithero, A.2    Godkin, A.3    Tissot, A.C.4    Pluckthun, A.5    Elliott, T.6    Hengartner, H.7    Zinkernagel, R.8
  • 71
    • 17644444485 scopus 로고    scopus 로고
    • Analysis of successful immune responses in persons infected with hepatitis C virus
    • Lechner F, Wong DK, Dunbar PR et al. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med 2000 191 : 1499 512.
    • (2000) J Exp Med , vol.191 , pp. 1499-512
    • Lechner, F.1    Wong, D.K.2    Dunbar, P.R.3
  • 72
    • 0027360051 scopus 로고
    • Peripheral clonal deletion of antiviral memory CD8+ T cells
    • Moskophidis D, Laine E, Zinkernagel RM. Peripheral clonal deletion of antiviral memory CD8+ T cells. Eur J Immunol 1993 23 : 3306 11.
    • (1993) Eur J Immunol , vol.23 , pp. 3306-11
    • Moskophidis, D.1    Laine, E.2    Zinkernagel, R.M.3
  • 73
    • 0027158798 scopus 로고
    • Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
    • Moskophidis D, Lechner F, Pircher H, Zinkernagel RM. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 1993 362 : 758 61.
    • (1993) Nature , vol.362 , pp. 758-61
    • Moskophidis, D.1    Lechner, F.2    Pircher, H.3    Zinkernagel, R.M.4
  • 74
    • 0035127132 scopus 로고    scopus 로고
    • Simian immunodeficiency virus (SIV) infection of a rhesus macaque induces SIV-specific CD8(+) T cells with a defect in effector function that is reversible on extended interleukin-2 incubation
    • Xiong Y, Luscher MA, Altman JD, Hulsey M, Robinson HL, Ostrowski M, Barber BH, MacDonald KS. Simian immunodeficiency virus (SIV) infection of a rhesus macaque induces SIV-specific CD8(+) T cells with a defect in effector function that is reversible on extended interleukin-2 incubation. J Virol 2001 75 : 3028 33.
    • (2001) J Virol , vol.75 , pp. 3028-33
    • Xiong, Y.1    Luscher, M.A.2    Altman, J.D.3    Hulsey, M.4    Robinson, H.L.5    Ostrowski, M.6    Barber, B.H.7    MacDonald, K.S.8
  • 76
    • 10744226519 scopus 로고    scopus 로고
    • High avidity antigen-specific CTL identified by CD8-independent tetramer staining
    • Choi EM, Chen JL, Wooldridge L et al. High avidity antigen-specific CTL identified by CD8-independent tetramer staining. J Immunol 2003 171 : 5116 23.
    • (2003) J Immunol , vol.171 , pp. 5116-23
    • Choi, E.M.1    Chen, J.L.2    Wooldridge, L.3
  • 77
    • 0042090453 scopus 로고    scopus 로고
    • The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities
    • Hutchinson SL, Wooldridge L, Tafuro S et al. The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. J Biol Chem 2003 278 : 24285 93.
    • (2003) J Biol Chem , vol.278 , pp. 24285-93
    • Hutchinson, S.L.1    Wooldridge, L.2    Tafuro, S.3
  • 78
    • 0037108790 scopus 로고    scopus 로고
    • Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules
    • Schott E, Bertho N, Ge Q, Maurice MM, Ploegh HL. Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules. Proc Natl Acad Sci USA 2002 99 : 13735 40.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13735-40
    • Schott, E.1    Bertho, N.2    Ge, Q.3    Maurice, M.M.4    Ploegh, H.L.5
  • 79
    • 0036919051 scopus 로고    scopus 로고
    • Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells
    • Schott E, Ploegh HL. Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells. Eur J Immunol 2002 32 : 3425 34.
    • (2002) Eur J Immunol , vol.32 , pp. 3425-34
    • Schott, E.1    Ploegh, H.L.2
  • 80
    • 0043092203 scopus 로고    scopus 로고
    • Alpha 3 domain mutants of peptide/MHC class I multimers allow the selective isolation of high avidity tumor-reactive CD8 T cells
    • Pittet MJ, Rubio-Godoy V, Bioley G et al. Alpha 3 domain mutants of peptide/MHC class I multimers allow the selective isolation of high avidity tumor-reactive CD8 T cells. J Immunol 2003 171 : 1844 9.
    • (2003) J Immunol , vol.171 , pp. 1844-9
    • Pittet, M.J.1    Rubio-Godoy, V.2    Bioley, G.3
  • 81
    • 34250373667 scopus 로고    scopus 로고
    • Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region
    • Wooldridge L, Lissina A, Vernazza J et al. Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region. Eur J Immunol 2007 37 : 1323 33.
    • (2007) Eur J Immunol , vol.37 , pp. 1323-33
    • Wooldridge, L.1    Lissina, A.2    Vernazza, J.3
  • 82
    • 58149317718 scopus 로고    scopus 로고
    • Detection of low avidity CD8+ T cells with coreceptor-enhanced peptide-MHC class I tetramers
    • Melenhorst JJ, Scheinberg P, Lissina A et al. Detection of low avidity CD8+ T cells with coreceptor-enhanced peptide-MHC class I tetramers. J Immunol Methods 2008 338 : 3390 402.
    • (2008) J Immunol Methods , vol.338 , pp. 3390-402
    • Melenhorst, J.J.1    Scheinberg, P.2    Lissina, A.3
  • 83
    • 40549089531 scopus 로고    scopus 로고
    • Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus
    • Kasprowicz V, Ward SM, Turner A et al. Defining the directionality and quality of influenza virus-specific CD8+ T cell cross-reactivity in individuals infected with hepatitis C virus. J Clin Invest 2008 118 : 1143 53.
    • (2008) J Clin Invest , vol.118 , pp. 1143-53
    • Kasprowicz, V.1    Ward, S.M.2    Turner, A.3
  • 84
    • 0037087319 scopus 로고    scopus 로고
    • A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape
    • Douek DC, Betts MR, Brenchley JM et al. A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape. J Immunol 2002 168 : 3099 104.
    • (2002) J Immunol , vol.168 , pp. 3099-104
    • Douek, D.C.1    Betts, M.R.2    Brenchley, J.M.3
  • 85
    • 0036644384 scopus 로고    scopus 로고
    • Quantitative clonotypic analysis of antigen-specific T-cell responses
    • Price DA, Sewell AK. Quantitative clonotypic analysis of antigen-specific T-cell responses. Trends Immunol 2002 23 : 336 7.
    • (2002) Trends Immunol , vol.23 , pp. 336-7
    • Price, D.A.1    Sewell, A.K.2
  • 86
    • 10344231446 scopus 로고    scopus 로고
    • T cell receptor recognition motifs govern immune escape patterns in acute SIV infection
    • Price DA, West SM, Betts MR et al. T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity 2004 21 : 793 803.
    • (2004) Immunity , vol.21 , pp. 793-803
    • Price, D.A.1    West, S.M.2    Betts, M.R.3
  • 87
    • 27944505610 scopus 로고    scopus 로고
    • Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses
    • Price DA, Brenchley JM, Ruff LE et al. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. J Exp Med 2005 202 : 1349 61.
    • (2005) J Exp Med , vol.202 , pp. 1349-61
    • Price, D.A.1    Brenchley, J.M.2    Ruff, L.E.3
  • 88
    • 34247580092 scopus 로고    scopus 로고
    • The T cell repertoire in infection and vaccination: implications for control of persistent viruses
    • Davenport MP, Price DA, McMichael AJ. The T cell repertoire in infection and vaccination: implications for control of persistent viruses. Curr Opin Immunol 2007 19 : 294 300.
    • (2007) Curr Opin Immunol , vol.19 , pp. 294-300
    • Davenport, M.P.1    Price, D.A.2    McMichael, A.J.3
  • 90
    • 0033564637 scopus 로고    scopus 로고
    • Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma
    • Dunbar PR, Chen JL, Chao D et al. Cutting edge: rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma. J Immunol 1999 162 : 6959 62.
    • (1999) J Immunol , vol.162 , pp. 6959-62
    • Dunbar, P.R.1    Chen, J.L.2    Chao, D.3
  • 92
    • 0035017468 scopus 로고    scopus 로고
    • A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex
    • Xu XN, Purbhoo MA, Chen N et al. A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex. Immunity 2001 14 : 591 602.
    • (2001) Immunity , vol.14 , pp. 591-602
    • Xu, X.N.1    Purbhoo, M.A.2    Chen, N.3
  • 93
    • 33748497618 scopus 로고    scopus 로고
    • Fluorescence-activated cell sorting and cloning of bona fide CD8+ CTL with reversible MHC-peptide and antibody Fab′ conjugates
    • Guillaume P, Baumgaertner P, Angelov GS, Speiser D, Luescher IF. Fluorescence-activated cell sorting and cloning of bona fide CD8+ CTL with reversible MHC-peptide and antibody Fab′ conjugates. J Immunol 2006 177 : 3903 12.
    • (2006) J Immunol , vol.177 , pp. 3903-12
    • Guillaume, P.1    Baumgaertner, P.2    Angelov, G.S.3    Speiser, D.4    Luescher, I.F.5
  • 95
    • 0035871754 scopus 로고    scopus 로고
    • Cutting edge: characterization of allorestricted and peptide-selective alloreactive T cells using HLA-tetramer selection
    • Moris A, Teichgraber V, Gauthier L, Buhring HJ, Rammensee HG. Cutting edge: characterization of allorestricted and peptide-selective alloreactive T cells using HLA-tetramer selection. J Immunol 2001 166 : 4818 21.
    • (2001) J Immunol , vol.166 , pp. 4818-21
    • Moris, A.1    Teichgraber, V.2    Gauthier, L.3    Buhring, H.J.4    Rammensee, H.G.5
  • 97
    • 33344455547 scopus 로고    scopus 로고
    • Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model
    • Kappel BJ, Pinilla-Ibarz J, Kochman AA et al. Remodeling specific immunity by use of MHC tetramers: demonstration in a graft-versus-host disease model. Blood 2006 107 : 2045 51.
    • (2006) Blood , vol.107 , pp. 2045-51
    • Kappel, B.J.1    Pinilla-Ibarz, J.2    Kochman, A.A.3
  • 98
    • 36749066635 scopus 로고    scopus 로고
    • Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells
    • Massey RC, Scriba TJ, Brown EL, Phillips RE, Sewell AK. Use of peptide-major histocompatibility complex tetramer technology to study interactions between Staphylococcus aureus proteins and human cells. Infect Immun 2007 75 : 5711 5.
    • (2007) Infect Immun , vol.75 , pp. 5711-5
    • Massey, R.C.1    Scriba, T.J.2    Brown, E.L.3    Phillips, R.E.4    Sewell, A.K.5
  • 101
    • 0029930984 scopus 로고    scopus 로고
    • The structure and ligand interactions of CD2: implications for T-cell function
    • Davis SJ, van der Merwe PA. The structure and ligand interactions of CD2: implications for T-cell function. Immunol Today 1996 17 : 177 87.
    • (1996) Immunol Today , vol.17 , pp. 177-87
    • Davis, S.J.1    Van Der Merwe, P.A.2
  • 102
    • 23144455728 scopus 로고    scopus 로고
    • T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
    • Choudhuri K, Wiseman D, Brown MH, Gould K, van der Merwe PA. T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature 2005 436 : 578 82.
    • (2005) Nature , vol.436 , pp. 578-82
    • Choudhuri, K.1    Wiseman, D.2    Brown, M.H.3    Gould, K.4    Van Der Merwe, P.A.5
  • 105
    • 0036499141 scopus 로고    scopus 로고
    • A single-chain class II MHC-IgG3 fusion protein inhibits autoimmune arthritis by induction of antigen-specific hyporesponsiveness
    • Zuo L, Cullen CM, DeLay ML, Thornton S, Myers LK, Rosloniec EF, Boivin GP, Hirsch R. A single-chain class II MHC-IgG3 fusion protein inhibits autoimmune arthritis by induction of antigen-specific hyporesponsiveness. J Immunol 2002 168 : 2554 9.
    • (2002) J Immunol , vol.168 , pp. 2554-9
    • Zuo, L.1    Cullen, C.M.2    DeLay, M.L.3    Thornton, S.4    Myers, L.K.5    Rosloniec, E.F.6    Boivin, G.P.7    Hirsch, R.8
  • 106
    • 17144471425 scopus 로고    scopus 로고
    • In vivo CTL immunity can be elicited by in vitro reconstituted MHC/peptide complex
    • Sakita I, Horig H, Sun R, Wang F, Nathenson SG. In vivo CTL immunity can be elicited by in vitro reconstituted MHC/peptide complex. J Immunol Methods 1996 192 : 105 15.
    • (1996) J Immunol Methods , vol.192 , pp. 105-15
    • Sakita, I.1    Horig, H.2    Sun, R.3    Wang, F.4    Nathenson, S.G.5
  • 107
    • 0035478651 scopus 로고    scopus 로고
    • Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers
    • Maile R, Wang B, Schooler W, Meyer A, Collins EJ, Frelinger JA. Antigen-specific modulation of an immune response by in vivo administration of soluble MHC class I tetramers. J Immunol 2001 167 : 3708 14.
    • (2001) J Immunol , vol.167 , pp. 3708-14
    • Maile, R.1    Wang, B.2    Schooler, W.3    Meyer, A.4    Collins, E.J.5    Frelinger, J.A.6
  • 108
    • 4944254829 scopus 로고    scopus 로고
    • Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers
    • Yuan RR, Wong P, McDevitt MR et al. Targeted deletion of T-cell clones using alpha-emitting suicide MHC tetramers. Blood 2004 104 : 2397 402.
    • (2004) Blood , vol.104 , pp. 2397-402
    • Yuan, R.R.1    Wong, P.2    McDevitt, M.R.3
  • 109
    • 34147119204 scopus 로고    scopus 로고
    • Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin
    • Hess PR, Barnes C, Woolard MD, Johnson MD, Cullen JM, Collins EJ, Frelinger JA. Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin. Blood 2007 109 : 3300 7.
    • (2007) Blood , vol.109 , pp. 3300-7
    • Hess, P.R.1    Barnes, C.2    Woolard, M.D.3    Johnson, M.D.4    Cullen, J.M.5    Collins, E.J.6    Frelinger, J.A.7
  • 110
    • 0032192469 scopus 로고    scopus 로고
    • Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]
    • Boniface JJ, Rabinowitz JD, Wulfing C et al. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]. Immunity 1998 9 : 459 66.
    • (1998) Immunity , vol.9 , pp. 459-66
    • Boniface, J.J.1    Rabinowitz, J.D.2    Wulfing, C.3
  • 111
    • 0032101405 scopus 로고    scopus 로고
    • Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes
    • Crawford F, Kozono H, White J, Marrack P, Kappler J. Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes. Immunity 1998 8 : 675 82.
    • (1998) Immunity , vol.8 , pp. 675-82
    • Crawford, F.1    Kozono, H.2    White, J.3    Marrack, P.4    Kappler, J.5
  • 112
    • 0032476622 scopus 로고    scopus 로고
    • Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor
    • Hamad AR, O'Herrin SM, Lebowitz MS, Srikrishnan A, Bieler J, Schneck J, Pardoll D. Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor. J Exp Med 1998 188 : 1633 40.
    • (1998) J Exp Med , vol.188 , pp. 1633-40
    • Hamad, A.R.1    O'Herrin, S.M.2    Lebowitz, M.S.3    Srikrishnan, A.4    Bieler, J.5    Schneck, J.6    Pardoll, D.7
  • 113
    • 27744549817 scopus 로고    scopus 로고
    • Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining
    • Scriba TJ, Purbhoo M, Day CL et al. Ultrasensitive detection and phenotyping of CD4+ T cells with optimized HLA class II tetramer staining. J Immunol 2005 175 : 6334 43.
    • (2005) J Immunol , vol.175 , pp. 6334-43
    • Scriba, T.J.1    Purbhoo, M.2    Day, C.L.3
  • 114
    • 38649128150 scopus 로고    scopus 로고
    • Class II major histocompatibility complex tetramer staining: progress, problems and prospects
    • Vollers SS, Stern LJ. Class II major histocompatibility complex tetramer staining: progress, problems and prospects. Immunology 2008 123 : 305 13.
    • (2008) Immunology , vol.123 , pp. 305-13
    • Vollers, S.S.1    Stern, L.J.2
  • 115
    • 57349118383 scopus 로고    scopus 로고
    • Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
    • in press)
    • Varela-Rohena A, Molloy PE, Dunn SM, et al. Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor. Nat Med 2008 (in press)
    • (2008) Nat Med
    • Varela-Rohena, A.1    Molloy, P.E.2    Dunn, S.M.3
  • 116
    • 0030869489 scopus 로고    scopus 로고
    • Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides
    • Sewell AK, Harcourt GC, Goulder PJ, Price DA, Phillips RE. Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides. Eur J Immunol 1997 27 : 2323 9.
    • (1997) Eur J Immunol , vol.27 , pp. 2323-9
    • Sewell, A.K.1    Harcourt, G.C.2    Goulder, P.J.3    Price, D.A.4    Phillips, R.E.5
  • 117
    • 2542568696 scopus 로고    scopus 로고
    • Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin
    • Green AE, Lissina A, Hutchinson SL et al. Recognition of nonpeptide antigens by human Vγ9Vδ2 T cells requires contact with cells of human origin. Clin Exp Immunol 2004 136 : 472 82.
    • (2004) Clin Exp Immunol , vol.136 , pp. 472-82
    • Green, A.E.1    Lissina, A.2    Hutchinson, S.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.