The CD8 T Cell Coreceptor Exhibits Disproportionate Biological Activity at Extremely Low Binding Affinities

Journal of Biological Chemistry

Volumn 278, Issue 27, 2003, Pages 24285-24293

  Hutchinson, Sarah L ^a   Wooldridge, Linda ^a   Tafuro, Sabrina ^b   Laugel, Bruno ^a   Glick, Meir ^c   Boulter, Jonathan M ^d   Jakobsen, Bent K ^d   Price, David A ^e   Sewell, Andrew K ^a  

^a T Cell Modulation Group   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Avidex Ltd   (United Kingdom)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CELLS; CHEMICAL BONDS; CYTOLOGY;

MUTATIONS;

BIOCHEMISTRY;

BETA 2 MICROGLOBULIN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN; MYOSIN HEAVY CHAIN; T LYMPHOCYTE RECEPTOR; HLA ANTIGEN CLASS 1;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; GENE MUTATION; GLYCOSYLATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TARGET CELL; ANTIGEN PRESENTATION; CD8+ T LYMPHOCYTE; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

ANIMALIA;

ANTIGEN PRESENTATION; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LYMPHOCYTE ACTIVATION;

EID: 0042090453     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M300633200     Document Type: Article

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