Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL

Journal of Experimental Medicine

Volumn 184, Issue 2, 1996, Pages 485-492

  Alexander Miller, Martha A ^a   Leggatt, Graham R ^a   Sarin, Apurva ^a   Berzofsky, Jay A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SELECTION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE;

EID: 0029813121     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.2.485     Document Type: Article

References (42)

1. Lenardo, M.J. 1991. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature (Lond.). 353:858-861.
2. Von Boehmer, H., H.S. Teh, and P. Kisielow. 1989. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol. Today. 10:57-61.
3. Miller, J.F.A.P., and W.R. Heath. 1993. Self-ignorance in the peripheral T-cell pool. Immunol. Rev. 133:131-150.
4. Jones, L.A., L.T. Chin, D.L. Longo, and A.M. Kruisbeek. 1990. Peripheral clonal elimination of functional T cells. Science (Wash. DC). 250:1726-1729.
5. Wieties, K., R.E. Hammer, S. Jones-Youngblood, and J. Forman. 1990. Peripheral tolerance in mice expressing a liver-specific class I molecule: inactivation/deletion of a T-cell subpopulation. Proc. Natl. Acad. Sci. USA. 87:6604-6608.
6. + antigen-specific T cells after in vivo exposure to male antigen. J. Immunol. 148:3740-3745.
7. Rocha, B., and H. Von Boehmer. 1991. Peripheral selection of the T cell repertoire. Science (Wash. DC). 251:1225-1228.
8. McCormack, J.E., J.E. Callahan, J. Kappler, and P.C. Marrack. 1993. Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen. J. Immunol. 150:3785-3792.
9. Aichele, P., K. Brduscha-Riem, R.M. Zinhernagel, H. Hengartner, and H. Pircher. 1995. T cell priming versus T cell tolerance induced by synthetic peptides. J. Exp. Med. 182: 261-266.
10. Chen, Y., J.-i. Inobe, R. Marks, P. Gonnella, V.K. Kuchroo, and H. L. Weiner. 1995. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature (Lond.). 376:177-180.
11. Ferber, I., G. Schönrich, J. Schenkel, A.L. Mellor, G.J. Hämmerling, and B. Arnold. 1994. Levels of peripheral T cell tolerance induced by different doses of tolerogen. Science (Wash. DC). 263:674-676.
12. Moskophidis, D., F. Lechner, H. Pircher, and R.M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature (Lond.). 362:758-761.
13. Suzuki, G., Y. Kawase, S. Koyasu, I. Yahara, Y. Kobayashi, and R.H. Schwartz. 1988. Antigen-induced suppression of the proliferative response of T cell clones. J. Immunol. 140: 1359-1365.
14. Critchfield, J.M., M.K. Racke, J.C. Zúñiga-Pflücker, B. Cannella, C.S. Raine, J. Goverman, and M.J. Lenardo. 1994. T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science (Wash. DC). 263:1139-1143.
15. Zheng, L., G. Fisher, R.E. Miller, J. Peschon, D.H. Lynch, and M.J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature (Lond.). 377:348-351.
16. Alexander-Miller, M.A., G.R. Leggatt, and J.A. Berzofsky. 1996. Selective expansion of high or low avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA. 93:4102-4107.
17. Townsend, A.R.M., J. Rothbard, F.M. Gotch, G. Bahadur, D. Wraith, and A.J. McMichael. 1986. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides. Cell. 44:959-968.
18. 2+-independent T cell-mediated cytotoxicity. J. Exp. Med. 177:195-200.
19. Stewart, J.M., and J.D. Young. 1984. Solid Phase Peptide Synthesis. Pierce Chemical Company, Rockford, IL.
20. Takahashi, H., J. Cohen, A. Hosmalin, K.B. Cease, R. Houghten, J. Cornette, C. DeLisi, B. Moss, R.N. Germain, and J.A. Berzofsky. 1988. An immunodominant epitope of the HIV gp160 envelope glycoprotein recognized by class I MHC molecule-restricted murine cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA. 85:3105-3109.
21. Shirai, M., C.D. Pendleton, and J.A. Berzofsky. 1992. Broad recognition of cytotoxic T-cell epitopes from the HIV-1 envelope protein with multiple class I histocompatibility molecules. J. Immunol. 148:1657-1667.
22. Kozlowski, S., M. Corr, T. Takeshita, L.F. Boyd, C.D. Pendleton, R.N. Germain, J.A. Berzofsky, and D.H. Margulies. 1992. Serum angiotensin-1-converting enzyme activity processes an HIV 1 gp160 peptide for presentation by MHC class I molecules. J. Exp. Med. 175:1417-1422.
23. d-restricted cytotoxic T lymphocytes. J. Exp. Med. 173:849-858.
24. Sarin, A., D.H. Adams, and P.A. Henkart. 1993. Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells. J. Exp. Med. 178:1693-1700.
25. Telford, W.G., L.E. King, and P.J. Fraker. 1994. Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry. J. Immunol. Methods. 172:1-16.
26. Vitiello, A., W.R. Heath, and L.A. Sherman. 1989. Consequences of self-presentation of peptide antigen by cytolytic T lymphocytes. J. Immunol. 143:1512-1517.
27. + cytolytic T lymphocytes. Proc. Natl. Acad. Sci. USA. 87:9015-9019.
28. Dutz, J.P., P.R. Walden, and H.N. Eisen. 1992. Effects of cognate peptides on cytolytic and proliferative activities of cloned cytotoxic T lymphocytes. Int. Immunol. 4:571-580.
29. + cytotoxic T lymphocytes is due to fratricide. J. Immunol. 151:658-667.
30. + cytotoxic T lymphocytes by free antigenic peptide: a self-veto mechanism? J. Exp. Med. 183:879-889.
31. Ucker, D.S., J. Meyers, and P.S. Obermiller. 1992. Activation-driven T cell death II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death. J. Immunol. 149:1583-1592.
32. Russell, J.H., C.L. White, D.Y. Loh, and P. Meleedy-Rey. 1991. Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc. Natl. Acad. Sci. USA. 88:2151-2155.
33. Russell, J.H., D.E. Manning, D.E. McCulley, and P. Meleedy-Rey. 1988. Antigen as a positive and negative regulator of proliferation in cytotoxic lymphocytes: a model for the differential regulation of proliferation and lytic activity. J. Immunol. 140:1796-1801.
34. Newell, M.K., L.J. Haughn, C.R. Maroun, and M.H. Julius. 1990. Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen. Nature (Lond.). 347:286-288.
35. + T cells. J. Immunol. 146:35-39.
36. Wesselborg, S., O. Janssen, and D. Kabelitz. 1993. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells. J. Immunol. 150:4338-4345.
37. Critchfield, J.M., J.C. Zúñiga-Pflücker, and M.J. Lenardo. 1995. Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression. Cell. Immunol. 160:71-78.
38. Russell, J.H., B.J. Rush, S.I. Abrams, and R. Wang. 1992. Sensitivity of T cells to anti-CD3-stimulated suicide is independent of functional phenotype. Eur. J. Immunol. 22:1655-1658.
39. Ju, S.-T., D.J. Panka, H. Cui, R. Ettinger, M. El-Khatib, D.H. Sherr, B.Z. Stanger, and A. Marshak-Rothstein. 1995. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature (Lond.). 373:444-448.
40. Ashwell, J.D., R.E. Cunningham, P.D. Noguchi, and D. Hernandez. 1987. Cell growth cycle block of T cell hybridomas upon activation with antigen. J. Exp. Med. 165:173-194.
41. Speiser, D.E., D. Kyburz, U. Stübi, H. Hengartner, and R.M. Zinkernagel. 1992. Discrepancy between in vitro measurable and in vivo virus neutralizing cytotoxic T cell reactivities: low T cell receptor specificity and avidity sufficient for in vitro proliferation or cytotoxicity to peptide-coated target cells but not for in vivo protection. J. Immunol. 149:972-980.
42. + T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity. Proc. Natl. Acad. Sci. USA. 87:4818-4822.