High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL

Journal of Immunology

Volumn 166, Issue 3, 2001, Pages 1690-1697

  Derby, M A ^a   Alexander Miller, M A ^a   Tse, R ^a   Berzofsky, J A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; IN VIVO STUDY; INFECTION CONTROL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; TARGET CELL; VIRUS INFECTION; VIRUS LOAD;

EID: 0035253434     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.3.1690     Document Type: Article

References (45)

1. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones
2. + HIV-specific T cells for HIV seropositive patients undergoing allogeneic bone marrow transplant
3. The putative natural killer decoy early gene m04 (gp34) of murine cytomegalovirus encodes an antigenic peptide recognized by protective antiviral
4. Establishment of anti-Epstein-Barr virus (EBV) cellular immunity by adoptive transfer of virus-specific cytotoxic T lymphocytes from an HLA-matched sibling to a patient with severe chronic active EBV infection
5. Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for the treatment of patients with EBV-positive relapsed Hodgkin's disease
6. Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease
7. Developing immunotherapeutic strategies for the control of Epstein-Barr virus-associated malignancies
8. + T-cell precursors on the outcome of virus infection
9. 3
10. Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome
11. In vivo migration and function of transferred HIV-1-specific cytotoxic T cells
12. Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2
13. In vitro predictors of therapeutic response in melanoma patients receiving tumor-infiltrating lymphocytes and interleukin-2
14. Adoptive immunotherapy of malignant glioma using tumor-infiltrating T lymphocytes
15. Adoptive transfer of cytotoxic T lymphocytes induced by CD86-transfected tumor cells suppresses multi-organ metastases of C1300 neuroblastoma in mice
16. Tumor site-selective localization of an adoptively transferred T cell line expressing a macrophage lectin
17. Adoptive-transfer therapy of tumors with the tumor-specific primary cytotoxic T cells induced in vitro with the B7.1-transduced MCA205 cell line
18. An antigen-targeted approach to adoptive transfer therapy of cancer
19. + tumor specific cytotoxic T lymphocytes from peripheral blood lymphocytes by in vitro stimulation with CD80-transfected autologous melanoma cells
20. Adoptive T-cell therapy for B-cell acute lymphoblastic leukemia: Preclinical studies
21. Adoptive immunotherapy for advanced cancer patients using in vitro activated cytotoxic T lymphocytes
22. Selective expansion of high or low avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy
23. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides
24. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers
25. High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy
26. An immunodominant epitope of the HIV gp160 envelope glycoprotein recognized by class I MHC molecule-restricted murine cytotoxic T lymphocytes
27. + CTL tumor immunosurveillance and regulation of tumor escape by CD4 T cells through an effect on quality of CTL
28. Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule
29. Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type I envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus
30. Expression of the HTLV-III envelope gene by a recombinant vaccinia virus
31. Reexamination of the efficacy of vaccination against mousepox
32. Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes
33. Cytokine-mediated control of viral infections
34. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy
35. + T cells
36. Cytotoxic T cells recognize very early, minor changes in ectromelia virus-infected target cells
37. Antiviral protection by virus-immune cytotoxic T cells: Infected target cells are lysed before infectious virus progeny is assembled
38. A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro
39. + CTL
40. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
41. Serial triggering of TCRs: A basis for the sensitivity and specificity of antigen recognition
42. In vivo migration and function of transferred HIV-1-specific cytotoxic T cells
43. Development, characterization and distribution of adoptively transferred peripheral blood lymphocytes primed by human papillomavirus 18 E7-pulsed autologous dendritic cells in a patient with metastatic adenocarcinoma of the uterine cervix
44. + T cell clones correlates with their levels of expression of adhesion molecules
45. + T lymphocytes that persist after peripheral tolerance to a self antigen expressed in the pancreas