CD4+CD25+ Foxp3+ regulatory T cells protect against T cell-mediated fulminant hepatitis in a TGF-β-dependent manner in mice

Journal of Immunology

Volumn 181, Issue 10, 2008, Pages 7221-7229

  Wei, Hua Xing ^a   Chuang, Ya Hui ^b   Li, Bofeng ^a   Wei, Haiming ^a   Sun, Rui ^a   Moritoki, Yuki ^b   Gershwin, M Eric ^b   Lian, Zhe Xiong ^b   Tian, Zhigang ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CONCANAVALIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOCORTICOID; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; ALPHA E INTEGRINS; ALPHA INTEGRIN; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; LEUKOCYTE ANTIGEN; MITOGENIC AGENT; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL PROTECTION; CONTROLLED STUDY; EXPERIMENTAL MOUSE; HEPATITIS; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; ANIMAL; APOPTOSIS; BIOSYNTHESIS; C57BL MOUSE; FLOW CYTOMETRY; IMMUNOLOGY; METABOLISM; NICK END LABELING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, CD; APOPTOSIS; CONCANAVALIN A; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HEPATITIS; IN SITU NICK-END LABELING; INTEGRIN ALPHA CHAINS; MICE; MICE, INBRED C57BL; MITOGENS; RECEPTORS, TUMOR NECROSIS FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 58149187111     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.10.7221     Document Type: Article

References (50)

1. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6: 345-352.
2. Belkaid, Y., and B. T. Rouse. 2005. Natural regulatory T cells in infectious disease. Nat. Immunol. 6: 353-360. (Pubitemid 41716772)
3. Maloy, K. J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2: 816-822. (Pubitemid 34906442)
4. + regulatory T cells. Nat. Immunol. 4: 330-336.
5. Fontenot, J. D., J. P. Rasmussen, L. M. Williams, J. L. Dooley, A. G. Farr, and A. Y. Rudensky. 2005. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 22: 329-341. (Pubitemid 40387475)
6. + T regulatory cells. Nat. Immunol. 4: 337-342.
7. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061. (Pubitemid 36222930)
8. Ziegler, S. F. 2006. FOXP3: of mice and men. Annu. Rev. Immunol. 24: 209-226.
9. + regulatory T cells induces a scurfy-like disease. J. Exp. Med. 204: 57-63.
10. Wan, Y. Y., and R. A. Flavell. 2007. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445: 766-770.
11. Kronenberg, M., and A. Rudensky. 2005. Regulation of immunity by self-reactive T cells. Nature 435: 598-604.
12. + regulatory T-cells in autoimmune liver disease. J. Hepatol. 41: 31-37.
13. + regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis. J. Autoimmun. 25: 63-71.
14. + regulatory T cells in health and autoimmune hepatitis. J. Immunol. 176: 4484-4491.
15. Lan, R. Y., C. Cheng, Z. X. Lian, K. Tsuneyama, G. X. Yang, Y. Moritoki, Y. H. Chuang, T. Nakamura, S. Saito, et al. 2006. Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis. Hepatology 43: 729-737.
16. Stoop, J. N., R. G. van der Molen, C. C. Baan, L. J. van der Laan, E. J. Kuipers, J. G. Kusters, and H. L. Janssen. 2005. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 41: 771-778. (Pubitemid 40462939)
17. Sugimoto, K., F. Ikeda, J. Stadanlick, F. A. Nunes, H. J. Alter, and K. M. Chang. 2003. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 38: 1437-1448. (Pubitemid 37466970)
18. + regulatory T lymphocytes in hepatitis C virus infection. Hepatology 40: 1062-1071.
19. Ormandy, L. A., T. Hillemann, H. Wedemeyer, M. P. Manns, T. F. Greten, and F. Korangy. 2005. Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res. 65: 2457-2464. (Pubitemid 40490158)
20. Unitt, E., S. M. Rushbrook, A. Marshall, S. Davies, P. Gibbs, L. S. Morris, N. Coleman, and G. J. Alexander. 2005. Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells. Hepatology 41: 722-730. (Pubitemid 40462933)
21. + regulatory T-cells in the liver of patients with hepatocellular carcinoma. J. Hepatol. 45: 254-262.
22. Tiegs, G., J. Hentschel, and A. Wendel. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90: 196-203.
23. Li, B., R. Sun, H. Wei, B. Gao, and Z. Tian. 2006. Interleukin-15 prevents concanavalin A-induced liver injury in mice via NKT cell-dependent mechanism. Hepatology 43: 1211-1219. (Pubitemid 43980099)
24. Louis, H., A. Le Moine, V. Flamand, N. Nagy, E. Quertinmont, F. Paulart, D. Abramowicz, O. Le Moine, M. Goldman, and J. Deviere. 2002. Critical role of interleukin 5 and eosinophils in concanavalin A-induced hepatitis in mice. Gastroenterology 122: 2001-2010. (Pubitemid 34651442)
25. Gorelik, L., and R. A. Flavell. 2000. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12: 171-181. (Pubitemid 30398631)
26. Oertelt, S., Z. X. Lian, C. M. Cheng, Y. H. Chuang, K. A. Padgett, X. S. He, W. M. Ridgway, A. A. Ansari, R. L. Coppel, M. O. Li, et al. 2006. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGF-β receptor II dominant-negative mice. J. Immunol. 177: 1655-1660. (Pubitemid 44092501)
27. + T cell- and STAT3-dependent manners. J. Immunol. 172: 5648-5655.
28. Dong, Z., H. Wei, R. Sun, Z. Hu, B. Gao, and Z. Tian. 2004. Involvement of natural killer cells in PolyI:C-induced liver injury. J. Hepatol. 41: 966-973. (Pubitemid 39575664)
29. Freudenberg, M. A., and C. Galanos. 1988. Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages. Infect. Immun. 56: 1352-1357.
30. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194: 629-644.
31. + regulatory T cell activity in both humans and mice. J. Immunol. 172: 834-842.
32. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004. (Pubitemid 29480828)
33. von Boehmer, H. 2005. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6: 338-344.
34. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192: 303-310.
35. + regulatory T cells abrogates their function in vivo. J. Immunol. 177: 4376-4383.
36. + regulatory cells that control intestinal inflammation. J. Exp. Med. 192: 295-302.
37. + regulatory T cells. J. Exp. Med. 202: 885-891.
38. + regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3: 135-142.
39. + as well as CD25- regulatory T cells. Proc. Natl. Acad. Sci. USA 99: 13031-13036.
40. + regulatory T cells. J. Exp. Med. 199: 303-313.
41. + Treg and control of Leishmania major infection. J. Immunol. 174: 5444-5455.
42. Erhardt, A., M. Biburger, T. Papadopoulos, and G. Tiegs. 2007. IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice. Hepatology 45: 475-485. (Pubitemid 46374604)
43. + T regulatory cells. J. Immunol. 176: 3301-3305.
44. McNeill, A., E. Spittle, and B. T. Backstrom. 2007. Partial depletion of CD69low-expressing natural regulatory T cells with the anti-CD25 monoclonal antibody PC61. Scand. J. Immunol. 65: 63-69. (Pubitemid 44968073)
45. + regulatory T cells following anti-CD25 treatment in malaria-infected mice. J. Immunol. 178: 4136-4146.
46. Fontenot, J. D., J. P. Rasmussen, M. A. Gavin, and A. Y. Rudensky. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6: 1142-1151. (Pubitemid 41541792)
47. + natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212: 8-27.
48. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196: 237-246.
49. + regulatory T cells. J. Exp. Med. 201: 737-746.
50. + T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. USA 100: 10878-10883.