Effect of CD4+CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis

Journal of Autoimmunity

Volumn 25, Issue 1, 2005, Pages 63-71

  Longhi, Maria Serena ^a   Ma, Yun ^a   Mitry, Ragai R ^a   Bogdanos, Dimitrios P ^a   Heneghan, Michael ^a   Cheeseman, Paul ^a   Mieli Vergani, Giorgina ^a   Vergani, Diego ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Autoimmunity; Cytokine; Hepatitis; IL 4; Immunosuppressive

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; INTERLEUKIN 2 RECEPTOR ALPHA; THYMIDINE; TRITIUM;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNE HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOMAGNETIC SEPARATION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REMISSION; SCHOOL CHILD; T LYMPHOCYTE;

CD4-CD8 RATIO; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; COCULTURE TECHNIQUES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HEPATITIS, AUTOIMMUNE; HUMANS; T-LYMPHOCYTES, REGULATORY;

EID: 22444436491     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaut.2005.05.001     Document Type: Article

References (38)

1. G.V. Gregorio, and B. Portmann Autoimmune hepatitis in childhood: a 20 years experience Hepatology 25 1997 541 547
2. G. Mieli-Vergani, and D. Vergani Progress in pediatric autoimmune hepatitis Semin Liver Dis 14 1994 282 288
3. F. Alvarez, and P.A. Berg International Autoimmune Hepatitis Group Report: review criteria for the diagnosis of autoimmune hepatitis J Hepatol 31 1999 929 938
4. U.M. Zanger, and H.P. Hauri Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II Proc Natl Acad Sci U S A 85 1988 8256 8260
5. J.C. Homberg, and N. Abuaf Chronic active hepatitis associated with anti-liver/kidney microsome antibody type 1: a second type of "autoimmune" hepatitis Hepatology 7 1987 1333 1339
6. G.V. Gregorio, and B. Portmann Autoimmune hepatitis/sclerosing cholangitis overlap syndrome in childhood: a 16-year prospective study Hepatology 33 2001 544 553
7. L. Wen, and M. Peakman T-cell-directed hepatocyte damage in autoimmune chronic active hepatitis Lancet 336 1990 1527 1530
8. S. Matsumura, and H. Kita Comprehensive mapping of HLA-A*0201- restricted CD8 T-cell epitopes on PDC-E2 in primary biliary cirrhosis Hepatology 36 2002 1125 1134
9. H. Kita, and S. Matsumura Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis J Clin Invest 109 2002 1231 1240
10. E.M. Shevach CD4+CD25+ suppressor T-cells: more questions than answers Nat Rev Immunol 2 2002 389 400
11. T. Takahashi, and Y. Kuniyasu Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T-cells: induction of autoimmune disease by breaking their anergic/suppressive state Int Immunol 10 1998 1969 1980
12. A.M. Thornton, and E.M. Shevach CD4+CD25+ immunoregulatory T-cells suppress polyclonal T-cell activation in vitro by inhibiting interleukin 2 production J Exp Med 188 1998 287 296
13. W.F. Ng, and P.J. Duggan Human CD4+CD25+ cells: a naturally occurring population of regulatory T-cells Blood 98 2001 2736 2744
14. E.A. Green, and L. Gorelik CD4+CD25+ T regulatory cells control anti-islet CD8 T-cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes Proc Natl Acad Sci U S A 100 2003 10878 10883
15. K. Nakamura, and A. Kitani TGF-β1 plays an important role in the mechanism of CD4+CD25+ regulatory T-cell activity in both humans and mice J Immunol 172 2004 834 842
16. O. Annacker, and R. Pimenta-Araujo CD25+CD4+ T-cells regulate the expansion of peripheral CD4 T-cells through the production of IL-10 J Immunol 166 2001 3008 3018
17. J.D. Fontenot, and M.A. Gavin Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat Immunol 4 2003 330 336
18. R. Khattri, and T. Cox An essential role for Scurfin in CD4+CD25+ T regulatory cells Nat Immunol 4 2003 337 342
19. M.S. Longhi, and Y. Ma Impairment of CD4+CD25+ regulatory T-cells in autoimmune liver disease J Hepatol 4 2004 31 37
20. C.A. Piccirillo, and E.M. Shevach Cutting edge: control of CD8 T-cell activation by CD4+CD25+ immunoregulatory cells J Immunol 167 2001 1137 1140
21. N.O. Camara, and F. Sebille Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T-cell activation Eur J Immunol 33 2003 3473 3483
22. E. Xystrakis, and A.S. Dejean Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation Blood 104 2004 3294 3301
23. N. Hill, and N. Sarvetnick Cytokines: promoters and dampeners of autoimmunity Curr Opin Immunol 14 2002 791 797
24. M.R. Amel-Kashipaz, and M.L. Huggins Quantitative and qualitative analysis of the balance between type 1 and type 2 cytokine-producing CD8- and CD8+ T-cells in systemic lupus erythematosus J Autoimmun 17 2001 155 163
25. P. Pala, and T. Hussell Flow cytometric measurement of intracellular cytokines J Immunol Methods 243 2000 107 124
26. T. Tsuchida, and K.C. Parker Autoreactive CD8 T-cell responses to human myelin protein-derived peptides Proc Natl Acad Sci U S A 91 1994 10859 10863
27. P. Panina-Bordignon, and R. Lang Cytotoxic T-cells specific for glutamic acid decarboxylase in autoimmune diabetes J Exp Med 181 1995 1923 1927
28. F.S. Wong, and J. Karttunen Identification of an MHC class-I restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library Nat Med 5 1999 1026 1031
29. M. Hebbar, and P. Jeannin Detection of circulating soluble CD28 in patients with systemic lupus erythematosus, primary Sjögren's syndrome and systemic sclerosis Clin Exp Immunol 136 2004 388 392
30. L.I. Salazar-Fontana, and E. Sanz Cell surface CD28 levels define four CD4+ T cell subsets: abnormal expression in rheumatoid arthritis Clin Immunol 99 2001 253 265
31. S.K. Subudhi, and P. Zhou Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection J Clin Invest 113 2004 694 700
32. G.M. Lauer, and E. Barnes High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection Gastroenterology 127 2004 924 936
33. L. Taams, and M. Vukmanovic-Stejic Immune regulation by CD4+CD25+ regulatory T cells: implications for transplantation tolerance Transpl Immunol 11 2003 277 285
34. + T suppressor cells are back to the game: are they players in autoimmunity? Autoimmun Rev 1 2002 279 283
35. A. Suto, and H. Nakajima Role of CD4(+)CD25(+) regulatory T cells in T helper 2 cell-mediated allergic inflammation in the airways Am J Respir Crit Care Med 164 2001 680 687
36. J.C. Brooks, and D.W. Hoskin The inhibitory effect of cyclophosphamide-induced MAC-1+ natural suppressor cells on IL-2 and IL-4 utilization in MLR Transplantation 58 1994 1096 1103
37. Y.Y. Kong, and M. Eto Regulatory T cells in maintenance and reversal of peripheral tolerance in vivo J Immunol 157 1996 5284 5289
38. S. Gregori, and M. Casorati Regulatory T-cells induced by 1α,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance J Immunol 167 2001 1945 1953