The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders

AIDS and Behavior

Volumn 13, Issue 1, 2009, Pages 118-132

  Levine, Andrew J ^a   Singer, Elyse J ^a   Shapshak, Paul ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Dopamine; HIV associated dementia; HIV associated neurocognitive disorders; HIV encephalitis; Polymorphism

Indexed keywords

ANTIRETROVIRUS AGENT; APOLIPOPROTEIN E; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; DOPAMINE; DOPAMINE BETA MONOOXYGENASE; DOPAMINE RECEPTOR; DOPAMINE TRANSPORTER; DOPAMINE TRANSPORTER 1; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; COGNITIVE DEFECT; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA POLYMORPHISM; GENETIC ANALYSIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; NEUROTRANSMISSION; REVIEW;

AIDS DEMENTIA COMPLEX; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; APOLIPOPROTEINS E; BRAIN-DERIVED NEUROTROPHIC FACTOR; CATECHOL O-METHYLTRANSFERASE; COGNITION DISORDERS; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GENETIC PREDISPOSITION TO DISEASE; HIV INFECTIONS; HUMANS; POLYMORPHISM, GENETIC; PREVALENCE; RECEPTORS, DOPAMINE;

EID: 58149090639     PISSN: 10907165     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10461-008-9360-x     Document Type: Review

References (160)

1. S. Abraham T. Sweet B. E. Sawaya J. Rappaport K. Khalili S. Amini 2005 Cooperative interaction of C/EBP beta and Tat modulates MCP-1 gene transcription in astrocytes Journal of Neuroimmunology 160 1-2 219 227
2. W. W. Agace A. Amara A. I. Roberts J. L. Pablos S. Thelen M. Uguccioni X. Y. Li J. Marsal F. Arenzana-Seisdedos T. Delaunay E. C. Ebert B. Moser C. M. Parker 2000 Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation Current Biology 10 6 325 328
3. B. M. Ances R. J. Ellis 2007 Dementia and neurocognitive disorders due to HIV-1 infection Seminars in Neurology 27 1 86 92
4. E. Anderson W. Zink H. Xiong H. E. Gendelman 2002 HIV-1-associated dementia: A metabolic encephalopathy perpetrated by virus-infected and immune-competent mononuclear phagocytes Journal of Acquired Immune Deficiency Syndrome 31 Suppl 2 S43 54
5. A. Antinori G. Arendt J. T. Becker B. J. Brew D. A. Byrd M. Cherner D. B. Clifford P. Cinque L. G. Epstein K. Goodkin M. Gisslen I. Grant R. K. Heaton J. Joseph K. Marder C. M. Marra J. C. McArthur M. Nunn R. W. Price L. Pulliam K. R. Robertson N. Sacktor V. Valcour V. E. Wojna 2007 Updated research nosology for HIV-associated neurocognitive disorders Neurology 69 18 1789 1799
6. G. Arendt H. J. von Giesen 2002 Human immunodeficiency virus dementia: Evidence of a subcortical process from studies of fine finger movements Journal of Neurovirology 8 Suppl 2 27 32
7. V. C. Asensio I. L. Campbell 1999 Chemokines in the CNS: Plurifunctional mediators in diverse states Trends in Neuroscience 22 11 504 512
8. M. J. Avison A. Nath R. Greene-Avison F. A. Schmitt R. A. Bales A. Ethisham R. N. Greenberg J. R. Berger 2004 Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia Journal of Neurovirology 10 4 223 232
9. M. J. Avison A. Nath R. Greene-Avison F. A. Schmitt R. N. Greenberg J. R. Berger 2004 Neuroimaging correlates of HIV-associated BBB compromise Journal of Neuroimmunology 157 1-2 140 146
10. E. H. Aylward J. D. Henderer J. C. McArthur P. D. Brettschneider G. J. Harris P. E. Barta G. D. Pearlson 1993 Reduced basal ganglia volume in HIV-1-associated dementia: Results from quantitative neuroimaging Neurology 43 10 2099 2104
11. J. T. Becker O. L. Lopez M. A. Dew H. J. Aizenstein 2004 Prevalence of cognitive disorders differs as a function of age in HIV virus infection AIDS 18 Suppl 1 S11 18
12. J. E. Bell 2004 An update on the neuropathology of HIV in the HAART era Histopathology 45 6 549 559
13. J. Benjamin L. Li C. Patterson B. D. Greenberg D. L. Murphy D. H. Hamer 1996 Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking Nature Genetics 12 1 81 84
14. B. A. Bennett D. E. Rusyniak C. K. Hollingsworth 1995 HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures Brain Research 705 1-2 168 176
15. D. J. Benos S. McPherson B. H. Hahn M. A. Chaikin E. N. Benveniste 1994 Cytokines and HIV envelope glycoprotein gp120 stimulate Na+/H+ exchange in astrocytes Journal of Biological Chemistry 269 19 13811 13816
16. J. R. Berger M. Kumar A. Kumar J. B. Fernandez B. Levin 1994 Cerebrospinal fluid dopamine in HIV-1 infection AIDS 8 1 67 71
17. J. R. Berger A. Nath 1997 HIV dementia and the basal ganglia Intervirology 40 2-3 122 131
18. J. R. Berger A. Nath R. N. Greenberg A. H. Andersen R. A. Greene A. Bognar M. J. Avison 2000 Cerebrovascular changes in the basal ganglia with HIV dementia Neurology 54 4 921 926
19. A. Bertolino G. Blasi V. Latorre V. Rubino A. Rampino L. Sinibaldi G. Caforio V. Petruzzella A. Pizzuti T. Scarabino M. Nardini D. R. Weinberger B. Dallapiccola 2006 Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain Journal of Neuroscience 26 15 3918 3922
20. R. M. Bilder J. Volavka P. Czobor A. K. Malhotra J. L. Kennedy X. Ni R. S. Goldman M. J. Hoptman B. Sheitman J. P. Lindenmayer L. Citrome J. P. McEvoy M. Kunz M. Chakos T. B. Cooper J. A. Lieberman 2002 Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia Biological Psychiatry 52 7 701 707
21. R. A. Bornstein H. A. Nasrallah M. F. Para C. C. Whitacre P. Rosenberger R. J. Fass 1993 Neuropsychological performance in symptomatic and asymptomatic HIV infection AIDS 7 4 519 524
22. L. A. Boven T. van der Bruggen B. S. van Asbeck J. J. Marx H. S. Nottet 1999 Potential role of CCR5 polymorphism in the development of AIDS dementia complex FEMS Immunology and Medical Microbiology 26 3-4 243 247
23. N. A. Brabers H. S. Nottet 2006 Role of the pro-inflammatory cytokines TNF-alpha and IL-1beta in HIV-associated dementia European Journal of Clinical Investigation 36 7 447 458
24. L. Cartier O. Hartley M. Dubois-Dauphin K. H. Krause 2005 Chemokine receptors in the central nervous system: Role in brain inflammation and neurodegenerative diseases Brain Research. Brain Research Reviews 48 1 16 42
25. L. Chang D. Tomasi R. Yakupov C. Lozar S. Arnold E. Caparelli T. Ernst 2004 Adaptation of the attention network in human immunodeficiency virus brain injury Annals of Neurology 56 2 259 272
26. C. C. Chao S. Hu 1994 Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures Developmental Neuroscience 16 3-4 172 179
27. M. Cherner R. J. Ellis D. Lazzaretto C. Young M. R. Mindt J. H. Atkinson I. Grant R. K. Heaton 2004 Effects of HIV-1 infection and aging on neurobehavioral functioning: Preliminary findings AIDS 18 Suppl 1 S27 34
28. M. Cherner S. Letendre R. K. Heaton J. Durelle J. Marquie-Beck B. Gragg I. Grant 2005 Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine Neurology 64 8 1343 1347
29. M. Cherner E. Masliah R. J. Ellis T. D. Marcotte D. J. Moore I. Grant R. K. Heaton 2002 Neurocognitive dysfunction predicts postmortem findings of HIV encephalitis Neurology 59 10 1563 1567
30. J. E. Clements M. Li L. Gama B. Bullock L. M. Carruth J. L. Mankowski M. C. Zink 2005 The central nervous system is a viral reservoir in simian immunodeficiency virus-infected macaques on combined antiretroviral therapy: A model for human immunodeficiency virus patients on highly active antiretroviral therapy Journal of Neurovirology 11 2 180 189
31. F. Cocchi A. L. DeVico A. Garzino-Demo S. K. Arya R. C. Gallo P. Lusso 1995 Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells Science 270 5243 1811 1815
32. E. H. Corder K. Robertson L. Lannfelt N. Bogdanovic G. Eggertsen J. Wilkins C. Hall 1998 HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy Nature Medicine 4 10 1182 1184
33. L. A. Cysique P. Maruff B. J. Brew 2004 Prevalence and pattern of neuropsychological impairment in human immunodeficiency virus-infected/acquired immunodeficiency syndrome (HIV/AIDS) patients across pre- and post-highly active antiretroviral therapy eras: A combined study of two cohorts Journal of Neurovirology 10 6 350 357
34. R. D'Hooge F. Franck L. Mucke P. P. De Deyn 1999 Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120 European Journal of Neuroscience 11 12 4398 4402
35. G. J. Dal Pan J. H. McArthur E. Aylward O. A. Selnes T. E. Nance-Sproson A. J. Kumar E. D. Mellits J. C. McArthur 1992 Patterns of cerebral atrophy in HIV-1-infected individuals: Results of a quantitative MRI analysis Neurology 42 11 2125 2130
36. G. Daly Z. Hawi M. Fitzgerald M. Gill 1999 Mapping susceptibility loci in attention deficit hyperactivity disorder: Preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children Molecular Psychiatry 4 2 192 196
37. R. Diaz-Arrastia Y. Gong C. J. Kelly B. B. Gelman 2004 Host genetic polymorphisms in human immunodeficiency virus-related neurologic disease Journal of Neurovirology 10 Suppl 1 67 73
38. H. Do A. Vasilescu W. Carpentier L. Meyer G. Diop T. Hirtzig C. Coulonges T. Labib J. L. Spadoni A. Therwath M. Lathrop F. Matsuda J. F. Zagury 2006 Exhaustive genotyping of the interleukin-1 family genes and associations with AIDS progression in a French cohort Journal of Infectious Diseases 194 11 1492 1504
39. G. J. Dore A. McDonald Y. Li J. M. Kaldor B. J. Brew 2003 Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy AIDS 17 10 1539 1545
40. T. Dragic V. Litwin G. P. Allaway S. R. Martin Y. Huang K. A. Nagashima C. Cayanan P. J. Maddon R. A. Koup J. P. Moore W. A. Paxton 1996 HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5 Nature 381 6584 667 673
41. H. Edelstein R. T. Knight 1987 Severe parkinsonism in two AIDS patients taking prochlorperazine Lancet 2 8554 341 342
42. M. F. Egan T. E. Goldberg B. S. Kolachana J. H. Callicott C. M. Mazzanti R. E. Straub D. Goldman D. R. Weinberger 2001 Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia Proceedings of the National Academy of Sciences of the United States of America 98 12 6917 6922
43. M. F. Egan M. Kojima J. H. Callicott T. E. Goldberg B. S. Kolachana A. Bertolino E. Zaitsev B. Gold D. Goldman M. Dean B. Lu D. R. Weinberger 2003 The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 112 2 257 269
44. N. El-Hage G. Wu J. Wang J. Ambati P. E. Knapp J. L. Reed A. J. Bruce-Keller K. F. Hauser 2006 HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines Glia 53 2 132 146
45. J. Engelmayer M. Larsson A. Lee M. Lee W. I. Cox R. M. Steinman N. Bhardwaj 2001 Mature dendritic cells infected with canarypox virus elicit strong anti-human immunodeficiency virus CD8+ and CD4+ T-cell responses from chronically infected individuals Journal of Virology 75 5 2142 2153
46. T. Ernst L. Chang M. Leonido-Yee O. Speck 2000 Evidence for long-term neurotoxicity associated with methamphetamine abuse: A 1H MRS study Neurology 54 6 1344 1349
47. M. F. Falangola A. Hanly B. Galvao-Castro C. K. Petito 1995 HIV infection of human choroid plexus: A possible mechanism of viral entry into the CNS Journal of Neuropathology and Experimental Neurology 54 4 497 503
48. J. Fellay K. V. Shianna D. Ge S. Colombo B. Ledergerber M. Weale K. Zhang C. Gumbs A. Castagna A. Cossarizza A. Cozzi-Lepri A. De Luca P. Easterbrook P. Francioli S. Mallal J. Martinez-Picado J. M. Miro N. Obel J. P. Smith J. Wyniger P. Descombes S. E. Antonarakis N. L. Letvin A. J. McMichael B. F. Haynes A. Telenti D. B. Goldstein 2007 A whole-genome association study of major determinants for host control of HIV-1 Science 317 5840 944 947
49. N. B. Freimer C. Sabatti 2007 Human genetics: Variants in common diseases Nature 445 7130 828 830
50. I. Galea I. Bechmann V. H. Perry 2007 What is immune privilege (not)? Trends in Immunology 28 1 12 18
51. S. Gartner 2000 HIV infection and dementia Science 287 5453 602 604
52. H. A. Gelbard H. S. Nottet S. Swindells M. Jett K. A. Dzenko P. Genis R. White L. Wang Y. B. Choi D. Zhang 1994 Platelet-activating factor: A candidate human immunodeficiency virus type 1-induced neurotoxin Journal of Virology 68 7 4628 4635
53. H. E. Gendelman J. M. Orenstein L. M. Baca B. Weiser H. Burger D. C. Kalter M. S. Meltzer 1989 The macrophage in the persistence and pathogenesis of HIV infection AIDS 3 8 475 495
54. T. E. Goldberg M. F. Egan T. Gscheidle R. Coppola T. Weickert B. S. Kolachana D. Goldman D. R. Weinberger 2003 Executive subprocesses in working memory: Relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia Archives of General Psychiatry 60 9 889 896
55. E. Gonzalez R. Dhanda M. Bamshad S. Mummidi R. Geevarghese G. Catano S. A. Anderson E. A. Walter K. T. Stephan M. F. Hammer A. Mangano L. Sen R. A. Clark S. S. Ahuja M. J. Dolan S. K. Ahuja 2001 Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: Impact on the epidemiology of the HIV-1 pandemic Proceedings of the National Academy of Sciences of the United States of America 98 9 5199 5204
56. E. Gonzalez B. H. Rovin L. Sen G. Cooke R. Dhanda S. Mummidi H. Kulkarni M. J. Bamshad V. Telles S. A. Anderson E. A. Walter K. T. Stephan M. Deucher A. Mangano R. Bologna S. S. Ahuja M. J. Dolan S. K. Ahuja 2002 HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels Proceedings of the National Academy of Sciences of the United States of America 99 21 13795 13800
57. A. K. Goplen K. Liestol O. Dunlop J. N. Bruun J. Maehlen 2001 Dementia in AIDS patients in Oslo; the role of HIV encephalitis and CMV encephalitis Scandinavian Journal of Infectious Diseases 33 10 755 758
58. F. Gray F. Chretien A. V. Vallat-Decouvelaere F. Scaravilli 2003 The changing pattern of HIV neuropathology in the HAART era Journal of Neuropathology and Experimental Neurology 62 5 429 440
59. O. Guillin J. Diaz P. Carroll N. Griffon J. C. Schwartz P. Sokoloff 2001 BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization Nature 411 6833 86 89
60. A. R. Hariri T. E. Goldberg V. S. Mattay B. S. Kolachana J. H. Callicott M. F. Egan D. R. Weinberger 2003 Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance Journal of Neuroscience 23 17 6690 6694
61. J. He Y. Chen M. Farzan H. Choe A. Ohagen S. Gartner J. Busciglio X. Yang W. Hofmann W. Newman C. R. Mackay J. Sodroski D. Gabuzda 1997 CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia Nature 385 6617 645 649
62. J. Hesselgesser D. Taub P. Baskar M. Greenberg J. Hoxie D. L. Kolson R. Horuk 1998 Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4 Current Biology 8 10 595 598
63. C. H. Hinkin W. G. van Gorp M. A. Mandelkern M. Gee P. Satz S. Holston T. D. Marcotte G. Evans D. H. Paz J. R. Ropchan 1995 Cerebral metabolic change in patients with AIDS: Report of a six-month follow-up using positron-emission tomography Journal of Neuropsychiatry and Clinical Neurosciences 7 2 180 187
64. M. Hirvonen A. Laakso K. Nagren J. O. Rinne T. Pohjalainen J. Hietala 2004 C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo Molecular Psychiatry 9 12 1060 1061
65. K. Itoh P. Mehraein S. Weis 2000 Neuronal damage of the substantia nigra in HIV-1 infected brains Acta Neuropathological (Berlin) 99 4 376 384
66. L. K. Jacobsen J. N. Giedd C. Gottschalk T. R. Kosten J. H. Krystal 2001 Quantitative morphology of the caudate and putamen in patients with cocaine dependence American Journal of Psychiatry 158 3 486 489
67. M. Jones K. Olafson M. R. Del Bigio J. Peeling A. Nath 1998 Intraventricular injection of human immunodeficiency virus type 1 (HIV-1) tat protein causes inflammation, gliosis, apoptosis, and ventricular enlargement Journal of Neuropathology and Experimental Neurology 57 6 563 570
68. M. Kaul S. A. Lipton 1999 Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis Proceedings of the National Academy of Sciences of the United States of America 96 14 8212 8216
69. M. Kaul J. Zheng S. Okamoto H. E. Gendelman S. A. Lipton 2005 HIV-1 infection and AIDS: Consequences for the central nervous system Cell Death and Differentiation 12 Suppl 1 878 892
70. K. D. Kieburtz L. G. Epstein H. A. Gelbard J. T. Greenamyre 1991 Excitotoxicity and dopaminergic dysfunction in the acquired immunodeficiency syndrome dementia complex. Therapeutic implications Archives of Neurology 48 12 1281 1284
71. E. Koutsilieri S. Sopper C. Scheller V. ter Meulen P. Riederer 2002 Parkinsonism in HIV dementia Journal of Neural Transmission 109 5-6 767 775
72. S. Kramer-Hammerle I. Rothenaigner H. Wolff J. E. Bell R. Brack-Werner 2005 Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus Virus Research 111 2 194 213
73. H. M. Lachman D. F. Papolos T. Saito Y. M. Yu C. L. Szumlanski R. M. Weinshilboum 1996 Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders Pharmacogenetics 6 3 243 250
74. T. D. Langford S. L. Letendre G. J. Larrea E. Masliah 2003 Changing patterns in the neuropathogenesis of HIV during the HAART era Brain Pathology 13 2 195 210
75. M. Larsson L. Hagberg A. Forsman G. Norkrans 1991 Cerebrospinal fluid catecholamine metabolites in HIV-infected patients Journal of Neuroscience Research 28 3 406 409
76. A. J. Levine D. J. Hardy E. Miller S. A. Castellon D. Longshore C. H. Hinkin 2006 The effect of recent stimulant use on sustained attention in HIV-infected adults Journal of Clinical and Experimental Neuropsychology 28 1 29 42
77. T. Li C. K. Chen X. Hu D. Ball S. K. Lin W. Chen P. C. Sham W. Loh el R. M. Murray D. A. Collier 2004 Association analysis of the DRD4 and COMT genes in methamphetamine abuse American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 129 1 120 124
78. J. B. Lichter C. L. Barr J. L. Kennedy H. H. Van Tol K. K. Kidd K. J. Livak 1993 A hypervariable segment in the human dopamine receptor D4 (DRD4) gene Human Molecular Genetics 2 6 767 773
79. K. Y. Little L. Zhang T. Desmond K. A. Frey G. W. Dalack B. J. Cassin 1999 Striatal dopaminergic abnormalities in human cocaine users American Journal of Psychiatry 156 2 238 245
80. H. Liu D. Chao E. E. Nakayama H. Taguchi M. Goto X. Xin J. K. Takamatsu H. Saito Y. Ishikawa T. Akaza T. Juji Y. Takebe T. Ohishi K. Fukutake Y. Maruyama S. Yashiki S. Sonoda T. Nakamura Y. Nagai A. Iwamoto T. Shioda 1999 Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression Proceedings of the National Academy of Sciences of the United States of America 96 8 4581 4585
81. A. K. Malhotra L. J. Kestler C. Mazzanti J. A. Bates T. Goldberg D. Goldman 2002 A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition American Journal of Psychiatry 159 4 652 654
82. C. L. Maslin K. Kedzierska N. L. Webster W. A. Muller S. M. Crowe 2005 Transendothelial migration of monocytes: The underlying molecular mechanisms and consequences of HIV-1 infection Current HIV Research 3 4 303 317
83. V. S. Mattay T. E. Goldberg F. Fera A. R. Hariri A. Tessitore M. F. Egan B. Kolachana J. H. Callicott D. R. Weinberger 2003 Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine Proceedings of the National Academy of Sciences of the United States of America 100 10 6186 6191
84. M. P. Mattson N. J. Haughey A. Nath 2005 Cell death in HIV dementia Cell Death and Differentiation 12 Suppl 1 893 904
85. D. H. McDermott M. J. Beecroft C. A. Kleeberger F. M. Al-Sharif W. E. Ollier P. A. Zimmerman B. A. Boatin S. F. Leitman R. Detels A. H. Hajeer P. M. Murphy 2000 Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study AIDS 14 17 2671 2678
86. O. Meucci A. Fatatis A. A. Simen T. J. Bushell P. W. Gray R. J. Miller 1998 Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity Proceedings of the National Academy of Sciences of the United States of America 95 24 14500 14505
87. A. Meyer-Lindenberg R. E. Straub B. K. Lipska B. A. Verchinski T. Goldberg J. H. Callicott M. F. Egan S. S. Huffaker V. S. Mattay B. Kolachana J. E. Kleinman D. R. Weinberger 2007 Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition Journal of Clinical Investigation 117 3 672 682
88. L. Meyer M. Magierowska J. B. Hubert C. Rouzioux C. Deveau F. Sanson P. Debre J. F. Delfraissy I. Theodorou 1997 Early protective effect of CCR-5 delta 32 heterozygosity on HIV-1 disease progression: Relationship with viral load. The SEROCO Study Group AIDS 11 11 F73 78
89. N. L. Michael J. P. Moore 1999 HIV-1 entry inhibitors: Evading the issue Nature Medicine 5 7 740 742
90. J. Mill N. Fisher S. Curran S. Richards E. Taylor P. Asherson 2003 Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder Neuroreport 14 11 1463 1466
91. R. Mossner S. Daniel D. Albert A. Heils O. Okladnova A. Schmitt K. P. Lesch 2000 Serotonin transporter function is modulated by brain-derived neurotrophic factor (BDNF) but not nerve growth factor (NGF) Neurochemistry International 36 3 197 202
92. A. Nath J. Geiger 1998 Neurobiological aspects of human immunodeficiency virus infection: Neurotoxic mechanisms Progress in Neurobiology 54 1 19 33
93. A. Nath N. J. Haughey M. Jones C. Anderson J. E. Bell J. D. Geiger 2000 Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: Protection by memantine Annals of Neurology 47 2 186 194
94. A. Nath W. F. Maragos M. J. Avison F. A. Schmitt J. R. Berger 2001 Acceleration of HIV dementia with methamphetamine and cocaine Journal of Neurovirology 7 1 66 71
95. B. A. Navia B. D. Jordan R. W. Price 1986 The AIDS dementia complex: I. Clinical features Annals of Neurology 19 6 517 524
96. B. A. Navia R. W. Price 1987 The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of human immunodeficiency virus infection Archives of Neurology 44 1 65 69
97. J. K. Neuenburg H. R. Brodt B. G. Herndier M. Bickel P. Bacchetti R. W. Price R. M. Grant W. Schlote 2002 HIV-related neuropathology, 1985 to 1999: Rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy Journal of Acquired Immune Deficiency Syndrome 31 2 171 177
98. K. A. Nolan R. M. Bilder H. M. Lachman J. Volavka 2004 Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: Differential effects of Val and Met alleles on cognitive stability and flexibility American Journal of Psychiatry 161 2 359 361
99. R. L. Nosheny I. Mocchetti A. Bachis 2005 Brain-derived neurotrophic factor as a prototype neuroprotective factor against HIV-1-associated neuronal degeneration Neurotoxicology Research 8 1-2 187 198
100. C. C. Ouimet A. S. LaMantia P. Goldman-Rakic P. Rakic P. Greengard 1992 Immunocytochemical localization of DARPP-32, a dopamine and cyclic-AMP-regulated phosphoprotein, in the primate brain Journal of Comparative Neurology 323 2 209 218
101. D. L. Palmer B. L. Hjelle C. A. Wiley S. Allen W. Wachsman R. G. Mills L. E. Davis T. L. Merlin 1994 HIV-1 infection despite immediate combination antiviral therapy after infusion of contaminated white cells American Journal of Medicine 97 3 289 295
102. H. Peng N. Erdmann N. Whitney H. Dou S. Gorantla H. E. Gendelman A. Ghorpade J. Zheng 2006 HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta Glia 54 6 619 629
103. Y. Persidsky H. E. Gendelman 2003 Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection Journal of Leukocyte Biology 74 5 691 701
104. Y. Persidsky L. Poluektova 2006 Immune privilege and HIV-1 persistence in the CNS Immunology Review 213 180 194
105. Y. Persidsky M. Stins D. Way M. H. Witte M. Weinand K. S. Kim P. Bock H. E. Gendelman M. Fiala 1997 A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis Journal of Immunology 158 7 3499 3510
106. Y. Persidsky J. Zheng D. Miller H. E. Gendelman 2000 Mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during HIV-1-associated dementia Journal of Leukocyte Biology 68 3 413 422
107. C. K. Petito 2004 Human immunodeficiency virus type 1 compartmentalization in the central nervous system Journal of Neurovirology 10 Suppl 1 21 24
108. L. Pezawas B. A. Verchinski V. S. Mattay J. H. Callicott B. S. Kolachana R. E. Straub M. F. Egan A. Meyer-Lindenberg D. R. Weinberger 2004 The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology Journal of Neuroscience 24 45 10099 10102
109. Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2001). Behavioral genetics (4th ed.). New York: Worth Publishers.
110. C. Power P. A. Kong T. O. Crawford S. Wesselingh J. D. Glass J. C. McArthur B. D. Trapp 1993 Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alterations of the blood-brain barrier Annals of Neurology 34 3 339 350
111. P. Price I. James S. Fernandez M. A. French 2004 Alleles of the gene encoding IL-1alpha may predict control of plasma viraemia in HIV-1 patients on highly active antiretroviral therapy AIDS 18 11 1495 1501
112. B. Puissant F. Roubinet P. Massip K. Sandres-Saune P. A. Apoil M. Abbal C. Pasquier J. Izopet A. Blancher 2006 Analysis of CCR5, CCR2, CX3CR1, and SDF1 polymorphisms in HIV-positive treated patients: Impact on response to HAART and on peripheral T lymphocyte counts AIDS Research and Human Retroviruses 22 2 153 162
113. M. W. Quasney Q. Zhang S. Sargent M. Mynatt J. Glass J. McArthur 2001 Increased frequency of the tumor necrosis factor-alpha-308 A allele in adults with human immunodeficiency virus dementia Annals of Neurology 50 2 157 162
114. A. I. Qureshi D. L. Hanson J. L. Jones R. S. Janssen 1998 Estimation of the temporal probability of human immunodeficiency virus (HIV) dementia after risk stratification for HIV-infected persons Neurology 50 2 392 397
115. A. B. Ragin Y. Wu P. Storey B. A. Cohen R. R. Edelman L. G. Epstein 2006 Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection Neurology 66 8 1255 1257
116. L. Resnick F. diMarzo-Veronese J. Schupbach W. W. Tourtellotte D. D. Ho F. Muller P. Shapshak M. Vogt J. E. Groopman P. D. Markham 1985 Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex New England Journal of Medicine 313 24 1498 1504
117. J. D. Rippeth R. K. Heaton C. L. Carey T. D. Marcotte D. J. Moore R. Gonzalez T. Wolfson I. Grant 2004 Methamphetamine dependence increases risk of neuropsychological impairment in HIV infected persons Journal of the International Neuropsychological Society 10 1 1 14
118. G. Rogers P. Joyce R. Mulder D. Sellman A. Miller M. Allington R. Olds E. Wells M. Kennedy 2004 Association of a duplicated repeat polymorphism in the 5′-untranslated region of the DRD4 gene with novelty seeking American Journal of Medical Genetics: Part B, Neuropsychiatric Genetics 126 1 95 98
119. T. Roman M. Schmitz G. V. Polanczyk M. Eizirik L. A. Rohde M. H. Hutz 2002 Further evidence for the association between attention-deficit/ hyperactivity disorder and the dopamine-beta-hydroxylase gene American Journal of Medical Geneticst 114 2 154 158
120. A. Rosa V. Peralta M. J. Cuesta A. Zarzuela F. Serrano A. Martinez-Larrea L. Fananas 2004 New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis American Journal of Psychiatry 161 6 1110 1112
121. D. A. Rottenberg J. J. Sidtis S. C. Strother K. A. Schaper J. R. Anderson M. J. Nelson R. W. Price 1996 Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia Journal of Nuclear Medicine 37 7 1133 1141
122. B. H. Rovin L. Lu R. Saxena 1999 A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression Biochemical and Biophysical Research Communications 259 2 344 348
123. M. Samson F. Libert B. J. Doranz J. Rucker C. Liesnard C. M. Farber S. Saragosti C. Lapoumeroulie J. Cognaux C. Forceille G. Muyldermans C. Verhofstede G. Burtonboy M. Georges T. Imai S. Rana Y. Yi R. J. Smyth R. G. Collman R. W. Doms G. Vassart M. Parmentier 1996 Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene Nature 382 6593 722 725
124. A. M. Sardar C. Czudek G. P. Reynolds 1996 Dopamine deficits in the brain: The neurochemical basis of parkinsonian symptoms in AIDS Neuroreport 7 4 910 912
125. P. Satz H. Morgenstern E. N. Miller O. A. Selnes J. C. McArthur B. A. Cohen J. Wesch J. T. Becker L. Jacobson L. F. D'Elia 1993 Low education as a possible risk factor for cognitive abnormalities in HIV-1: Findings from the multicenter AIDS Cohort Study (MACS) Journal of the Acquired Immune Deficiency Syndrome 6 5 503 511
126. K. Selmaj C. S. Raine 1988 Tumor necrosis factor mediates myelin damage in organotypic cultures of nervous tissue Annals of the New York Academy of Sciences 540 568 570
127. P. Shapshak D. M. Segal K. A. Crandall R. K. Fujimura B. T. Zhang K. Q. Xin K. Okuda C. K. Petito C. Eisdorfer K. Goodkin 1999 Independent evolution of HIV type 1 in different brain regions AIDS Research and Human Retroviruses 15 9 811 820
128. P. Shapshak M. Yoshioka N. C. Sun P. C. Schiller 1992 The use of combined in situ hybridization and immunocytochemistry to identify HIV-infected cells in brain tissue Modern Pathology 5 6 649 654
129. S. Shrestha S. A. Strathdee N. Galai T. Oleksyk M. D. Fallin S. Mehta D. Schaid D. Vlahov S. J. O'Brien M. W. Smith 2006 Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection Journal of Infectious Diseases 193 1 16 26
130. K. K. Singh C. F. Barroga M. D. Hughes J. Chen C. Raskino R. E. McKinney S. A. Spector 2003 Genetic influence of CCR5, CCR2, and SDF1 variants on human immunodeficiency virus 1 (HIV-1)-related disease progression and neurological impairment, in children with symptomatic HIV-1 infection Journal of Infectious Diseases 188 10 1461 1472
131. K. K. Singh R. J. Ellis J. Marquie-Beck S. Letendre R. K. Heaton I. Grant S. A. Spector 2004 CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults Journal of Neuroimmunology 157 1-2 185 192
132. S. L. Smalley J. N. Bailey C. G. Palmer D. P. Cantwell J. J. McGough M. A. Del'Homme J. R. Asarnow J. A. Woodward C. Ramsey S. F. Nelson 1998 Evidence that the dopamine D4 receptor is a susceptibility gene in attention deficit hyperactivity disorder Molecular Psychiatry 3 5 427 430
133. T. K. Smit B. J. Brew W. Tourtellotte S. Morgello B. B. Gelman N. K. Saksena 2004 Independent evolution of human immunodeficiency virus (HIV) drug resistance mutations in diverse areas of the brain in HIV-infected patients, with and without dementia, on antiretroviral treatment Journal of Virology 78 18 10133 10148
134. M. W. Smith M. Dean M. Carrington C. Winkler G. A. Huttley D. A. Lomb J. J. Goedert T. R. O'Brien L. P. Jacobson R. Kaslow S. Buchbinder E. Vittinghoff D. Vlahov K. Hoots M. W. Hilgartner S. J. O'Brien 1997 Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study Science 277 5328 959 965
135. Y. Stern 2002 What is cognitive reserve? Theory and research application of the reserve concept Journal of the International Neuropsychological Society 8 3 448 460
136. A. Thapar G. Harold F. Rice K. Langley M. O'donovan 2007 The contribution of gene-environment interaction to psychopathology Developmental Psychopathology 19 4 989 1004
137. S. A. Thomas 2004 Anti-HIV drug distribution to the central nervous system Current Pharmaceutical Design 10 12 1313 1324
138. D. Tomasi L. Chang E. de Castro Caparelli F. Telang T. Ernst 2006 The human immunodeficiency virus reduces network capacity: Acoustic noise effect Annals of Neurology 59 2 419 423
139. V. Tozzi P. Balestra P. Lorenzini R. Bellagamba S. Galgani A. Corpolongo C. Vlassi D. Larussa M. Zaccarelli P. Noto U. Visco-Comandini M. Giulianelli G. Ippolito A. Antinori P. Narciso 2005 Prevalence and risk factors for human immunodeficiency virus-associated neurocognitive impairment, 1996 to 2002: Results from an urban observational cohort Journal of Neurovirology 11 3 265 273
140. V. Valcour C. Shikuma B. Shiramizu M. Watters P. Poff O. A. Selnes J. Grove Y. Liu K. B. Abdul-Majid S. Gartner N. Sacktor 2004 Age, apolipoprotein E4, and the risk of HIV dementia: The Hawaii aging with HIV cohort Journal of Neuroimmunology 157 1-2 197 202
141. V. Valcour C. Shikuma B. Shiramizu A. Williams M. Watters P. Poff J. Grove O. Selnes N. Sacktor 2005 Diabetes, insulin resistance, and dementia among HIV-1-infected patients Journal of the Acquired Immune Deficiency Syndrome 38 1 31 36
142. V. Valcour C. Shikuma M. Watters N. Sacktor 2004 Cognitive impairment in older HIV-1-seropositive individuals: Prevalence and potential mechanisms AIDS 18 Suppl 1 S79 86
143. W. G. van Gorp M. A. Mandelkern M. Gee C. H. Hinkin C. E. Stern D. K. Paz W. Dixon G. Evans F. Flynn C. J. Frederick 1992 Cerebral metabolic dysfunction in AIDS: Findings in a sample with and without dementia Journal of Neuropsychiatry and Clinical Neurosciences 4 3 280 287
144. R. P. van Rij P. Portegies T. Hallaby J. M. Lange J. Visser A. M. de Roda Husman A. B. van 't Wout H. Schuitemaker 1999 Reduced prevalence of the CCR5 delta32 heterozygous genotype in human immunodeficiency virus-infected individuals with AIDS dementia complex Journal of Infectious Diseases 180 3 854 857
145. D. J. Vandenbergh A. M. Persico A. L. Hawkins C. A. Griffin X. Li E. W. Jabs G. R. Uhl 1992 Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR Genomics 14 4 1104 1106
146. N. D. Volkow L. Chang G. J. Wang J. S. Fowler M. Leonido-Yee D. Franceschi M. J. Sedler S. J. Gatley R. Hitzemann Y. S. Ding J. Logan C. Wong E. N. Miller 2001 Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers American Journal of Psychiatry 158 3 377 382
147. G. J. Wang L. Chang N. D. Volkow F. Telang J. Logan T. Ernst J. S. Fowler 2004 Decreased brain dopaminergic transporters in HIV-associated dementia patients Brain 127 Pt 11 2452 2458
148. J. Wei H. M. Xu C. N. Ramchand G. P. Hemmings 1997 Is the polymorphic microsatellite repeat of the dopamine beta-hydroxylase gene associated with biochemical variability of the catecholamine pathway in schizophrenia? Biological Psychiatry 41 7 762 767
149. D. Weissman M. Dybul M. B. Daucher R. T. Davey Jr. R. E. Walker J. A. Kovacs 2000 Interleukin-2 up-regulates expression of the human immunodeficiency virus fusion coreceptor CCR5 by CD4+ lymphocytes in vivo Journal of Infectious Diseases 181 3 933 938
150. S. L. Wesselingh K. Takahashi J. D. Glass J. C. McArthur J. W. Griffin D. E. Griffin 1997 Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunohistochemistry Journal of Neuroimmunology 74 1-2 1 8
151. C. A. Wiley J. A. Nelson 1990 Human immunodeficiency virus: Infection of the nervous system Current Topics in Microbiology and Immunology 160 157 172
152. C. A. Wiley R. D. Schrier J. A. Nelson P. W. Lampert M. B. Oldstone 1986 Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients Proceedings of the National Academy of Sciences of the United States of America 83 18 7089 7093
153. C. Winkler W. Modi M. W. Smith G. W. Nelson X. Wu M. Carrington M. Dean T. Honjo K. Tashiro D. Yabe S. Buchbinder E. Vittinghoff J. J. Goedert T. R. O'Brien L. P. Jacobson R. Detels S. Donfield A. Willoughby E. Gomperts D. Vlahov J. Phair S. J. O'Brien 1998 Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC) Science 279 5349 389 393
154. V. Wojna R. L. Skolasky R. Hechavarria R. Mayo O. Selnes J. C. McArthur L. M. Melendez E. Maldonado C. D. Zorrilla H. Garcia E. Kraiselburd A. Nath 2006 Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment Journal of Neurovirology 12 5 356 364
155. H. Xu C. B. Kellendonk E. H. Simpson J. G. Keilp G. E. Bruder H. J. Polan E. R. Kandel T. C. Gilliam 2007 DRD2 C957T polymorphism interacts with the COMT Val158Met polymorphism in human working memory ability Schizophrenia Research 90 1-3 104 107
156. M. W. Yeh M. Kaul J. Zheng H. S. Nottet M. Thylin H. E. Gendelman S. A. Lipton 2000 Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l-cysteine Journal of Immunology 164 8 4265 4270
157. M. Yoshioka P. Shapshak N. C. Sun S. J. Nelson A. Svenningsson L. G. Tate V. Pardo L. Resnick 1992 Simultaneous detection of ferritin and HIV-1 in reactive microglia Acta Neuropathologica (Berlin) 84 3 297 306
158. C. P. Zabetian G. M. Anderson S. G. Buxbaum R. C. Elston H. Ichinose T. Nagatsu K. S. Kim C. H. Kim R. T. Malison J. Gelernter J. F. Cubells 2001 A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: Evidence for a major functional polymorphism at the DBH locus American Journal of Human Genetics 68 2 515 522
159. H. Zhang F. Ozbay J. Lappalainen H. R. Kranzler C. H. van Dyck D. S. Charney L. H. Price S. Southwick B. Z. Yang A. Rasmussen J. Gelernter 2006 Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence American Journal of Medical Genetics: Part B, Neuropsychiatric Genetics 141 4 387 393
160. J. Zheng M. R. Thylin A. Ghorpade H. Xiong Y. Persidsky R. Cotter D. Niemann M. Che Y. C. Zeng H. A. Gelbard R. B. Shepard J. M. Swartz H. E. Gendelman 1999 Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia Journal of Neuroimmunology 98 2 185 200