Reduced prevalence of the CCR5 Δ32 heterozygous genotype in human immunodeficiency virus-infected individuals with AIDS dementia complex

Journal of Infectious Diseases

Volumn 180, Issue 3, 1999, Pages 854-857

  Van Rij, Ronald P ^a   Portegies, Peter ^b   Hallaby, Teysir ^b   Lange, Joep M A ^b   Visser, Janny ^a   De Roda Husman, Ana Maria ^a   Van't Wout, Angélique B ^a,c   Schuitemaker, Hanneke ^a  

^a CENTRAL LABORATORY   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5; RECEPTOR SUBTYPE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; HETEROZYGOTE DETECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; MAJOR CLINICAL STUDY; MICROGLIA; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; VIRUS REPLICATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; AIDS DEMENTIA COMPLEX; BRAIN; CASE-CONTROL STUDIES; GENOTYPE; HETEROZYGOTE; HIV-1; HOMOZYGOTE; HUMANS; MACROPHAGES; RECEPTORS, CCR5; SEQUENCE DELETION; VIRUS REPLICATION;

EID: 0032824223     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314940     Document Type: Article

References (15)

1. 1. De Roda Husman AM, Schuitemaker H. Chemokine receptors and the clinical course of HIV-1 infection. Trends in Microbiology 1998;6:244-9.
2. 2. Wu L, Paxton WA, Kassam N, et al. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J Exp Med 1997;185:1681-91.
3. 3. De Roda Husman AM, Koot M, Cornelissen M, et al. Association between CCR5 genotype and the clinical course of HIV-1 infection. Ann Intern Med 1997;127:882-90.
4. 4. Meyer L, Magierowska M, Hubert J-B, et al. Early protective effect of CCR5 Δ32 heterozygosity on HIV-1 disease progression: relationship with viral load. AIDS 1997;11:F73-8.
5. 5. Kostrikis LG, Huang Y, Moore JP, et al. A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promotor mutation. Nature Med 1998;4:350-3.
6. 6. Rizzardi GP, Morawetz RA, Vicenzi E, et al. Nature Med 1998;4:252-3.
7. 7. Van Rij RP, De Roda Husman AM, Brouwer M, Goudsmit J, Coutinho RA, Schuitemaker H. Role of CCR2 genotype in the clinical course of syncytium-inducing or non-syncytium inducing HIV-1 infection and in the conversion rate towards S1 virus variants. J Infect Dis 1998;178:1806-11.
8. 8. Albright AV, Shieh JTC, Itoh T, et al. Microglia express CCR5, CXCR4, and CCR3 but of these, CCR5 is the principal coreceptor for HIV-1 dementia isolates. J Virol 1999;73:205-13.
9. 9. Van 't Wout AB, De Jong MD, Kootstra NA, et al. Changes in cellular virus load and zidovudine resistance of syncytium-inducing and non-syncytium-inducing human immunodeficiency virus populations under zidovudine pressure: a clonal analysis. J Infect Dis 1996;174:845-9.
10. 10. Portegies P, de Gans J, Lange JMA, et al. Declining incidence of AIDS dementia complex after introduction of zidovudine treament. BMJ 1989;299:819-21.
11. 11. Naif HM, Shan L, Alali M, et al. CCR5 expression correlates with susceptibility of maturing monocytes to human immunodeficiency virus type 1 infection. J Virol 1998;72:830-6.
12. 12. Van 't Wout AB, Ran LJ, Kuiken CL, Kootstra NA, Pals ST, Schuitemaker H. Analysis of the temporal relationship between human immunodeficiency virus type 1 quasispecies in sequential blood samples and various organs obtained at autopsy. J Virol 1998;72:488-96.
13. 13. Barroga CF, Ellis R, Nelson J, et al. HIV-1 neurocognitive disorders and chemokine receptors. AIDS 1997;11:1651-2.
14. 14. McArthur JC, Selnes OA. HIV-associated dementia. in Berger, J. R. and Levy, R. M. AIDS and the nervous system. New York, Lippincot-Raven, 1997:527-67.
15. 15. Ellis RJ, Hsia K, Spector SA, et al. Cerebrospinal fluid human immunodeficieny virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome. Ann Neurol 1997;42:679-88.