Potential role of CCR5 polymorphism in the development of AIDS dementia complex

FEMS Immunology and Medical Microbiology

Volumn 26, Issue 3-4, 1999, Pages 243-247

  Van Der Bruggen, Tjomme ^a   Sweder Van Asbeck, B ^b   Marx, Joannes J M ^b   Nottet, Hans S L M ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NONE

Author keywords

AIDS dementia; CCR5; Macrophage

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR5;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; MACROPHAGE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; VIRUS PATHOGENESIS; VIRUS REPLICATION;

AIDS DEMENTIA COMPLEX; GENE PRODUCTS, TAT; GENOTYPE; HETEROZYGOTE; HIV-1; HUMANS; MACROPHAGES; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RECEPTORS, CCR5; RNA, VIRAL; VIRUS REPLICATION;

EID: 0033485349     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(99)00141-8     Document Type: Article

References (13)

1. Nottet H.S.L.M., Bar D.R., van Hassel H., Verhoef J., Boven L.A. Cellular aspects of HIV-1 infection of macrophages leading to neuronal dysfunction in in vitro models for HIV-1 encephalitis. J. Leukoc. Biol. 62:1997;107-116.
2. Power C., McArthur J.C., Johnson R.T., Griffin D.E., Glass J.D., Perryman S., Chesebro B. Demented and nondemented patients with AIDS differ in brain-derived human immunodeficiency virus type 1 envelope sequences. J. Virol. 68:1994;4643-4649.
3. Liu R., Paxton W.A., Choe S., Ceradini D., Martin S.R., Horuk R., MacDonald M.E., Stuhlmann H., Koup R.A., Landau N.R. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 86:1996;367-377.
4. Eugen Olsen J., Iversen A.K., Garred P., Koppelhus U., Pedersen C., Benfield T.L., Sorensen A.M., Katzenstein T., Dickmeiss E., Gerstoft J., Skinhoj P., Svejgaard A., Nielsen J.O., Hofmann B. Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS. 11:1997;305-310.
5. Wu L., Paxton W.A., Kassam N., Ruffing N., Rottman J.B., Sullivan N., Choe H., Sodroski J., Newman W., Koup R.A., Mackay C.R. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J. Exp. Med. 185:1997;1681-1691.
6. Benkirane M., Jin D.Y., Chun R.F., Koup R.A., Jeang K.T. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J. Biol. Chem. 272:1997;30603-30606.
7. Barroga C.F., Ellis R., Nelson J., Heaton R.K., Atkinson J.H., McCutchan J.A., Grant I., Spector S.A. HIV-1 neurocognitive disorders and chemokine receptors (letter). AIDS. 11:1997;1651-1652.
8. Nottet H.S., Persidsky Y., Sasseville V.G., Nukuna A.N., Bock P., Zhai Q.H., Sharer L.R., McComb R.D., Swindells S., Soderland C., Gendelman H.E. Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. J. Immunol. 156:1996;1284-1295.
9. Price R.W., Brew B., Sidtis J., Rosenblum M., Scheck A.C., Cleary P. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science. 239:1988;586-592.
10. Boven L.A., Gomes L., Hery C., Gray F., Verhoef J., Portegies P., Tardieu M., Nottet H.S.L.M. Increased peroxynitrite activity in AIDS Dementia Complex: Implications for the neuropathogenesis of HIV-1 infection. J. Immunol. 162:1999;4319-4327.
11. Tyor W.R., Glass J.D., Griffin J.W., Becker P.S., McArthur J.C., Bezman L., Griffin D.E. Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann. Neurol. 31:1992;349-360.
12. Vitkovic, L., da Cunha A., and Tyor, W.R. (1994) Cytokine Expression and Pathogenesis in AIDS Brain. In: HIV, AIDS and the Brain. (Price, R.W. and Perry, S.W., Eds.), pp. 203-222, Raven Press, New York.
13. Zhang L., Huang Y., He T., Cao Y., Ho D.D. HIV-1 subtype and second-receptor use (letter). Nature. 383:1996;768.