CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults

Journal of Neuroimmunology

Volumn 157, Issue 1-2 SPEC. ISS., 2004, Pages 185-192

  Singh, Kumud K ^a   Ellis, Ronald J ^a,b   Marquie Beck, Jennifer ^a,b   Letendre, Scott ^a   Heaton, Robert K ^a   Grant, Igor ^a   Spector, Stephen A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adults; CCR2; HIV 1; Neuropsychological impairment; Polymorphisms

Indexed keywords

CHEMOKINE RECEPTOR CCR2; VIRUS RNA;

ADULT; ALLELE; CONFERENCE PAPER; CONTROLLED STUDY; GENETIC POLYMORPHISM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSYCHOPATHY; SEROCONVERSION; VIRUS REPLICATION;

ADULT; ANALYSIS OF VARIANCE; CHEMOKINE CCL2; COGNITION DISORDERS; FEMALE; HIV; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; RECEPTORS, CCR5; RECEPTORS, CHEMOKINE;

EID: 9644270462     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2004.08.027     Document Type: Conference Paper

References (33)

1. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults MMWR Recomm Rep. 41 RR-17 1992 1 19 (Dec. 18)
2. A.V. Albright, J.T. Shieh, T. Itoh, B. Lee, D. Pleasure, M.J. O'Connor, R.W. Doms, and F. Gonzalez-Scarano Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates J. Virol. 73 1999 205 213
3. C.F. Barroga, R. Ellis, J. Nelson, R.K. Heaton, J.H. Atkinson, J.A. McCutchan, I. Grant, and S.A. Spector HIV-1 neurocognitive disorders and chemokine receptors AIDS 11 13 1997 1651 1652 (Nov.)
4. C.F. Barroga, C. Raskino, and M.C. Fangon The CCR5Delta32 allele slows disease progression of human immunodeficiency virus-1-infected children receiving antiretroviral treatment J. Infect. Dis. 182 2000 413 419
5. L.A. Boven, T. van der Bruggen, B. Sweder van Asbeck, J.J. Marx, and H.S. Nottet Potential role of CCR5 polymorphism in the development of AIDS dementia complex FEMS Immunol. Med. Microbiol. 26 3-4 1999 243 247 (Dec.)
6. S. Buch, Y. Sui, R. Potula, D. Pinson, I. Adany, Z. Li, M. Huang, S. Li, N. Dhillon, E. Major, and O. Narayan Role of interleukin-4 and monocyte chemoattractant protein-1 in the neuropathogenesis of X4 simian human immunodeficiency virus infection in macaques J. NeuroVirol. 10 Suppl 1 2004 118 124
7. K. Conant, A. Garzino-Demo, A. Nath, J.C. McArthur, W. Halliday, C. Power, R.C. Gallo, and E.O. Major Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia Proc. Natl. Acad. Sci. U. S. A. 95 6 1998 3117 3121 (Mar 17)
8. M. Dean, M. Carrington, and C. Winkler Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study Science 273 1996 1856 1862
9. A.R. Glabinski, M. Tani, S. Aras, M.H. Stoler, V.K. Tuohy, and R.M. Ransohoff Regulation and function of central nervous system chemokines Int. J. Dev. Neurosci. 13 1995 153 165
10. E. Gonzalez, B.H. Rovin, L. Sen, G. Cooke, R. Dhanda, S. Mummidi, H. Kulkarni, M.J. Bamshad, V. Telles, S.A. Anderson, E.A. Walter, K.T. Stephan, M. Deucher, A. Mangano, R. Bologna, S.S. Ahuja, M.J. Dolan, and S.K. Ahuja HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels Proc. Natl. Acad. Sci. U. S. A. 99 21 2002 13795 13800 (Oct. 15)
11. R.K. Heaton, I. Grant, N. Butters, D.A. White, D. Kirson, J.H. Atkinson, J.A. McCutchan, M.J. Taylor, M.D. Kelly, and R.J. Ellis The HNRC 500-neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center J. Int. Neuropsychol. Soc. 1 3 1995 231 251 (May)
12. W. Kelder, J.C. McArthur, T. Nance-Sproson, D. McClernon, and D.E. Griffin Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia Ann. Neurol. 44 5 1998 831 835 (Nov.)
13. S.A. Kolb, B. Sporer, F. Lahrtz, U. Koedel, H.W. Pfister, and A. Fontana Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-gamma inducible protein 10 J. Neuroimmunol. 93 1-2 1999 172 181 (Jan. 1)
14. L.G. Kostrikis, Y. Huang, and J.P. Moore A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation Nat. Med. 4 1998 350 353
15. L.G. Kostrikis, A.U. Neumann, and B. Thomson A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants J. Virol. 73 1999 10264 10271
16. B. Lee, B.J. Doranz, S. Rana, Y. Yi, M. Mellado, J.M. Frade, C. Martinez-A, S.J. O'Brien, M. Dean, R.G. Collman, and R.W. Doms Influence of the CCR2-V64I polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4 J. Virol. 72 9 1998 7450 7458 (Sep.)
17. R. Liu, W.A. Paxton, and S. Choe Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection Cell 86 1996 367 377
18. R. Mariani, S. Wong, L.C. Mulder, D.A. Wilkinson, A.L. Reinhart, G. LaRosa, R. Nibbs, T.R. O'Brien, N.L. Michael, R.I. Connor, M. Macdonald, M. Busch, R.A. Koup, and N.R. Landau CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function J. Virol. 73 3 1999 2450 2459 (Mar)
19. M.P. Martin, M. Dean, and M.W. Smith Genetic acceleration of AIDS progression by a promoter variant of CCR5 Science 282 1998 1907 1911
20. N.L. Michael Host genetic influences on HIV-1 pathogenesis Curr. Opin. Immunol. 11 1999 466 474
21. N.L. Michael, L.G. Louie, A.L. Rohrbaugh, K.A. Schultz, D.E. Dayhoff, C.E. Wang, and H.W. Sheppard The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression Nat. Med. 3 10 1997 1160 1162 (Oct.)
22. S.A. Mulherin, T.R. O'Brien, J.P. Ioannidis, J.J. Goedert, S.P. Buchbinder, R.A. Coutinho, B.D. Jamieson, L. Meyer, N.L. Michael, G. Pantaleo, G.P. Rizzardi, H. Schuitemaker, H.W. Sheppard, I.D. Theodorou, D. Vlahov, and P.S. Rosenberg Effects of CCR5-Delta32 and CCR2-64I alleles on HIV-1 disease progression: the protection varies with duration of infection AIDS 17 3 2003 377 387 (Feb. 14)
23. W.A. Paxton, and S. Kang Chemokine receptor allelic polymorphisms: relationships to HIV resistance and disease progression Semin. Immunol. 10 1998 187 194
24. B.H. Rovin, L. Lu, and R. Saxena A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression Biochem. Biophys. Res. Commun. 259 2 1999 344 348 (Jun. 7)
25. M. Samson, F. Libert, and B.J. Doranz Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene Nature 382 1996 722 725
26. V.J. Sanders, C.A. Pittman, M.G. White, G. Wang, C.A. Wiley, and C.L. Achim Chemokines and receptors in HIV encephalitis AIDS 12 9 1998 1021 1026 (Jun 18)
27. K.C. Sato-Matsumura, J. Berger, J.A. Hainfellner, P. Mazal, and H. Budka Development of HIV encephalitis in AIDS and TNF-alpha regulatory elements J. Neuroimmunol. 91 1-2 1998 89 92 (Nov. 2)
28. K.K. Singh Genetic influence of CCR5, CCR2 and SDF1 variants on HIV-1 related disease progression and neurological impairment in children with symptomatic HIV-1 infection J. Infect. Dis. 188 2003 1461 1472
29. M.W. Smith, M. Dean, and M. Carrington Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS),Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study Science 277 1997 959 965
30. R.P. van Rij, A.M. de Roda Husman, M. Brouwer, J. Goudsmit, R.A. Coutinho, and H. Schuitemaker Role of CCR2 genotype in the clinical course of syncytium-inducing (SI) or non-SI human immunodeficiency virus type 1 infection and in the time to conversion to SI virus variants J. Infect. Dis. 178 6 1998 1806 1811 (Dec.)
31. E. Vicenzi, S. Ghezzi, A. Brambilla, H.W. Sheppard, A. Lazzarin, G. Poli, and N.L. Michael CCR2-64I polymorphism, syncytium-inducing human immunodeficiency virus strains, and disease progression J. Infect. Dis. 182 5 2000 1579 1580 (Nov.)
32. E. Vicenzi, M. Alfano, and S. Ghezzi Divergent regulation of HIV-1 replication in peripheral blood mononuclear cells of infected individuals by CC chemokines: suppression by RANTES, MIP-1a, and MCP-3, and enhancement by MCP-1 J. Leukoc. Biol. 68 2000 405 412
33. J.M. Weiss, A. Nath, E.O. Major, and J.W. Berman HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes J. Immunol. 163 5 1999 2953 2959 (Sep. 1)