Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species

Journal of Biological Chemistry

Volumn 283, Issue 44, 2008, Pages 30205-30215

  Du, Jun Qing ^a   Wu, Jian ^b   Zhang, Hua Jie ^a   Zhang, Ya Hui ^a   Qiu, Bei Ying ^a   Wu, Fang ^a   Chen, Yi Hua ^a   Li, Jing Ya ^a   Nan, Fa Jun ^a   Ding, Jian Ping ^b,c   Li, Jia ^a,d  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c Institute of Biochemistry and Cell Biology

^d Chinese National Center for Drug Screening

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL DEATH; CHEMICAL DETECTION; DIMERS; ENZYMES; FREE RADICALS; INDICATORS (CHEMICAL); MAGNETIC MOMENTS; REACTIVE OXYGEN SPECIES; REDOX REACTIONS;

CATALYTIC CYSTEINES; DETECTION EXPERIMENTS; DIHYDROLIPOIC ACIDS; ELECTRON SPIN RESONANCE MEASUREMENTS; INACTIVATION PROCESS; MOLECULAR INHIBITORS; OXYGEN FREE RADICALS; SUPER OXIDE DISMUTASE;

OXYGEN;

CASPASE 3; CATALASE; CYSTEINE; DIHYDROLIPOATE; DITHIOTHREITOL; ISOQUINOLINE DERIVATIVE; OXYGEN; REACTIVE OXYGEN METABOLITE; SCAVENGER; SULFONIC ACID DERIVATIVE; SUPEROXIDE DISMUTASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CRYSTAL STRUCTURE; DRUG STRUCTURE; ELECTRON SPIN RESONANCE; ENZYME INACTIVATION; ENZYME INHIBITION; KINETICS; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

EID: 57649198442     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803347200     Document Type: Article

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