Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors

Journal of Medicinal Chemistry

Volumn 49, Issue 5, 2006, Pages 1613-1623

  Chen, Yi Hua ^a   Zhang, Ya Hui ^a   Zhang, Hua Jie ^a   Liu, Da Zhi ^a   Gu, Min ^a   Li, Jing Ya ^a   Wu, Fang ^a   Zhu, Xing Zu ^a   Li, Jia ^a   Nan, Fa Jun ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

(1,2,3,4 TETRAHYDRO 1,3,4 TRIOXOISOQUINOLIN 5 YLCARBAMOYL)(PHENYL)METHYL ACETATE; 4 OXO 4 PIPERIDIN 1 YL N (1,3,4 TRIOXO 1,2,3,4 TETRAHYDROISOQUINOLIN 6 YL)BUTYRAMIDE; CAMPTOTHECIN; CASPASE 3; CASPASE 3 INHIBITOR; ISOQUINOLINE DERIVATIVE; N (1,3,4 TRIOXO 1,2,3,4 TETRAHYDROISOQUINOLIN 5 YL) 3 NITROBENZAMIDE; N (2 METHOXYPHENYL) N' (1,3,4 TRIOXO 1,2,3,4 TETRAHYDROISOQUINOLIN 6 YL)SUCCINAMIDE; N (3 ETHOXYPHENYL) N' (1,3,4 TRIOXO 1,2,3,4 TETRAHYDROISOQUINOLIN 6 YL)SUCCINAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INFARCTION SIZE; CELL PROTECTION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; RAT; STROKE; STRUCTURE ACTIVITY RELATION;

ANIMALS; APOPTOSIS; ARTERIAL OCCLUSIVE DISEASES; CASPASE 3; CASPASES; DRUG DESIGN; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; ISOQUINOLINES; JURKAT CELLS; MALE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINATES;

EID: 33644849514     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050896o     Document Type: Article

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