Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1, 3-diones as potent caspase-3 inhibitors

Journal of Medicinal Chemistry

Volumn 48, Issue 11, 2005, Pages 3680-3683

  Kravchenko, Dmitri V ^a   Kuzovkova, Yulia A ^a   Kysil, Volodymyr M ^b   Tkachenko, Sergey E ^a,b   Maliarchouk, Sergey ^a,b   Okun, Ilya M ^a,b   Balakin, Konstantin V ^a,b   Ivachtchenko, Alexandre V ^b  

^a Chemical Diversity Research Institute   (Russian Federation)

^b CHEMDIV INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 ACETYLOXYETHYL) 8 (MORPHOLINE 4 SULFONYL)PYRROLO[3,4 C]QUINOLINE 1,3 DIONE DERIVATIVE; CASPASE 3; CASPASE 3 INHIBITOR; METHYL GROUP; PHENYL GROUP; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

APOPTOSIS; CASPASE 3; CASPASES; ENZYME INHIBITORS; HUMANS; JURKAT CELLS; MORPHOLINES; PYRROLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20144384669     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm048987t     Document Type: Article

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