Nigrostriatal dopaminergic neurodegeneration in the weaver mouse is mediated via neuroinflammation and alleviated by minocycline administration

Journal of Neuroscience

Volumn 26, Issue 45, 2006, Pages 11644-11651

  Peng, Jun ^a   Xie, Lin ^a   Stevenson, Fang Feng ^a   Melov, Simon ^a   Di Monte, Donato A ^b   Andersen, Julie K ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b PARKINSON S INSTITUTE   (United States)

Author keywords

Caspase independent cell death; Dopaminergic midbrain neurons; Microglial activation; Minocycline; Parkinson; Weaver

Indexed keywords

ANTIINFLAMMATORY AGENT; MINOCYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG INHIBITION; ENCEPHALITIS; FEMALE; IN VIVO STUDY; MALE; MICROGLIA; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; STRIATONIGRAL DEGENERATION; TEGMENTUM;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, CD11B; BETA 2-MICROGLOBULIN; BLOTTING, WESTERN; BRAIN CHEMISTRY; CELLS, CULTURED; CORPUS STRIATUM; DOPAMINE; EMBRYO; GLIAL FIBRILLARY ACIDIC PROTEIN; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOHISTOCHEMISTRY; MICE; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; MINOCYCLINE; MOTOR ACTIVITY; NEURODEGENERATIVE DISEASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOTRANSFERASES; SILVER STAINING; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 33751106151     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3447-06.2006     Document Type: Article

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