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Volumn 49, Issue 12, 2008, Pages 2246-2255

Potential role of sorafenib in the treatment of acute myeloid leukemia

Author keywords

AML; FLT3 mutations; MAP kinase signalling; Sorafenib

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CD135 ANTIGEN; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; PLACEBO; RAF PROTEIN; RAS PROTEIN; SORAFENIB;

EID: 57449110921     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190802510349     Document Type: Review
Times cited : (50)

References (77)
  • 3
    • 26944451381 scopus 로고    scopus 로고
    • Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia
    • Ricciardi, M. R., McQueen, T., Chism, D., Milella, M., Estey, E. Kaldjian, E. et al. (2005) Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia. Leukemia, 19, pp. 1543-1549.
    • (2005) Leukemia , vol.19 , pp. 1543-1549
    • Ricciardi, M.R.1    McQueen, T.2    Chism, D.3    Milella, M.4    Estey, E.5    Kaldjian, E.6
  • 4
    • 0037316909 scopus 로고    scopus 로고
    • Modulation of cellular signaling pathways: Prospects for targeted therapy in hematological malignancies
    • Ravandi, F., Talpaz, M. and Estrov, Z. (2003) Modulation of cellular signaling pathways: Prospects for targeted therapy in hematological malignancies. Clin Cancer Res, 9, pp. 535-550.
    • (2003) Clin Cancer Res , vol.9 , pp. 535-550
    • Ravandi, F.1    Talpaz, M.2    Estrov, Z.3
  • 5
    • 34547202520 scopus 로고    scopus 로고
    • Targeting receptor tyrosine kinase signaling in acute myeloid leukemia
    • Doepfner, K. T., Boller, D. and Arcaro, A. (2007) Targeting receptor tyrosine kinase signaling in acute myeloid leukemia. Crit Rev Oncol Hematol, 63, pp. 215-230.
    • (2007) Crit Rev Oncol Hematol , vol.63 , pp. 215-230
    • Doepfner, K.T.1    Boller, D.2    Arcaro, A.3
  • 6
    • 0034823632 scopus 로고    scopus 로고
    • Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia
    • Milella, M., Kornblau, S. M., Estrov, Z., Carter, B. Z., Lapillonne, H. Harris, D. et al. (2001) Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest, 108, pp. 851-859.
    • (2001) J Clin Invest , vol.108 , pp. 851-859
    • Milella, M.1    Kornblau, S.M.2    Estrov, Z.3    Carter, B.Z.4    Lapillonne, H.5    Harris, D.6
  • 7
    • 0036566242 scopus 로고    scopus 로고
    • Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia
    • Milella, M., Estrov, Z., Kornblau, S. M., Carter, B. Z., Konopleva, M. Tari, A. et al. (2002) Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia. Blood, 99, pp. 3461-3464.
    • (2002) Blood , vol.99 , pp. 3461-3464
    • Milella, M.1    Estrov, Z.2    Kornblau, S.M.3    Carter, B.Z.4    Konopleva, M.5    Tari, A.6
  • 8
    • 33847373890 scopus 로고    scopus 로고
    • MEK blockade converts AML differentiating response to retinoids into extensive apoptosis
    • Milella, M., Konopleva, M., Precupanu, C. M., Tabe, Y., Ricciardi, M. R. Gregorj, C. et al. (2007) MEK blockade converts AML differentiating response to retinoids into extensive apoptosis. Blood, 109, pp. 2121-2129.
    • (2007) Blood , vol.109 , pp. 2121-2129
    • Milella, M.1    Konopleva, M.2    Precupanu, C.M.3    Tabe, Y.4    Ricciardi, M.R.5    Gregorj, C.6
  • 9
    • 33749337234 scopus 로고    scopus 로고
    • Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia
    • Kornblau, S. M., Womble, M., Qiu, Y. H., Jackson, C. E., Chen, W. Konopleva, M. et al. (2006) Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia. Blood, 108, pp. 2358-2365.
    • (2006) Blood , vol.108 , pp. 2358-2365
    • Kornblau, S.M.1    Womble, M.2    Qiu, Y.H.3    Jackson, C.E.4    Chen, W.5    Konopleva, M.6
  • 10
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland, D. G. and Griffin, J. D. (2002) The roles of FLT3 in hematopoiesis and leukemia. Blood, 100, pp. 1532-1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 11
    • 0030002950 scopus 로고    scopus 로고
    • Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells
    • Drexler, H. G. (1996) Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia, 10, pp. 588-599.
    • (1996) Leukemia , vol.10 , pp. 588-599
    • Drexler, H.G.1
  • 12
    • 0031877978 scopus 로고    scopus 로고
    • Biologic effects and potential clinical applications of FLT3 ligand
    • Lyman, S. D. (1998) Biologic effects and potential clinical applications of FLT3 ligand. Curr Opin Hematol, 5, pp. 192-196.
    • (1998) Curr Opin Hematol , vol.5 , pp. 192-196
    • Lyman, S.D.1
  • 13
    • 0027955112 scopus 로고
    • STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells
    • Small, D., Levenstein, M., Kim, E., Carow, C., Amin, S. Rockwell, P. et al. (1994) STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Acad Sci USA, 91, pp. 459-463.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 459-463
    • Small, D.1    Levenstein, M.2    Kim, E.3    Carow, C.4    Amin, S.5    Rockwell, P.6
  • 14
    • 0013102301 scopus 로고    scopus 로고
    • CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)
    • Kelly, L. M., Yu, J. C., Boulton, C. L., Apatira, M., Li, J. Sullivan, C. M. et al. (2002) CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell, 1, pp. 421-432.
    • (2002) Cancer Cell , vol.1 , pp. 421-432
    • Kelly, L.M.1    Yu, J.C.2    Boulton, C.L.3    Apatira, M.4    Li, J.5    Sullivan, C.M.6
  • 15
    • 0027494860 scopus 로고
    • Mitogenic signalling and substrate specificity of the Flk2/FLT3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells
    • Dosil, M., Wang, S. and Lemischka, I. R. (1993) Mitogenic signalling and substrate specificity of the Flk2/FLT3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells. Mol Cell Biol, 13, pp. 6572-6585.
    • (1993) Mol Cell Biol , vol.13 , pp. 6572-6585
    • Dosil, M.1    Wang, S.2    Lemischka, I.R.3
  • 16
    • 0030054904 scopus 로고    scopus 로고
    • FLT3-ligand production by human bone marrow stromal cells
    • Lisovsky, M., Braun, S. E., Ge, Y., Takahira, H., Lu, L. Savchenko, V. G. et al. (1996) FLT3-ligand production by human bone marrow stromal cells. Leukemia, 10, pp. 1012-1018.
    • (1996) Leukemia , vol.10 , pp. 1012-1018
    • Lisovsky, M.1    Braun, S.E.2    Ge, Y.3    Takahira, H.4    Lu, L.5    Savchenko, V.G.6
  • 17
    • 0028803283 scopus 로고
    • Plasma/serum levels of FLT3 ligand are low in normal individuals and highly elevated in patients with Fanconi anemia and acquired aplastic anemia
    • Lyman, S. D., Seaberg, M., Hanna, R., Zappone, J., Brasel, K. Abkowitz, J. L. et al. (1995) Plasma/serum levels of FLT3 ligand are low in normal individuals and highly elevated in patients with Fanconi anemia and acquired aplastic anemia. Blood, 86, pp. 4091-4096.
    • (1995) Blood , vol.86 , pp. 4091-4096
    • Lyman, S.D.1    Seaberg, M.2    Hanna, R.3    Zappone, J.4    Brasel, K.5    Abkowitz, J.L.6
  • 18
    • 34548642127 scopus 로고    scopus 로고
    • Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: From bench to bedside
    • Martelli, A. M., Tazzari, P. L., Evangelisti, C., Chiarini, F., Blalock, W. L. Billi, A. M. et al. (2007) Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: From bench to bedside. Curr Med Chem, 14, pp. 2009-2023.
    • (2007) Curr Med Chem , vol.14 , pp. 2009-2023
    • Martelli, A.M.1    Tazzari, P.L.2    Evangelisti, C.3    Chiarini, F.4    Blalock, W.L.5    Billi, A.M.6
  • 19
    • 34147146014 scopus 로고    scopus 로고
    • Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
    • Zeng, Z., Sarbassov dos, D, Samudio, I. J., Yee, K. W., Munsell, M. F. Ellen Jackson, C et al. (2007) Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood, 109, pp. 3509-3512.
    • (2007) Blood , vol.109 , pp. 3509-3512
    • Zeng, Z.1    Sarbassov dos, D.2    Samudio, I.J.3    Yee, K.W.4    Munsell, M.F.5    Ellen Jackson, C.6
  • 21
    • 0035383812 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells
    • Ning, Z. Q., Li, J. and Arceci, R. J. (2001) Signal transducer and activator of transcription 3 activation is required for Asp(816) mutant c-Kit-mediated cytokine-independent survival and proliferation in human leukemia cells. Blood, 97, pp. 3559-3567.
    • (2001) Blood , vol.97 , pp. 3559-3567
    • Ning, Z.Q.1    Li, J.2    Arceci, R.J.3
  • 22
    • 0034009375 scopus 로고    scopus 로고
    • Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia: A marker for the monitoring of minimal residual disease
    • Nakao, M., Janssen, J. W., Erz, D., Seriu, T. and Bartram, C. R. (2000) Tandem duplication of the FLT3 gene in acute lymphoblastic leukemia: A marker for the monitoring of minimal residual disease. Leukemia, 14, pp. 522-524.
    • (2000) Leukemia , vol.14 , pp. 522-524
    • Nakao, M.1    Janssen, J.W.2    Erz, D.3    Seriu, T.4    Bartram, C.R.5
  • 23
    • 0029035716 scopus 로고
    • Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12-→q13
    • Carow, C. E., Kim, E., Hawkins, A. L., Webb, H. D., Griffin, C. A. Jabs, E. W. et al. (1995) Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12-→q13. Cytogenet Cell Genet, 70, pp. 255-257.
    • (1995) Cytogenet Cell Genet , vol.70 , pp. 255-257
    • Carow, C.E.1    Kim, E.2    Hawkins, A.L.3    Webb, H.D.4    Griffin, C.A.5    Jabs, E.W.6
  • 24
    • 0042662868 scopus 로고    scopus 로고
    • FLT3 ligand regulates dendritic cell development from FLT3+ lymphoid and myeloid-committed progenitors to FLT3+ dendritic cells in vivo
    • Karsunky, H., Merad, M., Cozzio, A., Weissman, I. L. and Manz, M. G. (2003) FLT3 ligand regulates dendritic cell development from FLT3+ lymphoid and myeloid-committed progenitors to FLT3+ dendritic cells in vivo. J Exp Med, 198, pp. 305-313.
    • (2003) J Exp Med , vol.198 , pp. 305-313
    • Karsunky, H.1    Merad, M.2    Cozzio, A.3    Weissman, I.L.4    Manz, M.G.5
  • 25
    • 0034850572 scopus 로고    scopus 로고
    • Stromal support augments extended long-term ex vivo expansion of hemopoietic progenitor cells
    • Kusadasi, N., Koevoet, J. L., van Soest, P. L. and Ploemacher, R. E. (2001) Stromal support augments extended long-term ex vivo expansion of hemopoietic progenitor cells. Leukemia, 15, pp. 1347-1358.
    • (2001) Leukemia , vol.15 , pp. 1347-1358
    • Kusadasi, N.1    Koevoet, J.L.2    van Soest, P.L.3    Ploemacher, R.E.4
  • 26
    • 0034210658 scopus 로고    scopus 로고
    • Mice lacking FLT3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    • McKenna, H. J., Stocking, K. L., Miller, R. E., Brasel, K., De Smedt, T. Maraskovsky, E. et al. (2000) Mice lacking FLT3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood, 95, pp. 3489-3497.
    • (2000) Blood , vol.95 , pp. 3489-3497
    • McKenna, H.J.1    Stocking, K.L.2    Miller, R.E.3    Brasel, K.4    De Smedt, T.5    Maraskovsky, E.6
  • 27
    • 0029097145 scopus 로고
    • Targeted disruption of the flk2/FLT3 gene leads to deficiencies in primitive hematopoietic progenitors
    • Mackarehtschian, K., Hardin, J. D., Moore, K. A., Boast, S., Goff, S. P. and Lemischka, I. R. (1995) Targeted disruption of the flk2/FLT3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity, 3, pp. 147-161.
    • (1995) Immunity , vol.3 , pp. 147-161
    • Mackarehtschian, K.1    Hardin, J.D.2    Moore, K.A.3    Boast, S.4    Goff, S.P.5    Lemischka, I.R.6
  • 28
    • 0036893435 scopus 로고    scopus 로고
    • Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations
    • Zheng, R., Friedman, A. D. and Small, D. (2002) Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations. Blood, 100, pp. 4154-4161.
    • (2002) Blood , vol.100 , pp. 4154-4161
    • Zheng, R.1    Friedman, A.D.2    Small, D.3
  • 29
    • 0030267526 scopus 로고    scopus 로고
    • The FLT3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta
    • Veiby, O. P., Jacobsen, F. W., Cui, L., Lyman, S. D. and Jacobsen, S. E. (1996) The FLT3 ligand promotes the survival of primitive hemopoietic progenitor cells with myeloid as well as B lymphoid potential. Suppression of apoptosis and counteraction by TNF-alpha and TGF-beta. J Immunol, 157, pp. 2953-2960.
    • (1996) J Immunol , vol.157 , pp. 2953-2960
    • Veiby, O.P.1    Jacobsen, F.W.2    Cui, L.3    Lyman, S.D.4    Jacobsen, S.E.5
  • 30
    • 9244260192 scopus 로고    scopus 로고
    • Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells
    • Rosnet, O., Buhring, H. J., Marchetto, S., Rappold, I., Lavagna, C. Sainty, D. et al. (1996) Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia, 10, pp. 238-248.
    • (1996) Leukemia , vol.10 , pp. 238-248
    • Rosnet, O.1    Buhring, H.J.2    Marchetto, S.3    Rappold, I.4    Lavagna, C.5    Sainty, D.6
  • 31
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede, C., Steudel, C., Mohr, B., Schaich, M., Schakel, U. Platzbecker, U. et al. (2002) Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis. Blood, 99, pp. 4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3    Schaich, M.4    Schakel, U.5    Platzbecker, U.6
  • 32
    • 0842310394 scopus 로고    scopus 로고
    • The structural basis for autoinhibition of FLT3 by the juxtamembrane domain
    • Griffith, J., Black, J., Faerman, C., Swenson, L., Wynn, M. Lu, F. et al. (2004) The structural basis for autoinhibition of FLT3 by the juxtamembrane domain. Mol Cell, 13, pp. 169-178.
    • (2004) Mol Cell , vol.13 , pp. 169-178
    • Griffith, J.1    Black, J.2    Faerman, C.3    Swenson, L.4    Wynn, M.5    Lu, F.6
  • 33
    • 65449180371 scopus 로고    scopus 로고
    • Identification of a novel type of ITD mutations located in non-juxtamembrane domains of the FLT3 tyrosine kinase receptor
    • Breitenbuecher, F., Schnittger, S., Grundler, R., Markova, B., Carius, B. Brecht, A. et al. Identification of a novel type of ITD mutations located in non-juxtamembrane domains of the FLT3 tyrosine kinase receptor. Blood
    • Blood
    • Breitenbuecher, F.1    Schnittger, S.2    Grundler, R.3    Markova, B.4    Carius, B.5    Brecht, A.6
  • 34
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger, S., Schoch, C., Dugas, M., Kern, W., Staib, P. Wuchter, C. et al. (2002) Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood, 100, pp. 59-66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3    Kern, W.4    Staib, P.5    Wuchter, C.6
  • 35
    • 16944365287 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and MDS among various hematological malignancies. A study on a large series of patients and cell lines
    • Yokota, S., Kiyoi, H., Nakao, M., Iwai, T., Misawa, S. Okuda, T. et al. (1997) Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and MDS among various hematological malignancies. A study on a large series of patients and cell lines. Leukemia, 11, pp. 1605-1609.
    • (1997) Leukemia , vol.11 , pp. 1605-1609
    • Yokota, S.1    Kiyoi, H.2    Nakao, M.3    Iwai, T.4    Misawa, S.5    Okuda, T.6
  • 36
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • Kiyoi, H., Naoe, T., Nakano, Y., Yokota, S., Minami, S. Miyawaki, S. et al. (1999) Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood, 93, pp. 3074-3080.
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3    Yokota, S.4    Minami, S.5    Miyawaki, S.6
  • 37
    • 0034554796 scopus 로고    scopus 로고
    • FLT3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki, M., Fenski, R., Halfter, H., Matsumura, I., Schmidt, R. Muller, C. et al. (2000) FLT3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood, 96, pp. 3907-3914.
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3    Matsumura, I.4    Schmidt, R.5    Muller, C.6
  • 38
    • 0000796896 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells
    • Fenski, R., Flesch, K., Serve, S., Mizuki, M., Oelmann, E. Kratz-Albers, K. et al. (2000) Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells. Br J Haematol, 108, pp. 322-330.
    • (2000) Br J Haematol , vol.108 , pp. 322-330
    • Fenski, R.1    Flesch, K.2    Serve, S.3    Mizuki, M.4    Oelmann, E.5    Kratz-Albers, K.6
  • 39
    • 0033820091 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation
    • Tse, K. F., Mukherjee, G. and Small, D. (2000) Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. Leukemia, 14, pp. 1766-1776.
    • (2000) Leukemia , vol.14 , pp. 1766-1776
    • Tse, K.F.1    Mukherjee, G.2    Small, D.3
  • 40
    • 0031835661 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors
    • Radomska, H. S., Huettner, C. S., Zhang, P., Cheng, T., Scadden, D. T. and Tenen, D. G. (1998) CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol, 18, pp. 4301-4314.
    • (1998) Mol Cell Biol , vol.18 , pp. 4301-4314
    • Radomska, H.S.1    Huettner, C.S.2    Zhang, P.3    Cheng, T.4    Scadden, D.T.5    Tenen, D.G.6
  • 42
    • 0033564978 scopus 로고    scopus 로고
    • C/EBP alpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts
    • Wang, X., Scott, E., Sawyers, C. L. and Friedman, A. D. (1999) C/EBP alpha bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts. Blood, 94, pp. 560-571.
    • (1999) Blood , vol.94 , pp. 560-571
    • Wang, X.1    Scott, E.2    Sawyers, C.L.3    Friedman, A.D.4
  • 43
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
    • Pabst, T., Mueller, B. U., Zhang, P., Radomska, H. S., Narravula, S. Schnittger, S. et al. (2001) Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet, 27, pp. 263-270.
    • (2001) Nat Genet , vol.27 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3    Radomska, H.S.4    Narravula, S.5    Schnittger, S.6
  • 44
    • 0036401105 scopus 로고    scopus 로고
    • BAY 43-9006: Preclinical data
    • Wilhelm, S. and Chien, D. S. (2002) BAY 43-9006: Preclinical data. Curr Pharm Des, 8, pp. 2255-2257.
    • (2002) Curr Pharm Des , vol.8 , pp. 2255-2257
    • Wilhelm, S.1    Chien, D.S.2
  • 45
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm, S. M., Carter, C., Tang, L., Wilkie, D., McNabola, A. Rong, H. et al. (2004) BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res, 64, pp. 7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3    Wilkie, D.4    McNabola, A.5    Rong, H.6
  • 46
    • 0038009044 scopus 로고    scopus 로고
    • Imatinib mesylate in the treatment of chronic myeloid leukaemia
    • Druker, B. J. (2003) Imatinib mesylate in the treatment of chronic myeloid leukaemia. Expert Opin Pharmacother, 4, pp. 963-971.
    • (2003) Expert Opin Pharmacother , vol.4 , pp. 963-971
    • Druker, B.J.1
  • 48
    • 53049091279 scopus 로고    scopus 로고
    • Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway
    • Kang, B., Hao, C., Wang, H., Zhang, J., Xing, R. Shao, J. et al. (2008) Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway. J Proteome Res, 7, pp. 3507-3515.
    • (2008) J Proteome Res , vol.7 , pp. 3507-3515
    • Kang, B.1    Hao, C.2    Wang, H.3    Zhang, J.4    Xing, R.5    Shao, J.6
  • 50
    • 16844362816 scopus 로고    scopus 로고
    • Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors
    • Sharma, A., Trivedi, N. R., Zimmerman, M. A., Tuveson, D. A., Smith, C. D. and Robertson, G. P. (2005) Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res, 65, pp. 2412-2421.
    • (2005) Cancer Res , vol.65 , pp. 2412-2421
    • Sharma, A.1    Trivedi, N.R.2    Zimmerman, M.A.3    Tuveson, D.A.4    Smith, C.D.5    Robertson, G.P.6
  • 51
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/ PRF/5
    • Liu, L., Cao, Y., Chen, C., Zhang, X., McNabola, A. Wilkie, D. et al. (2006) Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res, 66, pp. 11851-11858.
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6
  • 52
    • 33749238553 scopus 로고    scopus 로고
    • Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
    • Wilhelm, S., Carter, C., Lynch, M., Lowinger, T., Dumas, J. Smith, R. A. et al. (2006) Discovery and development of sorafenib: A multikinase inhibitor for treating cancer. Nat Rev Drug Discov, 5, pp. 835-844.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 835-844
    • Wilhelm, S.1    Carter, C.2    Lynch, M.3    Lowinger, T.4    Dumas, J.5    Smith, R.A.6
  • 53
    • 28844484134 scopus 로고    scopus 로고
    • Renal-cell carcinoma
    • Cohen, H. T. and McGovern, F. J. (2005) Renal-cell carcinoma. N Engl J Med, 353, pp. 2477-2490.
    • (2005) N Engl J Med , vol.353 , pp. 2477-2490
    • Cohen, H.T.1    McGovern, F.J.2
  • 54
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain, M. J., Eisen, T., Stadler, W. M., Flaherty, K. T., Kaye, S. B. Rosner, G. L. et al. (2006) Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol, 24, pp. 2505-2512.
    • (2006) J Clin Oncol , vol.24 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3    Flaherty, K.T.4    Kaye, S.B.5    Rosner, G.L.6
  • 56
    • 38849084202 scopus 로고    scopus 로고
    • Sorafenib (BAY 43-9006) directly targets FLT3-ITD in acute myelogenous leukemia
    • Zhang, W., Konopleva, M., Shi, Y. X., Harris, D., Small, D. Ling, X. et al. (2006) Sorafenib (BAY 43-9006) directly targets FLT3-ITD in acute myelogenous leukemia. Blood, p. 108.
    • (2006) Blood , pp. 108
    • Zhang, W.1    Konopleva, M.2    Shi, Y.X.3    Harris, D.4    Small, D.5    Ling, X.6
  • 57
    • 33847195060 scopus 로고    scopus 로고
    • Antitumor activity of sorafenib in FLT3-driven leukemic cells
    • Auclair, D., Miller, D., Yatsula, V., Pickett, W., Carter, C. Chang, Y. et al. (2007) Antitumor activity of sorafenib in FLT3-driven leukemic cells. Leukemia, 21, pp. 439-445.
    • (2007) Leukemia , vol.21 , pp. 439-445
    • Auclair, D.1    Miller, D.2    Yatsula, V.3    Pickett, W.4    Carter, C.5    Chang, Y.6
  • 58
    • 0034109650 scopus 로고    scopus 로고
    • The MEK inhibitor, PD98059, reduces survival but does not block acute myeloid leukemia blast maturation in vitro
    • Baines, P., Fisher, J., Truran, L., Davies, E., Hallett, M. Hoy, T. et al. (2000) The MEK inhibitor, PD98059, reduces survival but does not block acute myeloid leukemia blast maturation in vitro. Eur J Haematol, 64, pp. 211-218.
    • (2000) Eur J Haematol , vol.64 , pp. 211-218
    • Baines, P.1    Fisher, J.2    Truran, L.3    Davies, E.4    Hallett, M.5    Hoy, T.6
  • 59
    • 0345874509 scopus 로고    scopus 로고
    • An investigation of the effects of the MEK inhibitor U0126 on apoptosis in acute leukemia
    • James, J. A., Smith, M. A., Court, E. L., Yip, C., Ching, Y. Willson, C. et al. (2003) An investigation of the effects of the MEK inhibitor U0126 on apoptosis in acute leukemia. Hematol J, 4, pp. 427-432.
    • (2003) Hematol J , vol.4 , pp. 427-432
    • James, J.A.1    Smith, M.A.2    Court, E.L.3    Yip, C.4    Ching, Y.5    Willson, C.6
  • 60
    • 42349087045 scopus 로고    scopus 로고
    • Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway
    • Zhang, W., Konopleva, M., Ruvolo, V. R., McQueen, T., Evans, R. L. Bornmann, W. G. et al. (2008) Sorafenib induces apoptosis of AML cells via Bim-mediated activation of the intrinsic apoptotic pathway. Leukemia, 22, pp. 808-818.
    • (2008) Leukemia , vol.22 , pp. 808-818
    • Zhang, W.1    Konopleva, M.2    Ruvolo, V.R.3    McQueen, T.4    Evans, R.L.5    Bornmann, W.G.6
  • 61
    • 0142027948 scopus 로고    scopus 로고
    • Ways of dying: Multiple pathways to apoptosis
    • Adams, J. M. (2003) Ways of dying: Multiple pathways to apoptosis. Genes Dev, 17, pp. 2481-2495.
    • (2003) Genes Dev , vol.17 , pp. 2481-2495
    • Adams, J.M.1
  • 62
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A. and Greenberg, M. E. (1999) Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science, 286, pp. 1358-1362.
    • (1999) Science , vol.286 , pp. 1358-1362
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5    Greenberg, M.E.6
  • 63
    • 27144502652 scopus 로고    scopus 로고
    • The role of MCL-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006
    • Yu, C., Bruzek, L. M., Meng, X. W., Gores, G. J., Carter, C. A. Kaufmann, S. H. et al. (2005) The role of MCL-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene, 24, pp. 6861-6869.
    • (2005) Oncogene , vol.24 , pp. 6861-6869
    • Yu, C.1    Bruzek, L.M.2    Meng, X.W.3    Gores, G.J.4    Carter, C.A.5    Kaufmann, S.H.6
  • 64
    • 39149129114 scopus 로고    scopus 로고
    • Mutant FLT3: A direct target of sorafenib in acute myelogenous leukemia
    • Zhang, W., Konopleva, M., Shi, Y. X., McQueen, T., Harris, D. Ling, X. et al. (2008) Mutant FLT3: A direct target of sorafenib in acute myelogenous leukemia. J Natl Cancer Inst, 100, pp. 184-198.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 184-198
    • Zhang, W.1    Konopleva, M.2    Shi, Y.X.3    McQueen, T.4    Harris, D.5    Ling, X.6
  • 65
    • 33646468642 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of BAY 43-9006 (Sorafenib) in phase I clinical trials involving solid tumor and AML/MDS patients, using flow cytometry to monitor activation of the ERK pathway in peripheral blood cells
    • Tong, F. K., Chow, S. and Hedley, D. (2006) Pharmacodynamic monitoring of BAY 43-9006 (Sorafenib) in phase I clinical trials involving solid tumor and AML/MDS patients, using flow cytometry to monitor activation of the ERK pathway in peripheral blood cells. Cytometry B Clin Cytom, 70, pp. 107-114.
    • (2006) Cytometry B Clin Cytom , vol.70 , pp. 107-114
    • Tong, F.K.1    Chow, S.2    Hedley, D.3
  • 66
    • 77955710144 scopus 로고    scopus 로고
    • Update of a phase I study of Sorafenib in patients with refractory/ relapsed acute myeloid leukemia or high-risk myelodysplastic syndrome
    • Delmonte, J. (2007) Update of a phase I study of Sorafenib in patients with refractory/relapsed acute myeloid leukemia or high-risk myelodysplastic syndrome. Blood, p. 110.
    • (2007) Blood , pp. 110
    • Delmonte, J.1
  • 67
    • 56949083913 scopus 로고    scopus 로고
    • Sorafenib (Nexavar((R))) induces molecular remission and regression of extramedullary disease in a patient with FLT3-ITD(+) acute myeloid leukemia
    • Safaian, N. N., Czibere, A., Bruns, I., Fenk, R., Reinecke, P. Dienst, A. et al. Sorafenib (Nexavar((R))) induces molecular remission and regression of extramedullary disease in a patient with FLT3-ITD(+) acute myeloid leukemia. Leuk Res
    • Leuk Res
    • Safaian, N.N.1    Czibere, A.2    Bruns, I.3    Fenk, R.4    Reinecke, P.5    Dienst, A.6
  • 68
    • 0017190491 scopus 로고
    • Effects of radiation on hematopoietic stroma
    • Fried, W., Chamberlin, W., Kedo, A. and Barone, J. (1976) Effects of radiation on hematopoietic stroma. Exp Hematol, 4, pp. 310-314.
    • (1976) Exp Hematol , vol.4 , pp. 310-314
    • Fried, W.1    Chamberlin, W.2    Kedo, A.3    Barone, J.4
  • 69
    • 0031040924 scopus 로고    scopus 로고
    • The mechanisms involved in the impairment of hematopoiesis after autologous bone marrow transplantation
    • Domenech, J., Roingeard, F. and Binet, C. (1997) The mechanisms involved in the impairment of hematopoiesis after autologous bone marrow transplantation. Leuk Lymphoma, 24, pp. 239-256.
    • (1997) Leuk Lymphoma , vol.24 , pp. 239-256
    • Domenech, J.1    Roingeard, F.2    Binet, C.3
  • 70
    • 0036738149 scopus 로고    scopus 로고
    • Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
    • Konopleva, M., Konoplev, S., Hu, W., Zaritskey, A. Y., Afanasiev, B. V. and Andreeff, M. (2002) Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia, 16, pp. 1713-1724.
    • (2002) Leukemia , vol.16 , pp. 1713-1724
    • Konopleva, M.1    Konoplev, S.2    Hu, W.3    Zaritskey, A.Y.4    Afanasiev, B.V.5    Andreeff, M.6
  • 71
    • 0345359585 scopus 로고    scopus 로고
    • An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients
    • O'Farrell, A. M., Foran, J. M., Fiedler, W., Serve, H., Paquette, R. L. Cooper, M. A. et al. (2003) An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clin Cancer Res, 9, pp. 5465-5476.
    • (2003) Clin Cancer Res , vol.9 , pp. 5465-5476
    • O'Farrell, A.M.1    Foran, J.M.2    Fiedler, W.3    Serve, H.4    Paquette, R.L.5    Cooper, M.A.6
  • 72
    • 19944431093 scopus 로고    scopus 로고
    • A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
    • Fiedler, W., Serve, H., Dohner, H., Schwittay, M., Ottmann, O. G. O'Farrell, A. M. et al. (2005) A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood, 105, pp. 986-993.
    • (2005) Blood , vol.105 , pp. 986-993
    • Fiedler, W.1    Serve, H.2    Dohner, H.3    Schwittay, M.4    Ottmann, O.G.5    O'Farrell, A.M.6
  • 73
    • 0031785213 scopus 로고    scopus 로고
    • Evidence for involvement of MAP kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling
    • Jarvis, W. D., Fornari Jr, F. A., Tombes, R. M., Erukulla, R. K., Bittman, R. Schwartz, G. K. et al. (1998) Evidence for involvement of MAP kinase, rather than stress-activated protein kinase, in potentiation of 1-beta-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. Mol Pharmacol, 54, pp. 844-856.
    • (1998) Mol Pharmacol , vol.54 , pp. 844-856
    • Jarvis, W.D.1    Fornari Jr., F.A.2    Tombes, R.M.3    Erukulla, R.K.4    Bittman, R.5    Schwartz, G.K.6
  • 74
    • 31544456409 scopus 로고    scopus 로고
    • Eradication of leukemia stem cells as a new goal of therapy in leukemia
    • Ravandi, F. and Estrov, Z. (2006) Eradication of leukemia stem cells as a new goal of therapy in leukemia. Clin Cancer Res, 12, pp. 340-344.
    • (2006) Clin Cancer Res , vol.12 , pp. 340-344
    • Ravandi, F.1    Estrov, Z.2
  • 75
    • 33947220301 scopus 로고    scopus 로고
    • FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells
    • Li, L., Piloto, O., Kim, K. T., Ye, Z., Nguyen, H. B. Yu, X. et al. (2007) FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells. Br J Haematol, 137, pp. 64-75.
    • (2007) Br J Haematol , vol.137 , pp. 64-75
    • Li, L.1    Piloto, O.2    Kim, K.T.3    Ye, Z.4    Nguyen, H.B.5    Yu, X.6
  • 76
    • 7244251613 scopus 로고    scopus 로고
    • Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518
    • Clark, J. J., Cools, J., Curley, D. P., Yu, J. C., Lokker, N. A. Giese, N. A. et al. (2004) Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. Blood, 104, pp. 2867-2872.
    • (2004) Blood , vol.104 , pp. 2867-2872
    • Clark, J.J.1    Cools, J.2    Curley, D.P.3    Yu, J.C.4    Lokker, N.A.5    Giese, N.A.6
  • 77
    • 4644240387 scopus 로고    scopus 로고
    • Prediction of resistance to small molecule FLT3 inhibitors: Implications for molecularly targeted therapy of acute leukemia
    • Cools, J., Mentens, N., Furet, P., Fabbro, D., Clark, J. J. Griffin, J. D. et al. (2004) Prediction of resistance to small molecule FLT3 inhibitors: Implications for molecularly targeted therapy of acute leukemia. Cancer Res, 64, pp. 6385-6349.
    • (2004) Cancer Res , vol.64 , pp. 6349-6385
    • Cools, J.1    Mentens, N.2    Furet, P.3    Fabbro, D.4    Clark, J.J.5    Griffin, J.D.6


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