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Volumn 64, Issue 4, 2000, Pages 211-218

The MEK inhibitor, PD98059, reduces survival but does not block acute myeloid leukemia blast maturation in vitro

Author keywords

Acute myeloid leukemia; Bax; Bcl 2; Differentiation; MAPKinase; MEK; PD98059

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN BAX; PROTEIN BCL 2;

EID: 0034109650     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2000.90139.x     Document Type: Article
Times cited : (17)

References (52)
  • 1
    • 0018148864 scopus 로고
    • Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukemia
    • 1. Sachs L. Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukemia. Nature 1978;274:535-539.
    • (1978) Nature , vol.274 , pp. 535-539
    • Sachs, L.1
  • 2
    • 0020506009 scopus 로고
    • Induction of differentiation of human acute myelogenous leukemia cells: Therapeutic implications
    • 2. Koeffler HP. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood 1983;62:709-721.
    • (1983) Blood , vol.62 , pp. 709-721
    • Koeffler, H.P.1
  • 4
    • 0029557419 scopus 로고
    • In vitro treatment with retinoids or the topoisomerase inhibitor, VPl6, evidences different functional apoptotic pathways in acute promyelocytic leukemic cells
    • 4. Calabresse C, Barbey S, Venturini L, et al. In vitro treatment with retinoids or the topoisomerase inhibitor, VPl6, evidences different functional apoptotic pathways in acute promyelocytic leukemic cells. Leukemia 1995;9: 2049-2057.
    • (1995) Leukemia , vol.9 , pp. 2049-2057
    • Calabresse, C.1    Barbey, S.2    Venturini, L.3
  • 5
    • 0029738048 scopus 로고    scopus 로고
    • Down regulation of bcl-2 in AML blasts by all-trans retinoic acid and its relationship to CD34 antigen expression
    • 5. Bradbury DA, Aldington S, Zhu Y-M, Russell NH. Down regulation of bcl-2 in AML blasts by all-trans retinoic acid and its relationship to CD34 antigen expression. Br J Haematol 1996;94:671-675.
    • (1996) Br J Haematol , vol.94 , pp. 671-675
    • Bradbury, D.A.1    Aldington, S.2    Zhu, Y.-M.3    Russell, N.H.4
  • 6
    • 0029048139 scopus 로고
    • Apoptosis during HL60 differentiation is closely related to a G0/G1 cell cycle arrest
    • 6. Terui Y, Furukawa Y, Kikuchi J, Saito M. Apoptosis during HL60 differentiation is closely related to a G0/G1 cell cycle arrest. J Cell Physiol 1995;164:74-84.
    • (1995) J Cell Physiol , vol.164 , pp. 74-84
    • Terui, Y.1    Furukawa, Y.2    Kikuchi, J.3    Saito, M.4
  • 7
    • 0030067212 scopus 로고    scopus 로고
    • Induction of differentiation and enhancement of vincristine sensitivity of human erythroleukemia HEL cells by vesnarinone, a positive inotropic agent
    • 7. Sato S, Tomoyasu S, Okabe-Kado J, et al. Induction of differentiation and enhancement of vincristine sensitivity of human erythroleukemia HEL cells by vesnarinone, a positive inotropic agent. Expl Hematol 1996;24:37-42.
    • (1996) Expl Hematol , vol.24 , pp. 37-42
    • Sato, S.1    Tomoyasu, S.2    Okabe-Kado, J.3
  • 8
    • 0021910201 scopus 로고
    • Study of differentiation of fresh myelogenous leukemic cells by compounds that induce a human promyelocytic leukemic line (HL60) to differentiate
    • 8. Koeffler HP, Yelton L, Prokocimer M, Hirji K. Study of differentiation of fresh myelogenous leukemic cells by compounds that induce a human promyelocytic leukemic line (HL60) to differentiate. Leukemia Res 1985;9:73-81.
    • (1985) Leukemia Res , vol.9 , pp. 73-81
    • Koeffler, H.P.1    Yelton, L.2    Prokocimer, M.3    Hirji, K.4
  • 9
    • 0001679798 scopus 로고
    • Induction of differentiation of the human promyelocytic leukemia cell line (HL60) by retinoic acid
    • 9. Breitman TR, Selonick SE, Collins SJ. Induction of differentiation of the human promyelocytic leukemia cell line (HL60) by retinoic acid. Proc Natl Acad Sci USA 1980;77:2936-2940.
    • (1980) Proc Natl Acad Sci USA , vol.77 , pp. 2936-2940
    • Breitman, T.R.1    Selonick, S.E.2    Collins, S.J.3
  • 10
    • 0025241453 scopus 로고
    • All-trans retinoic acid in acute promyelocytic leukemia. II. In vitro studies: Structure - function relationship
    • 10. Chomienne C, Ballerini P, Balitrand N, et al. All-trans retinoic acid in acute promyelocytic leukemia. II. In vitro studies: structure - function relationship. Blood 1990;76: 1710-1717.
    • (1990) Blood , vol.76 , pp. 1710-1717
    • Chomienne, C.1    Ballerini, P.2    Balitrand, N.3
  • 11
    • 0026040363 scopus 로고
    • A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients
    • 11. Chen ZX, Xue YQ, Zhang R, et al. A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients. Blood 1991;78:1413-1419.
    • (1991) Blood , vol.78 , pp. 1413-1419
    • Chen, Z.X.1    Xue, Y.Q.2    Zhang, R.3
  • 12
    • 0023752982 scopus 로고
    • Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
    • 12. Huang HE, Ye YC, Chen SR, et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988;72:567-572.
    • (1988) Blood , vol.72 , pp. 567-572
    • Huang, H.E.1    Ye, Y.C.2    Chen, S.R.3
  • 13
    • 0028836169 scopus 로고
    • Expression of cell surface antigens during the differentiation of HL-60 cells induced by 1,25dihydroxyvitamin D3, retinoic acid and DMSO
    • 13. Brackman D, Lund-Johansen F, Aarskog D. Expression of cell surface antigens during the differentiation of HL-60 cells induced by 1,25dihydroxyvitamin D3, retinoic acid and DMSO. Leukemia Res 1995;19:57-64.
    • (1995) Leukemia Res , vol.19 , pp. 57-64
    • Brackman, D.1    Lund-Johansen, F.2    Aarskog, D.3
  • 14
    • 0022481138 scopus 로고
    • Vitamin D compounds. Effect on clonal proliferation and differentiation of human myeloid cells
    • 14. Munker R, Norman A, Koeffler HP. Vitamin D compounds. Effect on clonal proliferation and differentiation of human myeloid cells. J Clin Invest 1986;78:424-430.
    • (1986) J Clin Invest , vol.78 , pp. 424-430
    • Munker, R.1    Norman, A.2    Koeffler, H.P.3
  • 15
    • 0026682753 scopus 로고
    • Functional significance of induction of differentiation in human myeloid leukaemic blasts by 1,25-dihydroxyvitamin D3 and GM-CSF
    • 15. Kelsey SM, Makin HLJ, Newland C. Functional significance of induction of differentiation in human myeloid leukaemic blasts by 1,25-dihydroxyvitamin D3 and GM-CSF. Leukemia Res 1992;16:427-434.
    • (1992) Leukemia Res , vol.16 , pp. 427-434
    • Kelsey, S.M.1    Makin, H.L.J.2    Newland, C.3
  • 17
    • 0024592926 scopus 로고
    • Maturation of human acute myeloid leukemia in vitro: The response to five haematopoietic factors in a serum-free system
    • 17. Salem M, Delwel R, Mahmoud LA, Clark S, Elbasousy EM, Lowenberg B. Maturation of human acute myeloid leukemia in vitro: the response to five haematopoietic factors in a serum-free system. Br J Haematol 1989;71:363-370.
    • (1989) Br J Haematol , vol.71 , pp. 363-370
    • Salem, M.1    Delwel, R.2    Mahmoud, L.A.3    Clark, S.4    Elbasousy, E.M.5    Lowenberg, B.6
  • 18
    • 0023909825 scopus 로고
    • The effects of combinations of the recombinant growth factors GM-CSF, G-CSF, IL3 and CSF-1 on leukemic blast cells in suspension culture
    • 18. Miyauchi J, Kelleher CA, Wong GG, et al. The effects of combinations of the recombinant growth factors GM-CSF, G-CSF, IL3 and CSF-1 on leukemic blast cells in suspension culture. Leukemia 1988;2:382-387.
    • (1988) Leukemia , vol.2 , pp. 382-387
    • Miyauchi, J.1    Kelleher, C.A.2    Wong, G.G.3
  • 19
    • 0026047765 scopus 로고
    • Primary human acute myeloblastic leukaemia: An analysis of in vitro granulocyte maturation following stimulation with retinoic acid and G-CSF
    • 19. Colombat PH, Santini V, Delwel, R, Krefft J, Bredmond JL, Lowenberg B. Primary human acute myeloblastic leukaemia: an analysis of in vitro granulocyte maturation following stimulation with retinoic acid and G-CSF. Br J Haematol 1991;79:382-389.
    • (1991) Br J Haematol , vol.79 , pp. 382-389
    • Colombat, P.H.1    Santini, V.2    Delwel, R.3    Krefft, J.4    Bredmond, J.L.5    Lowenberg, B.6
  • 20
    • 0025755848 scopus 로고
    • Induction of granulocytic maturation in acute myeloid leukemia by G-CSF and retinoic acid
    • 20. Santini V, Colombat PH, Dewel R, Van Gurp R, Touw I, Lowenberg B. Induction of granulocytic maturation in acute myeloid leukemia by G-CSF and retinoic acid. Leukemia Res 1991;15:341-350.
    • (1991) Leukemia Res , vol.15 , pp. 341-350
    • Santini, V.1    Colombat, P.H.2    Dewel, R.3    Van Gurp, R.4    Touw, I.5    Lowenberg, B.6
  • 21
    • 0024512177 scopus 로고
    • Recombinant human IL3 and GCSF act synergistically in stimulating the growth of acute myeloid leukemia cells
    • 21. Pebusque M-J, Fay C, Lafage M, Sempere C, Saeland S, Caux C, Mannoni P. Recombinant human IL3 and GCSF act synergistically in stimulating the growth of acute myeloid leukemia cells. Leukemia 1989;3:200-205.
    • (1989) Leukemia , vol.3 , pp. 200-205
    • Pebusque, M.-J.1    Fay, C.2    Lafage, M.3    Sempere, C.4    Saeland, S.5    Caux, C.6    Mannoni, P.7
  • 22
    • 0025291990 scopus 로고
    • IL3 inhibits the binding of GM-CSF to AML blasts, but the two cytokines act synergistically in supporting blast proliferation
    • 22. Onetto-Pothier N, Aumont N, Haman A, et al. IL3 inhibits the binding of GM-CSF to AML blasts, but the two cytokines act synergistically in supporting blast proliferation. Leukemia 1990;4:329-336.
    • (1990) Leukemia , vol.4 , pp. 329-336
    • Onetto-Pothier, N.1    Aumont, N.2    Haman, A.3
  • 23
    • 0025718579 scopus 로고
    • Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells
    • 23. Ikeda H, Kanakura Y, Tamaki T, et al. Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells. Blood 1991;78:2962-2969.
    • (1991) Blood , vol.78 , pp. 2962-2969
    • Ikeda, H.1    Kanakura, Y.2    Tamaki, T.3
  • 24
    • 0026752860 scopus 로고
    • Human recombinant stem cell factor stimulates in vitro proliferation of acute myeloid leukemia cells and expands the clonogenic cell pool
    • 24. Carlesso N, Pregno P, Bresso P, et al. Human recombinant stem cell factor stimulates in vitro proliferation of acute myeloid leukemia cells and expands the clonogenic cell pool. Leukemia 1992;6:642-648.
    • (1992) Leukemia , vol.6 , pp. 642-648
    • Carlesso, N.1    Pregno, P.2    Bresso, P.3
  • 25
    • 0026775925 scopus 로고
    • Effects of human stem cell factor on proliferation of myeloid leukemia cells: Heterogeneity in response and synergy with other hematopoietic growth factors
    • 25. Pietsch T, Kyas U, Steffens U, et al. Effects of human stem cell factor on proliferation of myeloid leukemia cells: heterogeneity in response and synergy with other hematopoietic growth factors. Blood 1992;80:1199-1206.
    • (1992) Blood , vol.80 , pp. 1199-1206
    • Pietsch, T.1    Kyas, U.2    Steffens, U.3
  • 26
    • 0025282887 scopus 로고
    • Detection of minimal residual disease in acute myeloid leukemia
    • 26. Gerhartz HH, Schmetzer H. Detection of minimal residual disease in acute myeloid leukemia. Leukemia 1990;4: 508-516.
    • (1990) Leukemia , vol.4 , pp. 508-516
    • Gerhartz, H.H.1    Schmetzer, H.2
  • 27
    • 0032571294 scopus 로고    scopus 로고
    • The overexpression of bax produces cell death upon induction of the mitochondrial permiability transition
    • 27. Pastorino JG, Chen S-T, Tafani M, Snyder JW, Farber JL. The overexpression of Bax produces cell death upon induction of the mitochondrial permiability transition. J Biol Chem 1998;273:7770-7775.
    • (1998) J Biol Chem , vol.273 , pp. 7770-7775
    • Pastorino, J.G.1    Chen, S.-T.2    Tafani, M.3    Snyder, J.W.4    Farber, J.L.5
  • 28
    • 0032079892 scopus 로고    scopus 로고
    • A trace amount of the human pro-apoptotic factor Bax induces bacterial cell death accompanied by damage of DNA
    • 28. Asoh S, Nishimaki K, Nanbu-Wakao R, Ohta S. A trace amount of the human pro-apoptotic factor Bax induces bacterial cell death accompanied by damage of DNA. J Biol Chem 1998;273:11384-11391.
    • (1998) J Biol Chem , vol.273 , pp. 11384-11391
    • Asoh, S.1    Nishimaki, K.2    Nanbu-Wakao, R.3    Ohta, S.4
  • 29
    • 0030982224 scopus 로고    scopus 로고
    • The Bax-alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukemia
    • 29. Salomons GS, Brady HJM, Verwus-Janssen M, et al. The Bax-alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukemia. Int J Cancer 1997;71:959-965.
    • (1997) Int J Cancer , vol.71 , pp. 959-965
    • Salomons, G.S.1    Brady, H.J.M.2    Verwus-Janssen, M.3
  • 30
    • 0030737420 scopus 로고    scopus 로고
    • Activation of the mitogen-activated protein kinase pathway is involved in and sufficient for megakaryocyte differentiation of CMK cells
    • 30. Melemed AS, Ryder JW, Vik TA. Activation of the mitogen-activated protein kinase pathway is involved in and sufficient for megakaryocyte differentiation of CMK cells. Blood 1997;90:3462-3470.
    • (1997) Blood , vol.90 , pp. 3462-3470
    • Melemed, A.S.1    Ryder, J.W.2    Vik, T.A.3
  • 31
    • 0032521266 scopus 로고    scopus 로고
    • Inhibition of T cell activation by pharmacologic disruption of the MEK/ERK MAP Kinase or calcineurin signaling pathways results in differential modulation of cytokine production
    • 31. Dumont FJ, Staruch MJ, Fischer P, DaSilva C, Camacho R. Inhibition of T cell activation by pharmacologic disruption of the MEK/ERK MAP Kinase or calcineurin signaling pathways results in differential modulation of cytokine production. J Immunol 1998;160:2579-2598.
    • (1998) J Immunol , vol.160 , pp. 2579-2598
    • Dumont, F.J.1    Staruch, M.J.2    Fischer, P.3    DaSilva, C.4    Camacho, R.5
  • 32
    • 0026753999 scopus 로고
    • Granulocytemacrophage colony stimulating factor, interleukin-3 and steel factor induce rapid phosphorylation of p42 and p44 MAP kinase
    • 32. Okuda K, Sanghera JS, Pelech SL, et al. Granulocytemacrophage colony stimulating factor, Interleukin-3 and Steel Factor induce rapid phosphorylation of p42 and p44 MAP kinase. Blood 1992;79:2880-2887.
    • (1992) Blood , vol.79 , pp. 2880-2887
    • Okuda, K.1    Sanghera, J.S.2    Pelech, S.L.3
  • 34
    • 0028837491 scopus 로고
    • Suppression of apoptotic death in hematopoietic cells by signalling through the IL3/GMCSF receptors
    • 34. Kinoshita T, Yokota T, Arai K-i, Miyajima A. Suppression of apoptotic death in hematopoietic cells by signalling through the IL3/GMCSF receptors. EMBO J 1995;14: 266-275.
    • (1995) EMBO J , vol.14 , pp. 266-275
    • Kinoshita, T.1    Yokota, T.2    Arai, K.-I.3    Miyajima, A.4
  • 35
    • 0029033866 scopus 로고
    • Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells
    • 35. Kinoshita T, Yokota T, Arai K-i, Miyajima A. Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells. Oncogene 1995;10:2207-2212.
    • (1995) Oncogene , vol.10 , pp. 2207-2212
    • Kinoshita, T.1    Yokota, T.2    Arai, K.-I.3    Miyajima, A.4
  • 36
    • 0031439924 scopus 로고    scopus 로고
    • Coordinate regulation of stress-and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine
    • 36. Jarvis WD, Fornari FA, Auer KL, et al. Coordinate regulation of stress-and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine. Mol Pharmacol 1997;52:935-947.
    • (1997) Mol Pharmacol , vol.52 , pp. 935-947
    • Jarvis, W.D.1    Fornari, F.A.2    Auer, K.L.3
  • 37
    • 0030972025 scopus 로고    scopus 로고
    • Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells
    • 37. Towatari M, Iida H, Tanimoto M, Iwata H, Hamaguchi M, Saito HC. Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells. Leukemia 1997:11:479-484.
    • (1997) Leukemia , vol.11 , pp. 479-484
    • Towatari, M.1    Iida, H.2    Tanimoto, M.3    Iwata, H.4    Hamaguchi, M.5    Saito, H.C.6
  • 38
    • 0031785213 scopus 로고    scopus 로고
    • Evidence for involvement of mitogen-activated protein kinase rather than stress-activated protein kinase, in potentiation of 1-β-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling
    • 38. Jarvis WD, Fornari FA, Tombes RM, et al. Evidence for involvement of mitogen-activated protein kinase rather than stress-activated protein kinase, in potentiation of 1-β-D-arabinofuranosylcytosine-induced apoptosis by interruption of protein kinase C signaling. Mol Pharmacol 1998; 54:844-856.
    • (1998) Mol Pharmacol , vol.54 , pp. 844-856
    • Jarvis, W.D.1    Fornari, F.A.2    Tombes, R.M.3
  • 40
    • 0001403935 scopus 로고
    • Human long-term bone marrow culture in serum-free medium
    • abstr
    • 40. Drouet X, Douay L, Giarratana MC, et al. Human long-term bone marrow culture in serum-free medium. Expl Hematol 1988;16:abstr: 367.
    • (1988) Expl Hematol , vol.16 , pp. 367
    • Drouet, X.1    Douay, L.2    Giarratana, M.C.3
  • 41
    • 0025349131 scopus 로고
    • Anti-insulin receptor monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA
    • 41. Brindle NP, Tavare JM, Dickens M, Whittaker J, Siddle K. Anti-insulin receptor monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA. Biochem J 1990;268:615-620.
    • (1990) Biochem J , vol.268 , pp. 615-620
    • Brindle, N.P.1    Tavare, J.M.2    Dickens, M.3    Whittaker, J.4    Siddle, K.5
  • 42
    • 0026543962 scopus 로고
    • Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry
    • 42. Dive C, Gregory CD, Phipps DJ, Evans DL, Milner AE, Wyllie AH. Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry. Biochim Biophys Acta 1992;1133:275-285.
    • (1992) Biochim Biophys Acta , vol.1133 , pp. 275-285
    • Dive, C.1    Gregory, C.D.2    Phipps, D.J.3    Evans, D.L.4    Milner, A.E.5    Wyllie, A.H.6
  • 43
    • 0031929376 scopus 로고    scopus 로고
    • Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukemia and are correlated with in vitro chemoresistance
    • 43. Pepper C, Hoy T, Bentley P. Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukemia and are correlated with in vitro chemoresistance. Leukemia Lymphoma 1998;28:355-361.
    • (1998) Leukemia Lymphoma , vol.28 , pp. 355-361
    • Pepper, C.1    Hoy, T.2    Bentley, P.3
  • 44
    • 0031893236 scopus 로고    scopus 로고
    • Unconventional rapid ERK1,2 activation is indispensable for proliferation of the growth factor-independent myeloid leukemic line KGl
    • 44. Barge RMY, Dorrestijn J, Falkenburg JHF, Willemze R, Maassen JA. Unconventional rapid ERK1,2 activation is indispensable for proliferation of the growth factor-independent myeloid leukemic line KGl. Leukemia 1998;12:699-704.
    • (1998) Leukemia , vol.12 , pp. 699-704
    • Barge, R.M.Y.1    Dorrestijn, J.2    Falkenburg, J.H.F.3    Willemze, R.4    Maassen, J.A.5
  • 45
    • 0030861571 scopus 로고    scopus 로고
    • Bcl-2 and Bax function independently to regulate cell death
    • 45. Knudson CM, Korsmeyer SJ. Bcl-2 and Bax function independently to regulate cell death. Nature Genet 1997;16:358-363.
    • (1997) Nature Genet , vol.16 , pp. 358-363
    • Knudson, C.M.1    Korsmeyer, S.J.2
  • 46
    • 0032562682 scopus 로고    scopus 로고
    • The activation of p38 and apoptosis by the inhibition of ERK is antagonised by the phosphoinositide 3-kinase/Akt pathway
    • 46. Berra E, Diaz-Meco MT, Moscat J. The activation of p38 and apoptosis by the inhibition of ERK is antagonised by the phosphoinositide 3-kinase/Akt pathway. J Biol Chem 1998;273:10,792-10,797.
    • (1998) J Biol Chem , vol.273 , pp. 10
    • Berra, E.1    Diaz-Meco, M.T.2    Moscat, J.3
  • 47
    • 0030715570 scopus 로고    scopus 로고
    • An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 cells in the presence of IGF-1
    • 47. Suzuki J, Kaziro Y, Koide H. An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 cells in the presence of IGF-1. Oncogene 1997; 15:1689-1697.
    • (1997) Oncogene , vol.15 , pp. 1689-1697
    • Suzuki, J.1    Kaziro, Y.2    Koide, H.3
  • 48
    • 0033556255 scopus 로고    scopus 로고
    • Synergistic activation of mitogen-activated protein kinase by cyclic AMP and myeloid growth factors opposes cyclic AMP's growth-inhibitory effects
    • 48. Lee AW-M. Synergistic activation of mitogen-activated protein kinase by cyclic AMP and myeloid growth factors opposes cyclic AMP's growth-inhibitory effects. Blood 1999;93:537-553.
    • (1999) Blood , vol.93 , pp. 537-553
    • Lee, A.W.-M.1
  • 49
    • 0032473935 scopus 로고    scopus 로고
    • Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation
    • 49. Chaturvedi P, Reddy MVR, Reddy EP. Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation. Oncogene 1998;16:1749-1758.
    • (1998) Oncogene , vol.16 , pp. 1749-1758
    • Chaturvedi, P.1    Reddy, M.V.R.2    Reddy, E.P.3
  • 50
    • 0031825118 scopus 로고    scopus 로고
    • The study of apoptotic cells by flow cytometry
    • 50. Ormerod MG. The study of apoptotic cells by flow cytometry. Leukemia 1998;12:1013-1025.
    • (1998) Leukemia , vol.12 , pp. 1013-1025
    • Ormerod, M.G.1
  • 51
    • 0030294374 scopus 로고    scopus 로고
    • A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells
    • 51. Zhang C, Ao Zhaohui, Seth A, Schlossman SF. A mitochondrial membrane protein defined by a novel monoclonal antibody is preferentially detected in apoptotic cells. J Immunol 1996;157:3980-3987.
    • (1996) J Immunol , vol.157 , pp. 3980-3987
    • Zhang, C.1    Zhaohui, A.2    Seth, A.3    Schlossman, S.F.4
  • 52
    • 0031434775 scopus 로고    scopus 로고
    • Monitoring early cellular responses in apoptosis is aided by the mitochondrial membrane protein-specific monoclonal antibody APO2.7
    • 52. Koester SK, Roth P, Mikulka WR, Schlossman SF, Zhang C, Bolton WA. Monitoring early cellular responses in apoptosis is aided by the mitochondrial membrane protein-specific monoclonal antibody APO2.7. Cytometry 1997; 29:306-312.
    • (1997) Cytometry , vol.29 , pp. 306-312
    • Koester, S.K.1    Roth, P.2    Mikulka, W.R.3    Schlossman, S.F.4    Zhang, C.5    Bolton, W.A.6


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