Evaluation of hepatic-metastasis risk of colorectal cancer upon the protein signature of PI3K/AKT pathway

Journal of Proteome Research

Volumn 7, Issue 8, 2008, Pages 3507-3515

  Kang, Bin ^a   Hao, Chunyi ^b   Wang, Hongyi ^b   Zhang, Jun ^a   Xing, Rui ^a   Shao, Jianmin ^a   Li, Wenmei ^b   Xu, Ningzhi ^a   Lu, Youyong ^a,b   Liu, Siqi ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Colorectal cancer; Hepatic metastasis; PI3K AKT pathway; Protein signature

Indexed keywords

BIOLOGICAL MARKER; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 5A; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN MFAP3L; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PROTEOME; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER RISK; CELL STRAIN HT29; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MOUSE; NONHUMAN; NUDE MOUSE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; ANIMAL; COLORECTAL TUMOR; LIVER TUMOR; MASS SPECTROMETRY; METASTASIS; PATHOLOGY; PHYSIOLOGY; RISK ASSESSMENT; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

MUS MUSCULUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MASS SPECTROMETRY; MICE; MICE, NUDE; PROGNOSIS; PROTEOME; PROTO-ONCOGENE PROTEINS C-AKT; RISK ASSESSMENT; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TUMOR MARKERS, BIOLOGICAL;

EID: 53049091279     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr800238p     Document Type: Article

References (27)

1. Hao, G; Ji, J. Surgical treatment of liver metastases of colorectal cancer: Strategies and controversies in 2006. Eur. J. Surg. Oncol. 2006, 32, 473-483.
2. Brünagel, G.; Schoen, R. E.; Bauer, A. J. et al. Nuclear matrix protein alterations associated with colon cancer metastasis to the liver. Clin. Cancer Res. 2002, 8, 3039-3045.
3. Rudmik, L. R.; Magliocco, A. M. Molecular mechanisms of hepatic metastasis in colorectal cancer. J. Surg. Oncol. 2005, 92, 347-359.
4. (4)Dai, C. Y.; Haqq, C. M.; Puzas, J. E. Molecular correlates of site- specific metastasis. Semin. Radiat. Oncol. 2006, 16, 102-110.
5. Arrigo, A. D.; Belluco, C; Ambrosi, A.; et al. Metastatic transcriptional pattern revealed by gene expression profiling in primary colorectal carcinoma. Int. J. Cancer 2005, 115, 256-262.
6. Agrawal, D.; Chen, T.; Irby, R.; et al. Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J. Natl. Cancer Inst. 2002, 94, 513-521.
7. Kim, J.; Mori, T.; Chen, S. L.; et al. Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome. Ann. Surg. 2006, 244, 113-120.
8. Tang, Z.; Zhao, M.; Ji, J.; et al. Overexpression of gastrin and c-met protein involved in human gastric carcinomaa and intestinal metaplasia. Oncol. Rep. 2004, 11, 333-339.
9. Mamane, Y.; Petroulakis, E.; LeBacquer, O.; et al. mTOR, translation initiation and cancer. Oncogene 2006, 16, 6416-6422.
10. De Corte, V.; Van Impe, K.; Bruyneel, E.; et al. Increased importin- dependent nuclear import of the Actin modulating protein CapG promotes cell invasion. J. Cell Sci. 2004, 117, 5283-5292.
11. Babakov, V. N.; Bobkov, D. E.; Petukhova, O. A.; et al. Alpha- actinin-4 and p65/RelA subunit of NF-kappaB transcription factor are co-localized and migrate together into the nucleus in EGF- stimulated A431 cell. Tsitologiia 2004, 46, 1064-1072.
12. Clausse, N.; Van den Brule, F.; Delvenne, P.; et al. TNF-alpha and IFN-gamma down-regulate the expression of the metastasis associated bi-functional 37LRP/p40 gene and protein in transformed keratinocytes. Biochem. Biophys. Res. Commun. 1998, 251, 564- 569.
13. Dumic, J.; Lauc, G.; Flogel, M. Expression of galectin-3 in cells exposed to stress-roles of jun and NF-kappaB. Cell Physiol. Biochem. 2000, 10, 149-158.
14. Bien, S.; Ritter, C. A.; Gratz, M.; et al. Nuclear Factor-κB mediates up-regulation of cathepsin B by Doxorubicin in tumor cells. Mol. Pharmacol. 2004, 65, 1092-1102.
15. Lee, K. H.; Lee, C. T.; Kim, Y. W.; et al. Heat shock protein 70 negatively regulates the heat-shock-induced suppression of the IkappaB/NF-kappaB cascade by facilitating IkappaB kinase rena- turation and blocking its further denaturation. Exp. Cell Res. 2005, 307, 276-284.
16. Yeung, K. C; Rose, D. W.; Dhillon, A. S.; et al. Raf kinase inhibitor protein interacts with NF-κB-inducing kinase and TAK1 and inhibits NF-κB activation. Mol Cell. Biol. 2001, 21, 7207-7217.
17. Taylor, C. A.; Senchyna, M.; Flanagan, J.; et al. Role of eIF5A in TNF-a-mediated apoptosis of Lamina Cribrosa cells. Invest. Ophthalmol. Visual Sci. 2004, 45, 3568-3576.
18. Van Antwerp, D. J.; Martin, S. J.; Kafri, T.; et al. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 1996, 274, 787-789.
19. Xiao, J.; Yin, L.; Li., J.; et al. Molecular cloning, identification and characteristics of NYD-SP9: Gene coding protein kinase presumably involved in spermatogenesis. Chin. Sci. Bull. 2002, 47, 896- 901.
20. Agarwal, A.; Das, K.; Lerner, N.; et al. The AKT/κB kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-κB and β-catenin. Oncogene 2005, 24, 1021-1031.
21. Kang, Y.; Tulley, S.; Gupta, G. P.; et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc. Natl. Acad. Sci. U.S.A 2005, 102, 13909-13914.
22. Karhadkar, S. S.; Bova, G. S.; Abdallah, N.; et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004, 431, 707-712.
23. Celis, J. E.; Gromova, I.; Gromov, P.; et al. Molecular pathology of breast apocrine carcinomas: a protein expression signature specific for benign apocrine metaplasia. FEBS Lett. 2006, 580, 2935-2944.
24. Varambally, S.; Yu, J.; Laxman, B.; et al. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell 2005, 8, 393-406.
25. Rychahou, P. G.; Jackson, L. N.; Silva, S. R.; et al. Targeted molecular therapy of the PI3K pathway therapeutic significance of P13K subunlt targeting in colorectal carcinoma. Ann. Surg. 2006, 243, 833-844.
26. Hershey, J. W. Translational control in mammalian cells. Annu. Rev. Biochem. 1991, 60, 717-755.
27. Li, A.; Li, H. Y.; Jin, B. F.; et al. A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis. J. Biol. Chem. 2004, 279, 49251-49258.