Obese OLETF rats exhibit increased operant performance for palatable sucrose solutions and differential sensitivity to D2 receptor antagonism

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 293, Issue 5, 2007, Pages

  Hajnal, Andras ^a   Acharya, Nikhil K ^a   Grigson, Patricia S ^a   Covasa, Mihai ^b   Twining, Robert C ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Appetite; Dietary obesity; Food reward; Operant lick task; Palatability

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; CHOLECYSTOKININ A RECEPTOR; DOPAMINE 1 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; RACLOPRIDE; SUCROSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DOPAMINERGIC SYSTEM; HYPERPHAGIA; IMPAIRED GLUCOSE TOLERANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PALATABILITY; PRIORITY JOURNAL; RAT;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; AGING; ANIMALS; BODY WEIGHT; CONDITIONING, OPERANT; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD PREFERENCES; GLUCOSE TOLERANCE TEST; MALE; PREDIABETIC STATE; PSYCHOMOTOR PERFORMANCE; RACLOPRIDE; RATS; RATS, INBRED OLETF; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; REINFORCEMENT SCHEDULE; SUCROSE;

EID: 36048978602     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00461.2007     Document Type: Article

References (60)

1. Anderzhanova E, Covasa M, Hajnal A. Altered basal and stimulated accumbens dopamine release in obese OLETF rats as a function of age and diabetic status. Am J Physiol Regul Integr Comp Physiol 293: R603-R611, 2007.
2. Avena NM, Hoebel BG. A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine. Neuroscience 122: 17-20, 2003.
3. Bartoshuk LM, Duffy VB, Hayes JE, Moskowitz HR, Snyder DJ. Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. Philos Trans R Soc Lond B Biol Sci 361: 1137-1148, 2006.
4. Bednar I, Carrer H, Qureshi GA, Sodersten P. Dopamine D1 or D2 antagonists enhance inhibition of consummatory ingestive behavior by CCK-8. Am J Physiol Regul Integr Comp Physiol 269: R896-R903, 1995.
5. Beinfeld MC. What we know and what we need to know about the role of endogenous CCK in psychostimulant sensitization. Life Sci 73: 643-654, 2003.
6. Bellush LL, Rowland NE. Dietary self-selection in diabetic rats: an overview. Brain Res Bull 17: 653-661, 1986.
7. Berridge KC. Food reward: brain substrates of wanting and liking. Neurosci Biobehav Rev 20: 1-25, 1996.
8. Berridge KC, Robinson TE. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28: 309-369, 1998.
9. Bi S, Ladenheim EE, Schwartz GJ, Moran TH. A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats. Am J Physiol Regul Integr Comp Physiol 281: R254-R260, 2001.
10. Bi S, Scott KA, Tamashiro KL, Hyun J, Moran TH. Knockdown of dorsomedial hypothalamic NPY gene expression prevents hyperphagia and obesity of OLETF rats lacking CCK1 receptors. Society for the Study of Ingestive Behavior: Annual Meeting, 2007. Appetite, p. 279.
11. Booth DA. Conditioned satiety in the rat. J Comp Physiol Psychol 81: 457-471, 1972.
12. Cannon CM, Palmiter RD. Reward without dopamine. J Neurosci 23: 10827-10831, 2003.
13. Cincotta AH, Tozzo E, Scislowski PW. Bromocriptine/SKF38393 treatment ameliorates obesity and associated metabolic dysfunctions in obese (ob/ob) mice. Life Sci 61: 951-956, 1997.
14. Cooper SJ, Al-Naser HA. Dopaminergic control of food choice: contrasting effects of SKF 38393 and quinpirole on high-palatability food preference in the rat. Neuropharmacology 50: 953-963, 2006.
15. De Jonghe BC, Di Martino C, Hajnal A, Covasa M. Brief intermittent access to sucrose differentially modulates prepulse inhibition and acoustic startle response in obese CCK-1 receptor deficient rats. Brain Res 1052: 22-27, 2005.
16. De Jonghe BC, Hajnal A, Covasa M. Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation. Am J Physiol Regul Integr Comp Physiol 292: R1819-R1827, 2007.
17. De Jonghe BC, Hajnal A, Covasa M. Increased oral and decreased intestinal sensitivity to sucrose in obese, prediabetic CCK-A receptor-deficient OLETF rats. Am J Physiol Regul Integr Comp Physiol 288: R292-R300, 2005.
18. De Jonghe BC, Hajnal A, Covasa M. Increased sensitivity to D1 and D2 receptor antagonism in sucrose feeding OLETF rats. Society for the Study of Ingestive Behavior: Annual Meeting, 2005. Appetite, p. 329-392.
19. Drewnowski A. Taste preferences and food intake. Annu Rev Nutr 17: 237-253, 1997.
20. Drewnowski A, Brunzell JD, Sande K, Iverius PH, Greenwood MR. Sweet tooth reconsidered: taste responsiveness in human obesity. Physiol Behav 35: 617-622, 1985.
21. Feifel D, Shilling PD, Kuczenski R, Segal DS. Altered extracellular dopamine concentration in the brains of cholecystokinin-A receptor deficient rats. Neurosci Lett 348: 147-150, 2003.
22. Figlewicz DP, Bennett JL, Naleid AM, Davis C, Grimm JW. Intraventricular insulin and leptin decrease sucrose self-administration in rats. Physiol Behav 89: 611-616, 2006.
23. Figlewicz DP, Naleid AM, Sipols AJ. Modulation of food reward by adiposity signals. Physiol Behav 89: 611-616, 2006.
24. Garcia BG, Wei Y, Moron JA, Lin RZ, Javitch JA, Galli A. Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol 68: 102-109, 2005.
25. Giza BK, Scott TR. Blood glucose selectively affects taste-evoked activity in rat nucleus tractus solitarius. Physiol Behav 31: 643-650, 1983.
26. Hajnal A, Covasa M, Bello NT. Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors. Am J Physiol Regul Integr Comp Physiol 289: R1675-R1686, 2005.
27. Hajnal A, De Jonghe BC, Covasa M. Dopamine D2 receptors contribute to increased avidity for sucrose in obese OLETF rats lacking CCK-1 receptors. Neuroscience 148: 584-592, 2007.
28. Hajnal A, Norgren R. Sucrose Reward and Dopamine. In: The Senses: A Comprehensive Reference, edited by Firestein S and Smith DV, New York: Elsevier. In press.
29. Hajnal A, Margas WM, Covasa M. Altered dopamine D2 receptor function and binding in obese OLETF rat. Brain Res Bull. In press.
30. Hamilton ME, Redondo JL, Freeman AS. Overflow of dopamine and cholecystokinin in rat nucleus accumbens in response to acute drug administration. Synapse 38: 238-242, 2000.
31. Hill JO, Catenacci V, Wyatt HR. Obesity: overview of an epidemic. Psychiatr Clin North Am 28: 1-23, 2005.
32. Hokfelt T, Rehfeld JF, Skirboll L, Ivemark B, Goldstein M, Markey K. Evidence for coexistence of dopamine and CCK in meso-limbic neurones. Nature 285: 476-478, 1980.
33. Hurd YL, Lindefors N, Brodin E, Brene S, Persson H, Ungerstedt U, Hokfelt T. Amphetamine regulation of mesolimbic dopamine/cholecystokinin neurotransmission. Brain Res 578: 317-326, 1992.
34. Josselyn SA, De Cristofaro A, Vaccarino FJ. Evidence for CCK(A) receptor involvement in the acquisition of conditioned activity produced by cocaine in rats. Brain Res 763: 93-102, 1997.
35. Kanarek RB, Ho L. Patterns of nutrient selection in rats with streptozotocin-induced diabetes. Physiol Behav 32: 639-645, 1984.
36. Kawano K, Hirashima T, Mori S, Saitoh Y, Kurosumi M, Natori T. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41: 1422-1428, 1992.
37. la Fleur SE, Vanderschuren LJ, Luijendijk MC, Kloeze BM, Tiesjema B, Adan RA. A reciprocal interaction between food-motivated behavior and diet-induced obesity. Int J Obes 31: 1286-1294, 2007.
38. Mela DJ, Sacchetti DA. Sensory preferences for fats: relationships with diet and body composition. Am J Clin Nutr 53: 908-915, 1991.
39. Moran TH. Cholecystokinin and satiety: current perspectives. Nutrition 16: 858-865, 2000.
40. Moran TH, Bi S. Hyperphagia and obesity of OLETF rats lacking CCK1 receptors: developmental aspects. Dev Psychobiol 48: 360-367, 2006.
41. Ninomiya Y, Sako N, Imai Y. Enhanced gustatory neural responses to sugars in the diabetic db/db mouse. Am J Physiol Regul Integr Comp Physiol 269: R930-R937, 1995.
42. Pijl H. Reduced dopaminergic tone in hypothalamic neural circuits: expression of a "thrifty" genotype underlying the metabolic syndrome? Eur J Pharmacol 480: 125-131, 2003.
43. Reilly S. Reinforcement value of gustatory stimuli determined by progressive ratio performance. Pharmacol Biochem Behav 63: 301-311, 1999.
44. Rowlett JK. A labor-supply analysis of cocaine self-administration under progressive-ratio schedules: antecedents, methodologies, and perspectives. Psychopharmacology (Berl) 153: 1-16, 2000.
45. Sclafani A, Ackroff K. Reinforcement value of sucrose measured by progressive ratio operant licking in the rat. Physiol Behav 79: 663-670, 2003.
46. Seroogy K, Schalling M, Brene S, Dagerlind A, Chai SY, Hokfelt T, Persson H, Brownstein M, Huan R, Dixon J. Cholecystokinin and tyrosine hydroxylase messenger RNAs in neurons of rat mesencephalon: peptide/monoamine coexistence studies using in situ hybridization combined with immunocytochemistry. Exp Brain Res 74: 149-162, 1989.
47. Shimizu Y, Yamazaki M, Nakanishi K, Sakurai M, Sanada A, Takewaki T, Tonosaki K. Enhanced responses of the chorda tympani nerve to sugars in the ventromedial hypothalamic obese rat. J Neurophysiol 90: 128-133, 2003.
48. Simon SA, de Araujo IE, Gutierrez R, Nicolelis MA. The neural mechanisms of gustation: a distributed processing code. Nat Rev Neurosci 7: 890-901, 2006.
49. Sipols AJ, Stuber GD, Klein SN, Higgins MS, Figlewicz DP. Insulin and raclopride combine to decrease short-term intake of sucrose solutions. Peptides 21: 1361-1367, 2000.
50. Smith GP. Accumbens dopamine mediates the rewarding effect of orosensory stimulation by sucrose. Appetite 43: 11-13, 2004.
51. Smith JC, Gannon KS. Ingestion patterns of food, water, saccharin and sucrose in streptozotocin-induced diabetic rats. Physiol Behav 49: 189-199, 1991.
52. Sorensen LB, Moller P, Flint A, Martens M, Raben A. Effect of sensory perception of foods on appetite and food intake: a review of studies on humans. Int J Obes Relat Metab Disord 27: 1152-1166, 2003.
53. Szczypka MS, Rainey MA, Palmiter RD. Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet 25: 102-104, 2000.
54. Tepper BJ, Friedman MI. Altered acceptability of and preference for sugar solutions by diabetic rats is normalized by high-fat diet. Appetite 16: 25-38, 1991.
55. Tepper BJ, Seldner AC. Sweet taste and intake of sweet foods in normal pregnancy and pregnancy complicated by gestational diabetes mellitus. Am J Clin Nutr 70: 277-284, 1999.
56. Torregrossa AM, Davis JD, Smith GP. Orosensory stimulation is sufficient and postingestive negative feedback is not necessary for neuropeptide Y to increase sucrose intake. Physiol Behav 87: 773-780, 2006.
57. Wang GJ, Volkow ND, Fowler JS. The role of dopamine in motivation for food in humans: implications for obesity. Expert Opin Ther Targets 6: 601-609, 2002.
58. Weatherford SC, Greenberg D, Gibbs J, Smith GP. The potency of D-1 and D-2 receptor antagonists is inversely related to the reward value of sham-fed corn oil and sucrose in rats. Pharmacol Biochem Behav 37: 317-323, 1990.
59. Wise RA. Forebrain substrates of reward and motivation. J Comp Neurol 493: 115-121, 2005.
60. Yeomans MR, Blundell JE, Leshem M. Palatability: response to nutritional need or need-free stimulation of appetite? Br J Nutr 92, Suppl 1: S3-S14, 2004.