The thioredoxin-related redox-regulating protein nucleoredoxin inhibits wnt–β-catenin signalling through dishevelled

Nature Cell Biology

Volumn 8, Issue 5, 2006, Pages 501-508

  Funato, Yosuke ^a   Michiue, Tatsuo ^a   Asashima, Makoto ^a,b   Miki, Hiroaki ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DISHEVELLED PROTEINS; HYDROGEN PEROXIDE; NUCLEAR PROTEIN; NUCLEOREDOXIN; OXIDOREDUCTASE; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; T CELL FACTOR PROTEIN; THIOREDOXIN; WNT PROTEIN;

ANIMAL; ANIMAL EMBRYO; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL STRAIN 3T3; CELL STRAIN COS1; CERCOPITHECUS; CULTURE MEDIUM; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; MOUSE; OXIDATION REDUCTION REACTION; PRENATAL DEVELOPMENT; PROTEIN BINDING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSACTIVATION; XENOPUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BETA CATENIN; CELL PROLIFERATION; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CULTURE MEDIA, CONDITIONED; EMBRYO, NONMAMMALIAN; HUMANS; HYDROGEN PEROXIDE; MICE; NIH 3T3 CELLS; NUCLEAR PROTEINS; OXIDATION-REDUCTION; OXIDOREDUCTASES; PHOSPHOPROTEINS; PROTEIN BINDING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TCF TRANSCRIPTION FACTORS; THIOREDOXIN; TRANS-ACTIVATION (GENETICS); WNT PROTEINS; XENOPUS;

EID: 33646858497     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb1405     Document Type: Article

References (30)

1. Nelson, W. J. & Nusse, R. Convergence of Wnt, β-catenin, and cadherin pathways. Science 303, 1483–1487 (2004).
2. Reya, T. & Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 843–850 (2005).
3. Moon, R. T., Kohn, A. D., De Ferrari, G. V. & Kaykas, A. WNT and β-catenin signalling: diseases and therapies. Nature Rev. Genet. 5, 691–701 (2004).
4. Kurooka, H. et al. Cloning and characterization of the nucleoredoxin gene that encodes a novel nuclear protein related to thioredoxin. Genomics 39, 331–339 (1997).
5. Laurent, T. C., Moore, E. C. & Reichard, P. Enzymatic synthesis of deoxyribonucleotides. IV. Isolation and characterization of thioredoxin, the hydrogen donor from Escherichia coli B. J. Biol. Chem. 239, 3436–3444 (1964).
6. Chae, H. Z. et al. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Proc. Nat. Acad. Sci. USA 91, 7017–7021 (1994).
7. Saitoh, M. et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J. 17, 2596–2606 (1998).
8. Yanagawa, S., van Leeuwen, F., Wodarz, A., Klingensmith, J. & Nusse, R. The disheveled protein is modified by wingless signaling in Drosophila. Genes Dev. 9, 1087–1097 (1995).
9. Barth, A. I., Pollack, A. L., Altschuler, Y., Mostov, K. E. & Nelson, W. J. NH2-terminal deletion of β-catenin results in stable colocalization of mutant β-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. J. Cell Biol. 136, 693–706 (1997).
10. Li, L. et al. Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J. Biol. Chem. 274, 129–134 (1999).
11. Moriguchi, T. et al. Distinct domains of mouse dishevelled are responsible for the c-Jun N-terminal kinase–stress-activated protein kinase activation and the axis formation in vertebrates. J. Biol. Chem. 274, 30957–30962 (1999).
12. Yost, C. et al. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell 93, 1031–1041 (1998).
13. Li, L. et al. Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J. 18, 4233–4240 (1999).
14. Hino, S., Michiue, T., Asashima, M. & Kikuchi, A. Casein kinase Iε enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of β-catenin. J. Biol. Chem. 278, 14066–14073 (2003).
15. He, T. C. et al. Identification of c-MYC as a target of the APC pathway. Science 281, 1509–1512 (1998).
16. Tetsu, O. & McCormick, F. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422–426 (1999).
17. Rimerman, R. A., Gellert-Randleman, A. & Diehl, J. A. Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation. J. Biol. Chem. 275, 14736–14742 (2000).
18. Sokol, S. Y., Klingensmith, J., Perrimon, N. & Itoh, K. Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. Development 121, 1637–1647 (1995).
19. Kim, C. H. et al. Repressor activity of Headless–Tcf3 is essential for vertebrate head formation. Nature 407, 913–916 (2000).
20. Kiecker, C. & Niehrs, C. A morphogen gradient of Wnt–β-catenin signalling regulates anteroposterior neural patterning in Xenopus. Development 128, 4189–4201 (2001).
21. Michiue, T. et al. XIdax, an inhibitor of the canonical Wnt pathway, is required for anterior neural structure formation in Xenopus. Dev. Dyn. 230, 79–90 (2004).
22. Leyns, L., Bouwmeester, T., Kim, S. H., Piccolo, S. & De Robertis, E. M. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer. Cell 88, 747–756 (1997).
23. Wang, S., Krinks, M., Lin, K., Luyten, F. P. & Moos, M., Jr. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell 88, 757–766 (1997).
24. Burdon, R. H. & Rice-Evans, C. Free radicals and the regulation of mammalian cell proliferation. Free Radic. Res. Commun. 6, 345–358 (1989).
25. Sundaresan, M., Yu, Z. X., Ferrans, V. J., Irani, K. & Finkel, T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270, 296–299 (1995).
26. Finkel, T. Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 15, 247–254 (2003).
27. Rhee, S. G. et al. Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. Curr. Opin. Cell Biol. 17, 183–189 (2005).
28. Miki, H., Fukuda, M., Nishida, E. & Takenawa, T. Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling. J. Biol. Chem. 274, 27605–27609 (1999).
29. Molenaar, M., et al. XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell 86, 391–399 (1996).
30. Fujita, M. et al. Up-regulation of the ectodermal-neural cortex 1 (ENC1) gene, a downstream target of the β-catenin–T-cell factor complex, in colorectal carcinomas. Cancer Res. 61, 7722–7726 (2001).