Constitutive/hypoxic degradation of HIF-α proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation activity of the protein

Journal of Biological Chemistry

Volumn 282, Issue 21, 2007, Pages 15498-15505

  Kong, Xianguo ^a   Alvarez Castelao, Beatriz ^b   Lin, Zhao ^a   Castaño, José G ^b   Caro, Jaime ^a,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^c Cardeza Foundation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; HYPOXIC MICROENVIRONMENT; PROTEASOME; TRANSACTIVATION;

BINDING SITES; CELLS; COMPLEXATION; DNA; GENES; TISSUE;

ENZYME ACTIVITY;

HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEASOME; VON HIPPEL LINDAU PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HIF1A PROTEIN, HUMAN; IFT57 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA BINDING; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; UBIQUITINATION; CELL HYPOXIA; GLYCOLYSIS; HELA CELL; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PROTEIN PROCESSING; TRANSACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; GLYCOLYSIS; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; TRANS-ACTIVATION (GENETICS); UBIQUITIN;

EID: 34447522124     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M700704200     Document Type: Article

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