Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog

Journal of Clinical Investigation

Volumn 97, Issue 1, 1996, Pages 81-91

  Pagliassotti, Michael J ^a,b   Holste, Linda C ^a   Moore, Mary C ^a   Neal, Doss W ^a   Cherrington, Alan D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

glycogen synthase; hyperglycemia; liver

Indexed keywords

GLUCAGON; GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOG; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGEN LIVER LEVEL; GLYCOGEN METABOLISM; GLYCOLYSIS; HYPERGLYCEMIA; HYPERINSULINEMIA; LIVER BLOOD FLOW; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL;

EID: 0030034219     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118410     Document Type: Article

References (44)

1. Pagliassotti, M J., and A. D Cherrington. 1992. Regulation of net hepatic glucose uptake in vivo. Annu. Rev. Physiol. 54:847-860.
2. DeFronzo, R. A., E. Ferrannini, R. Hendler, J. Wahren, and P. Felig. 1978. Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange Proc. Natl Acad. Sci. USA. 75: 5173-5177
3. Sacca, L., M. Cicala, B. Trimarco, B. Ingaro, and C. Vigorito. 1982. Differential effects of insulin on splanchnic and peripheral glucose disposal after an intravenous glucose load in man. J. Clin. Invest 70:117-126.
4. Abumrad, N. N., A. D. Cherrington, P. E. Williams, W. W. Lacy, and D. Rabin. 1982 Absorption and disposition of a glucose load in the conscious dog. Am J. Physiol. 242:E398-E406.
5. Ferrannini, E., O. Bjorkman, G. A. Reichard, Jr., A. Pilo, M. Olsson, J. Wahren, and R. A. Defronzo. 1985. The disposal of an oral glucose load in healthy subjects: a quantitative study. Diabetes. 34.580-588.
6. Kelley, D., A. Mitrakou, J. Marsh, F. Schwenk, J. Benn, G. Sonnenberg, M. Arcangeli, T. Aoki, J. Sorensen, M. Berger, et al 1988. Skeletal muscle glycolysis. oxidation, and storage of an oral glucose load. J Clin. invest. 81:1563-1571.
7. Radziuk, J. 1987. Tracer methods and the metabolic disposal of a carbohydrate load in man. Diabetes Metab. Rev. 3:231-267.
8. Cherrington, A. D., R. W. Stevenson, K. E. Steiner, M. A. Davis, S R. Myers, B A. Adkins, N. N. Abumrad, and P. E. Williams. 1987. Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo Diabetes Metab. Rev. 3:307-332.
9. Mitrakou, A., R. Jones, Y. Okuda, J. Pena, N. Nurjhan, J. B. Field, and J. E. Gerich 1991. Pathway and carbon sources for hepatic glycogen repletion in dogs. Am. J. Physiol. 260:E194-E202.
10. Pagliassotti, M. J., S. R. Myers, M. C. Moore, D. W. Neal, and A. D. Cherrington. 1991. Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs. Diabetes. 40:1659-1668.
11. Insel, P. A., J. E. Liljenquist, J. D Tobin, R. S. Sherwin, P Watkins, R. Andres, and M. Berman 1975. Insulin control of glucose metabolism in man. A new kinetic analysis. J. Clin. Invest. 55:1057-1064.
12. Bergman, R. N., D. T. Finegood, and M Ader. 1985 Assessment of insulin sensitivity in vivo. Endocr. Rev 6:45-85.
13. Adkins-Marshall, B., M. J. Pagliassotti, J R. Asher, C C Connolly, D. W. Neal, P. E. Williams, S. R. Myers, G. K. Hendrick, R. B. Adkins, Jr , and A. D Cherrington. 1992. Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Am. J Physiol 262:E679-E686
14. Katz, J., and J. D. McGarry. 1984. The glucose paradox. Is glucose a substrate for liver metabolism? J. Clin. Invest 74:1901-1909.
15. Newgard, C. B , L J. Hirsch, D W Foster, and J. D. McGarry. 1983. Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? J. Biol. Chetn 258:8046-8052.
16. Shulman, G I , L. Rossetti, D L. Rothman, J B. Blair, and D. Smith. 1987. Quantitative analysis of glycogen repletion by nuclear magnetic resonance spectroscopy in the conscious rat. J Clin. Invest 80:387-393.
17. 13C NMR study. J. Biol Chem. 264:3930-3934.
18. Shulman, G. I., G. Cline, W C Schumann, V. Chandramouli, K. Kumaran, and B. R. Landau. 1990. Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans Am J. Physiol. 259:E335-E341.
19. Moore, M C. A. D. Cherrington, G. Cline, M. J. Pagliassotti, E. M. Jones, D. W. Neal, C. Badet, and G I Shulman. 1991. Sources of carbon for hepatic glycogen synthesis in the conscious dog. J Clin. Invest. 88:578-587
20. Hendrick, G. K., R. T. Frizzell, P. E Williams, and A. D. Cherrington. 1990. Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. Am. J. Physiol. 258:E841-E849.
21. Hartley, C. J., and J. S Cole. 1974 An ultrasonic pulsed Doppler system for measuring blood flow in small vessels. J. Appl Physiol. 37:626-629.
22. Liljenquist, J. E., G. L. Mueller, A. D. Cherrington, J. M Perry, and D. Rabinowitz. 1979. Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. J. Clin. Endocrinol. & Metab. 48: 171-175.
23. Goresky, C. A , C. G. Back, and B. E. Nadeau. 1975. Red cell carriage of label: its limiting effect on the exchange of materials in the liver. Cir. Res. 36: 328-351.
24. Kadish, A. H., R. L. Little, and J. C. Sternberg. 1968. A new and rapid method for the determination of glucose by measurement of rate of oxygen consumption Clin. Chem. 14:116-131.
25. Lloyd, B., J. Burrin, P. Smythe, and K. G. M. M. Alberti 1978. Enzymatic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin. Chem 24:1724-1729
26. Brun, C. 1951. A rapid method for the determination of para-aminohippuric acid in kidney function tests. J Lab. Clin. Med. 37:955-958.
27. Aguilar-Parada, E., A M. Eisentraut, and R. H Unger. 1969. Pancreatic glucagon secretion in normal and diabetic subjects. Am. J. Med. Sci. 257:415-419
28. Morgan, C. R., and A. L. Lazarow 1963 Immunoassay of insulin: two antibody system Plasma insulin of normal, subdiabetic, and diabetic rats. Am J. Med. Sci. 257:415-419.
29. Chan, T. M., and J. H. Exton. 1976. A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes. Anal. Biochem. 71:96-105.
30. Nuttall, F. O., and M. C. Gannon. 1989. An improved assay for hepatic glycogen synthase in liver extracts with emphasis on synthase R. Anal. Biochem 178:311-319.
31. Leevy, C. M., C. I. Mendenhall, W Lesko, and M. M. Howard 1962. Estimation of hepatic blood flow with indocyanine green. J. Clin. Invest. 41: 1169-1179.
32. Adkins, B. A , S. R. Myers, G. K. Hendrick, R. W. Stevenson, P. E. Williams, and A D. Cherrington 1987. Importance of the route of intravenous delivery to hepatic glucose balance in the conscious dog. J Clin. Invest. 79:557-565
33. Myers, S. R., D. W. Biggers, D W. Neal, and A. D. Cherrington. 1991. Intraportal glucose delivery enhances the effects of hepatic glucose load on net hepatic glucose uptake in vivo. J. Clin Invest. 88:158-167.
34. Allsop, J. R., R. R. Wolfe, and J F Burke 1978. The reliability of rates of glucose appearance in vivo calculated from constant tracer infusions. Biochem J 172:407-416
35. Finegood, D. T., R. N. Bergman, and M. Vranic. 1987. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps. Diabetes. 36:914-924.
36. Cobelli, C , A. Mari, and E. Ferrannim. 1987. Non-steady state: error analysis of Steele's model and developments for glucose kinetics. Am. J. Physiol. 252:E679-E689.
37. Moore, M. C , M. J. Pagliassotti, L. L Swift, J. Asher, J. Murrell, D. Neal, and A. D Cherrington. 1994. Disposition of a mixed meal by the conscious dog. Am. J Physiol 266:E666-E675.
38. Myers, S R., O. P. McGuinness, D. W Neal, and A. D. Cherrington. 1991. Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J. Clin. Invest. 87:930-939.
39. Bergman, R. N., J. R. Bier, and P. M. Hourigan 1982. Intraportal glucose infusion matched to oral glucose absorption: lack of evidence for "gut factor" involvement in hepatic glucose storage. Diabetes. 31:27-35
40. Ishida, T., Z Chap, J. Chou, R. Lewis, C. Hartley, M. Entman, and J B. Field 1983. Differential effects of oral, peripheral intravenous, and intraportal glucose on hepatic glucose uptake and insulin and glucagon fractional extraction in conscious dog. J. Clin Invest 72.590-600.
41. Gardemann, A. D., H. Strulik, and K Jungermann. 1986. A portal-arterial glucose concentration gradient as a signal for insulin-dependent net glucose uptake in perfused rat liver. FEBS Lett 292 255-259.
42. Newsholme, E. A., and C. Start. 1973. Regulation in Metabolism John Wiley & Sons, Ltd., England 186-193.
43. van de Werve, G., and B. Jeanrenaud 1987. Liver glycogen metabolism: an overview. Diabetes Metab Rev. 3.47-78
44. Youn, J H., and R. N. Bergman. 1990 Enhancement of hepatic glycogen by gluconeogenic precursors substrate flux or metabolic control? Am. J Physiol 258:E899-E906