Cdc48-Ufd1-Npl4: Stuck in the middle with Ub

Current Biology

Volumn 12, Issue 10, 2002, Pages

  Bays, Nathan W ^a   Hampton, Randolph Y ^b  

^a EXELIXIS INC   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP DEPENDENT 26S PROTEASE; CDC48 PROTEIN; CELL CYCLE PROTEIN; NPL4 PROTEIN, S CEREVISIAE; NUCLEAR PROTEIN; NUCLEOPORIN; PEPTIDE HYDROLASE; PROTEASOME; PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN; UFD1L PROTEIN, MOUSE;

ENDOPLASMIC RETICULUM; GENETICS; MACROMOLECULE; METABOLISM; MUTATION; NUCLEAR PORE; PROTEIN PROCESSING; REVIEW;

CELL CYCLE PROTEINS; ENDOPLASMIC RETICULUM; MACROMOLECULAR SUBSTANCES; MUTATION; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; PEPTIDE HYDROLASES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS; UBIQUITIN;

EID: 0037076507     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)00862-X     Document Type: Review

References (47)

1. Pathways of ubiquitin conjugation
2. The proteasome: A macromolecular assembly designed for controlled proteolysis
3. Themes and variations on ubiquitylation
4. The multiubiquitin-chain-binding protein Mcb1 is a component of the 26S proteasome in Saccharomyces cerevisiae and plays a nonessential, substratespecific role in protein turnover
5. Multiubiquitin chain binding and protein degradation are mediated by distinct domains within the 26 S proteasome subunit Mcb1
6. Purification and characterization of the 26S proteasome complex catalyzing ATP-dependent breakdown of ubiquitin-ligated proteins from rat liver
7. Nuclear transport defects and nuclear envelope alterations are associated with mutation of the Saccharomyces cerevisiae NPL4 gene
8. A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic
9. The yeast nuclear pore complex: Composition, architecture, and transport mechanism
10. Genetic analysis of macromolecular transport across the nuclear envelope
11. The nuclear pore complex: A protein machine bridging the nucleus and cytoplasm
12. Nuclear pores and nuclear assembly
13. HRD4/NPL4 Is required for the proteasomal processing of ubiquitinated ER proteins
14. cDNA cloning of p112, the largest regulatory subunit of the human 26S proteasome, and functional analysis of its yeast homologue
15. Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures
16. Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae
17. Involvement of valosin-containing protein, an ATPase co-purified with I-kappa-B-alpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of I-kappa-B-alpha
18. Proteasomal proteomics: Identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes
19. Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation
20. Recognition of the polyubiquitin proteolytic signal
21. The hydrophobic effect contributes to polyubiquitin chain recognition
22. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
23. The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate
24. The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
25. AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation
26. Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48
27. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein
28. Cholesterol homeostasis: ESCAPe from the ER
29. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing
30. The conserved Npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation
31. MGA2 or SPT23 is required for transcription of the delta9 fatty acid desaturase gene, OLE1, and nuclear membrane integrity in Saccharomyces cerevisiae
32. The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene
33. Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone
34. The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP- and NADH-concentrations and is completely inhibited by NEM
35. Role of the ubiquitin-selective CDC48(UFD1/NPL4)chaperone (segregase) in ERAD of OLE1 and other substrates
36. Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes
37. The formation of Golgi stacks from vesiculated Golgi membranes requires two distinct fusion events
38. An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments
39. Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly
40. Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration
41. VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration
42. Solution structure and interaction surface of the C-terminal domain from p47: A major p97-cofactor involved in SNARE disassembly
43. The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
44. p47 is a cofactor for p97-mediated membrane fusion
45. Organelle membrane fusion: A novel function for the syntaxin homolog Ufe1p in ER membrane fusion
46. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways
47. A proteolytic pathway that recognizes ubiquitin as a degradation signal