On the Network Properties of Mitochondria

Molecular System Bioenergetics: Energy for Life

Volumn , Issue , 2007, Pages 111-135

  Aon, Miguel A ^a   Cortassa, Sonia ^a   O'Rourke, Brian ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Biological oxidation; Cellular energetics; Dynamics; Inner membrane ion channels; Intracellular signaling; Mitochondrial morphodynamics; Mitochondrial network dynamics; Molecular system bioenergetics; Network properties mitochondria; Organization; Outer membrane ion channels

Indexed keywords

EID: 56149123045     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527621095.ch4     Document Type: Chapter

References (129)

1. Lane, N. (2005) Power, sex, suicide. Mitochondria and the meaning of life, Oxford University Press, Oxford.
2. Finkel, T. (2005) Opinion: Radical medicine: treating ageing to cure disease. Nat Rev Mol Cell Biol 6, 971-6.
3. Wright, A. F., Jacobson, S. G., Cideciyan, A. V., Roman, A. J., Shu, X., Vlachantoni, D., McInnes, R. R., Riemersma, R. A. (2004) Lifespan and mitochondrial control of neurodegeneration. Nat Genet 36, 1153-8.
4. Barabasi, A. L., Oltvai, Z. N. (2004) Network biology: understanding the cell's functional organization. Nat Rev Genet 5, 101-13.
5. Chan, D. C. (2006) Mitochondria: dynamic organelles in disease, aging, and development. Cell 125, 1241-52.
6. Mannella, C. A. (2006) The relevance of mitochondrial membrane topology to mitochondrial function. Biochim Biophys Acta 1762, 140-7.
7. Dimmer, K. S., Scorrano, L. (2006) (De)constructing mitochondria: what for? Physiology (Bethesda) 21, 233-41.
8. McBride, H. M., Neuspiel, M., Wasiak, S. (2006) Mitochondria: more than just a powerhouse. Curr Biol 16, R551-60.
9. Aon, M. A., Cortassa, S., Marban, E., O'Rourke, B. (2003) Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes. J Biol Chem 278, 44735-44.
10. Aon, M. A., Cortassa, S., O'Rourke, B. (2004) Percolation and criticality in a mitochondrial network. Proc Natl Acad Sci USA 101, 4447-52.
11. Vendelin, M., Beraud, N., Guerrero, K., Andrienko, T., Kuznetsov, A. V., Olivares, J., Kay, L., Saks, V. A. (2005) Mitochondrial regular arrangement in muscle cells: a ''crystal-like'' pattern. Am J Physiol Cell Physiol 288, C757-67.
12. Collins, T. J., Berridge, M. J., Lipp, P., Bootman, M. D. (2002) Mitochondria are morphologically and functionally heterogeneous within cells. Embo J 21, 1616-27.
13. Dedov, V. N., Roufogalis, B. D. (1999) Organisation of mitochondria in living sensory neurons. FEBS Lett 456, 171-4.
14. Skulachev, V. P., Bakeeva, L. E., Chernyak, B. V., Domnina, L. V., Minin, A. A., Pletjushkina, O. Y., Saprunova, V. B., Skulachev, I. V., Tsyplenkova, V. G., Vasiliev, J. M., Yaguzhinsky, L. S., Zorov, D. B. (2004) Thread-grain transition of mitochondrial reticulum as a step of mitoptosis and apoptosis. Mol Cell Biochem 256-257, 341-58.
15. Palmer, J. W., Tandler, B., Hoppel, C. L. (1977) Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. J Biol Chem 252, 8731-9.
16. Kuznetsov, A. V., Troppmair, J., Sucher, R., Hermann, M., Saks, V., Margreiter, R. (2006) Mitochondrial subpopulations and heterogeneity revealed by confocal imaging: possible physiological role? Biochim Biophys Acta 1757, 686-691.
17. Bakeeva, L. E., Chentsov Yu, S., Skulachev, V. P. (1983) Intermitochondrial contacts in myocardiocytes. J Mol Cell Cardiol 15, 413-20.
18. Amchenkova, A. A., Bakeeva, L. E., Chentsov, Y. S., Skulachev, V. P., Zorov, D. B. (1988) Coupling membranes as energy-transmitting cables. I. Filamentous mitochondria in fibroblasts and mitochondrial clusters in cardiomyocytes. J Cell Biol 107, 481-95.
19. Duchen, M. R., Leyssens, A., Crompton, M. (1998) Transient mitochondrial depolarizations reflect focal sarcoplasmic reticular calcium release in single rat cardiomyocytes. J Cell Biol 142, 975-88.
20. Juhaszova, M., Zorov, D. B., Kim, S. H., Pepe, S., Fu, Q., Fishbein, K. W., Ziman, B. D., Wang, S., Ytrehus, K., Antos, C. L., Olson, E. N., Sollott, S. J. (2004) Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest 113, 1535-49.
21. Loew, L. M., Tuft, R. A., Carrington, W., Fay, F. S. (1993) Imaging in five dimensions: time-dependent membrane potentials in individual mitochondria. Biophys J 65, 2396-407.
22. Aon, M. A., Cortassa, S. (1997) Dynamic biological organization. Fundamentals as applied to cellular systems, Chapman & Hall, London.
23. Cortassa, S., Aon, M. A. (1994) Spatiotemporal regulation of glycolysis and oxidative phosphorylation in vivo in tumor and yeast cells. Cell Biol Int 18, 687-713.
24. Romashko, D. N., Marban, E., O'Rourke, B. (1998) Subcellular metabolic transients and mitochondrial redox waves in heart cells. Proc Natl Acad Sci USA 95, 1618-23.
25. Saks, V. A., Kaambre, T., Sikk, P., Eimre, M., Orlova, E., Paju, K., Piirsoo, A., Appaix, F., Kay, L., Regitz-Zagrosek, V., Fleck, E., Seppet, E. (2001) Intracellular energetic units in red muscle cells. Biochem J 356, 643-57.
26. Aon, M. A., Cortassa, S. C., O'Rourke, B. (2006). The fundamental organization of cardiac mitochondria as a network of coupled oscillators. Biophys J 91, 4317-4327.
27. Akar, F. G., Aon, M. A., Tomaselli, G. F., O'Rourke, B. (2005) The mitochondrial origin of postischemic arrhythmias. J Clin Invest 115, 3527-35.
28. Aon, M. A., O'Rourke, B., Cortassa, S. (2004) The fractal architecture of cytoplasmic organization: scaling, kinetics and emergence in metabolic networks. Mol Cell Biochem 256-257, 169-84.
29. O'Rourke, B., Cortassa, S., Aon, M. A. (2005) Mitochondrial ion channels: Gatekeepers of life and death. Physiology 20, 303-315.
30. Strogatz, S. H. (2001) Exploring complex networks. Nature 410, 268-76.
31. Albert, R. (2005) Scale-free networks in cell biology. J Cell Sci 118, 4947-57.
32. Cortassa, S., Aon, M. A., Marban, E., Winslow, R. L., O'Rourke, B. (2003) An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J 84, 2734-55.
33. Ingwall, J. S., Weiss, R. G. (2004) Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res 95, 135-45.
34. Porter, K. R., Palade, G. E. (1957) Studies on the endoplasmic reticulum. III. Its form and distribution in striated muscle cells. J Biophys Biochem Cytol 3, 269-300.
35. Baumeister, W. (2002) Electron tomography: towards visualizing the molecular organization of the cytoplasm. Curr Opin Struct Biol 12, 679-84.
36. Frank, J., Wagenknecht, T., McEwen, B. F., Marko, M., Hsieh, C. E., Mannella, C. A. (2002) Threedimensional imaging of biological complexity. J Struct Biol 138, 85-91.
37. Crosta, G. F., Urani, C., Fumarola, L. (2006) Classifying structural alterations of the cytoskeleton by spectrum enhancement and descriptor fusion. J Biomed Opt 11, 024020.
38. Dey, P. (2005) Basic principles and applications of fractal geometry in pathology: a review. Anal Quant Cytol Histol 27, 284-90.
39. Erdos, P., Renyi, A. (1960) On the evolution of random graphs. Publ. Math. Inst. Hung. Acad. Sci. 5, 17-61.
40. Watts, D. J., Strogatz, S. H. (1998) Collective dynamics of 'small-world' networks. Nature 393, 440-2.
41. Almaas, E., Kovacs, B., Vicsek, T., Oltvai, Z. N., Barabasi, A. L. (2004) Global organization of metabolic fluxes in the bacterium Escherichia coli. Nature 427, 839-43.
42. Jeong, H., Tombor, B., Albert, R., Oltvai, Z. N., Barabasi, A. L. (2000) The largescale organization of metabolic networks. Nature 407, 651-4.
43. Papin, J. A., Hunter, T., Palsson, B. O., Subramaniam, S. (2005) Reconstruction of cellular signalling networks and analysis of their properties. Nat Rev Mol Cell Biol 6, 99-111.
44. Wagner, A., Fell, D. A. (2001) The small world inside large metabolic networks. Proc Biol Sci 268, 1803-10.
45. Barabasi, A. L. (2003) Linked, Plume, New York.
46. Varela, F., Maturana, H., Uribe, R. (1974) Autopoiesis: the organization of living sytems, its characterization and a model. Biosystems 5, 187-196.
47. Nicolis, G., Prigogine, I. (1977) Selforganization in nonequilibrium systems: from dissipative structures to order through fluctuations, Wiley, New York.
48. Capra, F. (1996) The web of life, Anchor books Doubleday, New York.
49. Aon, M. A., Cortassa, S. (2006) Metabolic dynamics in cells viewed as multilayered, distributed, mass-energy-information networks, Vol. Part 3. Proteomics. 3.8 Systems Biology, Wiley Interscience.
50. Lloyd, D., Aon, M. A., Cortassa, S. (2001) Why homeodynamics, not homeostasis? Scientific World Journal 1, 133-45.
51. Hackenbrock, C. R. (1968) Chemical and physical fixation of isolated mitochondria in low-energy and high-energy states. Proc Natl Acad Sci USA 61, 598-605.
52. Mannella, C. A., Pfeiffer, D. R., Bradshaw, P. C., Moraru, II, Slepchenko, B., Loew, L. M., Hsieh, C. E., Buttle, K., Marko, M. (2001) Topology of the mitochondrial inner membrane: dynamics and bioenergetic implications. IUBMB Life 52, 93-100.
53. Lloyd, D., Salgado, L. E., Turner, M. P., Suller, M. T., Murray, D. (2002) Cycles of mitochondrial energization driven by the ultradian clock in a continuous culture of Saccharomyces cerevisiae. Microbiology 148, 3715-24.
54. Rossignol, R., Gilkerson, R., Aggeler, R., Yamagata, K., Remington, S. J., Capaldi, R. A. (2004) Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res 64, 985-93.
55. Yi, M., Weaver, D., Hajnoczky, G. (2004) Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit. J Cell Biol 167, 661-72.
56. Anesti, V., Scorrano, L. (2006) The relationship between mitochondrial shape and function and the cytoskeleton. Biochim Biophys Acta 1757, 692-9.
57. Chen, H., Chan, D. C. (2006) Critical dependence of neurons on mitochondrial dynamics. Curr Opin Cell Biol 18, 453-9.
58. Twig, G., Graf, S. A., Wikstrom, J. D., Mohamed, H., Haigh, S. E., Elorza, A., Deutsch, M., Zurgil, N., Reynolds, N., Shirihai, O. S. (2006) Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP. Am J Physiol Cell Physiol 291, C176-84.
59. Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G. V., Rudka, T., Bartoli, D., Polishuck, R. S., Danial, N. N., De Strooper, B., Scorrano, L. (2006) OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 126, 177-89.
60. Cipolat, S., Martins de Brito, O., Dal Zilio, B., Scorrano, L. (2004) OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci USA 101, 15927-32.
61. Pich, S., Bach, D., Briones, P., Liesa, M., Camps, M., Testar, X., Palacin, M., Zorzano, A. (2005) The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum Mol Genet 14, 1405-15.
62. Youle, R. J., Karbowski, M. (2005) Mitochondrial fission in apoptosis. Nat Rev Mol Cell Biol 6, 657-63.
63. Bach, D., Naon, D., Pich, S., Soriano, F. X., Vega, N., Rieusset, J., Laville, M., Guillet, C., Boirie, Y., Wallberg-Henriksson, H., Manco, M., Calvani, M., Castagneto, M., Palacin, M., Mingrone, G., Zierath, J. R., Vidal, H., Zorzano, A. (2005) Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes 54, 2685-93.
64. Mitchell, P. (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature 191, 144-8.
65. Gunter, T. E., Pfeiffer, D. R. (1990) Mechanisms by which mitochondria transport calcium. Am J Physiol 258, C755-86.
66. O'Rourke, B. (2000) Pathophysiological and protective roles of mitochondrial ion channels. J Physiol 529 Pt 1, 23-36.
67. O'Rourke, B. (2004) Evidence for mitochondrial K+ channels and their role in cardioprotection. Circ Res 94, 420-32.
68. O'Rourke, B. (2006) Mitochondrial Ion Channels. Annu Rev Physiol.
69. Aon, M. A., Cortassa, S., Akar, F. G., O'Rourke, B. (2006) Mitochondrial criticality: A new concept at the turning point of life or death. Biochim Biophys Acta 1762, 232-40.
70. Palmieri, F. (2004) The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch 447, 689-709.
71. Balaban, R. S. (2002) Cardiac energy metabolism homeostasis: role of cytosolic calcium. J Mol Cell Cardiol 34, 1259-71.
72. Cortassa, S. C., Aon, M. A., O'Rourke, B., Jacques, R., Tseng, H. J., Marban, E., Winslow, R. L. (2006) A computational model integrating electrophysiology, contraction and mitochondrial bioenergetics in the ventricular myocyte. Biophys J. 91, 1564-89.
73. Saks, V., Dzeja, P., Schlattner, U., Vendelin, M., Terzic, A., Wallimann, T. (2006) Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. J Physiol 571, 253-73.
74. Babcock, D. F., Hille, B. (1998) Mitochondrial oversight of cellular Ca2+ signaling. Curr Opin Neurobiol 8, 398-404.
75. Mackenzie, L., Roderick, H. L., Berridge, M. J., Conway, S. J., Bootman, M. D. (2004) The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction. J Cell Sci 117, 6327-37.
76. Berridge, M. J., Bootman, M. D., Roderick, H. L. (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4, 517-29.
77. Meyer, T., Stryer, L. (1988) Molecular model for receptor-stimulated calcium spiking. Proc Natl Acad Sci USA 85, 5051-5.
78. Schuster, S., Marhl, M., Hofer, T. (2002) Modelling of simple and complex calcium oscillations. From single-cell responses to intercellular signalling. Eur J Biochem 269, 1333-55.
79. Marhl, M., Schuster, S., Brumen, M. (1998) Mitochondria as an important factor in the maintenance of constant amplitudes of cytosolic calcium oscillations. Biophys Chem 2, 125-32.
80. Hajnoczky, G., Robb-Gaspers, L. D., Seitz, M. B., Thomas, A. P. (1995) Decoding of cytosolic calcium oscillations in the mitochondria. Cell 82, 415-24.
81. Maack, C., Cortassa, S., Aon, M. A., Ganesan, A. N., Liu, T., O'Rourke, B. (2006) Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res. 99, 172-182.
82. Turrens, J. F. (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552, 335-44.
83. Cadenas, E. (2004) Mitochondrial free radical production and cell signaling. Mol Aspects Med 25, 17-26.
84. Droge, W. (2002) Free radicals in the physiological control of cell function. Physiol Rev 82, 47-95.
85. Haddad, J. J. (2004) Oxygen sensing and oxidant/redox-related pathways. Biochem Biophys Res Commun 316, 969-77.
86. Marin-Garcia, J., Goldenthal, M. J. (2004) Heart mitochondria signaling pathways: appraisal of an emerging field. J Mol Med 82, 565-78.
87. Morel, Y., Barouki, R. (1999) Repression of gene expression by oxidative stress. Biochem J 342 Pt 3, 481-96.
88. Storz, P. (2006) Reactive oxygen speciesmediated mitochondria-to-nucleus signaling: a key to aging and radicalcaused diseases. Sci STKE 2006, re3.
89. Finkel, T., Holbrook, N. J. (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-47.
90. Bao, J., Sato, K., Li, M., Gao, Y., Abid, R., Aird, W., Simons, M., Post, M. J. (2001) PR-39 and PR-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated I kappa B alpha degradation. Am J Physiol Heart Circ Physiol 281, H2612-8.
91. Kis, A., Yellon, D. M., Baxter, G. F. (2003) Role of nuclear factor-kappa B activation in acute ischaemiareperfusion injury in myocardium. Br J Pharmacol 138, 894-900.
92. Maulik, N., Goswami, S., Galang, N., Das, D. K. (1999) Regulation of cardiomyocyte apoptosis by redoxsensitive transcription factors. FEBS Lett 443, 331-6.
93. Misra, A., Haudek, S. B., Knuefermann, P., Vallejo, J. G., Chen, Z. J., Michael, L. H., Sivasubramanian, N., Olson, E. N., Entman, M. L., Mann, D. L. (2003) Nuclear factor-kappaB protects the adult cardiac myocyte against ischemiainduced apoptosis in a murine model of acute myocardial infarction. Circulation 108, 3075-8.
94. Sawa, Y., Morishita, R., Suzuki, K., Kagisaki, K., Kaneda, Y., Maeda, K., Kadoba, K., Matsuda, H. (1997) A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury. Circulation 96, II-280-4; discussion II-285.
95. Waris, G., Ahsan, H. (2006) Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog 5, 14.
96. Schroedl, C., McClintock, D. S., Budinger, G. R., Chandel, N. S. (2002) Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 283, L922-31.
97. Storz, P., Doppler, H., Toker, A. (2005) Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol 25, 8520-30.
98. Storz, P., Toker, A. (2003) Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. Embo J 22, 109-20.
99. Gopalakrishna, R., Anderson, W. B. (1989) Ca2+- and phospholipidindependent activation of protein kinase C by selective oxidative modification of the regulatory domain. Proc Natl Acad Sci USA 86, 6758-62.
100. Ono, Y., Fujii, T., Igarashi, K., Kuno, T., Tanaka, C., Kikkawa, U., Nishizuka, Y. (1989) Phorbol ester binding to protein kinase C requires a cysteine-rich zincfinger-like sequence. Proc Natl Acad Sci USA 86, 4868-71.
101. Quest, A. F., Bardes, E. S., Bell, R. M. (1994) A phorbol ester binding domain of protein kinase C gamma. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide. J Biol Chem 269, 2961-70.
102. Lloyd, D. (1998) Circadian and ultradian clock-controlled rhythms in unicellular microorganisms. Adv Microb Physiol 39, 291-338.
103. Editorial, B. (2000) Biological timing mechanisms: a thematic special issue for the new millennium. BioEssays 22, 1-2.
104. Edmunds, L. N., Jr. (1988) Cellular and molecular basis of biological clocks. Models and mechanisms for circadian timekeeping, Springer-Verlag, New York.
105. Sweeney, B. M., Hastings, J. W. (1960) Effects of temperature upon diurnal rhythms. Cold Spring Harb Symp Quant Biol 25, 87-104.
106. Schibler, U., Naef, F. (2005) Cellular oscillators: rhythmic gene expression and metabolism. Curr Opin Cell Biol 17, 223-9.
107. Cortassa, S., Aon, M. A., Winslow, R. L., O'Rourke, B. (2004) A mitochondrial oscillator dependent on reactive oxygen species. Biophys J 87, 2060-73.
108. Camello-Almaraz, M. C., Pozo, M. J., Murphy, M. P., Camello, P. J. (2006) Mitochondrial production of oxidants is necessary for physiological calcium oscillations. J Cell Physiol 206, 487-94.
109. Zorov, D. B., Filburn, C. R., Klotz, L. O., Zweier, J. L., Sollott, S. J. (2000) Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med 192, 1001-14.
110. Zorov, D. B., Juhaszova, M., Sollott, S. J. (2006) Mitochondrial ROS-induced ROS release: An update and review. Biochim Biophys Acta 1757, 509-17.
111. Winfree, A. T. (1967) Biological rhythms and the behavior of populations of coupled oscillators. J Theor Biol 16, 15-42.
112. Kuramoto, Y. (1984) Chemical oscillations, waves, and turbulence, Springer-Verlag, Berlin.
113. Strogatz, S. H. (2000) From Kuramoto to Crawford: exploring the onset of synchronization in population of coupled oscillators. Physica D 143, 1-20.
114. Strogatz, S. H. (2003) Sync. The emerging science of spontaneous order, Hyperion books, New York.
115. Aon, M. A., Cortassa, S., O'Rourke, B. (2006) The fundamental organization of cardiac mitochondria as a network of coupled oscillators. Biophys J 91, 4317-27.
116. Crompton, M. (1999) The mitochondrial permeability transition pore and its role in cell death. Biochem J 341 (Pt 2), 233-49.
117. Duchen, M. R. (1999) Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J Physiol 516 (Pt 1), 1-17.
118. Huser, J., Blatter, L. A. (1999) Fluctuations in mitochondrial membrane potential caused by repetitive gating of the permeability transition pore. Biochem J 343 Pt 2, 311-7.
119. Ichas, F., Jouaville, L. S., Mazat, J. P. (1997) Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 89, 1145-53.
120. Siemens, A., Walter, R., Liaw, L. H., Berns, M. W. (1982) Laser-stimulated fluorescence of submicrometer regions within single mitochondria of rhodamine-treated myocardial cells in culture. Proc Natl Acad Sci USA 79, 466-70.
121. West, B. J. (1999) Physiology, promiscuity and prophecy at The Millennium: A tale of tails, Vol. 7, World Scientific, Singapore.
122. West, B. J., Deering, B. (1995) The Lure of Modern Science. Fractal Thinking, Vol. 3, World Scientific, Singapore.
123. O'Rourke, B., Ramza, B. M., Marban, E. (1994) Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells. Science 265, 962-6.
124. Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., Sheu, S. S. (2004) Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol 287, C817-33.
125. Harman, D. (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11, 298-300.
126. Mathews, C. K., van Holde, K. E., Ahern, K. G. (2000) Biochemistry, Addison Wesley Longman, Inc., San Francisco, CA.
127. Nelson, D. L., Cox, M. M. (2005) Lehninger principles of biochemistry, Fourth ed., W.H. Freeman, New York.
128. Hunter, G. R., Kamishima, Y., Brierley, G. P. (1969) Ion transport by heart mitochondria. XV. Morphological changes associated with the penetration of solutes into isolated heart mitochondria. Biochim Biophys Acta 180, 81-97.
129. Stoner, C. D., Sirak, H. D. (1969) Osmotically-induced alterations in volume and ultrastructure of mitochondria isolated from rat liver and bovine heart. J Cell Biol 43, 521-38.