Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat

Physiological Genomics

Volumn 35, Issue 1, 2008, Pages 96-105

  Fuse, Masanori ^a   Yokoi, Norihide ^a   Shinohara, Masami ^b   Masuyama, Taku ^c   Kitazawa, Riko ^a   Kitazawa, Sohei ^a   Seino, Susumu ^a,d  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b CLEA Japan Inc   (Japan)

^c JAPAN TOBACCO INC   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Congenic analysis; Diabetes; Genetic factor; Glucose tolerance; Quantitative trait locus

Indexed keywords

GLUCOSE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 3; CONGENIC STRAIN; CONTROLLED STUDY; CYSTIC FIBROSIS; DIABETES MELLITUS; FEMALE; GENE IDENTIFICATION; GENE LOCUS; GENETIC ANALYSIS; GENETICS; GLUCOSE TOLERANCE; HEREDITY; HISTOLOGY; INTROSPECTION; MALE; NONHUMAN; PANCREAS; PANCREAS ISLET CELL; PANCREATITIS; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RAT; ANIMAL; CHROMOSOME; DISEASE MODEL; FIBROSIS; FISCHER 344 RAT; PANCREAS ISLET; PATHOLOGY; PHENOTYPE; RAT STRAIN;

RATTUS;

ALLELES; ANIMALS; CHROMOSOMES, MAMMALIAN; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; ISLETS OF LANGERHANS; MALE; PANCREATITIS; PHENOTYPE; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED F344; RATS, INBRED STRAINS;

EID: 56149102255     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.90214.2008     Document Type: Article

References (51)

1. Bilusic M, Bataillard A, Tschannen MR, Gao L, Barreto NE, Vincent M, Wang T, Jacob HJ, Sassard J, Kwitek AE. Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the Lyon hypertensive rat. Hypertension 44: 695-701, 2004.
2. Chua S Jr, Liu SM, Li Q, Yang L, Thassanapaff VT, Fisher P. Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB-Lepr (db)) and obese (DBALep (ob)) mice. Diabetologia 45: 976-990, 2002.
3. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics 138: 963-971, 1994.
4. Clark A, Nilsson MR. Islet amyloid: a complication of islet dysfunction or an aetiological factor in type 2 diabetes? Diabetologia 47: 157-169, 2004.
5. Clee SM, Attie AD. The genetic landscape of type 2 diabetes in mice. Endocr Rev 28: 48-83, 2007.
6. Fridlyand LE, Philipson LH. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells? Diabetes 53: 1942-1948, 2004.
7. Fridlyand LE, Philipson LH. Reactive species and early manifestation of insulin resistance in type 2 diabetes. Diabetes Obes Metab 8: 136-145, 2006.
8. Gauguier D, Froguel P, Parent V, Bernard C, Bihoreau MT, Portha B, James MR, Penicaud L, Lathrop M, Ktorza A. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 12: 38-43, 1996.
9. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38: 320-323, 2006.
10. Haley CS, Knott SA. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69: 315-324, 1992.
11. Helgason A, Pálsson S, Thorleifsson G, Grant SF, Emilsson V, Gunnarsdottir S, Adeyemo A, Chen Y, Chen G, Reynisdottir I, Benediktsson R, Hinney A, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Schäfer H, Faruque M, Doumatey A, Zhou J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Sigurdsson G, Hebebrand J, Pedersen O, Thorsteinsdottir U, Gulcher JR, Kong A, Rotimi C, Stefánsson K. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39: 218-225, 2007.
12. Homo-Delarche F, Calderari S, Irminger JC, Gangnerau MN, Coulaud J, Rickenbach K, Dolz M, Halban P, Portha B, Serradas P. Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat. Diabetes 55: 1625-33, 2006.
13. Ishikawa A, Kim EH, Bolor H, Mollah MB, Namikawa T. A growth QTL (Pbwg1) region of mouse chromosome 2 contains closely linked loci affecting growth and body composition. Mamm Genome 18: 229-239, 2007.
14. Iwata I, Nagafuchi S, Nakashima H, Kondo S, Koga T, Yokogawa Y, Akashi T, Shibuya T, Umeno Y, Okeda T, Shibata S, Kono S, Yasunami M, Ohkubo H, Niho Y. Association of polymorphism in the NeuroD/BETA2 gene with type 1 diabetes in the Japanese. Diabetes 48: 416-419, 1999.
15. Kakehashi A, Saito Y, Mori K, Sugi N, Ono R, Yamagami H, Shinohara M, Tamemoto H, Ishikawa SE, Kawakami M, Kanazawa Y. Characteristics of diabetic retinopathy in SDT rats. Diabetes Metab Res Rev 22: 455-461, 2006.
16. Ko SH, Kwon HS, Kim SR, Moon SD, Ahn YB, Song KH, Son HS, Cha BY, Lee KW, Son HY, Kang SK, Park CG, Lee IK, Yoon KH. Ramipril treatment suppresses islet fibrosis in Otsuka Long-Evans Tokushima fatty rats. Biochem Biophys Res Commun 316: 114-122, 2004.
17. Kolb H, Mandrup-Poulsen T. An immune origin of type 2 diabetes? Diabetologia 48: 1038-1050, 2005.
18. Kose H, Moralejo DH, Ogino T, Mizuno A, Yamada T, Matsumoto K. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Mamm Genome 13: 558-562, 2002.
19. Kovács P, van den Brandt J, Klöting I. Genetic dissection of the syndrome X in the rat. Biochem Biophys Res Commun 24: 660-665, 2000.
20. Kristinsson SY, Thorolfsdottir ET, Talseth B, Steingrimsson E, Thorsson AV, Helgason T, Hreidarsson AB, Arngrimsson R. MODY in Iceland is associated with mutations in HNF-1alpha and a novel mutation in NeuroD1. Diabetologia 44: 2098-2103, 2001.
21. Lander ES, Botstein D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199, 1989.
22. Larade K, Jiang ZG, Dejam A, Zhu H, Bunn HF. The reductase NCB5OR is responsive to the redox status in beta-cells and is not involved in the ER stress response. Biochem J 404: 467-476, 2007.
23. Lynch M, Walsh B. Mapping and characterizing QTLs: inbred line crosses. In: Genetics and Analysis of Quantitative Traits. Sunderland, MA: Sinauer, 1997, p. 431-489.
24. Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet 23: 323-328, 1999.
25. Manly KF, Cudmore RH Jr, Meer JM. Map Manager QTX, crossplatform software for genetic mapping. Mamm Genome 12: 930-932, 2001.
26. Masuyama T, Fuse M, Yokoi N, Shinohara M, Tsujii H, Kanazawa M, Kanazawa Y, Komeda K, Taniguchi K. Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat. Biochem Biophys Res Commun 304: 196-206, 2003.
27. Masuyama T, Komeda K, Hara A, Noda M, Shinohara M, Oikawa T, Kanazawa Y, Taniguchi K. Chronological characterization of diabetes development in male Spontaneously Diabetic Torii rats. Biochem Biophys Res Commun 314: 870-877, 2004.
28. Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11: 2323-2334, 1997.
29. Nishi M, Sasahara M, Shono T, Saika S, Yamamoto Y, Ohkawa K, Furuta H, Nakao T, Sasaki H, Nanjo K. A case of novel de novo paired box gene 6 (PAX6) mutation with early-onset diabetes mellitus and aniridia. Diabet Med 22: 641-644, 2005.
30. Ogino T, Wei S, Wei K, Moralejo DH, Kose H, Mizuno A, Shima K, Sasaki Y, Yamada T, Matsumoto K. Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF. Genomics 70: 19-25, 2000.
31. Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 109: 525-532, 2002.
32. Peters LL, Zhang W, Lambert AJ, Brugnara C, Churchill GA, Platt OS. Quantitative trait loci for base-line white blood cell count, platelet count, and mean platelet volume. Mamm Genome 16: 749-763, 2005.
33. Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes 47: 358-364, 1998.
34. Sander M, Neubüser A, Kalamaras J, Ee HC, Martin GR, German MS. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 11: 1662-1673, 1997.
35. Shimada K, Ito T, Tanemura M, Komoda H, Fumimoto Y, Kawamoto K, Nishida T, Kaneto H, Sawa Y. Development of beta-cells in the native pancreas after pancreas allo-transplantation in the Spontaneously Diabetic Torii rat. J Surg Res 145: 229-237, 2008.
36. Shimada K, Ito T, Miao G, Tanemura M, Komoda H, Fumimoto Y, Kawamoto K, Nishida T, Kaneto H, Sawa Y. Regeneration of beta cells in the native pancreata after syngeneic and allogeneic pancreas transplantations in spontaneously type 2 diabetic Torii rats. Transplant Proc 40: 438-440, 2008.
37. Shinohara M, Masuyama T, Shoda T, Takahashi T, Katsuda Y, Komeda K, Kuroki M, Kakehashi A, Kanazawa Y. A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications. Int J Exp Diabetes Res 1: 89-100, 2000.
38. Shinohara M, Masuyama T, Kakehashi A. The Spontaneously Diabetic Torii (SDT) rat with retinopathy lesions resembling those of humans. In: Animal Models of Diabetes: Frontiers in Research (2nd ed.), edited by Shafrir E. New York: Taylor and Francis, 2006, p. 311-321.
39. Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. A genomic-systems biology map for cardiovascular function. Science 294: 1723-1726, 2001.
40. Sund NJ, Vatamaniuk MZ, Casey M, Ang SL, Magnuson MA, Stoffers DA, Matschinsky FM, Kaestner KH. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes Dev 15: 1706-1715, 2001.
41. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 125: 2213-2221, 1998.
42. Vingsbo-Lundberg C, Nordquist N, Olofsson P, Sundvall M, Saxne T, Pettersson U, Holmdahl R. Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats. Nat Genet 20: 401-404, 1998.
43. Wakeland E, Morel L, Achey K, Yui M, Longmate J. Speed congenics: a classic technique in the fast lane (relatively speaking). Immunol Today 18: 472-477, 1997.
44. Watanabe TK, Okuno S, Oga K, Mizoguchi-Miyakita A, Tsuji A, Yamasaki Y, Hishigaki H, Kanemoto N, Takagi T, Takahashi E, Irie Y, Nakamura Y, Tanigami A. Genetic dissection of "OLETF," a rat model for non-insulin-dependent diabetes mellitus: quantitative trait locus analysis of (OLETF X BN) X OLETF. Genomics 58: 233-239, 1999.
45. Wei S, Wei K, Moralejo DH, Ogino T, Koike G, Jacob HJ, Sugiura K, Sasaki Y, Yamada T, Matsumoto K. Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Mamm Genome 10: 249-258, 1999.
46. Wester L, Olofsson P, Ibrahim SM, Holmdahl R. Chronicity of pristane-induced arthritis in rats is controlled by genes on chromosome 14. J Autoimmun 21: 305-313, 2003.
47. Xie J, Zhu H, Larade K, Ladoux A, Seguritan A, Chu M, Ito S, Bronson RT, Leiter EH, Zhang CY, Rosen ED, Bunn HF. Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. Proc Natl Acad Sci USA 101: 10750-10755, 2004.
48. Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 384: 458-460, 1996.
49. Yasuda T, Kajimoto Y, Fujitani Y, Watada H, Yamamoto S, Watarai T, Umayahara Y, Matsuhisa M, Gorogawa S, Kuwayama Y, Tano Y, Yamasaki Y, Hori M. PAX6 mutation as a genetic factor common to aniridia and glucose intolerance. Diabetes 51: 224-230, 2002.
50. Yokoi N, Hayashi C, Fujiwara Y, Wang HY, Seino S. Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat. Diabetes 56: 506-512, 2007.
51. Zhu Q, Yamagata K, Yu L, Tomura H, Yamada S, Yang Q, Yoshiuchi I, Sumi S, Miyagawa J, Takeda J, Hanafusa T, Matsuzawa Y. Identification of missense mutations in the hepatocyte nuclear factor-3beta gene in Japanese subjects with late-onset Type II diabetes mellitus. Diabetologia 43: 197-200, 2000.