Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats

Nature Genetics

Volumn 20, Issue 4, 1998, Pages 401-404

  Vingsbo Lundberg, Carina ^a   Nordquist, Niklas ^b   Olofsson, Peter ^a   Sundvall, Mats ^b   Saxne, Tore ^a   Pettersson, Ulf ^b   Holmdahl, Rikard ^a  

^a LUND UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 4; CHROMOSOME 6; CONTROLLED STUDY; GENETIC ANALYSIS; GENETIC RECOMBINATION; GENETIC REGULATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; IMMUNOGENICITY; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PENETRANCE; PRIORITY JOURNAL; PROGENY; RAT; RHEUMATOID ARTHRITIS;

ANIMALS; ARTHRITIS, RHEUMATOID; CHROMOSOME MAPPING; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FEMALE; MALE; PHENOTYPE; RATS; SEVERITY OF ILLNESS INDEX;

EID: 0031772326     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/3887     Document Type: Article

References (17)

1. Silman, A.J. et al. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br. J. Rheumatol. 32, 903-907 (1993).
2. Wordsworth, P. & Bell, J. Polygenic susceptibility in rheumatoid arthritis. Ann. Rheum. Dis. 50, 343-346 (1991).
3. Wordsworth, P. et al. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis.-Am. J. Hum. Genet. 51, 585-591 (1992).
4. Gough, A. et al. Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome. Arthritis Rheum. 37, 1166-1170 (1994).
5. Månsson, B. et al. Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism. J. Clin. Invest. 95, 1071-1077 (1995).
6. Vingsbo, C. et al. Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes. Am. J. Pathol. 149, 1675-1683 (1996).
7. Remmers, E.F. et al. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Nature Genet. 14, 82-85 (1996).
8. Jacob, H.J. et al. Genetic dissection of autoimmune type 1 diabetes in the BB rat. Nature Genet. 2, 56-60 (1992).
9. Pettersson, A. et al. Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes. J. Autoimmun. 8, 493-505 (1995).
10. Holmdahl, R. et al. Genetic analysis of murine models for rheumatoid arthritis, in Human Genome Methods (ed. Adolpho, K.W.) 215-238 (CRC press, New York, 1998).
11. Vingsbo-Lundberg, C., Saxne, T., Olsson, H. & Holmdahl, R. Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats. Arthritis Rheum. 41, 544-550 (1998).
12. Lincoln, S., Daly, M. & Lander, E. Constructing genetic maps with MAPMAKER/EXP 3.0. Whitehead Institute Technical Report (1992).
13. Lincoln, S., Daly, M. & Lander, E. Mapping genes controlling quantitative traits with MAPMAKER/QTL 1.1. Whitehead Institute Technical Report (1992).
14. Paterson, A.M. et al. Resolution of quantitative traits into mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature 335, 721-726 (1988).
15. Lander, E.S. et al. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1, 174-181 (1987).
16. Lander, E.S. & Kruglyak, L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet. 11, 241-247 (1996).
17. Lorentzen, J.C. et al. Identification of rat susceptibility loci for adjuvant-oil induced arthritis. Proc. Natl Acad. Sci. USA 95, 6383-6387 (1998).