Differential beta cell responses to hyperglycaemia and insulin resistance in two novel congenic strains of diabetes (FVB-Leprdb) and obese (DBA-Lepob) mice

Diabetologia

Volumn 45, Issue 7, 2002, Pages 976-990

  Chua, S ^a   Mei Liu, S ^b   Li, Q ^b   Yang, L ^b   Thassanapaff, V ^b   Fisher, P ^b  

^a Columbia University ^*  (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Genetic modifiers; Leptin receptor; Obesity; Type II diabetes mellitus

Indexed keywords

GLUCOSE; INSULIN; LEPTIN;

ANIMAL EXPERIMENT; ARTICLE; CONGENIC STRAIN; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; GENETIC REGULATION; GENETIC VARIABILITY; HISTOLOGY; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; KIDNEY; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; ANIMAL; BLOOD; C57BL MOUSE; COMPARATIVE STUDY; CROSS BREEDING; DBA MOUSE; FEMALE; GLOMERULUS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; MALE; METABOLISM; MOUSE MUTANT; PANCREAS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SEXUAL DEVELOPMENT; SPECIES DIFFERENCE;

ANIMAL; BLOOD GLUCOSE; COMPARATIVE STUDY; CROSSES, GENETIC; FEMALE; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; KIDNEY; KIDNEY GLOMERULUS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, MUTANT STRAINS; MICE, OBESE; PANCREAS; SEX CHARACTERISTICS; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS;

EID: 0036318533     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0880-z     Document Type: Article

References (46)

1. Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
2. A new mutation (db3 J) at the diabetes locus in strain 129/J mice. I. Physiological and histological characterization
3. Diabetes, a new mutation in the mouse
4. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. III. Effect of H-2 haplotype and sex
5. A new genetically obese-hyperglycemic rat (Wistar fatty)
6. Altered expression of muscle glucose transporter GLUT-4 in diabetic fatty Zucker rats (ZDF/Drt-fa)
7. Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia
8. Effect of dietary sucrose on the SHR/N-corpulent rat: A new model for insulin-independent diabetes
9. Hormonal and lipogenic and gluconeogenic enzymatic responses in LA/N-corpulent rats
10. Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice
11. Dietary control of pathogenesis in C57BL/KsJ db/db diabetes mice
12. Obesity and diabetes in TNF-alpha receptor-deficient mice
13. Polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) and electrophoretic assays for the mouse obese (Lepob) mutation
14. Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene
15. Development of hyperglycaemia and insulin resistance in conscious genetically diabetic (C57BL/KsJ-db/db) mice
16. Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans
17. AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
18. FVB/N: An inbred mouse strain preferable for transgenic analyses
19. Studies with crystalline insulin from obese and lean mice of the BL/6J strain
20. Monogenic models of obesity
21. OB protein: A peripheral signal linking adiposity and central neural networks
22. In vivo modulation of Hmgic reduces obesity
23. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
24. Thermogenesis in diabetes-obesity syndromes in mutant mice
25. Effect of the genetic background on the reproduction of leptin-deficient obese mice
26. Therapeutic effects of dehydroepiandrosterone metabolites in diabetes mutant mice (C57BL/KsJ-db/db)
27. Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4)
28. Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse
29. Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice
30. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
31. Life without white fat: A transgenic mouse
32. Spontaneous mutation in the db gene results in obesity and diabetes in CD-1 outbred mice
33. Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion
34. Diabetes mellitus and genetically programmed defects in beta-cell function
35. Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus
36. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling
37. High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: A potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
38. Antecedent hyperglycemia, not hyperlipidemia, is associated with increased islet triacylglycerol content and decreased insulin gene mRNA level in Zucker diabetic fatty rats
39. OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype
40. Genomic analysis of the C57BL/Ks mouse strain
41. The influence of genetic background on the expression of mutations at the diabetes locus in the mouse IV. Male lethal syndrome in CBA/Lt mice
42. Beta-cell adaptation and decompensation during the progression of diabetes
43. Beta-cell turnover: Its assessment and implications
44. The inheritance of glomerulosclerosis in mice is controlled by multiple quantitative trait loci
45. Nature and severity of the glomerular response to nephron reduction is strain-dependent in mice
46. Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice