Cough sensors. V. Pharmacological modulation of cough sensors

Handbook of Experimental Pharmacology

Volumn 187, Issue , 2009, Pages 99-127

  Mazzone, S B ^a   Undem, B J ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE TRIPHOSPHATE; BRADYKININ; BRADYKININ B2 RECEPTOR; CAPSAICIN; CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; HISTAMINE; HISTAMINE H1 RECEPTOR; LIPOXYGENASE; LOCAL ANESTHETIC AGENT; LOOP DIURETIC AGENT; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ DERIVATIVE; NICOTINE; NOCICEPTIN; OPIATE DERIVATIVE; OUABAIN; PEPTIDOLEUKOTRIENE; PROSTAGLANDIN E2; PURINERGIC P2X RECEPTOR; SEROTONIN; SEROTONIN 3 RECEPTOR; THROMBIN; UNINDEXED DRUG; VANILLOID RECEPTOR 1; ANTITUSSIVE AGENT;

BRONCHUS; COUGHING; HUMAN; MECHANICAL STIMULATION; MECHANORECEPTOR; NONHUMAN; PRIORITY JOURNAL; REVIEW; SENSORY NERVE; TRACHEA; ANIMAL; DRUG EFFECT; MYELINATED NERVE; NONMYELINATED NERVE; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSORY NERVE CELL;

ANIMALS; ANTITUSSIVE AGENTS; COUGH; HUMANS; NERVE FIBERS, MYELINATED; NERVE FIBERS, UNMYELINATED; NEURONS, AFFERENT;

EID: 56049125283     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-79842-2_6     Document Type: Review

References (148)

1. Adcock JJ, Douglas GJ, Garabette M, Gascoigne M, Beatch G, Walker M, Page CP (2003) RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br J Pharmacol138(3):407-16
2. Adcock JJ, Schneider C, Smith TW (1988) Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea-pig. Br J Pharmacol 93(1):93-100
3. Babes A, Zorzon D, Reid G (2004) Two populations of cold-sensitive neurons in rat dorsal root ganglia and their modulation by nerve growth factor. Eur J Neurosci 20(9):2276-82
4. Baker CVH (2005) The embryology of vagal sensory neurons. In: Undem BJ, Weinreich D (eds) Advances in vagal afferent neurobiology. Taylor and Francis, Florida
5. Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41(6):849-57
6. Barnes NC, Piper PJ, Costello JF (1984) Comparative effects of inhaled leukotriene C4, leukotriene D4, and histamine in normal human subjects. Thorax 39(7):500-4
7. Basoglu OK, Pelleg A, Essilfie-Quaye S, Brindicci C, Barnes PJ, Kharitonov SA (2005) Effects of aerosolized adenosine 5--triphosphate vs. adenosine 5--monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma. Chest 128(4):1905-9
8. Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D (2006) TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124(6):1269-82
9. Belvisi MG, Rogers DF, Barnes PJ (1989) Neurogenic plasma extravasation: inhibition by morphine in guinea pig airways in vivo. J Appl Physiol 66(1):268-72
10. Belvisi MG, Chung KF, Jackson DM, Barnes PJ (1988) Opioid modulation of non-cholinergic neural bronchoconstriction in guinea-pig in vivo. Br J Pharmacol 95(2):413-18
11. Bergren DR (2006) Prostaglandin involvement in lung C-fiber activation by substance P in guinea pigs. J Appl Physiol 100(6):1918-27
12. Bergren DR (1997) Sensory receptor activation by mediators of defense reflexes in guinea-pig lungs. Respir Physiol 108(3):195-204
13. Bergren DR, Sampson SR (1982) Characterization of intrapulmonary, rapidly adapting receptors of guinea pigs. Respir Physiol 47(1):83-95
14. Bolser DC, McLeod RL, Tulshian DB, Hey JA (2001) Antitussive action of nociceptin in the cat. Eur J Pharmacol 430(1):107-11
15. Bolser DC, DeGennaro FC, O'Reilly S, Hey JA, Chapman RW (1995) Pharmacological studies ofallergic cough in the guinea pig. Eur J Pharmacol 277(2-3):159-64
16. Bonham AC, Kott KS, Ravi K, Kappagoda CT, Joad JP (1996) Substance P contributes to rapidly adapting receptor responses to pulmonary venous congestion in rabbits. J Physiol 493 (Part 1): 229-38
17. Brouns I, Pintelon I, De Proost I, Alewaters R, Timmermans JP, Adriaensen D (2006) Neurochemical characterisation of sensory receptors in airway smooth muscle: comparison with pulmonary neuroepithelial bodies. Histochem Cell Biol 125(4):351-67
18. Brozmanova M, Plevkova J, Bartos V, Plank L, Tatar M (2005) Antileukotriene treatment and allergic rhinitis-related cough in guinea pigs. J Physiol Pharmacol 56 (Suppl 4):21-30
19. Burki NK, Dale WJ, Lee LY (2005) Intravenous adenosine and dyspnea in humans. J Appl Physiol98(1):180-5
20. Callaway JK, King RG, Boura AL (1991) Evidence for peripheral mechanisms mediating the antitussiveactions of opioids in the guinea pig. Gen Pharmacol 22(6):1103-8
21. Canning BJ, Farmer DG, Mori N (2006) Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 291(2):R454-R463
22. Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ (2004a) Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 557(Part 2):543-58
23. +-ATPase in regulating cough receptor activation in guinea pigs. Am J Respir Crit Care Med 169(7):A799
24. Canning BJ, Reynolds SM, Mazzone SB (2001) Multiple mechanisms of reflex bronchospasm in guinea pigs. J Appl Physiol 91(6):2642-53
25. Carr MJ (2006) Influence of mexiletine on action potential discharge and conduction in nodose Adelta afferent neurons innervating guinea pig isolated trachea. Pulm Pharmacol Ther 19(4):258-63
26. Carr MJ, Kollarik M, Meeker SN, Undem BJ (2003) A role for TRPV1 in bradykinin-induced excitation of vagal airway afferent nerve terminals. J Pharmacol Exp Ther 304(3):1275-9
27. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389(6653):816-24
28. Chapleau MW, Lu J, Hajduczok G, Abboud FM (1993) Mechanism of baroreceptor adaptation in dogs: attenuation of adaptation by the K+ channel blocker 4-aminopyridine. J Physiol 462:291-306
29. Chizh BA, Illes P (2001) P2X receptors and nociception. Pharmacol Rev 53(4):553-68
30. Choudry NB, Fuller RW, Pride NB (1989) Sensitivity of the human cough reflex: effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine. Am Rev Respir Dis 140(1):137-41
31. Chuang HH, Prescott ED, Kong H, Shields S, Jordt SE, Basbaum AI, Chao MV, Julius D (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411(6840):957-62
32. Chuaychoo B, LeeMG, Kollarik M, Pullmann R Jr, Undem BJ (2006) Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs. J Physiol575(Part 2):481-90
33. Chuaychoo B, Lee MG, Kollarik M, Undem BJ (2005) Effect of 5-hydroxytryptamine on vagal C-fiber subtypes in guinea pig lungs. Pulm Pharmacol Ther 18(4):269-76
34. Cliff MA, Green BG (1994) Sensory irritation and coolness produced by menthol: evidence for selective desensitization of irritation. Physiol Behav 56(5):1021-9
35. Cockayne DA, Dunn PM, Zhong Y, Rong W, Hamilton SG, Knight GE, Ruan HZ, Ma B, Yip P, Nunn P, McMahon SB, Burnstock G, Ford AP (2005) P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol 567Part 2):621-39
36. Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton JR, Moffatt JD (1999)A protective role for protease-activated receptors in the airways. Nature 398(6723):156-60
37. Coleridge HM, Coleridge JC, Schultz HD (1989) Afferent pathways involved in reflex regulation of airway smooth muscle. Pharmacol Ther 42(1):1-63
38. Coleridge HM, Coleridge JC, Ginzel KH, Baker DG, Banzett RB, Morrison MA (1976) Stimulation of 'irritant' receptors and afferent C-fibres in the lungs by prostaglandins. Nature 264(5585):451-3
39. Coleridge JC, Coleridge HM (1984) Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev Physiol Biochem Pharmacol 99:1-110
40. Corboz MR, Rivelli MA, Egan RW, Tulshian D, Matasi J, Fawzi AB, Benbow L, Smith-Torhan A, Zhang H, Hey JA (2000) Nociceptin inhibits capsaicin-induced bronchoconstriction in isolated guinea pig lung. Eur J Pharmacol 402(1-2):171-9
41. D'Agostino B, Marrocco G, De Nardo M, Calo G, Guerrini R, Gallelli L, Advenier C, Rossi F (2005) Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction andmicrovascular leakage in a rabbit model of gastroesophageal reflux. Br J Pharmacol 144(6):813-20
42. Dicpinigaitis PV, Dobkin JB, Reichel J (2002) Antitussive effect of the leukotriene receptor antagonist zafirlukast in subjects with cough-variant asthma. J Asthma 39(4):291-7
43. Ding YQ, Li JL, Lu BZ, Wang D, Zhang ML, Li JS (1998) Co-localization of mu-opioid receptorlike immunoreactivity with substance P-LI, calcitonin gene-related peptide-LI and nitric oxide synthase-LI in vagal and glossopharyngeal afferent neurons of the rat. Brain Res 792(1):149-53
44. Dobretsov M, Hastings SL, Sims TJ, Stimers JR, Romanovsky D (2003) Stretch receptorassociated expression of alpha 3 isoform of the Na+, K+-ATPase in rat peripheral nervous system. Neuroscience 116(4):1069-80
45. Doerner JF, Gisselmann G, Hatt H, Wetzel CH (2007) Transient receptor potential channel A1 is directly gated by calcium ions. J Biol Chem 282(18):13180-9
46. Fischer A, Forssmann WG, Undem BJ (1998) Nociceptin-induced inhibition of tachykinergic neurotransmission in guinea pig bronchus. J Pharmacol Exp Ther 285(2):902-7
47. Fowler JC,Wonderlin WF,Weinreich D (1985) Prostaglandins block a Ca2+-dependent slow spike after hyperpolarization independent of effects on Ca2+ influx in visceral afferent neurons. Brain Res 345(2):345-9
48. Fox AJ, Urban L, Barnes PJ, Dray A (1995a) Effects of capsazepine against capsaicin- and protonevoked excitation of single airway C-fibres and vagus nerve from the guinea-pig. Neuroscience 67(3):741-52
49. Fox AJ, Barnes PJ, Dray A (1995b) Stimulation of guinea-pig tracheal afferent fibres by nonisosmotic and low-chloride stimuli and the effect of frusemide. J Physiol 482(Part 1):179-87
50. Fox AJ, Barnes PJ, Urban L, Dray A (1993) An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J Physiol 469:21-35
51. Franova S (2001) The influence of inhaled furosemide on adverse effects of ACE-inhibitors inairways. Bratisl Lek Listy 102(7):309-13
52. Gatti R, Andre E, Amadesi S, Dinh TQ, Fischer A, Bunnett NW, Harrison S, Geppetti P,Trevisani M (2006) Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs. J Appl Physiol 101(2):506-11
53. Green BG, McAuliffe BL (2000) Menthol desensitization of capsaicin irritation. Evidence of a short-term anti-nociceptive effect. Physiol Behav 68(5):631-9
54. Gu Q, Lee LY (2006) Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease-activated receptor-2 in rats. J Physiol 574(Part 3):867-76
55. Gu Q, Lee LY (2005) Sensitization of pulmonary chemosensitive neurons by bombesin-like peptidesin rats. Am J Physiol Lung Cell Mol Physiol 289(6):L1104-L1112
56. Hamra M, McNeil RS, Runciman M, Kunze DL (1999) Opioid modulation of calcium currentin cultured sensory neurons: mu-modulation of baroreceptor input. Am J Physiol 277(2, Part 2):H705-H713
57. Hargreaves KM, Roszkowski MT, Swift JQ (1993) Bradykinin and inflammatory pain. Agents Actions Suppl 41:65-73
58. Ho CY, Gu Q, Lin YS, Lee LY (2001) Sensitivity of vagal afferent endings to chemical irritants in the rat lung. Respir Physiol 127(2-3):113-24
59. Ho CY, Gu Q, Hong JL, Lee LY (2000) Prostaglandin E(2) enhances chemical and mechanical sensitivities of pulmonary C fibers in the rat. Am J Respir Crit Care Med 162(2, Part 1):528-33
60. Hong JL, Ho CY, Kwong K, Lee LY (1998) Activation of pulmonary C fibres by adenosine in anaesthetized rats: role of adenosine A1 receptors. J Physiol 508(Part 1):109-18
61. Hong JL, Kwong K, Lee LY (1997) Stimulation of pulmonary C fibres by lactic acid in rats:contributions of H+ and lactate ions. J Physiol 500(Part 2):319-29
62. Horiuchi H, Nonaka T, Ito M, Kaniwa T, Kishimoto T, Fuchikami J, Kohjimoto Y, Kiyoki M (1995) Suppressive effect of clenbuterol on citric acid-induced cough reflex in guinea pigs. Res Commun Mol Pathol Pharmacol 88(3):293-301
63. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46(2):157-203
64. Hwang SW, Cho H, Kwak J, Lee SY, Kang CJ, Jung J, Cho S, Min KH, Suh YG, Kim D, OhU (2000) Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci USA 97(11):6155-60
65. Ingram SL, Williams JT (1996) Modulation of the hyperpolarization- activated current (Ih) by cyclic nucleotides in guinea-pig primary afferent neurons. J Physiol 492(Part 1):97-106
66. Jafri MS, Weinreich D (1998) Substance P regulates Ih via a NK-1 receptor in vagal sensory neurons of the ferret. J Neurophysiol 79(2):769-77
67. Jafri MS, Moore KA, Taylor GE, Weinreich D (1997) Histamine H1 receptor activation blocks two classes of potassium current, IK(rest) and IAHP, to excite ferret vagal afferents. J Physiol 503(Part 3):533-46
68. Jia Y,Wang X, Aponte SI, Rivelli MA, Yang R, Rizzo CA, Corboz MR, Priestley T, Hey JA (2002) Nociceptin/orphanin FQ inhibits capsaicin-induced guinea-pig airway contraction through an inward-rectifier potassium channel. Br J Pharmacol 135(3):764-70
69. Jonzon A, Pisarri TE, Coleridge JC, Coleridge HM (1986) Rapidly adapting receptor activity in dogs is inversely related to lung compliance. J Appl Physiol 61(5):1980-7
70. Joos G, Pauwels R, van der Straeten M (1987) Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax 42(10):779-83
71. Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Hogestatt ED, Meng ID, Julius D (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427(6971):260-5
72. Kajekar R, Proud D, Myers AC, Meeker SN, Undem BJ (1999) Characterization of vagal afferent subtypes stimulated by bradykinin in guinea pig trachea. J Pharmacol Exp Ther 289(2):682-7
73. Kamei J, Takahashi Y (2006) Involvement of ionotropic purinergic receptors in the histamineinduced enhancement of the cough reflex sensitivity in guinea pigs. Eur J Pharmacol 547(1-3): 160-4
74. Kamei J, Takahashi Y, Yoshikawa Y, Saitoh A (2005) Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity. Eur J Pharmacol 528(1-3):158-61
75. Karla W, Shams H, Orr JA, Scheid P (1992) Effects of the thromboxane A2 mimetic, U46,619, on pulmonary vagal afferents in the cat. Respir Physiol 87(3):383-96
76. Karlsson JA, Choudry NB, Zackrisson C, Fuller RW (1992) A comparison of the effect of inhaled diuretics on airway reflexes in humans and guinea pigs. J Appl Physiol 72(2):434-8
77. Karlsson JA, Lanner AS, Persson CG (1990) Airway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in guinea pigs. J Pharmacol Exp Ther 252(2):863-8
78. Kay IS, Armstrong DJ (1991) MDL 72222 (a selective 5-HT3 receptor antagonist) prevents stimulation of intrapulmonary C fibres by pulmonary embolization in anaesthetized rabbits. Exp Physiol 76(2):213-18
79. Klapproth H, Reinheimer T, Metzen J, Munch M, Bittinger F, Kirkpatrick CJ, Hohle KD, Schemann M, Racke K, Wessler I (1997) Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man. Naunyn Schmiedebergs Arch Pharmacol 355(4):515-23
80. Kobayashi K, Fukuoka T, Obata K, Yamanaka H, Dai Y, Tokunaga A, Noguchi K (2005) Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors. J Comp Neurol 493(4):596-606
81. Kollarik M, Undem BJ (2006) Sensory transduction in cough-associated nerves. Respir Physioleurobiol 152(3):243-54
82. Kollarik M, Undem BJ (2003) Activation of bronchopulmonary vagal afferent nerves with bradykinin, acid and vanilloid receptor agonists in wild-type and TRPV1t/t mice. J Physiol 555(Part 1):115-23
83. Kollarik M, Undem BJ (2002) Mechanisms of acid-induced activation of airway afferent nerve fibres in guinea-pig. J Physiol 543(Part 2):591-600
84. Kontani H, Koshiura R (1985) The effects of morphine and morphine-related compounds on the rate of afferent discharges from the pulmonary receptors in bullfrog. Jpn J Pharmacol 38(3):295-303
85. Kopp UC, Smith LA, Pence AL (1994) Na(+)-K(+)-ATPase inhibition sensitizes renal mechanoreceptors activated by increases in renal pelvic pressure. Am J Physiol 267(4, Part 2):R1109-R1117
86. Kopriva F, Sobolova L, Szotkowska J, Zapalka M (2004) Treatment of chronic cough in children with montelukast, a leukotriene receptor antagonist. J Asthma 41(7):715-20
87. Kwong K, Lee LY (2005) Prostaglandin E2 potentiates a TTX-resistant sodium current in rat capsaicin-sensitive vagal pulmonary sensory neurones. J Physiol 564(Part 2):437-50
88. Laduron PM (1984) Axonal transport of opiate receptors in capsaicin-sensitive neurones. Brain Res 294(1):157-60
89. Lankiewicz S, Lobitz N, Wetzel CH, Rupprecht R, Gisselmann G, Hatt H (1998) Molecular cloning, functional expression, and pharmacological characterization of 5-hydroxytryptamine3 receptor cDNA and its splice variants from guinea pig. Mol Pharmacol 53(2):202-12
90. Laude EA, Morice AH, Grattan TJ (1994) The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs. Pulm Pharmacol 7(3):179-84
91. Lee LY, Burki NK, Gerhardstein DC, Gu Q, Kou YR, Xu J (2007) Airway irritation and cough evoked by inhaled cigarette smoke: role of neuronal nicotinic acetylcholine receptors. Pulm Pharmacol Ther 20(4):355-64
92. Lee LY, Gerhardstein DC,Wang AL, Burki NK (1993) Nicotine is responsible for airway irritation evoked by cigarette smoke inhalation in men. J Appl Physiol 75(5):1955-61
93. Lee LY, Morton RF (1993) Histamine enhances vagal pulmonary C-fiber responses to capsaicin and lung inflation. Respir Physiol 93(1):83-96
94. Lee MG, Undem BJ, Brown C, Carr MJ (2006) Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigs. Am J Respir Crit Care Med 173(3):271-5
95. Lee MG, Macglashan DW Jr, Undem BJ (2005) Role of chloride channels in bradykinin-induced guinea pig airway vagal C-fibre activation. J Physiol 566(Part 1):205-12
96. Lukas RJ, Changeux JP, Le Novere N, Albuquerque EX, Balfour DJ, Berg DK, Bertrand D, Chiappinelli VA, Clarke PB, Collins AC, Dani JA, Grady SR, Kellar KJ, Lindstrom JM, Marks MJ, Quik M, Taylor PW, Wonnacott S (1999) International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol51(2):397-401
97. Rev Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM (2006) More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci 32(4):335-43 Mamet J, Baron A, Lazdunski M, Voilley N (2002) Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels. J Neurosci 22(24):10662-70
98. Mao D, Yasuda RP, Fan H, Wolfe BB, Kellar KJ (2006) Heterogeneity of nicotinic cholinergic receptors in rat superior cervical and nodose ganglia. Mol Pharmacol 70(5):1693-9
99. Mazzone SB, McGovern AE (2006) Na+-K+-2Cl- cotransporters and Cl- channels regulate citric acid cough in guinea pigs. J Appl Physiol 101(2):635-43
100. Mazzone SB, Mori N, Canning BJ (2005) Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs. J Physiol 569(Part 2):559-73
101. Mazzone SB (2005) An overview of the sensory receptors regulating cough. Cough 1:2 Mazzone SB (2004a) Sensory regulation of the cough reflex. Pulm Pharmacol Ther 17(6):361-8
102. Mazzone SB (2004b) Targeting tachykinins for the treatment of obstructive airways disease. Treat Respir Med 3(4):201-16
103. Mazzone SB, Canning BJ (2002) Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs. Am J Physiol Regul Integr Comp Physiol 283(1):R86-R98
104. McAlexander MA, Myers AC, Undem BJ (1999) Adaptation of guinea-pig vagal airway afferent neurones to mechanical stimulation. J Physiol 521(Part 1):239-47
105. McAlexander MA, Myers AC, Undem BJ (1998) Inhibition of 5-lipoxygenase diminishes neurally 51(2):397-401
106. evoked tachykinergic contraction of guinea pig isolated airway. J Pharmacol Exp Ther 285(2):602-7
107. McKemy DD, Neuhausser WM, Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416(6876):52-8
108. McLeod RL, Jia Y, Fernandez X, Parra LE, Wang X, Tulshian DB, Kiselgof EJ, Tan Z, Fawzi AB, Smith-Torhan A, Zhang H, Hey JA (2004) Antitussive profile of the NOP agonist Ro-64-6198 in the guinea pig. Pharmacology 71(3):143-9
109. McLeod RL, Parra LE, Mutter JC, Erickson CH, Carey GJ, Tulshian DB, Fawzi AB, Smith-Torhan A, Egan RW, Cuss FM, Hey JA (2001) Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors. Br J Pharmacol 132(6):1175-8
110. Mohammed SP, Higenbottam TW, Adcock JJ (1993) Effects of aerosol-applied capsaicin, histamine and prostaglandin E2 on airway sensory receptors of anaesthetized cats. J Physiol 469:51-66
111. Moore KA, Undem BJ, Weinreich D (2000) Antigen inhalation unmasks NK-2 tachykinin receptor-mediated responses in vagal afferents. Am J Respir Crit Care Med 161(1):232-6
112. Morice AH, Marshall AE, Higgins KS, Grattan TJ (1994) Effect of inhaled menthol on citric acid induced cough in normal subjects. Thorax 49(10):1024-6
113. Myers AC, Kajekar R, Undem BJ (2002) Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am J Physiol Lung Cell Mol Physiol 282(4):L775-L781
114. Nilius B, Owsianik G, Voets T, Peters JA (2007) Transient receptor potential cation channels in disease. Physiol Rev 87(1):165-217
115. Nishitsuji M, Fujimura M, Oribe Y, Nakao S (2007) Effect of montelukast in a guinea pig model of cough variant asthma. Pulm Pharmacol Ther 2008;21(1):142-5.
116. Oh EJ,Weinreich D (2004) Bradykinin decreases K(+) and increases Cl(-) conductances in vagal afferent neurones of the guinea pig. J Physiol 558(Part 2):513-26
117. Oh EJ, Thompson LP, Weinreich D (2000) Sexually dimorphic regulation of NK-1 receptormediated electrophysiological responses in vagal primary afferent neurons. J Neurophysiol 84(1):51-6
118. Ozaki N, Sengupta JN, Gebhart GF (2000) Differential effects of mu-, delta-, and kappa-opioidreceptor agonists on mechanosensitive gastric vagal afferent fibers in the rat. J Neurophysiol 83(4):2209-16
119. Pack AI, DeLaney RG (1983) Response of pulmonary rapidly adapting receptors during lung inflation.J Appl Physiol 55(3):955-63
120. Patel T, Ishiuji Y, Yosipovitch G (2007) Menthol: a refreshing look at this ancient compound. J AmAcad Dermatol 57(5):873-8
121. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A (2002) A TRP channel that senses cold stimuli and menthol. Cell 108(5):705-15
122. Pelleg A, Hurt CM (1996) Mechanism of action of ATP on canine pulmonary vagal C fibre nerve terminals. J Physiol 490(Part 1):265-75
123. Proudfoot CJ, Garry EM, Cottrell DF, Rosie R, Anderson H, Robertson DC, Fleetwood-Walker SM,Mitchell R (2006) Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain. Curr Biol 16(16):1591-605
124. Reid G (2005) ThermoTRP channels and cold sensing: what are they really up to? Pflugers Arch 451(1):250-63
125. Reid G, Babes A, Pluteanu F (2002) A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction. J Physiol 545(Part 2):595-614
126. Riccio MM, Proud D (1996) Evidence that enhanced nasal reactivity to bradykinin in patients with symptomatic allergy is mediated by neural reflexes. J Allergy Clin Immunol 97(6):1252-63
127. Riccio MM, Kummer W, Biglari B, Myers AC, Undem BJ (1996) Interganglionic segregation of distinct vagal afferent fibre phenotypes in guinea-pig airways. J Physiol 496(Part 2):521-30
128. Roberts AM, Schultz HD, Green JF, Armstrong DJ, Kaufman MP, Coleridge HM, Coleridge JC (1985) Reflex tracheal contraction evoked in dogs by bronchodilator prostaglandins E2 and I2. J Appl Physiol 58(6):1823-31
129. Sant'Ambrogio FB, Sant'Ambrogio G, Anderson JW (1993) Effect of furosemide on the response of laryngeal receptors to low-chloride solutions. Eur Respir J 6(8):1151-5
130. Shankley CE, Anderson CW, Adcock JJ (1992) Effect of BW443C81, a novel opioid, on noncholinergicbronchoconstrictor responses and neurogenic plasma extravasation in the guinea pig. Agents Actions 36(1-2):22-8
131. Shin J, Cho H, Hwang SW, Jung J, Shin CY, Lee SY, Kim SH, Lee MG, Choi YH, Kim J, Haber NA, Reichling DB, Khasar S, Levine JD, Oh U (2002) Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl Acad Sci USA 99(15):10150-5
132. Spies M, Lips KS, Kurzen H, Kummer W, Haberberger RV (2006) Nicotinic acetylcholine receptors containing subunits alpha3 and alpha5 in rat nociceptive dorsal root ganglion neurons. J Mol Neurosci 30(1-2):55-6
133. Stone R, Barnes PJ, Fuller RW (1992) Contrasting effects of prostaglandins E2 and F2 alpha on sensitivity of the human cough reflex. J Appl Physiol 73(2):649-53
134. Stone RA, Barnes PJ, Chung KF (1993) Effect of frusemide on cough responses to chloridedeficient solution in normal and mild asthmatic subjects. Eur Respir J 6(6):862-7
135. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112(6):819-29
136. Takahama K, Shirasaki T (2007) Central and peripheral mechanisms of narcotic antitussives:codeine-sensitive and -resistant coughs. Cough 3:8
137. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, BasbaumAI, Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21(3):531-43
138. Undem BJ, Chuaychoo B, Lee MG,Weinreich D, Myers AC, Kollarik M (2004) Subtypes of vagalafferent C-fibres in guinea-pig lungs. J Physiol 556(Part 3):905-17
139. ndem BJ, Weinreich D (1993) Electrophysiological properties and chemosensitivity of guineapig nodose ganglion neurons in vitro. J Auton Nerv Syst 44(1):17-33
140. Ventresca PG, Nichol GM, Barnes PJ, Chung KF (1990) Inhaled furosemide inhibits cough inducedby low chloride content solutions but not by capsaicin. Am Rev Respir Dis 142(1):143-6
141. Weinreich D, Koschorke GM, Undem BJ, Taylor GE (1995) Prevention of the excitatory actions of bradykinin by inhibition of PGI2 formation in nodose neurones of the guinea-pig. J Physiol 483(Part 3):735-46
142. Weinreich D,Wonderlin WF (1987) Inhibition of calcium-dependent spike after-hyperpolarization increases excitability of rabbit visceral sensory neurones. J Physiol 394:415-27
143. Winner E, Zhang JW, Proctor M, Yu J (2005) Ouabain stimulates slowly adapting pulmonary stretch receptors. Sheng Li Xue Bao 57(6):689-95
144. Wright CE, Laude EA, Grattan TJ, Morice AH (1997) Capsaicin and neurokinin A-induced bronchoconstriction in the anaesthetized guinea-pig: evidence for a direct action of menthol on isolated bronchial smooth muscle. Br J Pharmacol 121(8):1645-50
145. Xing H, Ling J, Chen M, Gu JG (2006) Chemical and cold sensitivity of two distinct populationsof TRPM8-expressing somatosensory neurons. J Neurophysiol 95(2):1221-30
146. Xu J, YangW, Zhang G, Gu Q, Lee LY (2007) Calcium transient evoked by nicotine in isolated rat vagal pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol 292(1):L54-L61
147. Yu J, Wang YF, Zhang JW (2003) Structure of slowly adapting pulmonary stretch receptors in the lung periphery. J Appl Physiol 95(1):385-93
148. Zhang L, Jones S, Brody K, CostaM, Brookes SJ (2004) Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse. Am J Physiol Gastrointest Liver Physiol 286(6):G983-G991