Antitussive profile of the NOP agonist Ro-64-6198 in the guinea pig

Pharmacology

Volumn 71, Issue 3, 2004, Pages 143-149

  McLeod, Robbie L ^a   Jia, Yanlin ^a   Fernandez, Xiomara ^a   Parra, Leonard E ^a   Wang, Xin ^a   Tulshian, Deen B ^a   Kiselgof, Eugenia J ^a   Tan, Zheng ^a   Fawzi, Ahmad B ^a   Smith Torhan, April ^a   Zhang, Hongtao ^a   Hey, John A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cough; Nociceptin; Nodose ganglia; NOP agonist; NOP stimulation; Ro 64 6198; Ro 64 6198, antitussive effects

Indexed keywords

1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 8 (2,3,3A,4,5,6 HEXAHYDRO 1H PHENALEN 1 YL) 1 PHENYL 1,3,8 TRIAZASPIRO[4.5]DECAN 4 ONE; 8 (2,3,3A,4,5,6 HEXAHYDRO 1H PHENALEN 1 YL)PHENYL 1,3,8 TRIAZASPIRO[4,5]DECAN 4 ONE; ANTITUSSIVE AGENT; BACLOFEN; BENZENE DERIVATIVE; CALCIUM ION; CAPSAICIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); NALTREXONE; NOCICEPTIN RECEPTOR AGONIST; NOCICEPTIN RECEPTOR ANTAGONIST; OPIATE ANTAGONIST; UNCLASSIFIED DRUG;

ADDICTION; AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING ASSAY; BLOOD BRAIN BARRIER; CALCIUM CELL LEVEL; CONSTIPATION; CONTROLLED STUDY; COUGHING; DOSE RESPONSE; DRUG BINDING; DRUG EFFECT; DRUG MECHANISM; DRUG PENETRATION; EXPERIMENTAL ANIMAL; EXPOSURE; GUINEA PIG; MALE; MOLECULAR INTERACTION; NODOSE GANGLION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RESPIRATION DEPRESSION; SEDATION; STATISTICAL SIGNIFICANCE;

AEROSOLS; ANIMALS; ANTITUSSIVE AGENTS; CALCIUM; CAPSAICIN; CHO CELLS; COUGH; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; IMIDAZOLES; INJECTIONS, INTRAPERITONEAL; MALE; NODOSE GANGLION; RECEPTORS, OPIOID; SPIRO COMPOUNDS;

EID: 2642563443     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077448     Document Type: Article

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