Molecular cloning, functional expression, and pharmacological characterization of 5-hydroxytryptamine3 receptor cDNA and its splice variants from guinea pig

Molecular Pharmacology

Volumn 53, Issue 2, 1998, Pages 202-212

  Lankiewicz, Silke ^a   Lobitz, Nicole ^a   Wetzel, Christian H R ^a   Rupprecht, Rainer ^b   Gisselmann, Günter ^a   Hatt, Hanns ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 CHLOROPHENYL)BIGUANIDE; 2 METHYLSEROTONIN; COMPLEMENTARY DNA; METOCLOPRAMIDE; PHENYLBIGUANIDE; SEROTONIN; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; SEROTONIN 3 RECEPTOR; TROPISETRON;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; EMBRYO; GENE EXPRESSION; GUINEA PIG; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR CLONING; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SYNAPTIC TRANSMISSION;

EID: 0031886383     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.53.2.202     Document Type: Article

References (37)

1. 3 receptor in mammalian brain: a new target for development of psychotropic drugs? Neuropsychopharmacology 8:117-130.
2. Barnard EA (1992) Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci 17:368-374.
3. Betz H (1990) Ligand-gated ion channels in the brain: the amino acid receptor superfamily. Neuron 5:383-392.
4. 3 receptor which modulates the release of 5-HT in the guinea-pig brain. Br J Pharmacol 108:13-22.
5. 3 receptors in three isolated preparations derived from guinea-pig tissues. Br J Pharmacol 101:591-598.
6. Costall B, Domeney AM, Kelly ME, Naylor RJ, and Tyers MB (1993) The antipsychotic potential of GR38032F, a selective antagonist of 5-HT3 receptors in the central nervous system. Br J Pharmacol 90:89.
7. Eisele JL, Bertrand S, Galzi JL, Devillers-Thiery A, Changgeux LP, and Bertrand D (1993) Chimaerie nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature (Lond) 366:479-483.
8. 3 receptor-A mRNA in NG108-15 cells. J Neurochem 65:1917-1925.
9. Geballe AP and Morris DR (1994) Initiation codons within 5′-leaders of mRNAs as regulators of translation. Trends Biochem Sci 19:159-164.
10. Gorman CM, Gies DR, and McCray G (1990) Transient production of proteins using an adenovirus transformed cell line. DNA Prot Eng Tech 2:3-10.
11. Gralla RJ, Hri LM, Pisko SE, Squillant AE, Kelsen DP, Braun DW, Bordin LA, Braun TJ, and Young CW (1991) Antiemetic efficacy of high dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med 305:905-909.
12. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflueg Arch Eur J Physiol 391:85-100.
13. 3 receptor A subunit. Eur J Pharmacol 245:187-192.
14. 3 receptors in rat brain using radioligand binding. Nature (Lond) 330:746-748.
15. 3H]GR65630 in rat brain using quantitative autoradiography. Neurosci Lett 94:156-160.
16. 3 receptor. Biochem Soc Trans 20:118-121.
17. Klug J, Wolf M, and Beato M (1991) Creating chimeric molecules by PCR directed homologous DNA recombination. Nucleic Acids Res 19:2793.
18. Kozak M (1989) The scanning model for translation: an update. J Cell Biol 108:229-241.
19. Lankiewicz S, Gisselmann G, and Hatt H (1997) Enhanced RACE method using specific enrichment by biotinylated oligonucleotides bound to streptavidin coated magnetic particles. Nucleic Acids Res 25:2037-2038.
20. 3 receptor, a serotonin-gated ion channel. Science (Washington DC) 254:432-437.
21. 3 receptor splice variants in the rat. J Neurochem 65:475-483.
22. Marshall RD (1972) Glycoproteins. Annu Rev Biochem 41:673-702.
23. 3 receptor: heterogeneity in distribution and function among species. Mol Pharmacol 48:407-416.
24. Munson PJ and Rodbard D (1980) LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107:220-239.
25. 3 receptors. Trends Pharmacol Sci 13:391-397.
26. Pinna LA (1990) Casein kinase 2: an 'eminence grise' in cellular regulation? Biochim Biophys Acta 1054:267-284.
27. 3 receptor antagonists, ondansetron and 100289, in the elevated plus-maze test of anxiety of mice. Psychopharmacology 117:306-312.
28. Sargent PB (1993) The diversity of neuronal nicotinic acetylcholine receptors. Annu Rev Neurosci 16:403-443.
29. Stroud RM, McCarthy MP, and Shuster M (1990) Nicotinic acetylcholine receptor superfamily of ligand-gated ion channels. Biochemistry 50:11009-11023.
30. 3 receptor mRNA. Proc Natl Acad Sci USA 90:1430-1434.
31. 3 receptor gene and assignment to human chromosome 11. FEBS Lett 339:302-306.
32. 3 receptor ligand-gated ion channels. Recept Channels 3:7-12.
33. Warburton AC, Joseph MH, Felden J, Weiner I, and Gray JA (1994) Antagonism of amphetamine-induced disruption of latent inhibition in rats by haloperidol and ondansetron implication for a possible antipsychotic action of ondansetron. Psychopharmacology 114:657-664.
34. 3 receptor gene and functional expression of two splice variants. Mol Brain Res 26:233-241.
35. Woodgett JR, Gould KL, and Hunter T (1986) Substrate specificity of protein kinase C. Eur J Biochem 161:177-184.
36. 3 Receptors (Hamon M, ed) pp 103-128, Academic Press, London.
37. Zoldan J, Friedberg G, Goldberg-Stern H, and Melamed E (1993) Ondansetron for hallucinosis in advanced Parkinson's disease. Lancet 341:562-563.