Characterization of vagal afferent subtypes stimulated by bradykinin in guinea pig trachea

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 2, 1999, Pages 682-687

  Kajekar, Radhika ^a   Proud, David ^a   Myers, Allen C ^a   Meeker, Sonya N ^a   Undem, Bradley J ^a  

^a JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ; BRADYKININ B2 RECEPTOR ANTAGONIST; NEUROPEPTIDE;

ACTION POTENTIAL; ANIMAL TISSUE; BRONCHUS; CONFERENCE PAPER; ELECTROPHYSIOLOGY; GANGLION; GUINEA PIG; MALE; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE; TRACHEA; VAGUS NERVE;

ACTION POTENTIALS; ANIMALS; BRADYKININ; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GUINEA PIGS; MALE; NERVE FIBERS; NEURAL CONDUCTION; NEURONS, AFFERENT; NODOSE GANGLION; PRESYNAPTIC TERMINALS; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; STIMULATION, CHEMICAL; TRACHEA; VAGUS NERVE;

EID: 0032926445     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (18)

1. Altman J and Bayer SA (1982) Development of the cranial nerve ganglia and related nuclei in the rat. Adv Anat Embryol Cell Biol 74:1-90.
2. Barnes PJ (1992) Effect of bradykinin on airway function. Agents Actions Suppl 38:432-438.
3. Bergren DR (1997) Sensory receptor activation by mediators of defense reflexes in guinea-pig lungs. Respir Physiol 108:195-204.
4. Dendorfer A, Vordermark D and Dominiak P (1997) Degradation of bradykinin by bovine tracheal epithelium and isolated epithelial cells. Br J Pharmacol 120:121-129.
5. Fox AJ, Barnes PJ, Urban L and Dray A (1993) An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J Physiol (Lond) 469:21-35.
6. Geppetti P (1993) Sensory neuropeptide release by bradykinin: Mechanisms and pathophysiological implications. Regul Pept 47:1-23.
7. Hock FJ, Wirth K, Albus U, Linz W, Gerhards HJ, Wiemer G, Henke S, Breipohl G, Konig W, Knolle J and Scholkens BA (1991) Hoe 140: A new potent and long acting bradykinin-antagonist: In vitro studies. Br J Pharmacol 102:769-773.
8. Ichinose M and Barnes PJ (1990) Bradykinin-induced airway microvascular leakage and bronchoconstriction are mediated via a bradykinin B2 receptor. Am Rev Respir Dis 142:1104-1107.
9. Ichinose M, Belvisi MG and Barnes PJ (1990) Bradykinin-induced bronchoconstriction in guinea pig in vivo: Role of neural mechanisms. J Pharmacol Exp Ther 263:594-599.
10. Inoue H, Koto H, Takata S, Aizawa H and Ikeda T (1992) Excitatory role of axon reflex in bradykinin-induced contraction of guinea pig tracheal smooth muscle. Am Rev Respir Dis 146:1548-1552.
11. Kummer W, Fischer A, Kurkowski R and Heym C (1992) The sensory and sympathetic innervation of guinea-pig lung and trachea as studied by retrograde neuronal tracing and double-labelling immunohistochemistry. Neuroscience 49:715-737.
12. Lundberg JM (1995) Tachykinins, sensory nerves, and asthma: An overview. Can J Physiol Pharmacol 73:908-914.
13. Miura M, Belvisi MG and Barnes PJ (1992) Effect of bradykinin on airway neural responses in vitro. J Appl Physiol 73:1537-1541.
14. Pedersen KE, Meeker SN, Riccio MM and Undem BJ (1998) Selective stimulation of jugular ganglion afferent neurons in guinea pig airways by hypertonic saline. J Appl Physiol 84:499-506.
15. Riccio MM, Kummer W, Biglari B, Myers AC and Undem BJ (1996) Interganglionic segregation of distinct vagal afferent fibre phenotypes in guinea-pig airways. J Physiol (Lond) 496:521-530.
16. Saria A, Lundberg JM, Skofitsch G and Lembeck F (1983) Vascular protein leakage in various tissues induced by Substance P, capsaicin, bradykinin, serotonin, histamine and by antigen challenge. Naunyn-Schmeidelberg's Arch Pharmacol 324: 212-218.
17. Undem BJ and Weinreich D (1993) Electrophysiological properties and chemosensitivity of guinea pig nodose ganglion neurons in vitro. J Auton Nerv Syst 44:17-34.
18. Weinreich D, Koschorke GM, Undem BJ and Taylor GE (1995) Prevention of the excitatory actions of bradykinin by inhibition of PGI(2) formation in nodose neurones of the guinea-pig. J Physiol (Lond) 483:735-746.